| Entry |
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| Name |
gamma-glutamylanilide synthase;
atdA1 (gene name);
tdnQ (gene name);
dcaQ (gene name)
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| Class |
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
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| Sysname |
L-glutamate:aniline ligase (ADP-forming)
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| Reaction(IUBMB) |
ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine [RN: R10772]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Mg2+. The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the first step in the degradation of aniline. It can also accept chlorinated and methylated forms of aniline, preferrably in the o- and p-positions.
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| History |
EC 6.3.1.18 created 2014
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| Orthology |
| K20419 | gamma-glutamylanilide synthase |
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| Reference |
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| Authors |
Takeo M, Ohara A, Sakae S, Okamoto Y, Kitamura C, Kato D, Negoro S |
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| Title |
Function of a glutamine synthetase-like protein in bacterial aniline oxidation via gamma-glutamylanilide. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.3.1.18 |
| ExPASy - ENZYME nomenclature database: | 6.3.1.18 |
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