KEGG   ENZYME: 6.2.1.47Help
Entry
EC 6.2.1.47                 Enzyme                                 

Name
medium-chain-fatty-acid---[acyl-carrier-protein] ligase;
jamA (gene name)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
medium-chain-fatty-acid:[acyl-carrier protein] ligase (AMP-forming)
Reaction(IUBMB)
ATP + a medium-chain fatty acid + a holo-[acyl-carrier protein] = AMP + diphosphate + a medium-chain acyl-[acyl-carrier protein] [RN:R12148]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
medium-chain fatty acid [CPD:C21925];
holo-[acyl-carrier protein] [CPD:C00229]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
medium-chain acyl-[acyl-carrier protein] [CPD:C21927]
Comment
The enzyme ligates medium chain fatty acids (with aliphatic chain of 6-12 carbons) to an acyl-carrier protein.
History
EC 6.2.1.47 created 2016
Orthology
K21107  medium-chain-fatty-acid---[acyl-carrier-protein] ligase
Reference
1  [PMID:15217615]
  Authors
Edwards DJ, Marquez BL, Nogle LM, McPhail K, Goeger DE, Roberts MA, Gerwick WH.
  Title
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.
  Journal
Chem Biol 11:817-33 (2004)
DOI:10.1016/j.chembiol.2004.03.030
  Sequence
Reference
2  [PMID:25531891]
  Authors
Zhu X, Liu J, Zhang W
  Title
De novo biosynthesis of terminal alkyne-labeled natural products.
  Journal
Nat Chem Biol 11:115-20 (2015)
DOI:10.1038/nchembio.1718
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.47
IUBMB Enzyme Nomenclature: 6.2.1.47
ExPASy - ENZYME nomenclature database: 6.2.1.47
BRENDA, the Enzyme Database: 6.2.1.47
CAS: 77322-37-3

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