| Entry |
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| Name |
aspartate---ammonia ligase;
asparagine synthetase;
L-asparagine synthetase
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| Class |
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
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| Sysname |
L-aspartate:ammonia ligase (AMP-forming)
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| Reaction(IUBMB) |
ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine [RN: R00483]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| History |
EC 6.3.1.1 created 1961
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| Pathway |
| ec00250 | Alanine, aspartate and glutamate metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K01914 | aspartate--ammonia ligase |
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| Genes |
| ABRU: | 129988106 129988108 |
| EHI: | EHI_148470(1.t00107) |
| TPS: | THAPSDRAFT_24816(ASA) |
| LMAT: | 92514125(LSCM1_04089) |
| LOI: | 92360973(LSCM4_05065) |
| LEIS: | 94180489(GH5_05081) |
| LENR: | 94171069(CUR178_03832) |
| LEIN: | 94188646(JIQ42_04999) |
| PHET: | 94290178(JKF63_04108) |
| ECOO: | ECRM13514_4806(asnA) |
| ECOH: | ECRM13516_4591(asnA) |
| ECW: | EcE24377A_4260(asnA) |
| EDJ: | ECDH1ME8569_3632(asnA) |
| ECOI: | ECOPMV1_04082(asnA) |
| SEM: | STMDT12_C40390(asnA) |
| REE: | electrica_05031(asnA) |
| RTG: | NCTC13098_07194(asnA) |
| CLAP: | NCTC11466_04624(asnA) |
| KIE: | NCTC12125_03758(asnA) |
| AHN: | NCTC12129_04995(asnA) |
| METY: | MRY16398_56230(asnA) |
| PSHI: | SAMEA2665130_0129(asnA) |
| YPG: | YpAngola_A0003(asnA) |
| YPI: | YpsIP31758_0003(asnA) |
| SMW: | SMWW4_v1c48230(asnA) |
| SFJ: | SAMEA4384070_4830(asnA) |
| SOF: | NCTC11214_01709(asnA) |
| SSAR: | SSARUM_004775(asnA) |
| PAQU: | DMB82_0020470(asnA) |
| PARL: | PEC302110_40650(asnA) |
| PHEI: | NCTC12003_00066(asnA) |
| PRJ: | NCTC6933_00050(asnA) |
| LRI: | NCTC12151_03624(asnA) |
| HIC: | NTHIC486_00426(asnA) |
| HPIT: | NCTC13334_00166(asnA) |
| HHZ: | NCTC10839_00394(asnA) |
| HAEG: | NCTC8502_00574(asnA) |
| PDAG: | 4362423_01717(asnA) |
| ADP: | NCTC12871_00950(asnA) |
| ALIG: | NCTC10568_02216(asnA) |
| ASEG: | NCTC10977_00613(asnA) |
| AVT: | NCTC3438_00231(asnA) |
| RPNE: | NCTC8284_03973(asnA) |
| PAET: | NCTC13378_00093(asnA) |
| LCJ: | NCTC11976_00880(asnA) |
| AEL: | NCTC12917_00206(asnA) |
| BSHI: | LGQ02_10390(asnA) LGQ02_16760(asnA) |
| MENL: | MVE64_15560(asnA) MVE64_21205 |
| SPYM: | M1GAS476_1333(asnA) |
| SPH: | MGAS10270_Spy1284(asnA) |
| SPI: | MGAS10750_Spy1376(asnA) |
| SPJ: | MGAS2096_Spy1288(asnA) |
| SPK: | MGAS9429_Spy1263(asnA) |
| STG: | MGAS15252_1151(asnA) |
| STZ: | SPYALAB49_001250(asnA) |
| SNV: | SPNINV200_17820(asnA) |
| SNC: | HMPREF0837_12239(asnA) |
| SPNG: | HMPREF1038_01953(asnA) |
| SPNE: | SPN034156_08110(asnA) |
| SPNU: | SPN034183_17340(asnA) |
| SPNM: | SPN994038_17230(asnA) |
| SPNO: | SPN994039_17240(asnA) |
| SGG: | SGGBAA2069_c04640(asnA) |
| SCP: | HMPREF0833_10037(asnA) |
| SVB: | NCTC12167_00413(asnA) |
| SMEN: | SAMEA4412692_0077(asnA) |
| SCAI: | NCTC12191_01209(asnA) |
| SPSU: | NCTC13786_00731(asnA) |
| SPOC: | NCTC10925_00509(asnA) |
| SAUP: | NCTC3168_00659(asnA) |
| SURN: | NCTC13766_00516(asnA) |
| SVF: | NCTC3166_00114(asnA) |
| LPW: | LpgJCM5343_17190(asnA) |
| LRU: | HMPREF0538_21101(asnA) |
| CCOH: | SAMEA4530647_0641(asnA) |
| HHW: | NCTC503_01403(asnA1) |
| CLO: | HMPREF0868_1563(asnA) |
| CSS: | Cst_c06140(asnA1) Cst_c17840(asnA2) |
| PFAA: | MM59RIKEN_33520(asnA) |
| VFA: | MM35RIKEN_06890(asnA) |
| VCOP: | MM50RIKEN_11080(asnA) |
| ACOL: | K5I23_03045(asnA) K5I23_08035(asnA) |
| PALM: | RBG61_00725(asnA) RBG61_04225(asnA) |
| BPRO: | PMF13cell1_01770(asnA) |
| BLUI: | Blut17040_27900(asnA) |
| CHYL: | CE91St63_17990(asnA) |
| ACEL: | acsn021_14460(asnA) |
| CBAR: | PATL70BA_0969(asnA) |
| ETM: | CE91St48_17430(asnA) |
| PDF: | CD630DERM_26950(asnA) |
| PHX: | KGNDJEFE_00812(asnA) |
| FAA: | HMPREF0389_00477(asnA) |
| PHAR: | NCTC13077_00717(asnA) |
| PIV: | NCTC13079_00863(asnA) |
| AARG: | Aargi30884_02530(asnA) |
| ABSI: | A9CBEGH2_03620(asnA) |
| FIT: | Fi14EGH31_12460(asnA) |
| MMY: | MSC_1015(asnA) MSC_1040(asnA) |
| MMYI: | mycmycITA_01070(asnA) |
| MCAP: | MCCPF38_00961(asnA) |
| MCAR: | MCCPILRI181_00960(asnA) |
| AAXA: | NCTC10138_01693(asnA) |
| SCR: | SCHRY_v1c00220(asnA) |
| SSYR: | SSYRP_v1c00220(asnA) |
| SDI: | SDIMI_v3c00190(asnA) |
| STAI: | STAIW_v1c00190(asnA) |
| SAPI: | SAPIS_v1c00200(asnA) |
| SCQ: | SCULI_v1c00200(asnA) |
| SSAB: | SSABA_v1c00190(asnA) |
| SATR: | SATRI_v1c00310(asnA) |
| SERI: | SERIO_v1c00410(asnA) |
| SLL: | SLITO_v1c00180(asnA) |
| SCJ: | SCANT_v1c00190(asnA) |
| SHJ: | SHELI_v1c00190(asnA) |
| SFZ: | SFLOR_v1c00190(asnA) |
| SCOU: | SCORR_v1c00180(asnA) |
| SPRN: | S100390_v1c00200(asnA) |
| SPIT: | STU14_v1c00200(asnA) |
| STAB: | STABA_v1c00190(asnA) |
| SMOO: | SMONO_v1c00190(asnA) |
| SALX: | SALLE_v1c00190(asnA) |
| SGQ: | SGLAD_v1c00190(asnA) |
| SCHI: | SCHIN_v1c00210(asnA) |
| MGLY: | NCTC10194_00242(asnA) |
| MCOU: | NCTC10179_00215(asnA) |
| MCOM: | NCTC10178_00004(asnA) |
| MGAL: | NCTC10186_00232(asnA) |
| MCIT: | NCTC10181_00727(asnA) |
| MMAU: | NCTC10168_00550(asnA) |
| MMEL: | NCTC10153_00004(asnA) |
| MCOB: | NCTC10184_00376(asnA) |
| MSAI: | NCTC10113_01545(asnA_2) |
| MOB: | NCTC10112_00663(asnA_4) |
| MGN: | HFMG06NCA_4748(asnA) |
| MGS: | HFMG95NCA_4772(asnA) |
| MGT: | HFMG01NYA_4836(asnA) |
| MGV: | HFMG94VAA_4844(asnA) |
| MGW: | HFMG01WIA_4691(asnA) |
| MGAC: | HFMG06CAA_4893(asnA) |
| MGAN: | HFMG08NCA_4679(asnA) |
| MGNC: | HFMG96NCA_4963(asnA) |
| FPOL: | ERS445057_01442(asnA) |
| LGO: | JCM16774_1467(asnA1) |
| BTHO: | Btheta7330_00913(asnA) |
| BCEL: | BcellWH2_01600(asnA) |
| PGOL: | K6V26_12985(asnA) K6V26_17675(asnA) |
| COPR: | Cop2CBH44_28300(asnA) |
| CFAS: | Cfast33896_24870(asnA) |
| PMZ: | HMPREF0659_A5982(asnA) |
| PDN: | HMPREF9137_1566(asnA) |
| PHER: | prwr041_05250(asnA) |
| POC: | NCTC13071_00319(asnA) |
| ALD: | GFH31_01780 GFH31_07655 |
| ADA: | A5CPEGH6_08390(asnA) |
| AIU: | NQ491_06945(asnA) NQ491_08620(asnA) |
| SMIZ: | 4412673_02077(asnA) |
| SDJ: | NCTC13534_02977(asnA) |
| STHA: | NCTC11429_05109(asnA) |
| CHG: | AXF12_11640 AXF12_11715 |
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| Reference |
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| Authors |
RAVEL JM, NORTON SJ, HUMPHREYS JS, SHIVE W. |
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| Title |
Asparagine biosynthesis in Lactobacillus arabinosus and its control by asparagine through enzyme inhibition and repression. |
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| Journal |
J Biol Chem 237:2845-9 (1962) |
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| Reference |
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| Authors |
WEBSTER GC, VARNER JE. |
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| Title |
Aspartate metabolism and asparagine synthesis in plant systems. |
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| Journal |
J Biol Chem 215:91-9 (1955) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.3.1.1 |
| ExPASy - ENZYME nomenclature database: | 6.3.1.1 |
| BRENDA, the Enzyme Database: | 6.3.1.1 |
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