KEGG   ENZYME: 6.2.1.48Help
Entry
EC 6.2.1.48                 Enzyme                                 

Name
carnitine---CoA ligase;
caiC (gene name)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
L-carnitine:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA [RN:R11632]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-carnitine [CPD:C00318];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
L-carnitinyl-CoA [CPD:C20750]
Comment
The enzyme, originally characterized from the bacterium Escherichia coli, can catalyse the transfer of CoA to L-carnitine, crotonobetaine and gamma-butyrobetaine. In vitro the enzyme also exhibits the activity of EC 2.8.3.21, L-carnitine CoA-transferase.
History
EC 6.2.1.48 created 2017
Orthology
K02182  carnitine-CoA ligase
Genes
ECO: b0037(caiC)
ECJ: JW0036(caiC)
ECD: ECDH10B_0038(caiC)
EBW: BWG_0035(caiC)
ECOK: ECMDS42_0030(caiC)
ECE: Z0043(caiC)
ECS: ECs0040(caiC)
ECF: ECH74115_0041(caiC)
ETW: ECSP_0040(caiC)
ELX: CDCO157_0039(caiC)
EOJ: ECO26_0038(caiC)
EOI: ECO111_0038(caiC)
EOH: ECO103_0039(caiC)
ECOO: ECRM13514_0038(caiC)
ECOH: ECRM13516_0040(caiC)
ECG: E2348C_0038(caiC)
EOK: G2583_0039(caiC)
ELR: ECO55CA74_00185(caiC)
ESO: O3O_04025(caiC)
ESM: O3M_21260(caiC)
ESL: O3K_21360(caiC)
ELH: ETEC_0037
EUN: UMNK88_37
ECC: c0046(caiC)
ECP: ECP_0037
ECI: UTI89_C0043(caiC)
ECV: APECO1_1944(caiC)
ECY: ECSE_0038
ECR: ECIAI1_0039(caiC)
ECQ: ECED1_0036(caiC)
ECK: EC55989_0037(caiC)
ECT: ECIAI39_0038(caiC)
EOC: CE10_0038(caiC)
EUM: ECUMN_0039(caiC)
ECZ: ECS88_0040(caiC)
ELO: EC042_0039(caiC)
ELN: NRG857_00195(caiC)
ESE: ECSF_0042
EBR: ECB_00041(caiC)
EBD: ECBD_3578
EKF: KO11_00185(caiC)
EAB: ECABU_c00420(caiC)
EDJ: ECDH1ME8569_0036(caiC)
ENA: ECNA114_0024(caiC)
ELU: UM146_22965(caiC)
ELW: ECW_m0037(caiC)
ELL: WFL_00185(caiC)
ELC: i14_0039(caiC)
ELD: i02_0039(caiC)
ELP: P12B_c0032(caiC)
EBL: ECD_00041(caiC)
EBE: B21_00040(caiC)
ELF: LF82_0259(caiC)
ECOA: APECO78_03645(caiC)
ECOL: LY180_00190(caiC)
ECOI: ECOPMV1_00038(fadK_1)
ECOJ: P423_00185(caiC)
ECOS: EC958_0171(caiC)
EFE: EFER_0045(caiC)
EAL: EAKF1_ch1385(caiC)
STY: STY0081(caiC)
STT: t0072(caiC)
SENT: TY21A_00370(caiC)
STM: STM0071(caiC)
SEO: STM14_0084(caiC)
SEY: SL1344_0072(caiC)
SEM: STMDT12_C00720(caiC)
SEJ: STMUK_0072(caiC)
SEB: STM474_0074(caiC)
SEF: UMN798_0079(caiC)
SETU: STU288_00355(caiC)
SENR: STMDT2_00721(caiC)
SEND: DT104_00721(caiC)
SENI: CY43_00350(caiC)
SPT: SPA0072(caiC)
SEK: SSPA0068
SEI: SPC_0076(caiC)
SEC: SCH_0065(caiC)
SHB: SU5_0706
SEEH: SEEH1578_09385(caiC)
SENS: Q786_00350
SED: SeD_A0077
SEL: SPUL_0076(caiC)
SEGA: SPUCDC_0076(caiC)
SET: SEN0072(caiC)
SENA: AU38_00350(caiC)
SENO: AU37_00350(caiC)
SENV: AU39_00350(caiC)
SENQ: AU40_00385(caiC)
SENL: IY59_00365(caiC)
SENJ: CFSAN001992_10670(caiC)
SEEP: I137_00330
SENB: BN855_740(caiC)
SENE: IA1_00360
SENC: SEET0819_07245(caiC)
SBG: SBG_0056(caiC)
SBZ: A464_59
SFL: SF0034(caiC)
SFX: S0036(caiC)
SFV: SFV_0031(caiC)
SFE: SFxv_0035(caiC)
SFN: SFy_0043
SFS: SFyv_0047
SFT: NCTC1_00034(caiC)
SSN: SSON_0043(caiC)
SDY: SDY_0059(caiC)
SHQ: A0259_04025(caiC)
CKO: CKO_03346
CRO: ROD_00391(caiC)
CFD: CFNIH1_09895(caiC)
CAMA: F384_00200(caiC)
EBT: EBL_c33160(caiC)
KLE: AO703_09850(caiC)
KIN: AB182_21545(caiC)
EBF: D782_3832
PMR: PMI2657(caiC)
PMIB: BB2000_2648(caiC)
PRG: RB151_007320(lcfB)
PHEI: NCTC12003_00740(fadD_1)
ETR: ETAE_2658(caiC1) ETAE_2661(caiC2)
ETC: ETAC_12775(caiC) ETAC_12785(caiC)
EDW: QY76_07190(caiC) QY76_07200(caiC)
EDL: AAZ33_14065(caiC) AAZ33_14075(caiC)
HAV: AT03_19290(caiC)
OPO: DSM2777_06095(caiC)
LRI: NCTC12151_02502(fadK)
PCQ: PcP3B5_37120(lcfB_4) PcP3B5_42340(fadD_5)
PFE: PSF113_3400(ditJ)
SLO: Shew_2673
SSE: Ssed_3226
SPL: Spea_4035
SHL: Shal_0223
SWP: swp_4935
CPS: CPS_3345
MAD: HP15_43(caiC)
GPS: C427_5374
MICC: AUP74_02415(lcfB_2)
ADI: B5T_02172
REH: H16_A1230(h16_A1230)
CNC: CNE_BB1p03950(fadD1) CNE_BB2p00470(lcfB)
BCJ: BCAM2136
BCEN: DM39_6283
BCEO: I35_6018
BMUL: NP80_3858
BPSL: WS57_16500
BUO: BRPE64_CCDS06690(caiC)
BPH: Bphy_7061
BFN: OI25_3873
PPNO: DA70_04815
PPNM: LV28_01440
PPUL: RO07_20385
PAPI: SG18_19500
BPET: B1917_0331
BHM: D558_1654
PUT: PT7_2712
AFQ: AFA_00970
VEI: Veis_3436
CTES: O987_22330
HYB: Q5W_23060
EBA: p2A386(ditJ)
AZA: AZKH_1894
CPIN: CPIN18020_0493(caiC)
DAL: Dalk_3833
DBR: Deba_3197
PLA: Plav_1667
SHZ: shn_26735
BRA: BRADO7132
BRS: S23_69410
AOL: S58_72750
BRAD: BF49_7309
RPA: RPA4829(caiC)
RPB: RPB_4705
RPD: RPD_4415
VGO: GJW-30_1_03251(sauT)
MET: M446_3855
MMED: Mame_01588(lcfB_3)
CAK: Caul_1907
SPSE: SULPSESMR1_01209(caiC)
HBA: Hbal_2589
NAR: Saro_2453
TMO: TMO_b0188(caiC) TMO_b0496(caiC) TMO_b0524(caiC)
BCZ: BCE33L2688(fadD)
BCX: BCA_3041
BAL: BACI_c29260(caiC)
BCF: bcf_14490
BTK: BT9727_2709(caiC)
BTL: BALH_2656(caiC)
BTW: BF38_4123
BWW: bwei_2056(fadD6)
BACI: B1NLA3E_21255(caiC)
BKW: BkAM31D_08820(lcfB_2) BkAM31D_08825(sauT) BkAM31D_08830(lcfB_3)
BTS: Btus_0314
RHO: RHOM_09540(caiC)
DRM: Dred_0576
MAO: MAP4_1481
MAVI: RC58_07355
MAVU: RE97_07355
MAVD: NF84_07285
MAVR: LA63_07420
MAVA: LA64_07445
MIA: OCU_17250
MID: MIP_02355
MYO: OEM_15050
MIR: OCQ_14720
MMM: W7S_07200
MPHL: MPHLCCUG_05080(lcfB_16)
MVQ: MYVA_0930(ditJ)
MJD: JDM601_3814(fadD13)
MTER: 4434518_03696(fadD_3)
RER: RER_59430
ROP: ROP_01080
REQ: REQ_43280
RHS: A3Q41_02906(lcfB_6)
SGB: WQO_31960
SFI: SFUL_6281
SLD: T261_7717
SALF: SMD44_00396(caiC)
PFR: PFREUD_02440(caiC)
PFRE: RM25_0222
NDK: I601_1184(lcfB_4) I601_3298(lcfB_7)
PSIM: KR76_22260
TFU: Tfu_1300
FAL: FRAAL5278
AMD: AMED_8399
AMN: RAM_43125
AMM: AMES_8270
AMZ: B737_8271
AOI: AORI_7172(caiC)
KAL: KALB_3250
AHE: Arch_1361
TPYO: X956_03590
ELE: Elen_1832
CBAC: JI75_07130(caiC)
CAU: Caur_3793
CAG: Cagg_0832
GAH: GAH_00623
HTU: Htur_3794
LOKI: Lokiarch_08450(lcfB_3) Lokiarch_19490(fadD_2)
 » show all
Taxonomy
Reference
1  [PMID:7815937]
  Authors
Eichler K, Bourgis F, Buchet A, Kleber HP, Mandrand-Berthelot MA
  Title
Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli.
  Journal
Mol Microbiol 13:775-86 (1994)
DOI:10.1111/j.1365-2958.1994.tb00470.x
  Sequence
[eco:b0037]
Reference
2  [PMID:18266698]
  Authors
Bernal V, Arense P, Blatz V, Mandrand-Berthelot MA, Canovas M, Iborra JL
  Title
Role of betaine:CoA ligase (CaiC) in the activation of betaines and the transfer  of coenzyme A in Escherichia coli.
  Journal
J Appl Microbiol 105:42-50 (2008)
DOI:10.1111/j.1365-2672.2008.03740.x
  Sequence
[eco:b0037]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.48
IUBMB Enzyme Nomenclature: 6.2.1.48
ExPASy - ENZYME nomenclature database: 6.2.1.48
BRENDA, the Enzyme Database: 6.2.1.48

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