4-hydroxybenzoate adenylyltransferase FadD22;
fadD22 (gene name);
Forming carbon-sulfur bonds;
4-hydroxybenzoate:holo-[4-hydroxyphenylalkanoate synthase] ligase (AMP-forming)
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] (overall reaction);
(1a) ATP + 4-hydroxybenzoate = 4-hydroxybenzoyl-adenylate + diphosphate [RN:
(1b) 4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC
, 4-hydroxyphenylalkanoate synthase.
EC 188.8.131.52 created 2017 as EC 184.108.40.206, transferred 2017 to EC 220.127.116.11
K12424 4-hydroxybenzoate adenylyltransferase
STRM: M444_36455 M444_37810
SESP: BN6_22800 BN6_35920 » show all
Simeone R, Leger M, Constant P, Malaga W, Marrakchi H, Daffe M, Guilhot C, Chalut C
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
Vergnolle O, Chavadi SS, Edupuganti UR, Mohandas P, Chan C, Zeng J, Kopylov M, Angelo NG, Warren JD, Soll CE, Quadri LE
Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.
ExplorEnz - The Enzyme Database: 18.104.22.168
ExPASy - ENZYME nomenclature database: 22.214.171.124