| Entry |
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| Name |
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase;
L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase;
ACV synthetase;
L-alpha-aminoadipyl-cysteinyl-valine synthetase
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| Class |
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
 |
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| Sysname |
L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)
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| Reaction(IUBMB) |
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O = 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine [RN: R04870]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
AMP [CPD: C00020];
diphosphate [CPD: C00013];
N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine [CPD: C05556]
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| Comment |
Requires Mg2+. The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction. Forms part of the penicillin biosynthesis pathway (for pathway, click here).
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| History |
EC 6.3.2.26 created 2002
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| Pathway |
| ec00311 | Penicillin and cephalosporin biosynthesis |
| ec01130 | Biosynthesis of antibiotics |
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| Orthology |
| K12743 | N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase |
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| Genes |
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| Reference |
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| Authors |
Byford MF, Baldwin JE, Shiau CY, Schofield CJ. |
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| Title |
The Mechanism of ACV Synthetase. |
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| Journal |
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| Reference |
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| Authors |
Theilgaard HB, Kristiansen KN, Henriksen CM, Nielsen J. |
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| Title |
Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum. |
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| Journal |
Biochem J 327 ( Pt 1):185-91 (1997) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.3.2.26 |
| ExPASy - ENZYME nomenclature database: | 6.3.2.26 |
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