KEGG   ENZYME: 6.3.1.18
Entry
EC 6.3.1.18                 Enzyme                                 
Name
gamma-glutamylanilide synthase;
atdA1 (gene name);
tdnQ (gene name);
dcaQ (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
Sysname
L-glutamate:aniline ligase (ADP-forming)
Reaction(IUBMB)
ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine [RN:R10772]
Reaction(KEGG)
R10772
Substrate
ATP [CPD:C00002];
L-glutamate [CPD:C00025];
aniline [CPD:C00292]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N5-phenyl-L-glutamine [CPD:C20843]
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the first step in the degradation of aniline. It can also accept chlorinated and methylated forms of aniline, preferrably in the o- and p-positions.
History
EC 6.3.1.18 created 2014
Orthology
K20419  gamma-glutamylanilide synthase
Reference
1  [PMID:23893114]
  Authors
Takeo M, Ohara A, Sakae S, Okamoto Y, Kitamura C, Kato D, Negoro S
  Title
Function of a glutamine synthetase-like protein in bacterial aniline oxidation via gamma-glutamylanilide.
  Journal
J Bacteriol 195:4406-14 (2013)
DOI:10.1128/JB.00397-13
  Sequence
[ag:BAA13010]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.1.18
IUBMB Enzyme Nomenclature: 6.3.1.18
ExPASy - ENZYME nomenclature database: 6.3.1.18
BRENDA, the Enzyme Database: 6.3.1.18

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Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (13)   
   UniProt (12)   
   SWISS-PROT (1)   
DNA sequence (11)   
   GenBank (7)   
   EMBL (4)   
Protein domain (4)   
   InterPro (4)   
All databases (39)   

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