KEGG ENZYME: 6.3.1.17

ENZYME: 6.3.1.17

Entry

EC 6.3.1.17                 Enzyme

Name

beta-citrylglutamate synthase;
NAAG synthetase I;
NAAGS-I;
RIMKLB (gene name) (ambiguous)

Class

Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)

Sysname

citrate:L-glutamate ligase (ADP-forming)

Reaction(IUBMB)

ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate [RN:R10677]

Reaction(KEGG)

R10677

Substrate

ATP [CPD:C00002];
citrate [CPD:C00158];
L-glutamate [CPD:C00025]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
beta-citryl-L-glutamate [CPD:C20775]

Comment

The enzyme, found in animals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.

History

EC 6.3.1.17 created 2014

Pathway

ec00250

Alanine, aspartate and glutamate metabolism

ec01100

Metabolic pathways

Orthology

K18310

beta-citrylglutamate/N-acetylaspartylglutamate synthase

Genes

HSA:	57494(RIMKLB)

PTR:	735860(RIMKLB)

PPS:	100974820(RIMKLB)

GGO:	101136567(RIMKLB)

PON:	100441104(RIMKLB)

NLE:	100593570(RIMKLB)

HMH:	116456202 116472644(RIMKLB) 116481450

MCC:	722261(RIMKLB)

MCF:	102124154(RIMKLB) 102128847 123572791

MTHB:

126931378 126935689 126940883

MNI:	105499881(RIMKLB)

CSAB:

103218536(RIMKLB)

CATY:

105587959(RIMKLB)

PANU:

101024010(RIMKLB)

TGE:	112635206(RIMKLB)

MLEU:

105552618(RIMKLB)

RRO:	104672842(RIMKLB)

RBB:	108543684(RIMKLB)

TFN:	117090541(RIMKLB)

PTEH:

111526616(RIMKLB)

CANG:

105519900(RIMKLB)

CJC:	100406491(RIMKLB)

SBQ:	101033047(RIMKLB)

CIMI:

108291858(RIMKLB) 108311366

CSYR:

103251714(RIMKLB)

MMUR:

105878274(RIMKLB)

LCAT:

123640042(RIMKLB)

PCOQ:

105805100(RIMKLB)

OGA:	100941690(RIMKLB)

MMU:	108653(Rimklb)

MCAL:

110296264(Rimklb)

MPAH:

110316335(Rimklb)

RNO:	362428(Rimklb)

MCOC:

116099539(Rimklb)

ANU:	117715398(Rimklb)

MUN:	110556298(Rimklb)

CGE:	100760031(Rimklb)

MAUA:

101842752(Rimklb)

PROB:

127236141(Rimklb)

PLEU:

114683483(Rimklb)

MORG:

121438947(Rimklb)

MFOT:

126514898

AAMP:

119808422(Rimklb)

NGI:	103727467(Rimklb)

HGL:	101706744(Rimklb)

CPOC:

100732576(Rimklb)

CCAN:

109697724(Rimklb)

DORD:

105991108(Rimklb)

DSP:	122127019(Rimklb)

PLOP:

125342895(Rimklb)

NCAR:

124983424

OCU:

100346793

OPI:	101523234(RIMKLB)

TUP:	102472940(RIMKLB)

GVR:	103597920(RIMKLB)

CFA:	486698(RIMKLB)

CLUD:

112675320(RIMKLB)

VVP:	112917302(RIMKLB)

VLG:	121479857(RIMKLB)

NPO:	129517123(RIMKLB)

AML:	100473320(RIMKLB)

UMR:	103669163(RIMKLB)

UAH:	113257923(RIMKLB)

UAR:	123781552(RIMKLB)

ELK:

111142053

LLV:

125106794

MPUF:

101680352(RIMKLB)

NVS:	122891599(RIMKLB)

ORO:	101374535(RIMKLB)

EJU:	114221687(RIMKLB)

ZCA:	113921819(RIMKLB)

MLX:	118025692(RIMKLB)

NSU:	110580730(RIMKLB)

LWW:	102741413(RIMKLB)

FCA:	101097740(RIMKLB)

PYU:	121022064(RIMKLB)

PCOO:

112867654(RIMKLB)

PBG:	122473789(RIMKLB)

LRUF:

124502657

PTG:	102963865(RIMKLB)

PPAD:

109276058(RIMKLB)

PUC:

125920076

AJU:

106965320

HHV:	120222721(RIMKLB)

BTA:	538579(RIMKLB)

BOM:	102269649(RIMKLB)

BIU:	109559695(RIMKLB)

BBUB:

102397788(RIMKLB) 112578013

BBIS:

104995473(RIMKLB)

CHX:	102176861(RIMKLB)

OAS:	101102554(RIMKLB)

BTAX:

128047549(RIMKLB)

ODA:	120858791(RIMKLB)

CCAD:

122423372(RIMKLB) 122439954

SSC:	100152915(RIMKLB)

CFR:	102503881(RIMKLB)

CBAI:

105062179(RIMKLB)

CDK:	105098170(RIMKLB)

VPC:	102526778(RIMKLB)

BACU:

103019013(RIMKLB)

LVE:	103069710(RIMKLB)

OOR:	101273054(RIMKLB)

DLE:	111176728(RIMKLB)

PCAD:

102981532(RIMKLB)

PSIU:

116746837 116760947(RIMKLB)

NASI:

112391802(RIMKLB)

ECB:	100061350(RIMKLB)

EPZ:	103564581(RIMKLB)

EAI:	106837431(RIMKLB)

MYB:	102245342(RIMKLB)

MYD:	102752373(RIMKLB)

MMYO:

118650363(RIMKLB)

MLF:	102441683(RIMKLB)

MNA:	107544073(RIMKLB)

PKL:	118728963(RIMKLB)

HAI:	109372752(RIMKLB)

DRO:	112322046(RIMKLB)

SHON:

119002540(RIMKLB)

AJM:	119065675(RIMKLB)

PDIC:

114514072(RIMKLB)

PHAS:

123819342(RIMKLB)

MMF:	118624708(RIMKLB)

RFQ:	117028564(RIMKLB)

PALE:

102880426(RIMKLB)

PGIG:

120611695(RIMKLB)

PVP:	105295916(RIMKLB)

RAY:	107501656(RIMKLB)

MJV:	108396116(RIMKLB)

TOD:	119247737(RIMKLB)

SARA:

101554225(RIMKLB)

LAV:	100657534(RIMKLB)

TMU:

101361972

ETF:	101645920(RIMKLB)

DNM:	101416522(RIMKLB)

MDO:	100013787(RIMKLB)

GAS:	123250757(RIMKLB)

SHR:	100930894(RIMKLB)

AFZ:

127539203

PCW:	110213807(RIMKLB)

OAA:	100090307(RIMKLB)

GGA:	418255(RIMKLB)

PCOC:

116240958(RIMKLB)

MGP:

104916636

CJO:	107318392(RIMKLB)

TPAI:

128089909(RIMKLB)

NMEL:

110397764(RIMKLB)

APLA:

101792875(RIMKLB)

ACYG:

106048091(RIMKLB)

AFUL:

116490791(RIMKLB)

TGU:	100220208(RIMKLB)

LSR:	110472321(RIMKLB)

SCAN:

103827201(RIMKLB)

PMOA:

120497743(RIMKLB)

OTC:	121341027(RIMKLB)

PRUF:

121349851(RIMKLB)

GFR:	102035986(RIMKLB)

FAB:	101814507(RIMKLB)

PHI:	102111957(RIMKLB)

PMAJ:

107210434(RIMKLB)

CCAE:

111925810(RIMKLB)

CCW:	104690266(RIMKLB)

CBRC:

103616673(RIMKLB)

ETL:	114069342(RIMKLB)

ZAB:	102064947(RIMKLB)

ACHL:

103811885(RIMKLB)

SVG:	106859828(RIMKLB)

FPG:	101913481(RIMKLB)

FCH:	102056126(RIMKLB)

CLV:	102098362(RIMKLB)

EGZ:	104122771(RIMKLB)

NNI:	104014577(RIMKLB)

PLET:

104626869(RIMKLB)

PCRI:

104036849(RIMKLA)

PCAO:

104053397(RIMKLB)

ACUN:

113491069(RIMKLB)

TALA:

104365181(RIMKLB)

PADL:

103915115(RIMKLB)

AFOR:

103899962(RIMKLB)

ACHC:

115352600(RIMKLB)

HALD:

104321852(RIMKLB)

HLE:	104836674(RIMKLB)

AGEN:

126047837

GCL:

127017595

CCRI:

104158756(RIMKLB)

CSTI:

104557469(RIMKLB)

EHS:	104510567(RIMKLB)

CMAC:

104474785(RIMKLB)

MUI:	104538317(RIMKLB)

BREG:

104641295(RIMKLB)

FGA:	104072777(RIMKLB)

GSTE:

104257247(RIMKLB)

LDI:	104343382(RIMKLB)

MNB:	103775226(RIMKLB)

OHA:	104332450(RIMKLB)

NNT:	104411662(RIMKLB)

SHAB:

115605282(RIMKLB)

DPUB:

104306895(RIMKLB)

PGUU:

104458927(RIMKLB)

ACAR:

104532919(RIMKLB)

CPEA:

104394530(RIMKLB)

AVIT:

104268972(RIMKLB)

CVF:	104294502(RIMKLB)

CUCA:

104060632(RIMKLB)

TEO:

104382280

BRHI:

104488456

AAM:	106495722(RIMKLB)

AROW:

112973974(RIMKLB)

NPD:	112952039(RIMKLB)

TGT:	104580212(RIMKLB)

DNE:	112992432(RIMKLB)

SCAM:

104152046(RIMKLB)

ASN:	102373845(RIMKLB)

AMJ:	102576775(RIMKLB)

CPOO:

109316234(RIMKLB)

GGN:	109296594(RIMKLB)

PSS:	102451018(RIMKLB)

CMY:	102933090(RIMKLB)

CPIC:

101943668(RIMKLB)

TST:	117884982(RIMKLB)

CABI:

116823843(RIMKLB)

MRV:	120404562(RIMKLB)

ACS:	100563778(rimklb)

PVT:	110069781(RIMKLB)

SUND:

121921715(RIMKLB)

PBI:	103055545(RIMKLB)

PMUR:

107288539(RIMKLB)

CTIG:

120318691(RIMKLB)

TSR:	106544566(RIMKLB)

PGUT:

117661914(RIMKLB)

PTEX:

113444557(RIMKLB)

NSS:	113425290(RIMKLB)

VKO:	123017759(RIMKLB)

PMUA:

114588043(RIMKLB)

ZVI:	118097943(RIMKLB)

HCG:	128346831(RIMKLB)

GJA:	107117747(RIMKLB)

STOW:

125437091(RIMKLB)

XLA:	108696039 108697330

XTR:	100486701(rimklb)

NPR:	108799485(RIMKLB)

RTEM:

120946910(RIMKLB)

BBUF:

121005412(RIMKLB)

BGAR:

122941782(RIMKLB)

DRE:	447815(rimkla)

SRX:	107711947 107717536

SANH:

107669631

SGH:	107556480 107591767

CCAR:

109084979 109084984

CAUA:

113078389 113093917 113107768

CGIB:

127964047 128018591

PTET:

122350397(rimkla)

LROH:

127170090(rimkla)

PPRM:

120483739(rimkla)

MAMB:

125279787(rimkla)

CIDE:

127517732

MASI:

127414466 127424193

IPU:

108265850

PHYP:

113529230

SMEO:

124399561(rimkla)

TFD:	113655760(rimkla)

AMEX:

103035057

CMAO:

118813696(rimkla)

EEE:

113572086

TRU:

101062827

TNG:	GSTEN00013753G001

LCO:

104920219

NCC:	104955181(rimkla)

CGOB:

115011073

ELY:	117258509(rimkla)

EFO:	125891718(rimkla)

PLEP:

121947276(rimkla)

SLUC:

116040663(rimkla)

ECRA:

117948232(rimkla)

ESP:

116692402

PFLV:

114558866

GAT:	120828693(rimkla)

PPUG:

119205701 119222662

MSAM:

119905637(rimkla)

SCHU:

122882832(rimkla)

CUD:	121518035(rimkla)

ALAT:

119022909(rimkla)

MZE:

101477475

ONL:

100698845

OAU:	116309725(rimkla)

OLA:	101169452(rimklb)

OML:	112159079(rimkla)

XMA:

102218635

XCO:

114141086

XHE:

116725681

PRET:

103467997(rimkla)

PFOR:

103138952(rimkla)

PLAI:

106957454(rimkla)

PMEI:

106907435(rimkla)

GAF:	122836233(rimkla)

CVG:	107088869(rimkla)

CTUL:

119797064(rimkla)

GMU:	124867677(rimkla)

NFU:

107390714

KMR:	108236831(rimkla)

ALIM:

106524174

NWH:	119417065(rimkla)

AOCE:

111585273

MCEP:

124997852(rimkla)

CSEM:

103384935

POV:	109630621(rimkla)

SSEN:

122776960(rimkla)

HHIP:

117764653(rimkla)

HSP:	118110963(rimkla)

LCF:

108891717

SDU:

111219047

SLAL:

111670604

XGL:	120804092(rimkla)

HCQ:

109526583

SSCV:

125988093

BPEC:

110161111

MALB:

109970719

BSPL:

114858903(rimkla)

SASA:

106567384 106572158

STRU:

115166047 115168921

OTW:	112215953 112221609

OMY:	110491822 110532211

OGO:	124017459 124031877

ONE:	115102623 115132092

SALP:

111966388 111976646

SNH:	120059373 120060966

CCLU:

121538272 121545958

ELS:

105013808

SFM:	108918203 108924922

PKI:	111856970 111859075(rimkla)

AANG:

118208179(rimkla)

LOC:	102687393(rimkla)

PSPA:

121296514 121325367 121328885 121329280

ARUT:

117424072 117425213 117425745 117432003

PSEX:

120530966(rimkla) 120535665

LCM:	102351441(RIMKLB) 102354509(RIMKLA)

CMK:	103190080(rimkla)

RTP:

109924989

CPLA:

122540248(rimkla)

» show all

Reference

1 [PMID:20657015]

Authors

Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E

Title

Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.

Journal

J Biol Chem 285:29826-33 (2010)
DOI:10.1074/jbc.M110.152629

Sequence

[mmu:108653]

Other DBs

ExplorEnz - The Enzyme Database:

6.3.1.17

IUBMB Enzyme Nomenclature:

6.3.1.17

ExPASy - ENZYME nomenclature database:

6.3.1.17

BRENDA, the Enzyme Database:

6.3.1.17

DBGET integrated database retrieval system