KEGG   ENZYME: 6.2.1.63Help
Entry
EC 6.2.1.63                 Enzyme                                 

Name
L-arginine---[L-arginyl-carrier protein] ligase;
vabF (gene name)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
L-arginine:[L-arginyl-carrier protein] ligase (AMP-forming)
Reaction(IUBMB)
ATP + L-arginine + holo-[L-arginyl-carrier protein] = AMP + diphosphate + L-arginyl-[L-arginyl-carrier protein] (overall reaction);
(1a) ATP + L-arginine = diphosphate + (L-arginyl)adenylate [RN:R12572];
(1b) (L-arginyl)adenylate + holo-[L-arginyl-carrier protein] = AMP + L-arginyl-[L-arginyl-carrier protein]
Reaction(KEGG)
R12572;
(other) R12573 R12574
Show
Substrate
ATP [CPD:C00002];
L-arginine [CPD:C00062];
holo-[L-arginyl-carrier protein];
(L-arginyl)adenylate [CPD:C22264]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
L-arginyl-[L-arginyl-carrier protein];
(L-arginyl)adenylate [CPD:C22264]
Comment
The adenylation domain of the enzyme catalyses the activation of L-arginine to (L-arginyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.
History
EC 6.2.1.63 created 2020
Orthology
K24101  L-arginine---[L-arginyl-carrier protein] ligase
Genes
YEL: LC20_00744
YFR: AW19_2624
YKR: CH54_3164
YRU: BD65_1348
YRB: UGYR_07465
YMA: DA391_07275
YHI: D5F51_19215
YCA: F0T03_18530
SMAR: SM39_1905
SMAC: SMDB11_1729
SMAF: D781_2012
SERF: L085_16425
SFJ: SAMEA4384070_1829(dhbF_3)
PEC: W5S_3874
DDQ: DDI_2787
DAQ: DAQ1742_01263(cbsF)
MINT: C7M51_02065(lgrD)
MTHI: C7M52_00776(lgrD)
XBO: XBJ1_1441
XBV: XBW1_1500
VAG: N646_0834
VAN: VAA_02398
HCH: HCH_03818
CVI: CV_2233(cbsF)
BVR: BVIR_3121
MSC: BN69_2716(dhbF)
SHY: SHJG_5930
SALU: DC74_964
TCU: Tcur_1886
 » show all
Taxonomy
Reference
1  [PMID:17159203]
  Authors
Balado M, Osorio CR, Lemos ML
  Title
A gene cluster involved in the biosynthesis of vanchrobactin, a chromosome-encoded siderophore produced by Vibrio anguillarum.
  Journal
Microbiology 152:3517-3528 (2006)
DOI:10.1099/mic.0.29298-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.63
IUBMB Enzyme Nomenclature: 6.2.1.63
ExPASy - ENZYME nomenclature database: 6.2.1.63
BRENDA, the Enzyme Database: 6.2.1.63

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