KEGG   ENZYME: 6.2.1.50Help
Entry
EC 6.2.1.50                 Enzyme                                 

Name
4-hydroxybenzoate adenylyltransferase FadD22;
fadD22 (gene name);
4-hydroxybenzoate adenylase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-hydroxybenzoate:holo-[4-hydroxyphenylalkanoate synthase] ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] (overall reaction);
(1a) ATP + 4-hydroxybenzoate = 4-hydroxybenzoyl-adenylate + diphosphate [RN:R11608];
(1b) 4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Reaction(KEGG)
R11608;
(other) R11872 R11873
Show
Substrate
ATP [CPD:C00002];
4-hydroxybenzoate [CPD:C00156];
holo-[4-hydroxyphenylalkanoate synthase];
4-hydroxybenzoyl-adenylate [CPD:C21497]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase];
4-hydroxybenzoyl-adenylate [CPD:C21497]
Comment
This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase.
History
EC 6.2.1.50 created 2017 as EC 2.7.7.98, transferred 2017 to EC 6.2.1.50
Orthology
K12424  4-hydroxybenzoate adenylyltransferase
Genes
MTU: Rv2948c(fadD22)
MTV: RVBD_2948c
MTC: MT3021
MRA: MRA_2975(fadD22)
MTF: TBFG_12962
MTB: TBMG_01023
MTK: TBSG_01031
MTZ: TBXG_001013
MTG: MRGA327_18125
MTI: MRGA423_18315
MTUR: CFBS_3107(fadD22)
MTO: MTCTRI2_3006(fadD22)
MTD: UDA_2948c(fadD22)
MTN: ERDMAN_3231(fadD22)
MTUC: J113_20530
MTUE: J114_15745
MTUH: I917_20710
MTUL: TBHG_02878
MTUT: HKBT1_3094(fadD22)
MTUU: HKBT2_3099(fadD22)
MTQ: HKBS1_3101(fadD22)
MBO: BQ2027_MB2972C(fadD22)
MBB: BCG_2969c(fadD22)
MBT: JTY_2964(fadD22)
MBM: BCGMEX_2964c(fadD22)
MBX: BCGT_2785
MAF: MAF_29530(fadD22)
MMIC: RN08_3250
MCE: MCAN_29681(fadD22)
MCQ: BN44_60423(fadD)
MCV: BN43_40655(fadD)
MCX: BN42_40947(fadD)
MCZ: BN45_51359(fadD)
MLE: ML0134(fadD22)
MLB: MLBr00134(fadD22)
MUL: MUL_2004(fadD22)
MMI: MMAR_1761(fadD22)
MMAE: MMARE11_16800(fadD22)
MLI: MULP_01916(fadD22)
MHAD: B586_03305
SCT: SCAT_5491
SBH: SBI_01640
SXI: SXIM_01890(ximA)
 » show all
Taxonomy
Reference
1  [PMID:20553505]
  Authors
Simeone R, Leger M, Constant P, Malaga W, Marrakchi H, Daffe M, Guilhot C, Chalut C
  Title
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
  Journal
FEBS J 277:2715-25 (2010)
DOI:10.1111/j.1742-464X.2010.07688.x
  Sequence
[mtu:Rv2948c]
Reference
2  [PMID:25561717]
  Authors
Vergnolle O, Chavadi SS, Edupuganti UR, Mohandas P, Chan C, Zeng J, Kopylov M, Angelo NG, Warren JD, Soll CE, Quadri LE
  Title
Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.
  Journal
J Bacteriol 197:1040-50 (2015)
DOI:10.1128/JB.02546-14
  Sequence
[mmi:MMAR_1761]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.50
IUBMB Enzyme Nomenclature: 6.2.1.50
ExPASy - ENZYME nomenclature database: 6.2.1.50
BRENDA, the Enzyme Database: 6.2.1.50

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