KEGG   ENZYME: 6.3.2.60
Entry
EC 6.3.2.60                 Enzyme                                 
Name
glutamate---[amino group carrier protein] ligase;
argX (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
L-glutamate:an [amino-group carrier protein]-C-terminal-L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + L-glutamate + an [amino-group carrier protein]-C-terminal-L-glutamate = ADP + phosphate + an [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate [RN:R10929]
Reaction(KEGG)
R10929
Substrate
ATP [CPD:C00002];
L-glutamate [CPD:C00025];
[amino-group carrier protein]-C-terminal-L-glutamate
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate
Comment
The enzyme, originally characterized from the archaeon Sulfolobus acidocaldarius, is involved in L-arginine biosynthesis. The enzyme from the archaeon Thermococcus kodakarensis is bifunctional and also catalyses the activity of EC 6.3.2.43, [amino-group carrier protein]---L-2-aminoadipate ligase.
History
EC 6.3.2.60 created 2021
Pathway
ec00220  Arginine biosynthesis
ec01100  Metabolic pathways
Orthology
K19412  glutamate---[amino group carrier protein] ligase
K25032  alpha-aminoadipate-LysW ligase/glutamate-LysW ligase
Genes
MIGMetig_0633
MVNMevan_0912
MOKMetok_1139
METFCFE53_00515
PFUPF1682
PFIPFC_10195
PHOPH1721(PH1721)
PABPAB0290(rimK)
PYNPNA2_0329 PNA2_0499
PYSPy04_1636
TKOTK0278
THSTES1_0507
THVADU37_CDS10050
TCHCHITON_1979
THEIK1720_00615(lysX)
FAIFAD_1383
IHOIgni_1403
IISEYM_00645
PFMPyrfu_0756
PDLPyrde_0370
STOSTK_15050(argE)
SOHD1869_08455(lysX)
SSOSSO0645(rimK-2)
SOLSsol_1704
SSOASULA_1732(lysX)
SSOLSULB_1733(lysX)
SSOFSULC_1731(lysX)
SSHIJ5U23_02762
SCASSACC_03370
SAISaci_1621
SACNSacN8_07870
SACRSacRon12I_07880
SACSSUSAZ_07680
SISLS215_1600
SIAM1425_1492
SIMM1627_1607
SIDM164_1489
SIYYG5714_1496
SINYN1551_1340
SIILD85_1699
SIHSiH_1458
SIRSiRe_1368
SICSiL_1371
SULABFU36_02820
SULEGFS03_08525(lysX)
SULOGFS33_00300(lysX)
SULLEWF20_09625(lysX)
MSEMsed_1991
MCNMcup_0295
MHKDFR87_08550(lysX)
MPRUDFR88_08220(lysX)
MTENGWK48_03775(lysX)
MJNMjAS7_0291
MEMJMJ1HA_2259
AHOAhos_1105
AMANB6F84_09595
ABRIDFR85_09220(lysX)
ASULDFR86_08280(lysX)
AAMBD1866_00395(lysX)
ACIHHS5_25000
SACDHS1genome_0140
SAZOD1868_05495(lysX)
CSTYKN1_27050
STEPIC006_1362
PYRP186_2397
TNETneu_0136
PYWPYWP30_00148
TUZTUZN_1890
VDIVdis_0196
VMOVMUT_1535
CSUCSUB_C0076
NAANps_00535
 » show all
Reference
1  [PMID:23434852]
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
  Sequence
[sai:Saci_1621]
Reference
2  [PMID:27566549]
  Authors
Yoshida A, Tomita T, Atomi H, Kuzuyama T, Nishiyama M
  Title
Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System.
  Journal
J Biol Chem 291:21630-21643 (2016)
DOI:10.1074/jbc.M116.743021
  Sequence
[tko:TK0278]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.60
IUBMB Enzyme Nomenclature: 6.3.2.60
ExPASy - ENZYME nomenclature database: 6.3.2.60
BRENDA, the Enzyme Database: 6.3.2.60

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