KEGG   ENZYME: 6.3.2.55
Entry
EC 6.3.2.55                 Enzyme                                 
Name
2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase;
sbnF (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate:L-2,3-diaminopropanoate ligase {2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate-forming}
Reaction(IUBMB)
ATP + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + L-2,3-diaminopropanoate = AMP + diphosphate + 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate [RN:R12311]
Reaction(KEGG)
R12311
Substrate
ATP [CPD:C00002];
2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD:C22073];
L-2,3-diaminopropanoate [CPD:C03401]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate [CPD:C22074]
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B. It belongs to a class of siderophore synthases known as type C nonribosomal peptide synthase-independent synthases (NIS). Type C NIS enzymes recognize esterified or amidated derivatives of carboxylic acids. The enzyme likely forms a 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate adenylate intermediate prior to ligation.
History
EC 6.3.2.55 created 2019
Pathway
ec00997  Biosynthesis of various other secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23374  2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
Genes
DDDDda3937_02851(acsC)
DZEDd1591_2674
DDCDd586_2581
DZCW909_07420
DSOA4U42_16815
CEDLH89_04360
DFNCVE23_08420
DDQDDI_1277
DAQDAQ1742_01514(acsC)
DICDpoa569_002355
LBQCKQ53_11530
LPOPI6N93_10210
SGLSGP1_0041
XDOXDD1_1966
VTAA3470
PFVPsefu_2383
PSBPsyr_2587
PSYRN018_14375
PSPPSPPH_2754
PSAVPSA3335_16160
PAMGBKM19_016035
PAVLBKM03_14810
PVDCFBP1590__2717
PCABJGS08_13335
PCOFPOR16_12185
PTREI9H09_12725
PSYIMME58_13590
PCGAXG94_01630
PBCCD58_14505
PCHEY04_15705
PCZPCL1606_28870
PCPJM49_14860
PSEMTO66_16020
PFKPFAS1_21425
PSILPMA3_09135
PALIA3K91_1226
PSYPE5677_07280
ABYABAYE2005
ABCACICU_01675
ABNAB57_1872
ABBABBFA_01825(iucC_2)
ABXABK1_2133
ABZABZJ_01836
ABRABTJ_02032
ABDABTW07_1891
ABHM3Q_2027
ABADABD1_16350
ABJBJAB07104_02077
ABABBJAB0715_01858
ABAJBJAB0868_01797
ABAZP795_9035
ABKLX00_08320
ABAUIX87_19070
ABAAIX88_10155
ABWBL01_08515
ABALABLAC_24810
ALCOTEC02_07345
ACIACIAD2121
ACVAMD27_03895
ARJDOM24_08495
ADSFPL17_05855
CEKD0B88_14035
CEGD0C16_05365
MMTMetme_3393
HELHELO_3334
HHUAR456_14830
HHHCLM76_01230
HPIZGYM47_13050
HSVHNO53_08395
HAAA5892_12600
RSORSp0422
RSLRPSI07_mp0383
RSNRSPO_m01406(rhbC)
RSMCMR15_mp10435
RSEF504_3902(sbnF)
RSYRSUY_34900(iucC_2)
RPUCDC45_19740
RSGJK151_14160
CNCCNE_2c14880(sbnA2)
CUHBJN34_08300
RMERmet_1112
BPLAbpln_2g05060
MFLAGO485_03160
NETNeut_1745
NLCEBAPG3_006475
BIDBind_2101
LEJETW24_21435
THACCSC3H3_23830
BBADK7T73_21425
PCALBV455_03919(iucC_1)
LGYT479_22385
SALEEPH95_16130
SAUSA0117(sbnF)
SAVSAV0121
SAWSAHV_0120
SAHSaurJH1_0112
SAJSaurJH9_0108
SAMMW0094(sbnF)
SASSAS0095
SARSAR0124
SACSACOL0105
SAXUSA300HOU_0132
SAASAUSA300_0123
SAOSAOUHSC_00080
SAENWMN_0065(sbnF)
SADSAAV_0089
SUUM013TW_0111(sbnF)
SUVSAVC_00345
SUESAOV_0068
SUJSAA6159_00104
SUKSAA6008_00099
SUCECTR2_77
SUTSAT0131_00107
SUQHMPREF0772_10376
SUZMS7_0113
SUDST398NM01_0133
SUXSAEMRSA15_00870
SUWSATW20_01330(sbnF)
SUGSAPIG0133
SUFSARLGA251_00960(sbnF)
SAUASAAG_00605
SAUERSAU_000075
SAUNSAKOR_00095
SAUSSA40_0088(sbnF)
SAUUSA957_0103(sbnF)
SAUGSA268_0100(sbnF)
SAUZSAZ172_0132(sbnF)
SAUTSAI1T1_2000770
SAUJSAI2T2_1000770
SAUKSAI3T3_1000770
SAUQSAI4T8_1000770
SAUVSAI7S6_1000770
SAUWSAI5S5_1000770
SAUXSAI6T6_1000770
SAUYSAI8T7_1000770
SAUFX998_0100
SABSAB0060
SUYSA2981_0122(sbnF)
SAUBC248_0109
SAUMBN843_1230
SAUCCA347_132
SAURSABB_03469
SAUIAZ30_00630
SAUDCH52_05115
SAMSNI36_00525
SUHSAMSHR1132_00970
SSDSPSINT_0339
SDTSPSE_2119
SDPNCTC12225_02336(iucC_3)
SHUSHYC_00380(sbnF)
SSCHLH95_00380
SSCZRN70_00600
SAGQEP23_09745(sbnF)
SEQOSE1039_25060
SLZB5P37_07615
SARLSAP2_02080
SSHNCTC13712_00074(iucC_2)
SRAILN051_00255(sbnF)
SFFFOB90_07410(sbnF)
MBRUMGG13_01650
BAGRBA6348_15330
PPOLX809_04490
PTAHPL003_19615
PPEOABE82_04645
PNPIJ22_24490
POWIJ21_46090
PXLBS614_08685
PKBB4V02_14040
PPSCEHS13_31655
PBACHUB98_21835
ANXACH33_02535 ACH33_02540
ATHEK3F53_16415
CCHLFPL14_15120
SACAFFV09_03640 FFV09_03645
TUMCBW65_11375 CBW65_11410
TABCIG75_02865
LFBC1X05_04255
KPULGXN76_14230
PABSJIR001_05140
SACGFDZ84_26455
PSEQAD006_29045
PECQAD017_29435
PMADBAY61_28590
 » show all
Reference
1  [PMID:19775248]
  Authors
Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE
  Title
Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
Mol Microbiol 74:594-608 (2009)
DOI:10.1111/j.1365-2958.2009.06880.x
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.55
IUBMB Enzyme Nomenclature: 6.3.2.55
ExPASy - ENZYME nomenclature database: 6.3.2.55
BRENDA, the Enzyme Database: 6.3.2.55

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