KEGG   ENZYME: 6.3.2.33Help
Entry
EC 6.3.2.33                 Enzyme                                 

Name
tetrahydrosarcinapterin synthase;
H4MPT:alpha-L-glutamate ligase;
MJ0620;
MptN protein
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
tetrahydromethanopterin:alpha-L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + tetrahydromethanopterin + L-glutamate = ADP + phosphate + 5,6,7,8-tetrahydrosarcinapterin [RN:R09594]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
tetrahydromethanopterin [CPD:C01217];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
5,6,7,8-tetrahydrosarcinapterin [CPD:C18802]
Comment
This enzyme catalyses the biosynthesis of 5,6,7,8-tetrahydrosarcinapterin, a modified form of tetrahydromethanopterin found in the Methanosarcinales. It does not require K+, and does not discriminate between ATP and GTP [1].
History
EC 6.3.2.33 created 2010
Pathway
ec00790  Folate biosynthesis
Orthology
K15740  tetrahydromethanopterin:alpha-L-glutamate ligase
Genes
BACW: QR42_02385
ANX: ACH33_11280
MJA: MJ_0620
MFE: Mefer_0208
MVU: Metvu_0791
MFS: MFS40622_1033
MIF: Metin_0376
MJH: JH146_0844
MIG: Metig_0603
MMP: MMP0702
MMD: GYY_02745
MAE: Maeo_0564
MVO: Mvol_0278
MAC: MA_3268(rimK)
MBAR: MSBR2_0806
MBAK: MSBR3_0066
MMA: MM_0111
MMAC: MSMAC_2562
METM: MSMTP_1203
MTHE: MSTHC_0590
MTHR: MSTHT_0138
MHOR: MSHOH_2484
MBU: Mbur_1276(mptN)
MMET: MCMEM_1723
MMH: Mmah_1581
MPY: Mpsy_2609
MTP: Mthe_1118
MCJ: MCON_0555(mptN)
MHI: Mhar_2185
LOKI: Lokiarch_28770(mptN)
 » show all
Taxonomy
Reference
1  [PMID:12909715]
  Authors
Li H, Xu H, Graham DE, White RH
  Title
Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses.
  Journal
Proc Natl Acad Sci U S A 100:9785-90 (2003)
DOI:10.1073/pnas.1733391100
  Sequence
[mja:MJ_0620]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.33
IUBMB Enzyme Nomenclature: 6.3.2.33
ExPASy - ENZYME nomenclature database: 6.3.2.33
BRENDA, the Enzyme Database: 6.3.2.33

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