KEGG   ENZYME: 6.3.2.53Help
Entry
EC 6.3.2.53                 Enzyme                                 

Name
UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase;
murD2 (gene name);
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate synthetase;
UDP-MurNAc-L-Ala-L-Glu synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + L-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate [RN:R12272]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-muramoyl-L-alanine [CPD:C01212];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate [CPD:C22053]
Comment
The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyses the ligation of a terminal L-glutamate to UDP-N-acetyl-alpha-D-muramoyl-L-alanine. The combined activity of this enzyme and EC 5.1.1.23, UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase, provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3, glutamate racemase, and EC 6.3.2.9, UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase.
History
EC 6.3.2.53 created 2018
Pathway
ec00471  D-Glutamine and D-glutamate metabolism
ec01100  Metabolic pathways
Orthology
K23169  UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase
Genes
XFA: XF_1118
XFT: PD_0410(murD)
XFM: Xfasm12_0463
XFN: XfasM23_0404
XFF: XFLM_07445(murD)
XFL: P303_01520(murD)
XFS: D934_03165(murD)
XFH: XFHB_09980(murD)
XCC: XCC2738(murD)
XCB: XC_1375
XCA: xcc-b100_1423(murD)
XCP: XCR_3103(murD)
XCV: XCV3053(murD)
XAX: XACM_2840(murD)
XAC: XAC2908(murD)
XCI: XCAW_03185(murD)
XFU: XFF4834R_chr17310(murD)
XAO: XAC29_14785(murD)
XOO: XOO1436(murD)
XOM: XOO1320(XOO1320)
XOP: PXO_02013(murD)
XOY: AZ54_17285(murD)
XOR: XOC_1508(murD)
XOZ: BE73_15870(murD)
XAL: XALC_1040(murD)
XSA: SB85_19215(murD)
XTN: FD63_12880(murD)
XPH: XppCFBP6546_21370(XppCFBP6546P_21370)
XAN: AC801_14450(murD)
XAR: XB05_09285(murD)
SML: Smlt1170(murD)
SMT: Smal_1013
SMZ: SMD_1091(murD)
SACZ: AOT14_11460(murD)
STEK: AXG53_12015(murD)
PSUW: WQ53_12435(murD)
PSD: DSC_05875(murD)
LAB: LA76x_1652(murD)
LAQ: GLA29479_622(murD)
LCP: LC55x_1440(murD)
LGU: LG3211_3705(murD)
LEZ: GLE_3730(murD)
LEM: LEN_1404(murD)
DKO: I596_815
RBD: ALSL_0763
SUA: Saut_0607
PHL: KKY_2208
DEI: C4375_13235(murD)
DEA: FPZ08_10315(murD)
YTI: FNA67_16185(murD)
FSA: C5Q98_01705(murD)
ESR: ES1_22010
ESU: EUS_07940
BFI: CIY_04060
RIX: RO1_21100
RIM: ROI_08450
CBOL: CGC65_00545(murD)
PXV: FXF36_08210(murD)
CBAR: PATL70BA_0973(murD)
LTR: EVS81_15155(murD)
NOI: FCL41_11765(murD)
NAK: EH165_15010(murD)
GOB: Gobs_4629
SAQ: Sare_3229
MIL: ML5_4080
VMA: VAB18032_25490(murD)
ASE: ACPL_1938(murD)
ACTN: L083_2284(murD)
AFS: AFR_11175(murD)
ACTS: ACWT_1816
CWO: Cwoe_3772
MIN: Minf_2246(murD)
MKC: kam1_2041
 » show all
Taxonomy
Reference
1  [PMID:28294606]
  Authors
Feng R, Satoh Y, Ogasawara Y, Yoshimura T, Dairi T
  Title
A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis.
  Journal
J Am Chem Soc 139:4243-4245 (2017)
DOI:10.1021/jacs.7b01221
  Sequence
[xom:XOO1320]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.53
IUBMB Enzyme Nomenclature: 6.3.2.53
ExPASy - ENZYME nomenclature database: 6.3.2.53
BRENDA, the Enzyme Database: 6.3.2.53

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