KEGG   ENZYME: 6.3.2.58Help
Entry
EC 6.3.2.58                 Enzyme                                 

Name
D-ornithine---citrate ligase;
sfnaD (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
D-ornithine:citrate ligase {3-[(2-aminopentan-5-oylcarbamoyl)methyl]-3-hydroxybutanoate-forming}
Reaction(IUBMB)
ATP + D-ornithine + citrate = AMP + diphosphate + N5-[(S)-citryl]-D-ornithine [RN:R12353]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
D-ornithine [CPD:C00515];
citrate [CPD:C00158]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
N5-[(S)-citryl]-D-ornithine [CPD:C22101]
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.
History
EC 6.3.2.58 created 2019
Pathway
ec00997  Biosynthesis of various secondary metabolites - part 3
ec01100  Metabolic pathways
Orthology
K23446  D-ornithine---citrate ligase
Genes
SDO: SD1155_00635
BWH: A9C19_09110
GCT: GC56T3_0420
GJF: M493_02165
GSR: GS3922_13795
HHD: HBHAL_4880
HLI: HLI_03740
SJE: AAV35_000865
SAU: SA1983
SAV: SAV2181
SAW: SAHV_2165
SAM: MW2107
SAS: SAS2082
SAR: SAR2272
SAC: SACOL2171
SAE: NWMN_2082
SAD: SAAV_2242
SUU: M013TW_2147(sfaD)
SUE: SAOV_2228
SUZ: MS7_2204
SUG: SAPIG2241
SAUA: SAAG_00016
SAUS: SA40_1936
SAUU: SA957_2020
SAUG: SA268_2091
SAUF: X998_2166
SAB: SAB2062
SAUB: C248_2219
SAUC: CA347_2266
SAUR: SABB_01481
SAUI: AZ30_11530
SAUD: CH52_08040
SAMS: NI36_10770
SEP: SE1772
SER: SERP1781
SEPP: SEB_01781
SEPS: DP17_725
SHA: SH0859
SSP: SSP0705
SCA: SCA_1684
SDT: SPSE_0632
SPAS: STP1_0610
SXO: SXYL_00747(sfaD)
SCAP: AYP1020_1374(iucC)
SSCH: LH95_03220
SSCZ: RN70_03495
SAGQ: EP23_06680
 » show all
Taxonomy
Reference
1  [PMID:19138128]
  Authors
Cotton JL, Tao J, Balibar CJ.
  Title
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.
  Journal
Biochemistry 48:1025-35 (2009)
DOI:10.1021/bi801844c
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.58
IUBMB Enzyme Nomenclature: 6.3.2.58
ExPASy - ENZYME nomenclature database: 6.3.2.58
BRENDA, the Enzyme Database: 6.3.2.58

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