sdgA (gene name)
Forming carbon-sulfur bonds;
salicylate:CoA ligase (AMP-forming)
ATP + salicylate + CoA = AMP + diphosphate + 2-hydroxybenzoyl-CoA (overall reaction) [RN:
(1a) ATP + salicylate = diphosphate + (2-hydroxybenzoyl)adenylate [RN:
(1b) (2-hydroxybenzoyl)adenylate + CoA = AMP + 2-hydroxybenzoyl-CoA [RN:
The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway. It activates salicylate by its adenylation to (2-hydroxybenzoyl)adenylate, followed by the transfer of the activated compound to coenzyme A.
EC 22.214.171.124 created 2020
K24408 salicylate---CoA ligase
Bonting CF, Fuchs G
Anaerobic metabolism of 2-hydroxybenzoic acid (salicylic acid) by a denitrifying bacterium.
Ishiyama D, Vujaklija D, Davies J
Novel pathway of salicylate degradation by Streptomyces sp. strain WA46.
ExplorEnz - The Enzyme Database: 126.96.36.199
ExPASy - ENZYME nomenclature database: 188.8.131.52