KEGG   ENZYME: 6.3.2.33Help
Entry
EC 6.3.2.33                 Enzyme                                 

Name
tetrahydrosarcinapterin synthase;
H4MPT:alpha-L-glutamate ligase;
MJ0620;
MptN protein
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
tetrahydromethanopterin:alpha-L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + tetrahydromethanopterin + L-glutamate = ADP + phosphate + 5,6,7,8-tetrahydrosarcinapterin [RN:R09594]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
tetrahydromethanopterin [CPD:C01217];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
5,6,7,8-tetrahydrosarcinapterin [CPD:C18802]
Comment
This enzyme catalyses the biosynthesis of 5,6,7,8-tetrahydrosarcinapterin, a modified form of tetrahydromethanopterin found in the Methanosarcinales. It does not require K+, and does not discriminate between ATP and GTP [1].
History
EC 6.3.2.33 created 2010
Pathway
ec00790  Folate biosynthesis
Orthology
K15740  tetrahydromethanopterin:alpha-L-glutamate ligase
Genes
PIN: Ping_2322
SPOI: IMCC21906_01613
MCA: MCA2864
METU: GNH96_03525
MMT: Metme_2266
MDN: JT25_019340
MDH: AYM39_08545
MKO: MKLM6_1779
METL: U737_14815
MAH: MEALZ_2426
MMAI: sS8_3393
TCX: Tcr_1768
MEJ: Q7A_45
MEC: Q7C_1773
NOC: Noc_0259
NHL: Nhal_3877
NWA: Nwat_0360
NTT: TAO_1754
HAM: HALO3126
BYI: BYI23_B014450(rimK)
BUO: BRPE64_BCDS01580(rimK)
BUE: BRPE67_BCDS01440(rimK)
MPT: Mpe_A2610
LCH: Lcho_3149
RGE: RGE_40260(rimK)
MFA: Mfla_1657
MMB: Mmol_1343
MEH: M301_1553
MEP: MPQ_1564(rimK)
MBAC: BN1209_0748(rimK)
DMA: DMR_18070
DGG: DGI_0284
DAS: Daes_1177
DPI: BN4_12184
DBA: Dbac_2700
ADE: Adeh_1691
DBR: Deba_0382
XAU: Xaut_1789
SNO: Snov_0749
MPO: Mpop_1783
MET: M446_5781
MNO: Mnod_6005
MOR: MOC_0686
MAQU: Maq22A_c16480(rimK)
MSL: Msil_2388
HDN: Hden_1476
MSC: BN69_1354
PLEO: OHA_1_01034(rimK)
MCG: GL4_1785
HDI: HDIA_2313(lysX)
RHC: RGUI_1595
LABT: FIU93_11455(lysX)
MALU: KU6B_45100
MAGQ: MGMAQ_0159
BACW: QR42_02385
PSL: Psta_3185
PIR: VN12_14460(lysX)
MFF: MFFC18_17590(rimK_2)
PEH: Spb1_33560(lysX)
PLH: VT85_05470(lysX)
FMR: Fuma_00365(lysX_1)
BVO: Pan97_33080(rimK_2)
PBOR: BSF38_00162(lysX)
AGV: OJF2_59290(lysX)
MOX: DAMO_0462
MJA: MJ_0620
MMP: MMP0702
MMD: GYY_02745
MMAK: MMKA1_07550(mptN)
MMAO: MMOS7_07480(mptN)
MMAD: MMJJ_02750(lysX_1)
MAE: Maeo_0564
MVO: Mvol_0278
MBAR: MSBR2_0806
MBAK: MSBR3_0066
MAC: MA_3268(rimK)
MMA: MM_0111
MMAC: MSMAC_2562
METM: MSMTP_1203
MTHR: MSTHT_0138
MTHE: MSTHC_0590
MHOR: MSHOH_2484
MBU: Mbur_1276(mptN)
MMET: MCMEM_1723
MMH: Mmah_1581
MPY: Mpsy_2609
MTP: Mthe_1118
MCJ: MCON_0555(mptN)
MHI: Mhar_2185
MHU: Mhun_1105
MLA: Mlab_1175
MEMA: MMAB1_3062
MPI: Mpet_1310
MPL: Mpal_2364
SOL: Ssol_0158
SSOA: SULA_0150
SSOL: SULB_0151
SSOF: SULC_0150
SID: M164_0162
SII: LD85_0147
SIH: SiH_0147
SIR: SiRe_0143
SIC: SiL_0134
PIS: Pisl_1747
VDI: Vdis_2361
VMO: VMUT_0713
BARC: AOA65_2016(mptN)
LOKI: Lokiarch_28770(mptN)
 » show all
Taxonomy
Reference
1  [PMID:12909715]
  Authors
Li H, Xu H, Graham DE, White RH
  Title
Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses.
  Journal
Proc Natl Acad Sci U S A 100:9785-90 (2003)
DOI:10.1073/pnas.1733391100
  Sequence
[mja:MJ_0620]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.33
IUBMB Enzyme Nomenclature: 6.3.2.33
ExPASy - ENZYME nomenclature database: 6.3.2.33
BRENDA, the Enzyme Database: 6.3.2.33

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