KEGG   ENZYME: 6.3.2.56Help
Entry
EC 6.3.2.56                 Enzyme                                 

Name
staphyloferrin B synthase;
sbnC (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate:2-oxoglutarate ligase (staphyloferrin B-forming)
Reaction(IUBMB)
ATP + 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate = AMP + diphosphate + staphyloferrin B [RN:R12312]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate [CPD:C22074];
2-oxoglutarate [CPD:C00026]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
staphyloferrin B [CPD:C22075]
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin B. It belongs to a class of siderophore synthases known as type B nonribosomal peptide synthase-independent synthases (NIS). Type B NIS enzymes recognize the delta-acid group of 2-oxoglutarate. The enzyme forms a 2-oxoglutarate adenylate intermediate prior to ligation.
History
EC 6.3.2.56 created 2019
Pathway
ec00997  Biosynthesis of various secondary metabolites - part 3
ec01100  Metabolic pathways
Orthology
K23375  staphyloferrin B synthase
Genes
ACC: BDGL_001499
ANO: RR32_07475
ACAL: BUM88_11505
ACD: AOLE_07110
ACW: A0J50_07095
RSL: RPSI07_mp0380
RSN: RSPO_m01409
RSM: CMR15_mp10432
RSE: F504_3905
RSY: RSUY_34870(iucC_1)
MAQU: Maq22A_c25435(rhbC)
SAU: SA0114(sbnC)
SAV: SAV0118
SAW: SAHV_0117
SAM: MW0091(sbnC)
SAS: SAS0092
SAR: SAR0121
SAC: SACOL0102
SAA: SAUSA300_0120(sbnC)
SAE: NWMN_0062(sbnC)
SAD: SAAV_0086
SUU: M013TW_0108(sbnC)
SUE: SAOV_0065
SUJ: SAA6159_00101(sbnC)
SUK: SAA6008_00096(sbnC)
SUC: ECTR2_74
SUZ: MS7_0110
SUW: SATW20_01300(sbnC)
SUG: SAPIG0129
SUF: SARLGA251_00930(sbnC)
SAUA: SAAG_00602
SAUE: RSAU_000072(sbnC)
SAUS: SA40_0085(sbnC)
SAUU: SA957_0100(sbnC)
SAUG: SA268_0097(sbnC)
SAUZ: SAZ172_0129(sbnC)
SAUF: X998_0097
SAB: SAB0057
SUY: SA2981_0119(sbnC)
SAUB: C248_0106
SAUM: BN843_1200
SAUC: CA347_129
SAUR: SABB_01722(sbnC)
SAUI: AZ30_00615
SAUD: CH52_05130
SAMS: NI36_00510
SDT: SPSE_2122
SSCH: LH95_00365
SSCZ: RN70_00585
SAGQ: EP23_09760
SALJ: SMD11_0168
 » show all
Taxonomy
Reference
1  [PMID:19775248]
  Authors
Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE
  Title
Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
Mol Microbiol 74:594-608 (2009)
DOI:10.1111/j.1365-2958.2009.06880.x
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.56
IUBMB Enzyme Nomenclature: 6.3.2.56
ExPASy - ENZYME nomenclature database: 6.3.2.56
BRENDA, the Enzyme Database: 6.3.2.56

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