KEGG   ENZYME: 6.3.2.42
Entry
EC 6.3.2.42                 Enzyme                                 
Name
N-acetylaspartylglutamylglutamate synthase;
N-acetylaspartylglutamylglutamate synthetase;
NAAG(2) synthase;
NAAG synthetase II;
NAAGS-II;
RIMKLA (gene name) (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming)
Reaction(IUBMB)
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [RN:R10679]
Reaction(KEGG)
R10679;
(other) R10678 R10693
Substrate
ATP [CPD:C00002];
N-acetyl-L-aspartate [CPD:C01042];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [CPD:C20776]
Comment
The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
History
EC 6.3.2.42 created 2014
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec01100  Metabolic pathways
Orthology
K18311  N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase
Genes
HSA284716(RIMKLA)
PTR748944(RIMKLA)
PPS100970527(RIMKLA)
GGO101137769(RIMKLA)
PON100457877(RIMKLA)
NLE100589997(RIMKLA)
MCC699767(RIMKLA)
MCF102128755(RIMKLA)
CSAB103225007(RIMKLA)
CATY105594671(RIMKLA)
PANU101017885(RIMKLA)
TGE112631615(RIMKLA)
RRO104668996(RIMKLA)
RBB108530380(RIMKLA)
TFN117092770(RIMKLA)
PTEH111548818(RIMKLA)
CJC100400904(RIMKLA)
SBQ101028223(RIMKLA)
CSYR103269612(RIMKLA)
MMUR105862291(RIMKLA)
LCAT123634283(RIMKLA)
OGA100962508(RIMKLA)
MMU194237(Rimkla)
MCAL110293598(Rimkla)
MPAH110323614(Rimkla)
MCOC116096541(Rimkla)
MUN110547458(Rimkla)
CGE100759423(Rimkla)
MAUA101843711(Rimkla)
PLEU114704934(Rimkla)
MORG121448391(Rimkla)
AAMP119818063(Rimkla)
NGI103735994(Rimkla)
HGL101721728(Rimkla)
CPOC100713055(Rimkla)
CCAN109702396(Rimkla)
DORD105986036(Rimkla)
DSP122111270(Rimkla)
NCAR124969199
OCU100356205(RIMKLA)
OPI101536112(RIMKLA)
TUP102474653(RIMKLA)
CFA482445(RIMKLA)
VVP112908198(RIMKLA)
VLG121481599(RIMKLA)
AML100472546(RIMKLA)
UMR103670923(RIMKLA)
UAH113254814(RIMKLA)
UAR123793822(RIMKLA)
ELK111143454
LLV125098454
MPUF101690597(RIMKLA)
ORO101368732(RIMKLA)
EJU114224206(RIMKLA)
ZCA113919895(RIMKLA)
MLX118019547(RIMKLA)
FCA101099388(RIMKLA)
PYU121026952(RIMKLA)
PBG122480352(RIMKLA)
PTG102959348(RIMKLA)
PPAD109254893(RIMKLA)
AJU106970196(RIMKLA)
HHV120236090(RIMKLA)
BTA507323(RIMKLA)
BOM102285876(RIMKLA)
BIU109556903(RIMKLA)
BBUB102407086(RIMKLA)
CHX102179728(RIMKLA)
OAS101104941(RIMKLA)
ODA120856323(RIMKLA)
CCAD122437135(RIMKLA)
SSC100522878(RIMKLA)
CFR102522941(RIMKLA)
CBAI105072857(RIMKLA)
CDK105105491(RIMKLA)
VPC102545512(RIMKLA)
BACU103018606(RIMKLA)
LVE103083571(RIMKLA)
OOR101275823(RIMKLA)
DLE111175673(RIMKLA)
PCAD102982103(RIMKLA)
PSIU116762902(RIMKLA)
ECB100067475(RIMKLA)
EPZ103557317(RIMKLA)
EAI106847814(RIMKLA)
MYB102249129(RIMKLA)
MYD102754710(RIMKLA)
MMYO118677485(RIMKLA)
MLF102430712(RIMKLA)
MNA107531164(RIMKLA)
PKL118723941(RIMKLA)
HAI109383339(RIMKLA)
DRO112299564(RIMKLA)
SHON118977580(RIMKLA)
AJM119052488(RIMKLA)
PDIC114497212(RIMKLA)
PHAS123831998(RIMKLA)
MMF118627179(RIMKLA)
RFQ117027770(RIMKLA)
PALE102882758(RIMKLA)
PGIG120607199(RIMKLA)
PVP105304029(RIMKLA)
RAY107508299(RIMKLA)
MJV108399391(RIMKLA) 108403838
TOD119236219(RIMKLA)
SARA101544446(RIMKLA)
LAV100664484(RIMKLA)
TMU101348075
DNM101421529(RIMKLA)
MDO100026482(RIMKLA)
GAS123243217(RIMKLA)
SHR100913508(RIMKLA)
PCW110206227(RIMKLA)
OAA100073839(RIMKLA)
XLA108696583
XTR100145548(rimkla)
NPR108783941(RIMKLA)
RTEM120915609(RIMKLA)
BBUF120998179(RIMKLA)
BGAR122926877(RIMKLA)
 » show all
Reference
1  [PMID:21454531]
  Authors
Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M
  Title
N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.
  Journal
J Biol Chem 286:16693-706 (2011)
DOI:10.1074/jbc.M111.230136
  Sequence
[mmu:194237] [hsa:284716]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.42
IUBMB Enzyme Nomenclature: 6.3.2.42
ExPASy - ENZYME nomenclature database: 6.3.2.42
BRENDA, the Enzyme Database: 6.3.2.42

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