KEGG ENZYME: 6.3.1.18

ENZYME: 6.3.1.18

Entry

EC 6.3.1.18                 Enzyme

Name

gamma-glutamylanilide synthase;
atdA1 (gene name);
tdnQ (gene name);
dcaQ (gene name)

Class

Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)

Sysname

L-glutamate:aniline ligase (ADP-forming)

Reaction(IUBMB)

ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine [RN:R10772]

Reaction(KEGG)

R10772

Substrate

ATP [CPD:C00002];
L-glutamate [CPD:C00025];
aniline [CPD:C00292]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
N5-phenyl-L-glutamine [CPD:C20843]

Comment

Requires Mg2+. The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the first step in the degradation of aniline. It can also accept chlorinated and methylated forms of aniline, preferrably in the o- and p-positions.

History

EC 6.3.1.18 created 2014

Orthology

K20419

gamma-glutamylanilide synthase

Reference

1 [PMID:23893114]

Authors

Takeo M, Ohara A, Sakae S, Okamoto Y, Kitamura C, Kato D, Negoro S

Title

Function of a glutamine synthetase-like protein in bacterial aniline oxidation via gamma-glutamylanilide.

Journal

J Bacteriol 195:4406-14 (2013)
DOI:10.1128/JB.00397-13

Sequence

[ag:BAA13010]

Other DBs

ExplorEnz - The Enzyme Database:

6.3.1.18

IUBMB Enzyme Nomenclature:

6.3.1.18

ExPASy - ENZYME nomenclature database:

6.3.1.18

BRENDA, the Enzyme Database:

6.3.1.18

All links

Protein sequence (15)   
   UniProt (14)   
   SWISS-PROT (1)   
DNA sequence (19)   
   GenBank (10)   
   EMBL (9)   
Protein domain (4)   
   InterPro (4)   
All databases (38)   

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