Entry
Name
4-hydroxybutyrate---CoA ligase (AMP-forming);
4-hydroxybutyrate-CoA synthetase (ambiguous);
4-hydroxybutyrate:CoA ligase (ambiguous);
hbs (gene name);
4-hydroxybutyrate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-hydroxybutanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA [RN:
R09279 ]
Reaction(KEGG)
Substrate
Product
Comment
Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle. cf. EC
6.2.1.56 , 4-hydroxybutyrate---CoA ligase (ADP-forming).
History
EC 6.2.1.40 created 2014, modified 2019
Pathway
ec00720 Other carbon fixation pathways
ec01120 Microbial metabolism in diverse environments
Orthology
K14466 4-hydroxybutyrate---CoA ligase (AMP-forming)
K14467 4-hydroxybutyrate---CoA ligase (AMP-forming)
K18861 4-hydroxybutyrate---CoA ligase (AMP-forming)
K25774 4-hydroxybutyrate---CoA ligase (AMP-forming)
Genes
SCAS : SACC_13950 SACC_26260
SACN : SacN8_05595 SacN8_10445
SACR : SacRon12I_05585 SacRon12I_10700
SACS : SUSAZ_05485 SUSAZ_09795
MSE : Msed_0394 Msed_0406 Msed_1422
MEMJ : MJ1HA_0488 MJ1HA_0500 MJ1HA_1635
MCN : Mcup_0813 Mcup_1674 Mcup_1685
MHK : DFR87_04145 DFR87_04415 DFR87_11765
MPRU : DFR88_04555 DFR88_04635 DFR88_11205
MTEN : GWK48_03480 GWK48_07380 GWK48_07475
MJN : MjAS7_1080 MjAS7_1095 MjAS7_2493
ABRI : DFR85_01145 DFR85_14760 DFR85_15495
ACIH : HS5_10870 HS5_22950
CSTY : KN1_05110 KN1_25190 KN1_28400
SMET : RQ359_000462 RQ359_000992
» show all
Taxonomy
Reference
Authors
Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G
Title
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.
Journal
Sequence
Reference
Authors
Hawkins AS, Han Y, Bennett RK, Adams MW, Kelly RM
Title
Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.40
ExPASy - ENZYME nomenclature database: 6.2.1.40