KEGG   ENZYME: 6.2.1.58Help
Entry
EC 6.2.1.58                 Enzyme                                 

Name
isophthalate---CoA ligase;
IPCL
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
isophthalate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + isophthalate + CoA = AMP + diphosphate + isophthalyl-CoA [RN:R12485]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
isophthalate [CPD:C22203];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
isophthalyl-CoA [CPD:C22204]
Comment
The enzyme, characterized from the bacterium Syntrophorhabdus aromaticivorans, catalyses the first step in an anaerobic isophthalate degradation pathway.
History
EC 6.2.1.58 created 2019
Reference
1  [PMID:30647456]
  Authors
Junghare M, Spiteller D, Schink B
  Title
Anaerobic degradation of xenobiotic isophthalate by the fermenting bacterium Syntrophorhabdus aromaticivorans.
  Journal
ISME J 13:1252-1268 (2019)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.58
IUBMB Enzyme Nomenclature: 6.2.1.58
ExPASy - ENZYME nomenclature database: 6.2.1.58
BRENDA, the Enzyme Database: 6.2.1.58

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