KEGG   ENZYME: 6.2.1.6Help
Entry
EC 6.2.1.6                  Enzyme                                 

Name
glutarate---CoA ligase;
glutaryl-CoA synthetase;
glutaryl coenzyme A synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
glutarate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA [RN:R02402]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
glutarate [CPD:C00489];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
glutaryl-CoA [CPD:C00527]
Comment
GTP or ITP can act instead of ATP.
History
EC 6.2.1.6 created 1961
Pathway
ec00071  Fatty acid degradation
ec00310  Lysine degradation
Reference
1  [PMID:13769477]
  Authors
MENON GK, FRIEDMAN DL, STERN JR.
  Title
Enzymic synthesis of glutaryl-coenzyme A.
  Journal
Biochim Biophys Acta 44:375-7 (1960)
DOI:10.1016/0006-3002(60)91583-3
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.6
IUBMB Enzyme Nomenclature: 6.2.1.6
ExPASy - ENZYME nomenclature database: 6.2.1.6
BRENDA, the Enzyme Database: 6.2.1.6
CAS: 9023-68-1

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