KEGG   ENZYME: 6.2.1.60Help
Entry
EC 6.2.1.60                 Enzyme                                 

Name
marinolic acid---CoA ligase;
tmlU (gene name)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
marinolic acid:CoA ligase (AMP-forming)
Reaction(IUBMB)
(1) ATP + a marinolic acid + CoA = AMP + diphosphate + a marinoloyl-CoA [RN:R12494];
(2) ATP + a pseudomonic acid + CoA = AMP + diphosphate + a pseuodomonoyl-CoA [RN:R12495]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
marinolic acid [CPD:C22211];
CoA [CPD:C00010];
pseudomonic acid [CPD:C22213]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
marinoloyl-CoA [CPD:C22212];
pseuodomonoyl-CoA [CPD:C22214]
Comment
The enzyme, characterized from the bacterium Pseudoalteromonas sp. SANK 73390, catalyses the CoA acylation of pseudomonic and marinolic acids, as part of the biosynthesis of thiomarinols and related compounds.
History
EC 6.2.1.60 created 2019
Reference
1  [PMID:25726835]
  Authors
Dunn ZD, Wever WJ, Economou NJ, Bowers AA, Li B
  Title
Enzymatic basis of "hybridity" in thiomarinol biosynthesis.
  Journal
Angew Chem Int Ed Engl 54:5137-41 (2015)
DOI:10.1002/anie.201411667
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.60
IUBMB Enzyme Nomenclature: 6.2.1.60
ExPASy - ENZYME nomenclature database: 6.2.1.60
BRENDA, the Enzyme Database: 6.2.1.60

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