KEGG   ENZYME: 6.3.2.41
Entry
EC 6.3.2.41                 Enzyme                                 
Name
N-acetylaspartylglutamate synthase;
N-acetylaspartylglutamate synthetase;
NAAG synthetase;
NAAGS;
RIMKLA (gene name) (ambiguous);
RIMKLB (gene name) (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamate-forming)
Reaction(IUBMB)
ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate [RN:R10678]
Reaction(KEGG)
R10678
Substrate
ATP [CPD:C00002];
N-acetyl-L-aspartate [CPD:C01042];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N-acetyl-L-aspartyl-L-glutamate [CPD:C12270]
Comment
The enzyme, found in animals, produces the neurotransmitter N-acetyl-L-aspartyl-L-glutamate. One isoform also has the activity of EC 6.3.1.17, beta-citrylglutamate synthase [2], while another isoform has the activity of EC 6.3.2.42, N-acetylaspartylglutamylglutamate synthase [3].
History
EC 6.3.2.41 created 2014
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec01100  Metabolic pathways
Orthology
K18310  beta-citrylglutamate/N-acetylaspartylglutamate synthase
K18311  N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase
Genes
HSA284716(RIMKLA) 57494(RIMKLB)
PTR735860(RIMKLB) 748944(RIMKLA)
PPS100970527(RIMKLA) 100974820(RIMKLB)
GGO101136567(RIMKLB) 101137769(RIMKLA)
PON100441104(RIMKLB) 100457877(RIMKLA)
NLE100589997(RIMKLA) 100593570(RIMKLB)
MCC699767(RIMKLA) 722261(RIMKLB)
MCF102124154(RIMKLB) 102128755(RIMKLA) 102128847 123572791
CSAB103218536(RIMKLB) 103225007(RIMKLA)
CATY105587959(RIMKLB) 105594671(RIMKLA)
PANU101017885(RIMKLA) 101024010(RIMKLB)
TGE112631615(RIMKLA) 112635206(RIMKLB)
RRO104668996(RIMKLA) 104672842(RIMKLB)
RBB108530380(RIMKLA) 108543684(RIMKLB)
TFN117090541(RIMKLB) 117092770(RIMKLA)
PTEH111526616(RIMKLB) 111548818(RIMKLA)
CJC100400904(RIMKLA) 100406491(RIMKLB)
SBQ101028223(RIMKLA) 101033047(RIMKLB)
CSYR103251714(RIMKLB) 103269612(RIMKLA)
MMUR105862291(RIMKLA) 105878274(RIMKLB)
OGA100941690(RIMKLB) 100962508(RIMKLA)
MMU108653(Rimklb) 194237(Rimkla)
MCAL110293598(Rimkla) 110296264(Rimklb)
MPAH110316335(Rimklb) 110323614(Rimkla)
RNO362428(Rimklb)
MCOC116096541(Rimkla) 116099539(Rimklb)
MUN110547458(Rimkla) 110556298(Rimklb)
CGE100759423(Rimkla) 100760031(Rimklb)
PLEU114683483(Rimklb) 114704934(Rimkla)
NGI103727467(Rimklb) 103735994(Rimkla)
HGL101706744(Rimklb) 101721728(Rimkla)
CPOC100713055(Rimkla) 100732576(Rimklb)
CCAN109697724(Rimklb) 109702396(Rimkla)
DORD105986036(Rimkla) 105991108(Rimklb)
DSP122111270(Rimkla) 122127019(Rimklb)
NCAR124969199 124983424
OCU100346793(RIMKLB) 100356205(RIMKLA)
OPI101523234(RIMKLB) 101536112(RIMKLA)
TUP102472940(RIMKLB) 102474653(RIMKLA)
CFA482445(RIMKLA) 486698(RIMKLB)
VVP112908198(RIMKLA) 112917302(RIMKLB)
VLG121479857(RIMKLB) 121481599(RIMKLA)
AML100472546(RIMKLA) 100473320(RIMKLB)
UMR103669163(RIMKLB) 103670923(RIMKLA)
UAH113254814(RIMKLA) 113257923(RIMKLB)
UAR123781552(RIMKLB) 123793822(RIMKLA)
ELK111142053 111143454
LLV125098454 125106794
MPUF101680352(RIMKLB) 101690597(RIMKLA)
ORO101368732(RIMKLA) 101374535(RIMKLB)
EJU114221687(RIMKLB) 114224206(RIMKLA)
ZCA113919895(RIMKLA) 113921819(RIMKLB)
MLX118019547(RIMKLA) 118025692(RIMKLB)
FCA101097740(RIMKLB) 101099388(RIMKLA)
PYU121022064(RIMKLB) 121026952(RIMKLA)
PBG122473789(RIMKLB) 122480352(RIMKLA)
PTG102959348(RIMKLA) 102963865(RIMKLB)
PPAD109254893(RIMKLA) 109276058(RIMKLB)
AJU106965320(RIMKLB) 106970196(RIMKLA)
HHV120222721(RIMKLB) 120236090(RIMKLA)
BTA507323(RIMKLA) 538579(RIMKLB)
BOM102269649(RIMKLB) 102285876(RIMKLA)
BIU109556903(RIMKLA) 109559695(RIMKLB)
BBUB102397788(RIMKLB) 102407086(RIMKLA)
CHX102176861(RIMKLB) 102179728(RIMKLA)
OAS101102554(RIMKLB) 101104941(RIMKLA)
ODA120856323(RIMKLA) 120858791(RIMKLB)
CCAD122423372(RIMKLB) 122437135(RIMKLA) 122439954
SSC100152915(RIMKLB) 100522878(RIMKLA)
CFR102503881(RIMKLB) 102522941(RIMKLA)
CBAI105062179(RIMKLB) 105072857(RIMKLA)
CDK105098170(RIMKLB) 105105491(RIMKLA)
VPC102526778(RIMKLB) 102545512(RIMKLA)
BACU103018606(RIMKLA) 103019013(RIMKLB)
LVE103069710(RIMKLB) 103083571(RIMKLA)
OOR101273054(RIMKLB) 101275823(RIMKLA)
DLE111175673(RIMKLA) 111176728(RIMKLB)
PCAD102981532(RIMKLB) 102982103(RIMKLA)
PSIU116746837 116760947(RIMKLB) 116762902(RIMKLA)
ECB100061350(RIMKLB) 100067475(RIMKLA)
EPZ103557317(RIMKLA) 103564581(RIMKLB)
EAI106837431(RIMKLB) 106847814(RIMKLA)
MYB102245342(RIMKLB) 102249129(RIMKLA)
MYD102752373(RIMKLB) 102754710(RIMKLA)
MMYO118650363(RIMKLB) 118677485(RIMKLA)
MLF102430712(RIMKLA) 102441683(RIMKLB)
MNA107531164(RIMKLA) 107544073(RIMKLB)
PKL118723941(RIMKLA) 118728963(RIMKLB)
HAI109372752(RIMKLB) 109383339(RIMKLA)
DRO112299564(RIMKLA) 112322046(RIMKLB)
SHON118977580(RIMKLA) 119002540(RIMKLB)
AJM119052488(RIMKLA) 119065675(RIMKLB)
PDIC114497212(RIMKLA) 114514072(RIMKLB)
PHAS123819342(RIMKLB) 123831998(RIMKLA)
MMF118624708(RIMKLB) 118627179(RIMKLA)
RFQ117027770(RIMKLA) 117028564(RIMKLB)
PALE102880426(RIMKLB) 102882758(RIMKLA)
PGIG120607199(RIMKLA) 120611695(RIMKLB)
PVP105295916(RIMKLB) 105304029(RIMKLA)
RAY107501656(RIMKLB) 107508299(RIMKLA)
MJV108396116(RIMKLB) 108399391(RIMKLA) 108403838
TOD119236219(RIMKLA) 119247737(RIMKLB)
SARA101544446(RIMKLA) 101554225(RIMKLB)
LAV100657534(RIMKLB) 100664484(RIMKLA)
TMU101348075 101361972
DNM101416522(RIMKLB) 101421529(RIMKLA)
MDO100013787(RIMKLB) 100026482(RIMKLA)
GAS123243217(RIMKLA) 123250757(RIMKLB)
SHR100913508(RIMKLA) 100930894(RIMKLB)
PCW110206227(RIMKLA) 110213807(RIMKLB)
OAA100073839(RIMKLA) 100090307(RIMKLB)
GGA418255(RIMKLB)
PCOC116240958(RIMKLB)
MGP104916636
CJO107318392(RIMKLB)
NMEL110397764(RIMKLB)
APLA101792875(RIMKLB)
ACYG106048091(RIMKLB)
AFUL116490791(RIMKLB)
TGU100220208(RIMKLB)
LSR110472321(RIMKLB)
SCAN103827201(RIMKLB)
PMOA120497743(RIMKLB)
OTC121341027(RIMKLB)
PRUF121349851(RIMKLB)
GFR102035986(RIMKLB)
FAB101814507(RIMKLB)
PHI102111957(RIMKLB)
PMAJ107210434(RIMKLB)
CCAE111925810(RIMKLB)
CCW104690266(RIMKLB)
ETL114069342(RIMKLB)
ZAB102064947(RIMKLB)
FPG101913481(RIMKLB)
FCH102056126(RIMKLB)
CLV102098362(RIMKLB)
EGZ104122771(RIMKLB)
NNI104014577(RIMKLB)
ACUN113491069(RIMKLB)
TALA104365181(RIMKLB)
PADL103915115(RIMKLB)
ACHC115352600(RIMKLB)
AAM106495722(RIMKLB)
AROW112973974(RIMKLB)
NPD112952039(RIMKLB)
DNE112992432(RIMKLB)
ASN102373845(RIMKLB)
AMJ102576775(RIMKLB)
CPOO109316234(RIMKLB)
GGN109296594(RIMKLB)
PSS102451018(RIMKLB)
CMY102933090(RIMKLB)
CPIC101943668(RIMKLB)
TST117884982(RIMKLB)
CABI116823843(RIMKLB)
MRV120404562(RIMKLB)
ACS100563778(rimklb)
PVT110069781(RIMKLB)
SUND121921715(RIMKLB)
PBI103055545(RIMKLB)
PMUR107288539(RIMKLB)
TSR106544566(RIMKLB)
PGUT117661914(RIMKLB)
VKO123017759(RIMKLB)
PMUA114588043(RIMKLB)
ZVI118097943(RIMKLB)
GJA107117747(RIMKLB)
XLA108696039 108696583 108697330
XTR100145548(rimkla) 100486701(rimklb)
NPR108783941(RIMKLA) 108799485(RIMKLB)
RTEM120915609(RIMKLA) 120946910(RIMKLB)
BBUF120998179(RIMKLA) 121005412(RIMKLB)
BGAR122926877(RIMKLA) 122941782(RIMKLB)
DRE447815(rimkla)
SRX107711947 107717536
SANH107669631
SGH107556480 107591767
CCAR109084979 109084984
CAUA113078389 113093917 113107768
IPU108265850(rimkla)
PHYP113529230
SMEO124399561(rimkla)
TFD113655760(rimkla)
AMEX103035057
EEE113572086
TRU101062827
TNGGSTEN00013753G001
LCO104920219
NCC104955181(rimkla)
CGOB115011073
ELY117258509(rimkla)
PLEP121947276(rimkla)
SLUC116040663(rimkla)
ECRA117948232(rimkla)
PFLV114558866
GAT120828693(rimkla)
PPUG119205701 119222662
MSAM119905637(rimkla)
CUD121518035(rimkla)
MZE101477475
ONL100698845
OAU116309725(rimkla)
OLA101169452(rimklb)
OML112159079(rimkla)
XMA102218635
XCO114141086
XHE116725681
PRET103467997(rimkla)
PFOR103138952(rimkla)
PLAI106957454(rimkla)
PMEI106907435(rimkla)
GAF122836233(rimkla)
CVG107088869(rimkla)
CTUL119797064(rimkla)
GMU124867677(rimkla)
NFU107390714
KMR108236831(rimkla)
ALIM106524174
NWH119417065(rimkla)
AOCE111585273
CSEM103384935
POV109630621(rimkla)
SSEN122776960(rimkla)
HHIP117764653(rimkla)
LCF108891717(rimkla)
SDU111219047
SLAL111670604
XGL120804092(rimkla)
HCQ109526583
BPEC110161111
MALB109970719
SASA106567384 106572158
OTW112215953 112221609
OMY110491822 110532211
OGO124017459 124031877
ONE115102623 115132092
SALP111966388 111976646
SNH120059373 120060966
ELS105013808
SFM108918203 108924922
PKI111856970 111859075(rimkla)
AANG118208179(rimkla)
LOC102687393(rimkla)
PSPA121296514 121325367 121328885 121329280
ARUT117424072 117425213 117425745 117432003
LCM102351441(RIMKLB) 102354509(RIMKLA)
CMK103190080(rimkla)
RTP109924989
 » show all
Reference
1  [PMID:20643647]
  Authors
Becker I, Lodder J, Gieselmann V, Eckhardt M
  Title
Molecular characterization of N-acetylaspartylglutamate synthetase.
  Journal
J Biol Chem 285:29156-64 (2010)
DOI:10.1074/jbc.M110.111765
  Sequence
[mmu:108653] [hsa:57494]
Reference
2  [PMID:20657015]
  Authors
Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E
  Title
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
  Journal
J Biol Chem 285:29826-33 (2010)
DOI:10.1074/jbc.M110.152629
  Sequence
Reference
3  [PMID:21454531]
  Authors
Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M
  Title
N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.
  Journal
J Biol Chem 286:16693-706 (2011)
DOI:10.1074/jbc.M111.230136
  Sequence
[mmu:194237] [hsa:284716]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.41
IUBMB Enzyme Nomenclature: 6.3.2.41
ExPASy - ENZYME nomenclature database: 6.3.2.41
BRENDA, the Enzyme Database: 6.3.2.41

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