KEGG   ENZYME: 6.3.1.11
Entry
EC 6.3.1.11                 Enzyme                                 
Name
glutamate---putrescine ligase;
gamma-glutamylputrescine synthetase;
YcjK
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
Sysname
L-glutamate:putrescine ligase (ADP-forming)
Reaction(IUBMB)
ATP + L-glutamate + putrescine = ADP + phosphate + gamma-L-glutamylputrescine [RN:R07414]
Reaction(KEGG)
R07414
Substrate
ATP [CPD:C00002];
L-glutamate [CPD:C00025];
putrescine [CPD:C00134]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
gamma-L-glutamylputrescine [CPD:C15699]
Comment
Forms part of a novel bacterial putrescine utilization pathway in Escherichia coli.
History
EC 6.3.1.11 created 2005
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K09470  gamma-glutamylputrescine synthase
Genes
ECOb1297(puuA)
ECJJW5201(puuA)
ECDECDH10B_1414(puuA)
EBWBWG_1129(puuA)
ECOKECMDS42_1095(puuA)
ECEZ2491
ECSECs_1874(puuA)
ECFECH74115_1939(puuA)
ETWECSP_1822(puuA)
ELXCDCO157_1794
EOIECO111_1680(puuA)
EOJECO26_1864(puuA)
EOHECO103_1461(puuA)
ECOOECRM13514_1722
ECOHECRM13516_1688
ESLO3K_13845
ESOO3O_11785
ESMO3M_13820
ECKEC55989_1459(puuA)
EOKG2583_1644(puuA)
ELRECO55CA74_08005
ELHETEC_1401
ECWEcE24377A_1506(puuA)
EUNUMNK88_1630
ECOAAPECO78_10360
ECXEcHS_A1412(puuA)
ECMEcSMS35_1825(puuA)
ECYECSE_1349
ECRECIAI1_1322(puuA)
EUMECUMN_1603(puuA)
ECTECIAI39_1648(puuA)
EOCCE10_1545(puuA)
EBRECB_01274(ycjK)
EBLECD_01274(puuA)
EBEB21_01285(puuA)
EBDECBD_2320
ELOEC042_1425(puuA)
ECLEcolC_2328
EKOEKO11_2553
EKFKO11_16325(puuA)
EDHEcDH1_2349
EDJECDH1ME8569_1239(puuA)
ELWECW_m1393(puuA)
ELLWFL_06790(puuA)
ELPP12B_c1797(puuA)
ECOLLY180_06605
EALEAKF1_ch0121(puuA)
ESZFEM44_21585
SFLSF1302
SFXS1384
SFVSFV_1311
SFESFxv_1475(puuA)
SFNSFy_1870
SFSSFyv_1927
SFTNCTC1_01377(puuA)
SSNSSON_1843
SBOSBO_1765
SBCSbBS512_E1533(puuA)
SDZAsd1617_02624
SHQA0259_10610
ENCECL_02225
ENLA3UG_10020 A3UG_15575
ECLGEC036_19410
ECLNECNIH4_07635 ECNIH4_12700
EAUDI57_04170 DI57_08920
EKBBFV64_10370
ENOECENHK_09945 ECENHK_15025
EECEcWSU1_03061(puuA)
ELGBH714_11365
ECANCWI88_14355
ERNBFV67_09515 BFV67_14610
ECLSLI67_011095 LI67_016160
ECHGFY206_11410 FY206_16665
ESHC1N69_15385
EASEntas_2914
ENRH650_07825
ENXNI40_015070
ENFAKI40_4007
LNICWR52_20020
EBGFAI37_14080 FAI37_19210
ENDA4308_14660 A4308_19690
ENZG0034_09785 G0034_15640
EMORL6Y89_14715
ESAESA_02078 ESA_04256
CSKES15_0194 ES15_2235(puuA)
CSZCSSP291_09880 CSSP291_19610
CSJCSK29544_01154 CSK29544_03371
CCONAFK62_18985
CDMAFK67_08765 AFK67_19615
CSIP262_00299 P262_03228
CMJAFK66_001035 AFK66_010915
CUIAFK65_08625 AFK65_18695
CMWAFK63_09865 AFK63_19645
CTUCTU_18860(puuA) CTU_40070(puuA)
KPNKPN_01021
KPUKP1_2006
KPMKPHS_18960
KPPA79E_3212
KPHKPNIH24_19030
KPZKPNIH27_08955
KPVKPNIH29_09485
KPWKPNIH30_10000
KPYKPNIH31_09375
KPGKPNIH32_09840
KPCKPNIH10_09495
KPQKPR0928_09665
KPTVK055_1456(puuA)
KPOKPN2242_08165
KPRKPR_3501(puuA)
KPJN559_3266
KPID364_05310
KPAKPNJ1_03507
KPSKPNJ2_03496
KPXPMK1_03361(puuA)
KPBFH42_00960
KPNEKU54_016660
KPNULI86_16970
KPNKBN49_2109(puuA)
KVAKvar_3358
KPEKPK_3539(puuA)
KPKA593_19605
KVDKR75_17275
KVQSP68_23655
KOXKOX_16935
KOEA225_2235
KOYJ415_20600
KOMHR38_15455
KMIVW41_06405 VW41_14385
KOKKONIH1_10935
KOCAB185_25200
KQUAVR78_13935
EAEEAE_15935
EARCCG30720
KQVB8P98_18165
KLLBJF97_11210
KLWDA718_17640
KARLGL98_16120
KGRJJJ10_17590(puuA)
RORRORB6_09555
RONTE10_11025
RAODSD31_16190
RTGNCTC13098_04765(puuA_1)
CROROD_03561(puuA)
CFDCFNIH1_11625
CBRAA6J81_11665
CYOCD187_18785
CPOTFOB25_06240
CFQC2U38_05165
CIEAN232_24810
CITZE4Z61_12070
CARSE1B03_06255
CNTJT31_05805 JT31_20735
CEMLH23_12125 LH23_20340
CENLH86_11535 LH86_18975
CLAPNCTC11466_03162(puuA)
PGELG71_13300
ESCEntcl_1590 Entcl_1710
KLEAO703_13440 AO703_14000
KSAC813_22630
KRDA3780_16470
KPSEIP581_16080
LAZA8A57_07995
LEFLJPFL01_2811
YREHEC60_09600
SGOEA8O29_008305
KINAB182_12295
IZHFEM41_12205
PSGCG163CM_17510(puuA)
EBFD782_2781
EBUCUC76_06180
PSTSE05_49370
SMARSM39_1531(puuA) SM39_2780 SM39_4908
SMACSMDB11_1341(puuA) SMDB11_2544 SMDB11_4654
SMWSMWW4_v1c05240 SMWW4_v1c20870 SMWW4_v1c33120
SPESpro_0584 Spro_2068 Spro_3216
SRRSerAS9_0522 SerAS9_2005 SerAS9_3356
SRLSOD_c04620(puuA1) SOD_c18800(puuA2) SOD_c31290(puuA)
SRYM621_02375 M621_10370 M621_17055
SPLYQ5A_002500(puuA_1) Q5A_010400(puuA_2) Q5A_017000(puuA_3)
SRSSerAS12_0522 SerAS12_2005 SerAS12_3357
SRASerAS13_0522 SerAS13_2006 SerAS13_3359
SMAFD781_0539 D781_1892
SLQM495_02295 M495_10025 M495_16450
SERFL085_01440 L085_12115 L085_18330
SERSSERRSCBI_02540 SERRSCBI_09780 SERRSCBI_15985
SFWWN53_19620 WN53_24965
SFGAV650_14995 AV650_20605
SRZAXX16_3237 AXX16_4570
SERMCLM71_02615 CLM71_09395
SQUE4343_05875 E4343_13730 E4343_24710
SFJSAMEA4384070_0608(puuA_1) SAMEA4384070_2125(puuA_2) SAMEA4384070_3327(puuA_3)
SOFNCTC11214_03509(puuA_2) NCTC11214_04758(puuA_3)
SSURATE40_006930 ATE40_013075 ATE40_023330
SURIJ0X03_07455 J0X03_13565 J0X03_21300
SRHZFO014_00155 FO014_07205
SENPKHA73_02355 KHA73_10460 KHA73_16090
SFOZ042_02945 Z042_23800
RAHRahaq_1578
RACEJHW33_02140
RAQRahaq2_1642
RAAQ7S_07630
ROXBV494_03025 BV494_18795
RVCJ9880_15630
EAMEGXP68_07190
RBADH2866_00975
CEDLH89_04065
DFNCVE23_08755
DAQDAQ1742_00071(puuA)
SODSant_1485(puuA)
SLIGGTU79_18195
EBIEbC_29010
EGEEM595_2349(puuA)
EPECI789_04205
ERWIGN242_07305
PAMPANA_2462(puuA)
PLFPANA5342_1624(ycjK)
PAJPAJ_1759(puuA)
PAQPAGR_g1567
PVAPvag_1945(ycjK)
PAGGAL522_16620
PAOPat9b_2554
KLNLH22_09820
PANTPSNIH1_15795
PANPPSNIH2_05250
PAGCBEE12_00315
PSTWDSJ_15835
PALHB1H58_14675
PANSFCN45_12310
PEYEE896_06985
PDISD8B20_10930
PERLAC65_09780
PGZC2E15_13340
PCDC2E16_13550
MINTC7M51_01856(puuA)
MTHIC7M52_00954(puuA)
HAVAT03_07550
HPARAL518_18040
OPODSM2777_12835
VPAVP1781
VPBVPBB_1637
VPKM636_13180
VPFM634_10405
VPHVPUCM_1860
VAGN646_0402
VNAPN96_04975
VEJVEJY3_08300
VFUvfu_A02176
VFLAL536_14615
VBRA6E01_13670
VSHBSZ05_19070
VNLD3H41_06780
VKABTD91_16580
PGHFH974_08430
ACBA1S_2136
ABMABSDF1602
ABYABAYE1425
ABCACICU_02336
ABNAB57_2469
ABBABBFA_01311(puuA)
ABXABK1_1353
ABZABZJ_02488
ABRABTJ_01407
ABDABTW07_2528
ABHM3Q_2584
ABADABD1_21350
ABJBJAB07104_02492
ABABBJAB0715_02519
ABAJBJAB0868_02375
ABAZP795_6275
ABKLX00_11555
ABAUIX87_06670
ABAAIX88_13220
ABWBL01_17250
ABALABLAC_13710
ACCBDGL_001623(puuA)
ANORR32_07165
ALCOTEC02_06675
ACALBUM88_12160
ASEII8T81_07055
ACDAOLE_06470
AJORZ95_14110
ACWA0J50_06445
ASOLBEN76_01595
ARJDOM24_09745
ACUMC9E88_001415
AGUAS4_00340(puuA)
AUGURS_2283
ADSFPL17_18450
ABERBSR55_21030
ACHICDG60_17815
AGYLFPL18_11030
HAAA5892_00915
ASRWL1483_2278(puuA)
ASIMFE240_03990
OCEGU3_14525
ZDFAN401_15160
MSGMSMEI_3737
MSBLJ00_19010
MSNLI99_19015
MSHLI98_19020
KOVK9N68_06075
HAADMW046_08100
HAXZM0R88_09125
HHIHAH_4293(glnA2)
HHNHISP_16680
HABSG26_00890
HMEHFX_1688(glnA)
HBOHbor_38380
HRAEI982_01260
SRUBC2R22_13375
HALGHUG10_07595
HLRHALLA_03560
 » show all
Reference
1  [PMID:15590624]
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
  Sequence
[eco:b1297]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.1.11
IUBMB Enzyme Nomenclature: 6.3.1.11
ExPASy - ENZYME nomenclature database: 6.3.1.11
BRENDA, the Enzyme Database: 6.3.1.11
CAS: 914090-78-1

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