KEGG   ENZYME: 6.3.2.61
Entry
EC 6.3.2.61                 Enzyme                                 
Name
tubulin-glutamate ligase;
alpha-tubulin-glutamate ligase;
tubulin polyglutamylase;
TTLL1 (ambiguous);
TTLL5 (ambiguous);
TTLL6 (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
[tubulin]-L-glutamate:L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
n ATP + [tubulin]-L-glutamate + n L-glutamate = [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate (overall reaction);
(1a) ATP + [tubulin]-L-glutamate + L-glutamate = [tubulin]-(gamma-L-glutamyl)-L-glutamate + ADP + phosphate;
(1b) ATP + [tubulin]-(gamma-L-glutamyl)-L-glutamate + L-glutamate = [tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + ADP + phosphate;
(1c) ATP + [tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate = [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
Substrate
ATP [CPD:C00002];
[tubulin]-L-glutamate;
L-glutamate [CPD:C00025];
[tubulin]-(gamma-L-glutamyl)-L-glutamate;
[tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate
Product
[tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate;
ADP [CPD:C00008];
phosphate [CPD:C00009];
[tubulin]-(gamma-L-glutamyl)-L-glutamate;
[tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate
Comment
The eukaryotic tubulin proteins, which polymerize into microtubules, are highly modified by the addition of side-chains. The polyglutamylation reaction catalysed by this group of enzymes consists of two biochemically distinct steps: initiation and elongation. Initiation comprises the formation of an isopeptide bond with the gamma-carboxyl group of the glutamate acceptor site in a glutamate-rich C-terminal region of tubulin, whereas elongation consists of the addition of glutamate residues linked by regular peptide bonds to the gamma-linked residue. This entry describes enzymes that act on both alpha- and beta-tubulins.
History
EC 6.3.2.61 created 2021
Orthology
K16582  tubulin polyglutamylase TTLL6/13
K16599  tubulin polyglutamylase TTLL1
K16602  tubulin polyglutamylase TTLL5
K16603  tubulin polyglutamylase TTLL9
Genes
HSA164395(TTLL9) 23093(TTLL5) 25809(TTLL1) 284076(TTLL6) 440307(TTLL13)
PTR453052(TTLL5) 458886(TTLL1) 468294(TTLL6) 742763(TTLL9) 746756
PPS100969010(TTLL6) 100981466 100983749(TTLL9) 100990315(TTLL5) 100991355(TTLL1)
GGO101129406(TTLL6) 101130722(TTLL5) 101147848(TTLL9) 101151786 101153146(TTLL1)
PON100172924(TTLL5) 100434512(TTLL1) 100444533 100449886(TTLL6) 100451693(TTLL9)
NLE100580685(TTLL6) 100586863(TTLL9) 100590497(TTLL5) 100595172 100595841(TTLL1)
MCC100424963(TTLL9) 100430938 697698(TTLL6) 703116(TTLL5) 714668(TTLL1)
MCF102115419(TTLL5) 102128869 102130316(TTLL1) 102136656(TTLL6) 102144391(TTLL9)
CSAB103223433(TTLL1) 103229365(TTLL5) 103231171 103243626(TTLL6) 103248091(TTLL9)
CATY105579475(TTLL6) 105582240(TTLL9) 105590878(TTLL5) 105592386 105598328(TTLL1)
PANU101000392 101016758(TTLL6) 101017639(TTLL9) 101023657(TTLL1) 101026808(TTLL5)
TGE112609669(TTLL6) 112628319 112629299(TTLL5) 112632957(TTLL1) 112633113(TTLL9)
RRO104653714(TTLL9) 104659635(TTLL6) 104668589(TTLL1) 104674332 104677598(TTLL5)
RBB108513993(TTLL1) 108516510(TTLL6) 108521400 108524120(TTLL9) 108534935(TTLL5)
TFN117067174(TTLL6) 117068622(TTLL9) 117069300(TTLL5) 117070212 117096365(TTLL1)
PTEH111521197(TTLL5) 111522865 111537283(TTLL6) 111548128(TTLL9) 111549120(TTLL1)
CJC100390358(TTLL9) 100392681(TTLL13) 100398344(TTLL6) 100401316(TTLL1) 100412873(TTLL5) 108593534
SBQ101034051 101036749(TTLL9) 101047061 101048179(TTLL5) 101053979(TTLL1)
CSYR103250277 103255161(TTLL9) 103264734(TTLL6) 103265800(TTLL1) 103266539(TTLL5)
MMUR105858623(TTLL1) 105858935(TTLL5) 105865973(TTLL9) 105870606 105872184(TTLL6)
LCAT123620756(TTLL6) 123622840(TTLL9) 123640267(TTLL1) 123645119(TTLL13) 123646419(TTLL5)
OGA100945239(TTLL6) 100950261(TTLL1) 100953664(TTLL9) 100954592(TTLL5)
MMU237930(Ttll6) 269954(Ttll13) 319953(Ttll1) 320244(Ttll5) 74711(Ttll9)
MCAL110290315(Ttll9) 110298666 110306116(Ttll6) 110306816(Ttll5) 110310289(Ttll1)
MPAH110319041(Ttll9) 110324191(Ttll5) 110331402 110332312(Ttll6) 110334839(Ttll1)
RNO287646(Ttll6) 299208(Ttll5) 308762(Ttll13) 311548(Ttll9) 362969(Ttll1)
MCOC116076951(Ttll1) 116078201(Ttll6) 116080281(Ttll5) 116091184(Ttll9) 116102454
MUN110546946 110550098(Ttll9) 110552074(Ttll1) 110553393 110553394 110553414(Ttll6) 110553420 110558195(Ttll5)
CGE100755087(Ttll9) 100756538(Ttll5) 100760107(Ttll6) 100767980(Ttll1) 100772034
MAUA101823083(Ttll1) 101827072 101830209(Ttll5) 101841627(Ttll6) 101844611(Ttll9)
PLEU114682759(Ttll1) 114692925(Ttll6) 114696185 114697915(Ttll5) 114705560(Ttll9)
MORG121450053 121452177(Ttll5) 121456904(Ttll6) 121460301(Ttll9) 121461312(Ttll1)
AAMP119802756 119811417(Ttll6) 119815823(Ttll9) 119818410(Ttll5) 119823173(Ttll1)
NGI103731098(Ttll9) 103738353(Ttll6) 103739789 103743441(Ttll1) 103749894
HGL101711738(Ttll9) 101712056(Ttll13) 101713873(Ttll5) 101715040(Ttll6) 101717967(Ttll1)
CPOC100714683(Ttll5) 100719402(Ttll6) 100721988(Ttll1) 100726136 100734285(Ttll9)
CCAN109686151(Ttll5) 109691778(Ttll9) 109692961(Ttll6) 109693098(Ttll1) 109695081
DORD105981477(Ttll9) 105982294 105983552(Ttll5) 105992128(Ttll1) 106003058(Ttll6)
DSP122100009 122103477(Ttll6) 122118855(Ttll5) 122120316(Ttll9) 122123578(Ttll1)
NCAR124977341 124977367 124977682 124980242 124983202
OCU100338959(TTLL1) 100344465(TTLL9) 100346409 100351603(TTLL6) 100359240(TTLL5)
OPI101526179(TTLL6) 101526894(TTLL9) 101532389(TTLL1) 101534854(TTLL5) 101535816
TUP102471974(TTLL1) 102486862(TTLL6) 102489526(TTLL9) 102492881(TTLL5) 102501409
CFA100855660(TTLL1) 477188(TTLL9) 479047 480394(TTLL5) 480544(TTLL6)
VVP112909916(TTLL9) 112917834(TTLL6) 112921571 112927294(TTLL5) 112933971(TTLL1)
VLG121473499 121477844(TTLL9) 121489984 121492015(TTLL1) 121493193(TTLL5)
AML100474817(TTLL1) 100475959(TTLL9) 100478837 100481977(TTLL5) 100483083(TTLL6)
UMR103660193 103660651(TTLL6) 103670932(TTLL5) 103674148(TTLL1) 103674473(TTLL9)
UAH113241683(TTLL1) 113258468(TTLL9) 113263708 113265587(TTLL6) 113270310(TTLL5)
UAR123780803(TTLL1) 123798958(TTLL5) 123800420(TTLL9) 123802399(TTLL13) 123802884(TTLL6)
ELK111141869 111148532 111151684 111152556 111157543
LLV125088089 125103648 125105669 125107484 125110054
MPUF101671605(TTLL9) 101671973(TTLL6) 101678605 101679011(TTLL5) 101689580(TTLL1)
ORO101364162(TTLL6) 101364881(TTLL5) 101375059 101377162(TTLL9) 101377477(TTLL1)
EJU114201176(TTLL6) 114202696(TTLL5) 114218420(TTLL1) 114220734(TTLL9) 114223290
ZCA113909745(NGRN) 113910185(TTLL5) 113922135(TTLL1) 113937340(TTLL9) 113939706(TTLL6)
MLX117998597(TTLL1) 118002622(TTLL5) 118011343(TTLL9) 118023067 118025053(TTLL6)
FCA101080271(TTLL9) 101081093(TTLL6) 101081807 101084291(TTLL5) 101086406(TTLL1)
PYU121012333(TTLL9) 121032075(TTLL5) 121040221(TTLL1) 121042371 121044835(TTLL6)
PBG122467545 122469351(TTLL5) 122472863(TTLL1) 122485411(TTLL6) 122496398(TTLL9)
PTG102950051(TTLL5) 102959513(TTLL9) 102960136(TTLL13) 102967578(TTLL1) 102969765(TTLL6)
PPAD109247342(TTLL6) 109253861(TTLL5) 109265676(TTLL1) 109272586(TTLL9) 109273461
AJU106965884 106967277(TTLL1) 106974411(TTLL5) 106974620(TTLL9) 106980567(TTLL6)
HHV120228976(TTLL6) 120231919(TTLL5) 120234953(TTLL1) 120235371(TTLL9) 120248958
BTA526482(TTLL6) 529246(TTLL9) 538422(TTLL5) 539530(TTLL1)
BOM102273860(TTLL6) 102273905(TTLL5) 102275755(TTLL9) 102285989(TTLL1)
BIU109559890(TTLL1) 109565369(TTLL5) 109567676(TTLL9) 109574582(TTLL6)
BBUB102390762(TTLL1) 102397914(TTLL6) 102413073(TTLL9) 102413451(TTLL5)
CHX102169415(TTLL6) 102183430(TTLL9) 102189314(TTLL5) 102190671(TTLL1)
OAS101103255(TTLL9) 101110944(TTLL5) 101116134(TTLL1) 101120098(TTLL6)
ODA120852692(TTLL5) 120857560(TTLL1) 120867281(TTLL6) 120868753(TTLL9)
CCAD122423762(TTLL1) 122442910(TTLL6) 122444322(TTLL5) 122448006(TTLL9)
SSC100523818(TTLL6) 100525758(TTLL5) 100621517(TTLL1) 100625251 100739146(TTLL9)
CFR102506625(TTLL9) 102510419 102511348(TTLL6) 102514193(TTLL1) 102518194(TTLL5)
CBAI105069072 105073044(TTLL1) 105073316(TTLL6) 105073579(TTLL9) 105075326(TTLL5)
CDK105086080(TTLL5) 105091868(TTLL1) 105094756 105095778(TTLL6) 105100826(TTLL9)
VPC102529924(TTLL9) 102534603(TTLL5) 102544359 102545916(TTLL6)
BACU102999387(TTLL5) 103001370 103013303(TTLL1) 103014461(TTLL6) 103016307(TTLL9)
LVE103069120(TTLL6) 103086278(TTLL5) 103089295(TTLL9) 103091101(TTLL1)
OOR101276286(TTLL1) 101277528 101287434(TTLL6) 101288347(TTLL5) 101288408(TTLL9)
DLE111166286(TTLL6) 111169681 111176229(TTLL5) 111184319(TTLL9) 111186350(TTLL1)
PCAD102976803 102983155(TTLL6) 102985292(TTLL9) 102989691(TTLL5) 102990482(TTLL1) 112063061 112063166
PSIU116740571(TTLL9) 116746178(TTLL6) 116748744(TTLL5) 116760935(TTLL1)
ECB100051705(TTLL5) 100053576 100056216(TTLL1) 100068497(TTLL9) 100069471(TTLL6)
EPZ103555508(TTLL5) 103558646 103559171(TTLL9) 103559305(TTLL6) 103564656(TTLL1)
EAI106826483(TTLL6) 106830934(TTLL5) 106832040 106833722(TTLL9) 106845940(TTLL1)
MYB102249209(TTLL5) 102249429(TTLL6) 102258571(TTLL9) 102259438(TTLL13) 102263265(TTLL1)
MYD102755573(TTLL9) 102756811(TTLL6) 102763331(TTLL13) 102766239(TTLL5) 102774527(TTLL1)
MMYO118651666(TTLL1) 118658294(TTLL5) 118662883(TTLL9) 118672488(TTLL6) 118679197
MLF102417282(TTLL9) 102418848 102423453(TTLL1) 102426005(TTLL5) 102432765(TTLL6)
MNA107527779(TTLL9) 107533842(TTLL5) 107534957(TTLL1) 107540398 107544243(TTLL6)
PKL118706321 118707777(TTLL9) 118712075(TTLL1) 118715088(TTLL5) 118726532(TTLL6)
HAI109371479(TTLL1) 109380681(TTLL6) 109381495 109381572(TTLL5) 109384411(TTLL9)
DRO112304214(TTLL9) 112305929 112311254(TTLL5) 112316578(TTLL6) 112321835(TTLL1)
SHON118974938(TTLL1) 118976724(TTLL5) 118978163(TTLL6) 118985347(TTLL9) 118991956
AJM119047729(TTLL9) 119049086 119049263(TTLL5) 119052670(TTLL6) 119060571(TTLL1)
PDIC114488603 114491670(TTLL5) 114503950(TTLL6) 114506812(TTLL9) 114513152(TTLL1)
PHAS123808281(TTLL5) 123809645(TTLL13) 123815239(TTLL9) 123816160(TTLL1) 123817447(TTLL6)
MMF118619029(TTLL9) 118624660(TTLL1) 118630644(TTLL5) 118634498(TTLL6) 118640963
RFQ117013554(TTLL6) 117015965(TTLL9) 117018793 117023032(TTLL5) 117029359(TTLL1)
PALE102883745(TTLL1) 102885546 102886876(TTLL6) 102892292(TTLL9) 102892813(TTLL5)
PGIG120599242 120602915(TTLL1) 120603525(TTLL9) 120611264(TTLL6) 120619520(TTLL5)
PVP105298018(TTLL1) 105299265(TTLL5) 105305173 105305530(TTLL9) 105307277(TTLL6)
RAY107498897(TTLL5) 107505553(TTLL1) 107512880(TTLL9) 107514133 107520690(TTLL6)
MJV108387048 108391048(TTLL6) 108397284(TTLL9) 108400964(TTLL5) 108410082(TTLL1)
TOD119232097(TTLL6) 119234357(TTLL9) 119239349(TTLL5) 119245117 119247176(TTLL1)
SARA101540642(TTLL6) 101544820 101548846(TTLL1) 101557724(TTLL9) 101558873(TTLL5)
LAV100654067(TTLL1) 100659998(TTLL9) 100661075 100673397(TTLL6) 100675649(TTLL5)
TMU101340554 101344044 101352173 101355665 101359945
DNM101413460(TTLL1) 101416100(TTLL6) 101424946(TTLL9) 101428679 101447368(TTLL5)
MDO100010622(TTLL9) 100011528(TTLL1) 100014932(NGRN) 100017971(TTLL5) 100619202(TTLL6)
GAS123235424(TTLL9) 123237806(TTLL5) 123238102 123246177(TTLL6) 123248618(TTLL1)
SHR100920826(TTLL6) 100921544 100923206(TTLL5) 100928322 100932925(TTLL9)
PCW110193474 110205881(TTLL1) 110208303(TTLL5) 110211418(TTLL9) 110215811(TTLL6)
OAA100074879(TTLL5) 100076725(TTLL1) 100077963(TTLL6) 100090129(NGRN) 100682072(TTLL9)
GGA418225(TTLL1) 423367(TTLL5) 431480(C10H15ORF58) 771843(TTLL9)
PCOC116225525(TTLL6) 116225987(TTLL9) 116228766(TTLL5) 116231437(TTLL1)
MGP100542512(TTLL1) 100542965(TTLL9) 100544395(TTLL5) 116217113(TTLL6)
CJO107315118(TTLL5) 107317289(TTLL1) 107318938(TTLL6) 107323184(TTLL9)
NMEL110396688(TTLL1) 110400936(TTLL5) 110403478(TTLL6) 110408075(TTLL9)
APLA101789772(TTLL6) 101795946(TTLL9) 101802091(TTLL5) 101803736(TTLL1)
ACYG106038248(TTLL1) 106038832(TTLL5) 106047173(TTLL9) 106048662
AFUL116489678(TTLL5) 116490451(TTLL1) 116493559(TTLL6) 116495851(TTLL9)
TGU100219185(TTLL1) 100219995(TTLL5) 100225172(TTLL6)
LSR110473179(TTLL1) 110476689(TTLL6) 110477234(TTLL5)
SCAN103816281(TTLL6) 103819565(TTLL1) 103826907(TTLL5)
PMOA120500440(TTLL5) 120507366(TTLL1) 120508947(NGRN)
OTC121332766(TTLL5) 121343673(TTLL6) 121347854(TTLL1)
PRUF121351900(TTLL1) 121352235(NGRN) 121356064(TTLL5)
GFR102031817(TTLL5) 102037614(TTLL6) 102042366(TTLL1)
FAB101808794(TTLL5) 101812254(TTLL6) 101818501(TTLL1)
PHI102101809(TTLL1) 102102425(TTLL5) 102109824(TTLL6)
PMAJ107204448(TTLL1) 107205524(TTLL5) 107209300
CCAE111929373(TTLL1) 111929566(TTLL5) 111933941(TTLL6)
CCW104684045(TTLL6) 104688617(TTLL5) 104696132(TTLL1)
ETL114056018(TTLL5) 114064259(TTLL6) 114068613(TTLL1)
ZAB102067057(TTLL5) 102071256(TTLL1) 102074386(TTLL6)
FPG101916264(TTLL1) 101922218(TTLL5) 106112632(HDDC3)
FCH102050422(HDDC3) 102054485(TTLL1) 102058447(TTLL5)
CLV102085647(TTLL6) 102087228(TTLL1) 102087937(TTLL5)
EGZ104133280(TTLL5) 104133489(TTLL6) 104135153(TTLL1)
NNI104012680(TTLL1) 104017181(TTLL6) 104020997(TTLL5)
PLET104617812(TTLL5) 104619100(TTLL1) 104625230(TTLL6)
ACUN113480466(TTLL5) 113483830(TTLL6) 113487866(TTLL1)
TALA104358044(TTLL5) 104361266(TTLL6) 104368891(TTLL1)
PADL103913052(TTLL5) 103922201(TTLL9) 103924309(TTLL1)
ACHC115336312(TTLL5) 115338794(TTLL9) 115342060(TTLL6) 115352304(TTLL1)
AAM106482876(TTLL5) 106488901(TTLL1) 106491440(TTLL6) 106497375(TTLL9)
AROW112961508(TTLL9) 112961715(TTLL5) 112963569(TTLL6) 112967066(TTLL1)
NPD112948354(TTLL6) 112949541(TTLL9) 112958016(TTLL5) 112960140(TTLL1)
DNE112987280(TTLL9) 112991540(TTLL1) 112995339(TTLL6) 112995405(TTLL5)
ASN102368384 102378212(TTLL6) 102379370(TTLL9) 102383070(TTLL1) 102384821(TTLL5)
AMJ102561683(TTLL9) 102564318 102568863(TTLL5) 102570539(TTLL1) 106737017(TTLL6)
CPOO109313079(TTLL9) 109316358(TTLL1) 109318997(TTLL6) 109321302(TTLL5)
GGN109292351(TTLL9) 109296330(TTLL1) 109298604(TTLL5) 109301688(TTLL6)
PSS102450005(TTLL6) 102459960(TTLL1) 102462037(TTLL9) 102463066(TTLL5)
CMY102932378(TTLL9) 102934349(TTLL5) 102936953(TTLL1) 102940450(TTLL6) 102940882
CPIC101933807 101939840(TTLL6) 101939948(TTLL5) 101942578(TTLL9) 101953522(TTLL1)
TST117869410(TTLL6) 117876371(TTLL5) 117883738(TTLL1) 117884249 117885807(TTLL9)
CABI116814688(TTLL1) 116816780(TTLL9) 116831444(TTLL6) 116833019 116837519(TTLL5)
MRV120373463 120380510(TTLL9) 120392319(TTLL6) 120404355(TTLL5) 120406980(TTLL1)
ACS100551812(ttll6) 100551909(ttll5) 100553512(ttll1) 100557125(ttll9) 100566462
PVT110079075(TTLL5) 110086730(TTLL9) 110087163(TTLL1) 110087896(TTLL6) 110091458
SUND121928618(TTLL9) 121932234(TTLL1) 121933387(TTLL5) 121933424 121935786(TTLL6)
PBI103048034(TTLL1) 103048898 103057998 103061360 103063025(TTLL6) 103067259
PMUR107282589(TTLL6) 107283911 107285959(TTLL5) 107294334(TTLL1) 107299760(TTLL9)
TSR106545090(TTLL5) 106545438(TTLL6) 106549232 106551169
PGUT117657990(TTLL9) 117664546(TTLL6) 117665842(TTLL5) 117676216 117679810(TTLL1)
VKO123026826(TTLL5) 123030595(TTLL6) 123030715 123033934(TTLL1) 123036312(TTLL9)
PMUA114582402(TTLL6) 114584118 114591773(TTLL5) 114596894(TTLL1) 114599833(TTLL9)
ZVI118081761(TTLL5) 118089403(TTLL9) 118092443 118094941(TTLL6) 118096373(TTLL1)
GJA107108714(TTLL6) 107116460(TTLL5) 107120311(TTLL1) 107125334
STOW125426555(TTLL5) 125433443(TTLL9) 125435899(TTLL1) 125439073 125443965(TTLL6)
XLA100036964(ttll1.S) 108698677(ttll5.L) 108700968 108710716(ttll1.L) 108711444(ttll13p.L) 108712862(ttll13p.S)
XTR100158545(ttll5) 100492422(ttll13p) 100495095(ttll1) 116408011(ttll9)
NPR108784602(TTLL1) 108786986(TTLL9) 108799567(TTLL6) 108803593(TTLL5)
RTEM120918628(TTLL9) 120920843(TTLL5) 120931230(TTLL6) 120932949(TTLL1)
BBUF120981990(TTLL5) 120985909(TTLL6) 121004755(TTLL9) 121006756(TTLL1)
BGAR122922820(TTLL5) 122926465(TTLL1) 122929599 122940294(TTLL9)
DRE100006339(ttll5) 393994(ttll1) 556794(ttll9) 564075(ttll6)
SRX107706894 107722777(ttll9) 107724243(ttll5) 107725792(ttll1) 107727303
SANH107656691(ttll1) 107666932 107669465 107696924(ttll9) 107702239(ttll5)
SGH107551497(ttll9) 107552736 107554797(ttll5) 107569114(ttll1) 107582749
CCAR109057029 109058433 109062592(ttll1) 109076875
CAUA113041096(ttll9) 113066467(ttll1) 113111523(ttll6) 113116938(ttll5)
PPRM120462418(ttll5) 120463569(ttll9) 120474529(ttll6) 120478363
MAMB125244521 125256055(ttll6) 125260008(ttll9) 125260712 125268279(ttll5) 125277592
IPU108270127(ttll5) 108273737(ttll6) 108275643(ttll9) 108279717(ttll1)
PHYP113527136(ttll6) 113530780(ttll9) 113531760(ttll1) 113538919(ttll5)
SMEO124388553(ttll6) 124389548(ttll5) 124399067(ttll9) 124400970(ttll1)
TFD113637136(ttll6) 113641753(ttll9) 113645490(ttll1) 113659807(ttll5)
AMEX103033767(ttll5) 103040554(ttll1) 103042535(ttll6) 103046501(ttll9)
EEE113573525(ttll1) 113574839(ttll6) 113582253(ttll9) 113585929(ttll5)
TRU101067152(ttll5) 101072375(ttll6) 101075034(ttll1) 101078948 101080034
TNGGSTEN00013336G001 GSTEN00019142G001 GSTEN00021557G001 GSTEN00032322G001
LCO104919430(ttll9) 104921352(ttll5) 104926733(ttll1) 104933437(ttll6)
NCC104943710(ttll5) 104945484(ttll6) 104947758(ttll9) 104950108(ttll1)
CGOB115010690(ttll9) 115025055(ttll6) 115027214(ttll5) 115028575(ttll1)
ELY117247379(ttll6) 117249099(ttll1) 117258504(ttll9) 117267018(ttll5)
PLEP121947476(ttll9) 121953309(ttll5) 121958602(ttll6) 121961437(ttll1)
SLUC116035544(ttll5) 116041029(ttll9) 116060159(ttll1) 116061285(ttll6)
ECRA117935616(ttll5) 117936510(ttll6) 117938938(ttll1) 117948256(ttll9)
PFLV114546435(ttll5) 114548385(ttll6) 114550252(ttll1) 114558899(ttll9)
GAT120817676(ttll1) 120819460(ttll6) 120829547(ttll9) 120832681(ttll5)
PPUG119210362(ttll1) 119212473(ttll6) 119223681(ttll9) 119227881
MSAM119905754(ttll9) 119910737(ttll5) 119915588(ttll6) 119918436(ttll1)
CUD121505559(ttll1) 121517492(ttll9) 121526005(ttll5) 121528418(ttll6)
ALAT119004336(ttll5) 119009561(ttll6) 119022110(ttll9) 119032351(ttll1)
MZE101471129(ttll5) 101474099(ttll1) 101477995(ttll6) 101484252(ttll9)
ONL100695389(ttll1) 100700568(ttll6) 100702091(ttll9) 100708377(ttll5)
OAU116309789(ttll9) 116313324(ttll5) 116334915(ttll1) 116335657(ttll6)
OLA101159875(ttll1) 101164261(ttll6) 101167086(ttll5) 101172578(ttll9)
OML112143446(ttll5) 112154014(ttll1) 112154127(ttll6) 112159075(ttll9)
XMA102216670(ttll6) 102220510(ttll5) 102223827(ttll9) 102233958(ttll1)
XCO114134075(ttll5) 114144323(ttll9) 114152369(ttll6) 114160842(ttll1)
XHE116708846(ttll5) 116725778(ttll9) 116726927(ttll6) 116736664(ttll1)
PRET103459050(ttll5) 103459185(ttll1) 103467242(ttll9) 103481727(ttll6)
PFOR103136164(ttll5) 103139015(ttll9) 103152197(ttll6) 103156931(ttll1)
PLAI106945164(ttll9) 106945433(ttll6) 106949781(ttll1) 106949826(ttll5)
PMEI106914477(ttll1) 106915969(ttll6) 106920411(ttll9) 106923530(ttll5)
GAF122823217(ttll6) 122826188(ttll1) 122836203(ttll9) 122845872(ttll5)
CVG107092368(ttll5) 107093804(ttll6) 107098894(ttll1) 107102926
CTUL119782250(ttll9) 119782492(ttll6) 119787580(ttll5) 119789325(ttll1)
GMU124855837(ttll5) 124873307(ttll9) 124874963(ttll6) 124883166(ttll1)
NFU107386059(ttll1) 107387457(ttll6) 107390731(ttll9) 107392042(ttll5)
KMR108233189(ttll1) 108235238(ttll5) 108236730(ttll9) 108248053(ttll6)
ALIM106514799(ttll1) 106520476(ttll5) 106521966(ttll6) 106534780(ttll9)
NWH119417046(ttll9) 119423556(ttll6) 119427732(ttll5) 119427988(ttll1)
AOCE111566399(ttll9) 111572019 111577420(ttll1) 111588311(ttll6)
CSEM103381909(ttll6) 103382693(ttll1) 103384967(ttll9) 103399877(ttll5)
POV109623568 109628153(ttll5) 109630886(ttll9) 109632787(ttll1) 109641961
SSEN122759619(ttll6) 122766707(ttll1) 122777256(ttll9) 122780627 122782590(ttll5)
HHIP117752887(ttll6) 117756641(ttll5) 117757554(ttll1) 117764603(ttll9) 117769812
HSP118100098(ttll6) 118101684(ttll1) 118110554(ttll9) 118112673 118116103(ttll5)
LCF108876482(ttll9) 108890225(ttll1) 108892019(ttll6) 108892509(ttll5)
SDU111219091(ttll9) 111219583(ttll6) 111224748(ttll1) 111225944(ttll5)
SLAL111655435(ttll6) 111656459(ttll1) 111663126(ttll5) 111670705(ttll9)
XGL120794035(ttll6) 120795078(ttll5) 120804027(ttll9) 120804259(ttll1)
HCQ109506975 109507743(ttll5) 109523651(ttll1) 109526537(ttll6) 109526638(ttll9)
BPEC110154351(ttll6) 110155434(ttll9) 110155449(ttll5) 110161885(ttll1)
MALB109955086(ttll5) 109959897(ttll1) 109962740(ttll6) 109970384(ttll9)
BSPL114846287(ttll6) 114847973(ttll5) 114859461(ttll9) 114862143(ttll1)
SASA100380708(ttl1) 106572065(ttll9) 106576374 106579309(BAC05032) 106589177(ttll6) 106590462(ttll5)
OTW112216039(ttll9) 112223247(ttll6) 112233165(ttll5) 112234239 112267811
OMY110490559(ttll1) 110491509(ttll6) 110497919(ttll5) 110532310(ttll9)
OGO123994393 124002149(ttll5) 124014052 124031962(ttll9) 124047583(ttll6)
ONE115106478(ttll6) 115132185(ttll9) 115132935 115132940 115146229(ttll5)
SALP111966473(ttll9) 111968733 111977417 112070835
SNH120045472(ttll6) 120050011(ttll1) 120059322(ttll9) 120059993(ttll5)
ELS105007191(ttll6) 105015721(ttll5) 105020407(ttll1) 105022982(ttll9)
SFM108925529 108930707(ttll5) 108942118(ttll1) 114911101 114911103
PKI111838514(ttll1) 111840362(ttll9) 111852441(ttll5)
AANG118207310(ttll9) 118221728(ttll6) 118226115(ttll5) 118231510(ttll1) 118235954
LOC102686343(ttll5) 102690559(ttll9) 102692395 102694222(ttll1)
PSPA121298535 121301810(ttll6) 121318447 121319403(ttll9) 121324803 121329915(ttll5)
ARUT117415019 117420114 117421665 117422234 117424546 117428342 117429656 117429720 117433227
LCM102346355(TTLL6) 102348206(TTLL13) 102358714(TTLL9) 102360066(TTLL5) 102362485(TTLL1)
CMK103171682(ttll9) 103179067(ttll1) 103187904(ttll5) 103189511(ttll6)
RTP109911650 109913932 109919295(ttll9) 109927398(ttll6)
BFO118414439 118417530 118430330
BBEL109463065 109472146 109475087 109482092
CIN100177360 100181540 100185893 104265811
SCLV120329341 120335337 120340617 120346769
SPU115919072 576275 582217 583590 584220
APLC110974838 110979241 110987362 110987786
SKO100371480 100372717 100375554(TTLL1) 100378711
DMEDmel_CG16716(TTLL6A) Dmel_CG31108(TTLL5) Dmel_CG32238(TTLL1B) Dmel_CG5987(TTLL6B)
DER6543954 6547492 6554686 6555485
DSE6609967 6610814 6617160 6619658
DSIDsimw501_GD11467(Dsim_GD11467) Dsimw501_GD13857(Dsim_GD13857) Dsimw501_GD15082(Dsim_GD15082) Dsimw501_GD18234(Dsim_GD18234)
DYADyak_GE10574 Dyak_GE10739 Dyak_GE12065 Dyak_GE21463
DAN6494590 6499888 6501490 6507712
DSR110177376 110178915 110190364 110191377
DPODpse_GA14100 Dpse_GA16014 Dpse_GA16777 Dpse_GA19278
DPE6587892 6590629 6591634 6599667
DMN108152615 108155005 108156650 108159162
DWI6638617 6640845 6649820 6651379
DGR6563362 6568514 6568737
DMODmoj_GI12743 Dmoj_GI21073 Dmoj_GI22299 Dmoj_GI23779
DAZ108614277 108616629 108620812 108621595
DNV108648967 108651776 108654493 108659490
DHE111594442 111597808 111599537 111600852
DVI6626397 6630858 6633065 6636605
CCAT101450246 101462107
BOD106618931 106622299 106624161
MDE101888623 101891554 101899208
SCAC106083209 106083583 106083670
LCQ111675004 111675754 111681668
LSQ119610809 119611263 119615099
HIS119648844 119653009 119660303
AGAAgaP_AGAP002623 AgaP_AGAP004288 AgaP_AGAP010336
ACOZ120948417 120948449 120954757
AARA120894198 120898393 120902066
ASTE118504653 118504924 118517663
AAG5566058 5569462 5578570
AALB109400801 109412405 109418335 109427272 115262638
CQUCpipJ_CPIJ006090 CpipJ_CPIJ012875 CpipJ_CPIJ013436
CPII120414815 120423714 120425956
CNS116341939 116342513
BCOO119069956 119071230 119081628
AME409770 413973 414032
ACER107992592 107994443 108002804 108003735
ALAB122715217 122717352 122718718
BIM100747024 100748176 100750124 112212352
BBIF117207584 117208386 117210501
BVK117231058 117234898 117237700
BVAN117157969 117158921 117164845
BTER100645328 100651151 100651835 110119941
BPYO122567790 122577814
CCAL108624448 108626770 108631539 113464565
OBB114871876 114875670 114879918
MGEN117221294 117222182 117229542
NMEA116427390 116430152 116434596
CGIG122396132 122397916 122398809
SOC105202769 105208150
MPHA105837231 105837655 105838173
AEC105145413 105148260 105153252 105154523
ACEP105618164 105621116 105621429 105624376
PBAR105423583 105429403 105430308 105431618
VEM105557777 105560414 105564604 105566135
HST105182857 105192028 105192348 105192567
DQU106741379 106743623 106749440 106752336
CFO105248151 105253091 105259392
FEX115234594 115241364 115244054
LHU105672398 105672918 105673370 105679918
PGC109853701 109859964 109861616
OBO105275972 105279856 105280912 105284237
PCF106785990 106790950 106793018
PFUC122514785 122519957 122525118
VPS122630581 122632848 122636665
NVI100118299 100119308 100123092
CSOL105361205 105364464 105366127
TPRE106656483 106658037 106660057
MDL103570039 103576705
CGLO123271591 123274236
FAS105263411 105265073 105268648
DAM107036568 107043252 107043886
AGIF122855902 122856539 122859271
CCIN107265789 107268486 107271769
TCA659532 663328 664244
DPA109533434 109536838 109543099
SOY115875828 115887956 115891296
ATD109598107 109602871 109602880 109607471 109609365
CSET123307417 123310610 123315138
AGB108908976 108909074 108916746
LDC111507064 111509974 111518194
NVL108556333 108564977 108568074
APLN108738546 108738833 108741345
PPYR116163262 116168913 116170046
OTU111416639 111425056 111428444
BMOR101736733 101740464 101741885 101742089
BMAN114240663 114241140 114251189
MSEX115440123 115440417 115440418 115449323 119191223
DPLKGM_202506 KGM_204034 KGM_209916
BANY112053933 112054546 112057702
PMAC106708604 106710038 106721166
PPOT106104929 106106842
PXU106118995 106119555 106119892
PRAP110995644 110995645 111001366 111003563
ZCE119828570 119832490 119832572
HAW110376852 110377590 110379252 110384271
TNL113492405 113503582 113504710
SLIU111350222 111355102 111359619
OFU114356322 114364636 114366271
PXY105381244 105382843 105385537 105395526
API100163909 100164351 100168319 100570187
DNX107163834 107171835 107173935
AGS114121241 114121281
RMD113555812 113559084 113560190
BTAB109033966 109036040
DCI103506776 103516641 103516981 103519909 108253601
CLEC106661912 106665953 106667739
HHAL106683507 106683559 106692383
NLU111048516 111049462 111053071
PHUPhum_PHUM245560 Phum_PHUM313700 Phum_PHUM364090
FOC113201771 113202635 113205006
TPAL117644488 117648401
ZNE110826596 110828599 110837094
CSEC111864383 111866358 111872973
FCD110842903 110843326 110844263 110844821 110852702
DPXDAPPUDRAFT_31735 DAPPUDRAFT_324141
DMK116929456 116930461
PVM113801177 113816652
PJA122247614 122257963
PCHN125036467 125046718
HAME121862424 121871024
PCLA123759670 123767737
PTRU123509539 123510436
HAZT108673339 108682243
EAF111708710
LSM121121001 121128648
PPOI119091898 119094398 119094400 119102522 119103737
ISCIscW_ISCW013298
DSV119457099
RSAN119393086
RMP119183927
VDE111246359
VJA111268051
CSCU111621007
PTEP107441527
SDM118199449
CELCELE_C55A6.2(ttll-5) CELE_F25C8.5(ttll-9)
CBRCBG_05549(Cbr-ttll-9) CBG_23229(Cbr-ttll-5)
BMYBM_BM2948(Bma-ttll-5)
LOALOAG_00072
HROHELRODRAFT_63814 HELRODRAFT_66362 HELRODRAFT_75380 HELRODRAFT_83982
LGILOTGIDRAFT_124780 LOTGIDRAFT_132183 LOTGIDRAFT_214448 LOTGIDRAFT_214949 LOTGIDRAFT_221527
PCAN112554589 112560288 112570340 112576504 112576682
BGT106054269 106057052 106067233 106073697 106079045
GAE121369993 121382083 121384047 121388719 121389568
HRF124113390 124118759 124124610 124137539 124140642 124140727 124145800
HRJ124268060 124273806 124279362 124284383 124289129
CRG105318195 105331498 105331932 105344081
MYI110442315 110446976 110447949 110464784
PMAX117323250 117334656 117336445 117338346
MMER123524761 123536696 123549809 123566434
OBI106872258 106873676 106875928 106880315
OSN115211979 115213106 115214205 115232355
LAK106150411 106159945 106170573 106181981
SMMSmp_043920 Smp_074830 Smp_210200
SHXMS3_0015793 MS3_0016821
OVIT265_05614 T265_08957 T265_10230
EGLEGR_00784 EGR_03336 EGR_04718 EGR_06487
NVE116601534 5505739 5511838 5512270
EPA110233201 110240443 110244080 110245504
ATEN116291602 116294348 116303908 116306802
ADF107331643 107334253 107350697 107352938
AMIL114954081 114965844 114969081 114970136
PDAM113666177 113666542 113670105 113681409
SPIS111341078 111343070 111343737 111347458
DGT114516542 114518421 114519919 114529485
XEN124436628 124443109 124459384
HMG100202383 100202518 105847710
TADTRIADDRAFT_22537 TRIADDRAFT_23726 TRIADDRAFT_27246 TRIADDRAFT_33013
AQU100631813 100634892 100636820 100639419
NCOL116245217
SMOSELMODRAFT_126219 SELMODRAFT_130241 SELMODRAFT_135958 SELMODRAFT_137401 SELMODRAFT_91571
PPP112283373 112291374
CRECHLRE_01g050451v5 CHLRE_02g117350v5 CHLRE_02g146650v5 CHLRE_17g699500v5
VCNVOLCADRAFT_30444(ttlB) VOLCADRAFT_57487(ssa11) VOLCADRAFT_66113(mot11) VOLCADRAFT_69077(ttlF)
MNGMNEG_3008
CVRCHLNCDRAFT_8655
OLUOSTLU_35218
OTAOT_ostta07g03240
BPGBathy04g02660
MISMICPUN_55947 MICPUN_82271 MICPUN_86576 MICPUN_88360
MPPMICPUCDRAFT_17705 MICPUCDRAFT_34426 MICPUCDRAFT_3463 MICPUCDRAFT_3527
MBRMONBRDRAFT_1395 MONBRDRAFT_15528 MONBRDRAFT_1873 MONBRDRAFT_30326
SREPTSG_02223 PTSG_02290 PTSG_05189
DFADFA_09109
PFAPF3D7_0514000 PF3D7_1009700
PFDPFDG_02099 PFDG_02990
PFHPFHG_00203 PFHG_02665
PREIPRSY57_1009100
PGABPGSY75_0514000 PGSY75_1009700
PYOPY17X_1114800 PY17X_1211200
PCBPCHAS_111330(PC000726.01.0) PCHAS_120870(PC000113.02.0)
PBEPBANKA_1113700 PBANKA_1208000
PVVPVVCY_1101450 PVVCY_1200880
PKNPKNH_0809400 PKNH_1019100
PVXPVX_080540 PVX_094700
PCYPCYB_081930 PCYB_102760
TGOTGME49_230670 TGME49_278930
TETTTHERM_00136210 TTHERM_00145320 TTHERM_00284020 TTHERM_00327110 TTHERM_00564100 TTHERM_00773080 TTHERM_00837850
PTMGSPATT00002557001 GSPATT00004164001 GSPATT00004278001 GSPATT00006016001 GSPATT00007204001 GSPATT00008481001 GSPATT00009364001 GSPATT00010132001 GSPATT00010915001 GSPATT00014191001 GSPATT00014403001 GSPATT00015058001 GSPATT00015736001 GSPATT00016477001 GSPATT00017266001 GSPATT00018943001 GSPATT00019446001 GSPATT00019849001 GSPATT00020367001 GSPATT00023605001 GSPATT00024583001 GSPATT00027770001 GSPATT00030537001 GSPATT00031797001 GSPATT00032286001 GSPATT00034860001 GSPATT00035735001 GSPATT00037175001
SMINv1.2.004468.t1(symbB.v1.2.004468.t1) v1.2.005217.t1(symbB.v1.2.005217.t1) v1.2.005941.t1(symbB.v1.2.005941.t1) v1.2.009519.t1(symbB.v1.2.009519.t1) v1.2.014359.t1(symbB.v1.2.014359.t1) v1.2.017649.t1(symbB.v1.2.017649.t1) v1.2.029079.t1(symbB.v1.2.029079.t1)
TPSTHAPSDRAFT_262179
AAFAURANDRAFT_10854 AURANDRAFT_11535 AURANDRAFT_1640 AURANDRAFT_33385 AURANDRAFT_70560
PIFPITG_02721 PITG_03077 PITG_08756 PITG_09938 PITG_19158
PSOJPHYSODRAFT_304629 PHYSODRAFT_308885 PHYSODRAFT_358804 PHYSODRAFT_468874 PHYSODRAFT_542654
SPARSPRG_08375 SPRG_08476 SPRG_10656 SPRG_13914 SPRG_14754 SPRG_15792 SPRG_17283
EHXEMIHUDRAFT_116665 EMIHUDRAFT_117907 EMIHUDRAFT_42298 EMIHUDRAFT_465781 EMIHUDRAFT_469304
GTTGUITHDRAFT_157823 GUITHDRAFT_158162 GUITHDRAFT_159528 GUITHDRAFT_45369 GUITHDRAFT_52231 GUITHDRAFT_57949 GUITHDRAFT_58134 GUITHDRAFT_66166 GUITHDRAFT_72357 GUITHDRAFT_82077 GUITHDRAFT_96370
TBRTb10.61.3050 Tb927.5.3860
TBGTbgDal_V5360 TbgDal_X17050
TCR506743.210 509253.20 511277.440
LMALMJF_16_0380 LMJF_18_0370
LIFLINJ_16_0390 LINJ_18_0370
LDOLDBPK_160390 LDBPK_180370
LMILMXM_16_0380 LMXM_18_0370
LBZLBRM_16_0390 LBRM_18_0390
LPANLPMP_160390 LPMP_180360
NGRNAEGRDRAFT_33283 NAEGRDRAFT_61312 NAEGRDRAFT_80835
TVATVAG_008670 TVAG_012430 TVAG_013340 TVAG_027640 TVAG_056900 TVAG_067870 TVAG_071110 TVAG_084720 TVAG_094180 TVAG_096130 TVAG_112970 TVAG_123200 TVAG_124960 TVAG_133960 TVAG_163740 TVAG_176940 TVAG_203830 TVAG_211600 TVAG_217040 TVAG_226390 TVAG_235620 TVAG_245270 TVAG_259360 TVAG_318890 TVAG_367550 TVAG_406000 TVAG_424160 TVAG_425960 TVAG_455890 TVAG_483220 TVAG_484740
GLAGL50803_0010382 GL50803_0014498 GL50803_0095661
 » show all
Reference
1  [PMID:9622491]
  Authors
Regnard C, Audebert S, Desbruyeres, Denoulet P, Edde B.
  Title
Tubulin polyglutamylase: partial purification and enzymatic properties.
  Journal
Biochemistry 37:8395-404 (1998)
DOI:10.1021/bi9804131
Reference
2  [PMID:10564646]
  Authors
Regnard C, Desbruyeres E, Denoulet P, Edde B.
  Title
Tubulin polyglutamylase: isozymic variants and regulation during the cell cycle in HeLa cells.
  Journal
J Cell Sci 112 ( Pt 23):4281-9 (1999)
Reference
3  [PMID:10508923]
  Authors
Westermann S, Plessmann U, Weber K.
  Title
Synthetic peptides identify the minimal substrate requirements of tubulin polyglutamylase in side chain elongation.
  Journal
FEBS Lett 459:90-4 (1999)
DOI:10.1016/s0014-5793(99)01227-2
Reference
4  [PMID:15890843]
  Authors
Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Edde B
  Title
Tubulin polyglutamylase enzymes are members of the TTL domain protein family.
  Journal
Science 308:1758-62 (2005)
DOI:10.1126/science.1113010
Reference
5  [PMID:17499049]
  Authors
van Dijk J, Rogowski K, Miro J, Lacroix B, Edde B, Janke C
  Title
A targeted multienzyme mechanism for selective microtubule polyglutamylation.
  Journal
Mol Cell 26:437-48 (2007)
DOI:10.1016/j.molcel.2007.04.012
  Sequence
Reference
6  [PMID:18586949]
  Authors
Wloga D, Rogowski K, Sharma N, Van Dijk J, Janke C, Edde B, Bre MH, Levilliers N, Redeker V, Duan J, Gorovsky MA, Jerka-Dziadosz M, Gaertig J.
  Title
Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila.
  Journal
Eukaryot Cell 7:1362-72 (2008)
DOI:10.1128/EC.00084-08
  Sequence
Reference
7  [PMID:18045879]
  Authors
van Dijk J, Miro J, Strub JM, Lacroix B, van Dorsselaer A, Edde B, Janke C.
  Title
Polyglutamylation is a post-translational modification with a broad range of substrates.
  Journal
J Biol Chem 283:3915-22 (2008)
DOI:10.1074/jbc.M705813200
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.61
IUBMB Enzyme Nomenclature: 6.3.2.61
ExPASy - ENZYME nomenclature database: 6.3.2.61
BRENDA, the Enzyme Database: 6.3.2.61

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