KEGG   ENZYME: 6.3.2.57Help
Entry
EC 6.3.2.57                 Enzyme                                 

Name
staphyloferrin A synthase;
sfnaB (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
N5-[(S)-citryl]-D-ornithine:citrate ligase (staphyloferrin A-forming)
Reaction(IUBMB)
ATP + N5-[(S)-citryl]-D-ornithine + citrate = AMP + diphosphate + staphyloferrin A [RN:R12354]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
N5-[(S)-citryl]-D-ornithine [CPD:C22101];
citrate [CPD:C00158]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
staphyloferrin A [CPD:C22102]
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.
History
EC 6.3.2.57 created 2019
Pathway
ec00997  Biosynthesis of various secondary metabolites - part 3
ec01100  Metabolic pathways
Orthology
K23447  staphyloferrin A synthase
Genes
SDO: SD1155_00625
BWH: A9C19_09105
GCT: GC56T3_0421
GJF: M493_02170
GSR: GS3922_13790
HHD: HBHAL_4881(figA)
HLI: HLI_03745
SJE: AAV35_000860
SAU: SA1981
SAV: SAV2179
SAW: SAHV_2163
SAM: MW2105
SAS: SAS2080
SAR: SAR2270
SAC: SACOL2169
SAE: NWMN_2080
SAD: SAAV_2240
SUU: M013TW_2145(sfaB)
SUZ: MS7_2202
SUG: SAPIG2239
SAUA: SAAG_00014
SAUS: SA40_1934
SAUU: SA957_2018
SAUG: SA268_2089
SAUF: X998_2164
SAB: SAB2060c
SAUB: C248_2217
SAUC: CA347_2264
SAUR: SABB_01483
SAUI: AZ30_11520
SAUD: CH52_08050
SAMS: NI36_10760
SEP: SE1770
SER: SERP1779
SEPP: SEB_01779
SEPS: DP17_723
SHA: SH0861
SSP: SSP0707
SCA: SCA_1682
SDT: SPSE_0634
SPAS: STP1_0608
SXO: SXYL_00749(sfaB)
SCAP: AYP1020_1372(iucA)
SSCH: LH95_03230
SSCZ: RN70_03505
SAGQ: EP23_06670
SHY: SHJG_0928
AFS: AFR_21250
 » show all
Taxonomy
Reference
1  [PMID:19138128]
  Authors
Cotton JL, Tao J, Balibar CJ.
  Title
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.
  Journal
Biochemistry 48:1025-35 (2009)
DOI:10.1021/bi801844c
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.57
IUBMB Enzyme Nomenclature: 6.3.2.57
ExPASy - ENZYME nomenclature database: 6.3.2.57
BRENDA, the Enzyme Database: 6.3.2.57

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