KEGG   ENZYME: 6.2.1.50
Entry
EC 6.2.1.50                 Enzyme                                 
Name
4-hydroxybenzoate adenylyltransferase FadD22;
fadD22 (gene name);
4-hydroxybenzoate adenylase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
4-hydroxybenzoate:holo-[4-hydroxyphenylalkanoate synthase] ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] (overall reaction);
(1a) ATP + 4-hydroxybenzoate = 4-hydroxybenzoyl-adenylate + diphosphate [RN:R11608];
(1b) 4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] = AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase]
Reaction(KEGG)
R11608;
(other) R11872 R11873
Substrate
ATP [CPD:C00002];
4-hydroxybenzoate [CPD:C00156];
holo-[4-hydroxyphenylalkanoate synthase];
4-hydroxybenzoyl-adenylate [CPD:C21497]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase];
4-hydroxybenzoyl-adenylate [CPD:C21497]
Comment
This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase.
History
EC 6.2.1.50 created 2017 as EC 2.7.7.98, transferred 2017 to EC 6.2.1.50
Orthology
K12424  4-hydroxybenzoate adenylyltransferase
Genes
HCHHCH_02501
HAHEENC22_11340
MTURv2948c(fadD22)
MTVRVBD_2948c
MTCMT3021
MRAMRA_2975(fadD22)
MTFTBFG_12962
MTBTBMG_01023
MTKTBSG_01031
MTZTBXG_001013
MTGMRGA327_18125
MTIMRGA423_18315
MTECCDC5079_2708
MTURCFBS_3107(fadD22)
MTLCCDC5180_2672
MTOMTCTRI2_3006(fadD22)
MTDUDA_2948c(fadD22)
MTNERDMAN_3231(fadD22)
MTJJ112_15780
MTUBMT7199_2983
MTUCJ113_20530
MTUEJ114_15745
MTXM943_15185
MTUHI917_20710
MTULTBHG_02878
MTUTHKBT1_3094(fadD22)
MTUUHKBT2_3099(fadD22)
MTQHKBS1_3101(fadD22)
MBOBQ2027_MB2972C(fadD22)
MBBBCG_2969c(fadD22)
MBTJTY_2964(fadD22)
MBMBCGMEX_2964c(fadD22)
MBKK60_030540
MBXBCGT_2785
MAFMAF_29530(fadD22)
MMICRN08_3250
MCEMCAN_29681(fadD22)
MCQBN44_60423(fadD)
MCVBN43_40655(fadD)
MCXBN42_40947(fadD)
MCZBN45_51359(fadD)
MLEML0134(fadD22)
MLBMLBr00134(fadD22)
MULMUL_2004(fadD22)
MMIMMAR_1761(fadD22)
MMAEMMARE11_16800(fadD22)
MLIMULP_01916(fadD22)
MKNMKAN_23940
MHADB586_03305
MBAIMB901379_01576
MPSEMPSD_40750(fadD22)
MSHOMSHO_54820(fadD22)
MLJMLAC_28860(fadD22)
MSHJMSHI_07220(fadD22)
MOTLTS72_16050
MLMMLPF_0162(fadD22)
MAUBMAUB_36910(fadD22)
SCBSCAB_8391
SVLStrvi_3914
SRCM271_05895
SCTSCAT_5491
SCYSCATT_54890
SXISXIM_01890(ximA)
STRMM444_36455 M444_37810
STSIA4E84_25000
STIRDDW44_31240
SHAWCEB94_25390
SPHVF9278_43570
SCOECP976_26830
SSPBCP982_00250
THAONI17_019195
NDANdas_1765
SROSros_3763
SENSACE_4037
AMYBBKN51_40540
PHHAFB00_14380
APRECNX65_18010
AMIAmir_3554
SESPBN6_22800 BN6_35920
SSYIEKG83_31190
KPHYAOZ06_18880
PLKCIK06_25340
 » show all
Reference
1  [PMID:20553505]
  Authors
Simeone R, Leger M, Constant P, Malaga W, Marrakchi H, Daffe M, Guilhot C, Chalut C
  Title
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
  Journal
FEBS J 277:2715-25 (2010)
DOI:10.1111/j.1742-464X.2010.07688.x
  Sequence
[mtu:Rv2948c]
Reference
2  [PMID:25561717]
  Authors
Vergnolle O, Chavadi SS, Edupuganti UR, Mohandas P, Chan C, Zeng J, Kopylov M, Angelo NG, Warren JD, Soll CE, Quadri LE
  Title
Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.
  Journal
J Bacteriol 197:1040-50 (2015)
DOI:10.1128/JB.02546-14
  Sequence
[mmi:MMAR_1761]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.50
IUBMB Enzyme Nomenclature: 6.2.1.50
ExPASy - ENZYME nomenclature database: 6.2.1.50
BRENDA, the Enzyme Database: 6.2.1.50

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