KEGG   ENZYME: 6.2.1.75
Entry
EC 6.2.1.75                 Enzyme                                 
Name
indoleacetate---CoA ligase;
iaaB (gene name)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
(indol-3-yl)acetate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + (indol-3-yl)acetate + CoA = AMP + diphosphate + (indol-3-yl)acetyl-CoA [RN:R12968]
Reaction(KEGG)
R12968
Substrate
ATP [CPD:C00002];
(indol-3-yl)acetate [CPD:C00954];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
(indol-3-yl)acetyl-CoA [CPD:C15489]
Comment
The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate. It is also active with phenylacetate and the non-physiological compound (2-naphthyl)acetate.
History
EC 6.2.1.75 created 2022
Orthology
K25760  indoleacetate---CoA ligase
Genes
EBAebA2050(fcs)
ABREpbN1_13070
APETToN1_50350
AZIAzCIB_1782
TCLTchl_1910
TAKTharo_2542
DDZDSYM_16390
RPERPE_3218
MAGXXM1_2486
Reference
1  [PMID:27102732]
  Authors
Schuhle K, Nies J, Heider J.
  Title
An indoleacetate-CoA ligase and a phenylsuccinyl-CoA transferase involved in anaerobic metabolism of auxin.
  Journal
Environ Microbiol 18:3120-32 (2016)
DOI:10.1111/1462-2920.13347
  Sequence
[eba:ebA2050]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.75
IUBMB Enzyme Nomenclature: 6.2.1.75
ExPASy - ENZYME nomenclature database: 6.2.1.75
BRENDA, the Enzyme Database: 6.2.1.75

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