KEGG   ENZYME: 6.3.2.36Help
Entry
EC 6.3.2.36                 Enzyme                                 

Name
4-phosphopantoate---beta-alanine ligase;
phosphopantothenate synthetase;
TK1686 protein
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
(R)-4-phosphopantoate:beta-alanine ligase (AMP-forming)
Reaction(IUBMB)
ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate [RN:R09379]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(R)-4-phosphopantoate [CPD:C18911];
beta-alanine [CPD:C00099]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
(R)-4'-phosphopantothenate [CPD:C03492]
Comment
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 [pantoate---beta-alanine ligase] and EC 2.7.1.33 [pantothenate kinase], respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine. The two archaeal enzymes that catalyse this conversion are EC 2.7.1.169, pantoate kinase, and this enzyme.
History
EC 6.3.2.36 created 2011
Pathway
ec00410  beta-Alanine metabolism
ec00770  Pantothenate and CoA biosynthesis
ec01100  Metabolic pathways
Orthology
K09722  4-phosphopantoate---beta-alanine ligase
Genes
SSM: Spirs_1722
STA: STHERM_c02160
STQ: Spith_0200
MJA: MJ_0209
MFE: Mefer_0471
MVU: Metvu_1598
MFS: MFS40622_0017
MIF: Metin_0068
MJH: JH146_1594
MIG: Metig_1648
MMP: MMP1306
MMD: GYY_07355
MAE: Maeo_0765
MVO: Mvol_0285
MAC: MA_1278
MBAR: MSBR2_0501
MBAK: MSBR3_0048
MMA: MM_2281
MMAC: MSMAC_2034
METM: MSMTP_0821
MTHE: MSTHC_2318
MTHR: MSTHT_0989
MHOR: MSHOH_1049
MBU: Mbur_1184
MMET: MCMEM_1652
MMH: Mmah_0519
MPY: Mpsy_1001
MTP: Mthe_1434
MCJ: MCON_3477
MHI: Mhar_0610
MHU: Mhun_0832
MLA: Mlab_0920
MPI: Mpet_0987
MBN: Mboo_1665
MPL: Mpal_1882
MPD: MCP_2267
MEZ: Mtc_0974
RCI: RCIX860
MTH: MTH_435
METC: MTCT_0375
METE: tca_00400
MST: Msp_0560
MSI: Msm_0140
MRU: mru_1225(panC)
MEB: Abm4_0816(panC)
MMIL: sm9_0909(panC)
MEYE: TL18_05735
MOL: YLM1_0788
METH: MBMB1_1178
MFC: BRM9_1383
MCUB: MCBB_1081
MFV: Mfer_0656
MKA: MK0712
AFU: AF_0927
FPL: Ferp_1528
GAC: GACE_1473
GAH: GAH_01054
HAL: VNG_0250C
HSL: OE_1394R
HHB: Hhub_1405
HALH: HTSR_1478
HHSR: HSR6_1550(pps)
HMA: rrnAC1793
HHI: HAH_2321
NPH: NP_0848A
NMO: Nmlp_1060
HUT: Huta_2721
HTI: HTIA_2468
HMU: Hmuk_3221
HWA: HQ_1272A
HWC: Hqrw_1301
HVO: HVO_0674
HME: HFX_0637
HLA: Hlac_1180
HTU: Htur_2675
NMG: Nmag_1075
NAT: NJ7G_1983
SALI: L593_09565
MARC: AR505_1789
PHO: PH1470(PH1470)
PAB: PAB1906
PFU: PF1387
PFI: PFC_06160
PYN: PNA2_0056
PYS: Py04_1364
TKO: TK1686
TON: TON_1374
TGA: TGAM_0403
TSI: TSIB_0551
THE: GQS_08705
THA: TAM4_1085
THM: CL1_1361
TLT: OCC_04345
THS: TES1_1388
TNU: BD01_1978
TEU: TEU_04510
PPAC: PAP_09620
ABI: Aboo_1374
ACJ: ACAM_1211
SMR: Smar_1379
IHO: Igni_0452
IIS: EYM_02255
DKA: DKAM_0336
TAG: Tagg_0656
HBU: Hbut_0343
STO: STK_05320
SSO: SSO2399
SOL: Ssol_0205
SSOA: SULA_0197
SSOL: SULB_0198
SSOF: SULC_0197
SAI: Saci_0949
SID: M164_0209
SII: LD85_0194
SIH: SiH_0196
SIR: SiRe_0190
SIC: SiL_0183
MSE: Msed_0614
MCN: Mcup_1489
AHO: Ahos_2193
PAI: PAE3406
PIS: Pisl_1361
PCL: Pcal_0384
PAS: Pars_2001
PYR: P186_1236
POG: Pogu_0121
TNE: Tneu_0315
CMA: Cmaq_1781
TUZ: TUZN_1336
TTN: TTX_1081
VDI: Vdis_0593
VMO: VMUT_1928
ASC: ASAC_0272
NMR: Nmar_1719
NCT: NMSP_1635
NEV: NTE_02600
NCV: NCAV_0022
NBV: T478_1432
NDV: NDEV_2028(pps)
BARB: AOA66_0497
 » show all
Taxonomy
Reference
1  [PMID:19666462]
  Authors
Yokooji Y, Tomita H, Atomi H, Imanaka T
  Title
Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea.
  Journal
J Biol Chem 284:28137-45 (2009)
DOI:10.1074/jbc.M109.009696
  Sequence
[tko:TK1686]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.36
IUBMB Enzyme Nomenclature: 6.3.2.36
ExPASy - ENZYME nomenclature database: 6.3.2.36
BRENDA, the Enzyme Database: 6.3.2.36

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