KEGG   ENZYME: 6.3.2.59
Entry
EC 6.3.2.59                 Enzyme                                 
Name
3-methyl-D-ornithine---L-lysine ligase;
N6-[(2R,3R)-3-methylornithyl]-L-lysine synthase;
3-methylornithine---L-lysine ligase;
pylC (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
(3R)-3-methyl-D-ornithine:L-lysine gamma-ligase (ADP-forming)
Reaction(IUBMB)
ATP + (3R)-3-methyl-D-ornithine + L-lysine = ADP + phosphate + N6-[(3R)-3-methyl-D-ornithinyl]-L-lysine [RN:R10011]
Reaction(KEGG)
R10011
Substrate
ATP [CPD:C00002];
(3R)-3-methyl-D-ornithine [CPD:C20277];
L-lysine [CPD:C00047]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N6-[(3R)-3-methyl-D-ornithinyl]-L-lysine [CPD:C20278]
Comment
The enzyme participates in the biosynthesis of L-pyrrolysine, a naturally occurring, genetically coded amino acid found in some methanogenic archaea and a few bacterial species. L-pyrrolysine is present in several methyltransferases that are involved in methyl transfer from methylated amine compounds to coenzyme M.
History
EC 6.3.2.59 created 2021
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16181  3-methylornithine--L-lysine ligase
Genes
WHJH9Q79_07360(pylC)
DSYDSY4957
DHDDhaf_4856
DDHDesde_0575
DORDesor_1624 Desor_3053
DMIDesmer_1593
DAEDtox_0029
FWADCMF_28150 DCMF_28350
AACXDEACI_4243
TJRTherJR_0024
DGIDesgi_3924
ELIMB2M23_05180
AMIJEQM06_09280(pylC)
AMICAmi3637_11540(pylC)
ABUTAmi103574_12090(pylC)
ETMCE91St48_13130
TPZTph_c24760
AARAcear_0359
MANAMAMMFC1_01956
MBAMbar_A0837
MBYMSBRM_0157
MBWMSBRW_0164
MBARMSBR2_2224
MBAKMSBR3_2275
MACMA_0153
MMAMM_1443
MMAZMmTuc01_1501
MMJMSMAS_3221
MMACMSMAC_3243
MVCMSVAZ_3359
MEKMSKOL_3318
MLSMSLAZ_3209
METMMSMTP_3121
MEFMSWH1_3070
MEQMSWHS_3281
MSJMSSAC_0135
MSZMSSIH_0122
MSWMSSIT_0126
MTHRMSTHT_1932
MTHEMSTHC_1351
MHORMSHOH_3967
MFZAOB57_008960(pylC)
MBUMbur_2084(pylC)
MMETMCMEM_0283
MELOJ7W08_11510(pylC)
MMHMmah_0281
MHAZBHR79_02115
MEVMetev_0936
MZHMzhil_1027
MPYMpsy_1723
MZIHWN40_00975(pylC)
MHZMetho_0020
MEAMMU439_03275
TARTALC_01090
MAXMMALV_11270
MERMMINT_08910
MEARMpt1_c05680(pylC)
MEUZKRP56_05615(pylC)
MARCAR505_1323
 » show all
Reference
1  [PMID:21455182]
  Authors
Gaston MA, Zhang L, Green-Church KB, Krzycki JA
  Title
The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine.
  Journal
Nature 471:647-50 (2011)
DOI:10.1038/nature09918
Reference
2  [PMID:21525873]
  Authors
Cellitti SE, Ou W, Chiu HP, Grunewald J, Jones DH, Hao X, Fan Q, Quinn LL, Ng K, Anfora AT, Lesley SA, Uno T, Brock A, Geierstanger BH.
  Title
D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine.
  Journal
Nat Chem Biol 7:528-30 (2011)
DOI:10.1038/nchembio.586
Reference
3  [PMID:22985965]
  Authors
Quitterer F, List A, Beck P, Bacher A, Groll M.
  Title
Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
  Journal
J Mol Biol 424:270-82 (2012)
DOI:10.1016/j.jmb.2012.09.007
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.59
IUBMB Enzyme Nomenclature: 6.3.2.59
ExPASy - ENZYME nomenclature database: 6.3.2.59
BRENDA, the Enzyme Database: 6.3.2.59

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