KEGG   ENZYME: 6.2.1.9
Entry
EC 6.2.1.9                  Enzyme                                 
Name
malate---CoA ligase;
malyl-CoA synthetase;
malyl coenzyme A synthetase;
malate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
malate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + malate + CoA = ADP + phosphate + malyl-CoA [RN:R01256]
Reaction(KEGG)
R01256
Substrate
ATP [CPD:C00002];
malate [CPD:C00149];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
malyl-CoA [CPD:C04348]
History
EC 6.2.1.9 created 1972
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08692  malate-CoA ligase subunit alpha
K14067  malate-CoA ligase subunit beta
Genes
MCAMCA1740(sucC-2) MCA1741(sucD-2)
METUGNH96_10425(sucC)
MMTMetme_2693 Metme_2694
MDNJT25_000145 JT25_000150(sucC)
MDHAYM39_08395(sucC) AYM39_08400
MKOMKLM6_1753 MKLM6_1754
METLU737_10265 U737_10270(sucD)
MPADKEF85_03355 KEF85_03360(sucD)
MELLIVG45_03095 IVG45_03100(sucD)
MAHMEALZ_3215(mtkB) MEALZ_3216(mtkA)
MBUREQU24_04635 EQU24_04640(sucD)
MPSYCEK71_18040 CEK71_18045
MMAIsS8_2224
MMOBF6R98_20175(sucC)
MEINmethR_P0950 methR_P0951
MOZMoryE10_14050(sucC) MoryE10_14060(sucD)
MISZMishRS11D_11810(sucD_2) MishRS11D_11820(sucC_2)
MESLKKZ03_00250(sucD) KKZ03_00255
TSNW908_06420 W908_06425(sucC)
BPHBphy_5926 Bphy_5927
BCAIK788_0001576 K788_0001577
PHSC2L64_21715 C2L64_21720
PTERC2L65_26275 C2L65_26280
MPTMpe_A3256 Mpe_A3257
METPC1M51_05905 C1M51_05910
NEUNE1810 NE1811
NETNeut_0605 Neut_0606
NITNAL212_0421 NAL212_0422
NIINit79A3_0104 Nit79A3_0105
NCOAAW31_08290(sucC) AAW31_08295
NURATY38_03745 ATY38_03750(sucC)
NSTNstercoris_01829 Nstercoris_01830
NMUNmul_A1079 Nmul_A1080
NLCEBAPG3_012570 EBAPG3_012575
NIZNNRS527_01105 NNRS527_01106
METRBSY238_255(sucD) BSY238_256(sucC)
NIMW01_13790(sucC_1)
NARCNTG6680_0559(mtkB) NTG6680_0560(mtkA)
FMYHO273_03885 HO273_03890(sucD)
MLOmlr1324 mlr1326
MLNA9174_19855 A9174_19860
MOPMesop_3791 Mesop_3792
MAMMesau_03582 Mesau_03583
MAMOA6B35_22115(sucC) A6B35_22120
MESPC1M53_18675 C1M53_18680
MHUAMCHK_2943 MCHK_2944(sucD)
MJREB229_19615(sucD) EB229_19620
MERDEB233_16960(sucD) EB233_16965
AAKAA2016_5787 AA2016_5788
AMIHCO731_05426(sucC_2) CO731_05427(sucD_2)
PHTBLM14_27155 BLM14_27160
RHINGR_c26240 NGR_c26250
SFHSFHH103_02475(succ1) SFHH103_02476(sucd1)
SFDUSDA257_c22010(mtkB) USDA257_c22020(mtkA)
SAMESAMCFNEI73_pC0657(mtkA) SAMCFNEI73_pC0658(mtkB)
SINOSS05631_b61270 SS05631_b61280
ESJSJ05684_b48790 SJ05684_b48800
EAKEKH55_4316 EKH55_4317
LNEFZC33_08685(sucD) FZC33_08690
MEAMex_1p1730(mtkA) Mex_1p1731(mtkB)
MDIMETDI2482(mtkA) METDI2483(mtkB)
MEXMext_1799 Mext_1800
MCHMchl_2135 Mchl_2136
MPOMpop_1751 Mpop_1752
MZAB2G69_16655 B2G69_16660
MRDMrad2831_3665 Mrad2831_3666
METM446_6556 M446_6557
MNOMnod_7116 Mnod_7117
MORMOC_4188 MOC_4189
METAY590_08600(sucC) Y590_08605
MAQUMaq22A_c19260(mtkB) Maq22A_c19265(mtkA)
MPHYMCBMB27_03147 MCBMB27_03148
MEEDA075_26540 DA075_26545
METDC0214_10365 C0214_10370
METXA3862_13155 A3862_13160
METSDK389_15345 DK389_15350
METIDK427_15540 DK427_15545
MMESMMSR116_21300
MTEADK419_14275 DK419_14280
MINDmvi_28880 mvi_28890(sucC_2)
MOGMMB17_01135 MMB17_01140(sucD)
MTADM6G65_20430(sucD) M6G65_20435
MSLMsil_1716 Msil_1717
MTUNMTUNDRAET4_3404 MTUNDRAET4_3406(mtkA)
MLGCWB41_04705 CWB41_04710
BBARRHAL1_03823(sucC_2) RHAL1_03824(sucD_2)
HDNHden_3151 Hden_3152
HDTHYPDE_38933 HYPDE_38938
HMCHYPMC_4393(mtkB) HYPMC_4394(mtkA)
HNIW911_15810(sucC) W911_15815
FILBN1229_v1_1241(sucC) BN1229_v1_1242(sucD) BN1229_v1_2531(mtkA)
FIYBN1229_v1_1239(sucC) BN1229_v1_1240(sucD) BN1229_v1_3385(mtkA)
MCGGL4_3373 GL4_3374
METGHT051_02830 HT051_02835(sucD)
MSCBN69_1173 BN69_1174(sucC1)
MBRYB1812_17525 B1812_17530
MROSEHO51_12195(sucD) EHO51_12200
MHEYH2LOC_011815(sucD) H2LOC_011820
MPARF7D14_09160 F7D14_09165(sucD)
MTWCQW49_12220 CQW49_12225
CMETK6K41_15070(sucD)
PLEOOHA_1_00679(sucD_1) OHA_1_00680(sucC_1)
HDIHDIA_2218(sucC_1) HDIA_2219(sucD_2)
NOHG5V57_12990(sucD) G5V57_12995
SILSPO1568 SPO1569
RUAD1823_20505 D1823_20510
RUTFIU92_19880(sucD2) FIU92_19885(sucC2)
RCONK3740_20015 K3740_20020(sucD)
RDERD1_1162(mtkA) RD1_4246(mtkB)
RLIRLO149_c036810(mtkB) RLO149_c036820(mtkA)
DSHDshi_2491(sucC2) Dshi_2492(sucD2)
LMDMETH_18370 METH_18375(sucC)
LEJETW24_17890(sucD) ETW24_17895
LAQUR2C4_19805 R2C4_19810(sucD)
LEVETW23_00265 ETW23_00270(sucD)
LCAEK3721_16165(sucD) K3721_16170
REDroselon_02261 roselon_02262
CIDP73_3959 P73_3960
RMMROSMUCSMR3_01020(sucC) ROSMUCSMR3_03453(sucD) ROSMUCSMR3_03454(sucC)
ROKRAK1035_2338 RAK1035_2339 RAK1035_3888
RIDRIdsm_02780(sucC_1) RIdsm_02781(sucD_1)
ROMEI983_08260(sucD) EI983_08265
ROHFIU89_03745(sucC1) FIU89_11590(sucC3) FIU89_11595(sucD3)
SAGUCDO87_15510 CDO87_15515
RMHLVO79_00250 LVO79_00255(sucD)
MALUKU6B_14470(sucC_1) KU6B_14480 KU6B_40000 KU6B_40010(sucC_2)
PALXGQA70_23235 GQA70_23240(sucD)
PAMIJCM7686_2766 JCM7686_2767
PZHCX676_04825 CX676_04830
PAMNpAMV1p0131(mtkA) pAMV1p0132(mtkB)
RBGBG454_05620 BG454_05625
GEHHYN69_16135 HYN69_16140
GFUKM031_08945(sucD) KM031_08950
TAWEI545_00085 EI545_00090(sucD)
PAEDG5B38_01655(sucD) G5B38_01660
NSMJO391_00305(sucD) JO391_00310
AMAQGO499_03740 GO499_03745(sucD)
GBEGbCGDNIH1_0052 GbCGDNIH1_0053
GBHGbCGDNIH2_0052 GbCGDNIH2_0053
GBCGbCGDNIH3_0052 GbCGDNIH3_0053
GBSGbCGDNIH4_0052 GbCGDNIH4_0053
 » show all
Reference
1  [PMID:14244056]
  Authors
MUE S, TUBOI S, KIKUCHI G.
  Title
ON MALYL-COENZYME A SYNTHETASE.
  Journal
J Biochem 56:545-51 (1964)
DOI:10.1093/oxfordjournals.jbchem.a128032
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.9
IUBMB Enzyme Nomenclature: 6.2.1.9
ExPASy - ENZYME nomenclature database: 6.2.1.9
BRENDA, the Enzyme Database: 6.2.1.9
CAS: 37318-58-4

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