Entry
Name
long-chain fatty acid adenylase/transferase FadD26;
FadD26
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
long-chain fatty acid:holo-[(phenol)carboxyphthiodiolenone synthase] ligase (AMP-forming)
Reaction(IUBMB)
ATP + a long-chain fatty acid + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase] (overall reaction);
(1a) ATP + a long-chain fatty acid = diphosphate + a long-chain fatty-acyl adenylate ester;
(1b) a long-chain fatty-acyl adenylate ester + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase]
Substrate
ATP [CPD:
C00002 ];
long-chain fatty acid [CPD:
C00638 ];
holo-[(phenol)carboxyphthiodiolenone synthase];
long-chain fatty-acyl adenylate ester
Product
AMP [CPD:
C00020 ];
diphosphate [CPD:
C00013 ];
long-chain acyl-[(phenol)carboxyphthiodiolenone synthase];
long-chain fatty-acyl adenylate ester
Comment
The enzyme, present in pathogenic species of mycobacteria, participates in the pathway for biosynthesis of phthiocerols. It catalyses the adenylation of the long-chain fatty acids arachidate (C20) or behenate (C22) [1] and potentially the very-long-chain fatty acid lignocerate (C24) [2]. The activated fatty acids are then loaded to EC
2.3.1.292 , (phenol)carboxyphthiodiolenone synthase.
History
EC 6.2.1.59 created 2019
Orthology
K12426 long-chain fatty acid adenylase/transferase FadD26
Genes
MTO : MTCTRI2_2987(fadD26)
MBO : BQ2027_MB2955(fadD26)
MMAE : MMARE11_16970(fadD26)
MKN : MKAN_08435 MKAN_24045
MSTO : MSTO_18490 MSTO_18500
MNM : MNVM_34650(fadD29) MNVM_38350(fadD26)
MGAU : MGALJ_49390(fadD26)
MMAM : K3U93_07850(fadD26)
MSPG : F6B93_07170 F6B93_18595
MMEH : M5I08_15205 M5I08_15260 M5I08_15340
MSP : Mspyr1_27250 Mspyr1_27270
MCB : Mycch_2759 Mycch_2761
MVQ : MYVA_2945(fadD26) MYVA_2947
MDU : MDUV_13150(fadD26_1) MDUV_13180(fadD26_2)
MAUU : NCTC10437_03022 NCTC10437_03024
MPSC : MPSYJ_36600(fadD26_1) MPSYJ_36620(fadD26_2)
MPOF : MPOR_14530(fadD26_1) MPOR_33380(fadD26_2) MPOR_33400(fadD26_3)
MSEI : MSEDJ_33360(fadD26)
MRF : MJO55_13945 MJO55_13955
MAUS : JN090_14920 JN090_14930
MJD : JDM601_2216(fadD26) JDM601_2582(fadD28)
MTER : 4434518_02138(fadD26) 4434518_02530(fadD28)
MHIB : MHIB_16650(fadD26_1) MHIB_20260(fadD26_2)
MHER : K3U94_12465 K3U94_14730
MVM : MJO54_12410 MJO54_14750
TPUL : TPB0596_38140(fadD26)
SSIA : A7J05_00480 A7J05_36255
» show all
Taxonomy
Reference
Authors
Azad AK, Sirakova TD, Fernandes ND, Kolattukudy PE
Title
Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria.
Journal
Reference
Authors
Simeone R, Leger M, Constant P, Malaga W, Marrakchi H, Daffe M, Guilhot C, Chalut C
Title
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
Journal
Reference
Authors
Vergnolle O, Chavadi SS, Edupuganti UR, Mohandas P, Chan C, Zeng J, Kopylov M, Angelo NG, Warren JD, Soll CE, Quadri LE
Title
Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.59
ExPASy - ENZYME nomenclature database: 6.2.1.59