KEGG   ENZYME: 6.3.2.62
Entry
EC 6.3.2.62                 Enzyme                                 
Name
beta-tubulin-glutamate ligase;
beta-tubulin polyglutamylase;
TTLL4 (ambiguous);
TTLL7 (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
[beta-tubulin]-L-glutamate:L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate = [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate (overall reaction);
(1a) ATP + [beta-tubulin]-L-glutamate + L-glutamate = [beta-tubulin]-(gamma-L-glutamyl)-L-glutamate + ADP + phosphate;
(1b) ATP + [beta-tubulin]-(gamma-L-glutamyl)-L-glutamate + L-glutamate = [beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + ADP + phosphate;
(1c) n ATP + [beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate = [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
Substrate
ATP [CPD:C00002];
[beta-tubulin]-L-glutamate;
L-glutamate [CPD:C00025];
[beta-tubulin]-(gamma-L-glutamyl)-L-glutamate;
[beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate
Product
[beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate;
ADP [CPD:C00008];
phosphate [CPD:C00009];
[beta-tubulin]-(gamma-L-glutamyl)-L-glutamate;
[beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate
Comment
The eukaryotic tubulin proteins, which polymerize into microtubules, are highly modified by the addition of side-chains. The polyglutamylation reaction catalysed by this group of enzymes consists of two biochemically distinct steps: initiation and elongation. Initiation comprises the formation of an isopeptide bond with the gamma-carboxyl group of the glutamate acceptor site, whereas elongation consists of the addition of glutamate residues linked by regular peptide bonds to the gamma-linked residue. This entry describes enzymes that act on beta-tubulins and other proteins with glutamate-rich regions but not on alpha-tubulins.
History
EC 6.3.2.62 created 2021
Orthology
K16583  tubulin polyglutamylase TTLL7
K16601  tubulin polyglutamylase TTLL4
Genes
HSA79739(TTLL7) 9654(TTLL4)
PTR456975(TTLL7) 459949(TTLL4)
PPS100969896(TTLL7) 100989250(TTLL4)
GGO101131187(TTLL4) 101139105(TTLL7)
PON100439538(TTLL4) 100457636(TTLL7)
PPYG129031808(TTLL4) 129035987(TTLL7)
NLE100583242(TTLL7) 100598713(TTLL4)
HMH116467976(TTLL7) 116810285(TTLL4)
SSYN129488445(TTLL4) 134733691(TTLL7)
MCC700064(TTLL4) 709536(TTLL7)
MCF101925426(TTLL4) 102126179(TTLL7)
MTHB126932979 126963480
MNI105481229(TTLL4) 105482740(TTLL7)
CSAB103217879(TTLL4) 103224541(TTLL7)
CATY105587104(TTLL4) 105593560(TTLL7)
PANU101006322(TTLL7) 101026846(TTLL4)
TGE112610414(TTLL7) 112636530(TTLL4)
MLEU105528046(TTLL4) 105538054(TTLL7)
RRO104660031(TTLL4) 104677488(TTLL7)
RBB108518471(TTLL4) 108527681(TTLL7)
TFN117092157(TTLL7) 117094513(TTLL4)
PTEH111540448(TTLL7) 111548680(TTLL4)
CANG105504717(TTLL4) 105521809(TTLL7)
CJC100393425(TTLL4) 100407330(TTLL7)
SBQ101029335(TTLL4) 101049008(TTLL7)
CIMI108283457(TTLL7) 108309071(TTLL4)
ANAN105710379(TTLL7) 105712881(TTLL4)
CSYR103261234(TTLL4)
MMUR105857700(TTLL4) 105863923(TTLL7)
LCAT123635478(TTLL7) 123644000(TTLL4)
PCOQ105808839(TTLL4) 105823797(TTLL7)
OGA100948580(TTLL4) 100967049(TTLL7)
MMU67534(Ttll4) 70892(Ttll7)
MCAL110290921(Ttll7) 110292286(Ttll4)
MPAH110320073(Ttll7) 110321819(Ttll4)
RNO310982(Ttll7) 690512(Ttll4)
MCOC116088581(Ttll4) 116093930(Ttll7)
ANU117705500(Ttll4) 117706945(Ttll7)
ASYL127682568(Ttll7) 127692260(Ttll4)
MUN110555017(Ttll7) 110566754(Ttll4)
CGE100767380(Ttll7) 100770741(Ttll4)
MAUA101827444(Ttll7) 101842948(Ttll4)
PROB127226443(Ttll4) 127229934(Ttll7)
PLEU114698261(Ttll7) 114709279(Ttll4)
MORG121445770(Ttll7) 121447069(Ttll4)
MFOT126492939 126512373
AAMP119801024(Ttll7) 119820575(Ttll4)
NGI103727726(Ttll4) 103728094(Ttll7)
HGL101700742(Ttll4) 101722842(Ttll7)
CPOC100712966(Ttll7) 100725277(Ttll4)
CCAN109675273(Ttll4) 109700438(Ttll7)
DORD105982307(Ttll4) 105987030(Ttll7)
DSP122107440(Ttll4) 122110527(Ttll7)
PLOP125350296(Ttll4) 125355338(Ttll7)
NCAR124980195 124986825
MMMA107138704(Ttll4) 107158245(Ttll7)
ITI101962595(Ttll4) 101968357(Ttll7)
OCU100342462 100347979
OPI101527045(TTLL7) 101530495(TTLL4)
TUP102469123(TTLL7) 102472286(TTLL4)
GVR103586503(TTLL7) 103588920(TTLL4)
CFA479976(TTLL7) 488525(TTLL4)
CLUD112640992(TTLL7) 112656367(TTLL4)
VVP112922545(TTLL4) 112924476(TTLL7)
VLG121480743(TTLL4) 121487685(TTLL7)
NPO129520147(TTLL7) 129523008(TTLL4)
AML100470797(TTLL7) 100480405(TTLL4)
UMR103662756(TTLL4) 103662973(TTLL7)
UAH113250447(TTLL4) 113254488(TTLL7)
UAR123779436(TTLL4) 123795274(TTLL7)
ELK111143226 111144057
LLV125095157 125098057
MPUF101689941(TTLL4) 101693743(TTLL7)
MNP132001062(TTLL7) 132013554(TTLL4)
MLK131809081(TTLL7) 131827447(TTLL4)
NVS122900128(TTLL7) 122902314(TTLL4)
ORO101368001(TTLL7) 101374019(TTLL4)
EJU114200165(TTLL4) 114208459(TTLL7)
ZCA113912271(TTLL7) 113920108(TTLL4)
MLX118012035(TTLL4) 118019229(TTLL7)
NSU110580440(TTLL7) 110591912(TTLL4)
LWW102734576(TTLL7) 102750551(TTLL4)
FCA101090956(TTLL7) 101099141(TTLL4)
PYU121027377(TTLL7) 121031076(TTLL4)
PCOO112848407(TTLL7) 112867035(TTLL4)
PBG122480697(TTLL7) 122481777(TTLL4)
PVIV125173238(TTLL4) 125173604(TTLL7)
LRUF124515831 124516174
LGF123598132(TTLL7) 123599475(TTLL4)
AJU106970104 106973353
PTG102958552(TTLL4) 102972445(TTLL7)
PPAD109246174(TTLL7) 109265058(TTLL4)
PUC125911176 125912462
PLEZ122226648(TTLL4) 122227721(TTLL7)
HHV120232433(TTLL4) 120241643(TTLL7)
BTA511853(TTLL4) 522221(TTLL7)
BOM102269774(TTLL7) 102275485(TTLL4)
BIU109556139(TTLL7) 109570709(TTLL4)
BBUB102398101(TTLL4) 102412604(TTLL7)
BBIS105003250(TTLL7) 105003776(TTLL4)
CHX102169242(TTLL7) 102171385(TTLL4)
OAS101108264(TTLL7) 101112884(TTLL4)
BTAX128045151(TTLL7) 128066835(TTLL4)
CSUM138074075(TTLL7) 138076121(TTLL4)
ODA120854367(TTLL4) 120856948(TTLL7)
CCAD122426476(TTLL4) 122436775(TTLL7)
MREE136149714(TTLL7) 136164907(TTLL4)
OVR110135916(TTLL7) 110144748(TTLL4)
MBEZ129537807(TTLL4) 129541777(TTLL7)
SSC100522876(TTLL7) 106506366(TTLL4)
CFR102507367(TTLL7) 102517472(TTLL4)
CBAI105064022(TTLL4) 105075500(TTLL7)
CDK105095032(TTLL7) 105096089(TTLL4)
VPC102536099(TTLL7) 102536359(TTLL4)
BACU102998378(TTLL4) 103008034(TTLL7)
BMUS118897920(TTLL4) 118904794(TTLL7)
LVE103080434(TTLL4) 103080907(TTLL7)
OOR101273672(TTLL7) 101289107(TTLL4)
LALB132514669(TTLL7) 132522092(TTLL4)
DLE111171836(TTLL4) 111178382(TTLL7)
PCAD102973710(TTLL4) 102991608(TTLL7)
PSIU116740797(TTLL7) 116756852(TTLL4)
PPHC136125754(TTLL4) 136126338(TTLL7)
NASI112392792(TTLL7) 112411896(TTLL4)
ECB100052881(TTLL7) 100055898(TTLL4)
EPZ103555094(TTLL7) 103561964(TTLL4)
EAI106824033(TTLL7) 106838457(TTLL4)
MYB102245218(TTLL7) 102255767(TTLL4)
MYD102759071(TTLL7) 102761112(TTLL4)
MMYO118661601(TTLL4) 118676798(TTLL7)
MLF102424449(TTLL4) 102437471(TTLL7)
MDT132230904(TTLL7) 132238240(TTLL4)
MYUM139003500(TTLL7) 139015017(TTLL4)
PKL118717007(TTLL4) 118723386(TTLL7)
EFUS103284155(TTLL7) 103289310(TTLL4)
MNA107524768(TTLL4) 107543198(TTLL7)
DRO112307975(TTLL4) 112309213(TTLL7)
SHON118975310(TTLL4) 118997373(TTLL7)
AJM119039519(TTLL4) 119062902(TTLL7)
PDIC114495270(TTLL4) 114497382(TTLL7)
PHAS123816577(TTLL7) 123829279(TTLL4)
MMF118625176(TTLL4) 118626387(TTLL7)
PPAM129065639(TTLL7) 129080342(TTLL4)
HAI109380588(TTLL4) 109385431(TTLL7)
RFQ117026016(TTLL4) 117027011(TTLL7)
PALE102884218(TTLL4) 102898710(TTLL7)
PGIG120583267(TTLL7) 120587663(TTLL4)
PVP105289143(TTLL7) 105291054(TTLL4)
RAY107511592(TTLL7) 107516748(TTLL4)
MJV108390515(TTLL4) 108408345(TTLL7)
TOD119235085(TTLL7) 119256215(TTLL4)
SARA101541736(TTLL4) 101553494(TTLL7)
SFUM130020968(TTLL4) 130032068(TTLL7)
SETR126000859(TTLL4) 126005923(TTLL7)
LAV100657249(TTLL7) 100662547(TTLL4)
TMU101342378 101347163
ETF101646012(TTLL7) 101661914(TTLL4)
DNM101421927(TTLL7) 101423821(TTLL4)
MDO100010987(TTLL4) 100011255(TTLL7)
GAS123240149(TTLL4) 123245425(TTLL7)
SHR100917952(TTLL7) 100934089(TTLL4)
AFZ127553099 127563013
PCW110209922(TTLL7) 110219464(TTLL4)
TVP118847439(TTLL4) 118849199(TTLL7)
PBRV138151621(TTLL4) 138166180(TTLL7)
OAA100075137(TTLL7) 114811195(TTLL4)
TACU119926997(TTLL7) 119934838(TTLL4)
GGA424209(TTLL4) 424543(TTLL7)
PCOC116227311(TTLL4) 116233379(TTLL7)
MGP100539357 100551316(TTLL7) 104911681
CJO107316912(TTLL4) 107317469(TTLL7)
TPAI128072852(TTLL7) 128077277(TTLL4)
LMUT125694171(TTLL7)
NMEL110400528(TTLL4) 110402969(TTLL7)
APLA101790601(TTLL7) 101803632(TTLL4)
ACYG106034069(TTLL7) 106039369(TTLL4)
CATA118243682(TTLL7) 118252589(TTLL4)
AFUL116490904(TTLL4) 116492146(TTLL7)
TGU100225080(TTLL7) 100225583(TTLL4)
LSR110468347(TTLL4) 110468835(TTLL7)
SCAN103814666(TTLL4) 103814928(TTLL7)
PMOA120496618(TTLL4) 120510815(TTLL7)
OTC121335653(TTLL4) 121344952(TTLL7)
PRUF121356762(TTLL4) 121361917(TTLL7)
ATRC139593789(TTLL4) 139594384(TTLL7)
GFR102036790(TTLL4) 102039813(TTLL7)
FAB101818914(TTLL4) 101821262(TTLL7)
OMA130255401(TTLL4) 130256325(TTLL7)
PHI102102484(TTLL4) 102113109(TTLL7)
PMAJ107207519(TTLL4) 107208346(TTLL7)
CCAE111932185(TTLL4) 111932865(TTLL7)
CCW104694194 104695297(TTLL7)
CBRC103611349(TTLL4) 103612626(TTLL7)
ACOE138113072(TTLL4) 138114010(TTLL7)
ETL114055260(TTLL4) 114064915(TTLL7)
ZAB102065157(TTLL4) 102069321(TTLL7)
ZLE135450105(TTLL4) 135451178(TTLL7)
ACHL103799280(TTLL7) 103804599(TTLL4)
SVG106857366(TTLL7) 106860298(TTLL4)
MMEA130574378(TTLL4) 130578656(TTLL7)
HRT120754942(TTLL4) 120756440(TTLL7)
SATI136363599(TTLL4) 136364927(TTLL7)
CCIC134046697(TTLL7) 134047159(TTLL4)
FPG101917588(TTLL7) 101921043(TTLL4)
FCH102051624(TTLL7) 102054406(TTLL4)
CCRI104160641(TTLL7) 104164402
NNT104401932(TTLL4) 104402396(TTLL7)
SHAB115607822(TTLL4) 115612312(TTLL7)
ACUN113482390(TTLL4) 113483001(TTLL7)
TALA104366402(TTLL7) 104368005(TTLL4)
ACHC115342633(TTLL4) 115349378(TTLL7)
HALD104317355(TTLL7) 104323040(TTLL4)
HLE104832157(TTLL4) 104841218(TTLL7)
AGEN126042052 126044519
HHAR128143949(TTLL4) 128147932(TTLL7)
GCL127018672 127019092
CSTI104554112(TTLL4) 104564069(TTLL7)
LDI104341170 104341272(TTLL4)
MNB103771213(TTLL4) 103776926(TTLL7)
DPUB104300084(TTLL7) 104309745(TTLL4)
PPUS135177620(TTLL7) 135186906(TTLL4)
AVIT104267233 104271748(TTLL7) 104281007(TTLL4)
BRHI104494748(TTLL4) 104499294(TTLL7)
EGZ104122906(TTLL7) 104132406(TTLL4)
NNI104010069(TTLL4) 104015566(TTLL7)
PCRI104035022(TTLL7) 104036434
PCAO104046163(TTLL4) 104049507(TTLL7)
PADL103917662(TTLL4) 103925151(TTLL7)
AFOR103894720(TTLL7) 103895378(TTLL4)
FGA104072910(TTLL4) 104074198(TTLL7)
GSTE104255035(TTLL4) 104258733(TTLL7)
CBOY140654703(TTLL7) 140657757(TTLL4)
CLV102084260(TTLL4) 102093862(TTLL7)
CNIC135990536(TTLL4) 136001667(TTLL7)
MUI104538407(TTLL4) 104546793
PGUU104465504(TTLL7) 104468424(TTLL4)
PLET104619748(TTLL7) 104625565(TTLL4)
EHS104507017(TTLL4) 104512917(TTLL7)
CMAC104481459(TTLL4) 104481577(TTLL7)
CUCA104055226(TTLL7) 104056634(TTLL4)
TEO104372895(TTLL7) 104378237(TTLL4)
BREG104637984(TTLL4) 104643858(TTLL7)
OHA104338868(TTLL7) 104339153(TTLL4)
ACAR104520962(TTLL4) 104522878(TTLL7)
CPEA104387485(TTLL4) 104396831(TTLL7)
CVF104285508(TTLL4) 104286143(TTLL7)
RTD128914182(TTLL7)
CRID134518344(TTLL4) 134519421(TTLL7)
AAM106499325(TTLL4) 106499822(TTLL7)
AROW112961919(TTLL7) 112972006(TTLL4)
NPD112946261(TTLL7) 112959787(TTLL4)
TGT104568472(TTLL4) 104571999(TTLL7)
DNE112980284(TTLL4) 112993151(TTLL7)
SCAM104143005(TTLL7) 104153720(TTLL4)
ASN102372829(TTLL7) 102377954(TTLL4)
AMJ102570549(TTLL4) 102572371(TTLL7)
CPOO109307349(TTLL7) 109323171(TTLL4)
GGN109286783(TTLL7) 109301589(TTLL4)
PSS102455547(TTLL7) 102460067(TTLL4)
CMY102936581(TTLL4) 102943081(TTLL7)
CCAY125641333(TTLL7) 125644561(TTLL4)
DCC119860730(TTLL7) 119863637(TTLL4)
CPIC101943962(TTLL4) 101946119(TTLL7)
TST117881804(TTLL7) 117884947(TTLL4)
CABI116824546(TTLL4) 116835752(TTLL7)
MRV120369996(TTLL7) 120375023(TTLL4)
ACS100558945(ttll7) 100564234(ttll4)
ASAO132773729(TTLL4) 132774077(TTLL7)
PVT110078180(TTLL4) 110079749(TTLL7)
SUND121928524(TTLL7) 121930706(TTLL4)
PBI103053262(TTLL4) 103058112(TTLL7)
PMUR107294018(TTLL7) 107298011(TTLL4)
CTIG120297874(TTLL7) 120318323(TTLL4)
TSR106543376(TTLL7) 106547371(TTLL4)
PGUT117675272(TTLL4) 117677127(TTLL7)
PCAE139313947(TTLL7) 139325458(TTLL4)
APRI131195939(TTLL7)
PTEX113435996(TTLL7) 113441095(TTLL4)
NSS113410822(TTLL4) 113419179(TTLL7)
VKO123024557(TTLL7) 123027356(TTLL4)
PMUA114598816(TTLL7) 114602828(TTLL4)
PRAF128415571(TTLL7) 128420065(TTLL4)
ZVI118088696(TTLL7) 118090814(TTLL4)
HCG128322262(TTLL7) 128327679(TTLL4)
GJA107117294(TTLL7) 107122045(TTLL4)
STOW125425948(TTLL4) 125432720(TTLL7)
EMC129324159(TTLL4) 129330482(TTLL7)
XLA108701293(ttll4.L) 108702932(ttll4.S) 108715498(ttll7.S) 443899(ttll7.L)
XTR100038218(ttll7) 100144652(ttll4)
NPR108784346(TTLL7) 108785768(TTLL4)
RTEM120944177(TTLL4) 120945983(TTLL7)
ACAT141103737(TTLL7) 141147158(TTLL4)
BBUF120979294(TTLL7) 121008117(TTLL4)
BGAR122943582(TTLL7) 122944872(TTLL4)
DTC141048828(TTLL7) 141049226(TTLL4)
PWL138286673(TTLL4) 138293154(TTLL7)
MUO115472149(TTLL7) 115474002(TTLL4)
GSH117346677(TTLL7) 117360910(TTLL4)
DRE558702(ttll4) 565243(ttll7)
SRX107738099 107742903(ttll7) 107745334 107752897
SANH107658573(ttll7) 107668375 107669020 107688755
SGH107560414 107592566(ttll7) 107593000 107596548
CCAR109062974 109068721 109085108 109085112
CAUA113053618 113069367 113108868
CGIB127965352 127967773 128019637
PTET122351871(ttll4) 122353932(ttll7)
LROH127170527(ttll4) 127172932(ttll7)
GRF141340562(ttll4)
OMC131547444(ttll4) 131549763(ttll7)
PPRM120464255(ttll7) 120486951(ttll4)
RKG130078090(ttll7) 130085741(ttll4)
MAMB125256616(ttll7) 125270103(ttll4) 125270104
CIDE127518300 127522427
CERY137021705(ttll7) 137036281(ttll4)
MASI127426440 127428164 127447296 127447693
TROS130555523(ttll4) 130571508(ttll7)
TDW130410570(ttll7) 130427931(ttll4)
MANU129427094(ttll7) 129452282(ttll4)
PDAB135719277(ttll7) 135782520(ttll4)
IPU108266949 108270711
IFU128608976(ttll4) 128613492(ttll7)
PHYP113526280(ttll4) 113530372(ttll7)
SMEO124382925(ttll4) 124391338(ttll7)
TFD113651541(ttll7) 113654155(ttll4)
TVC132850296(ttll4) 132853775(ttll7)
CGAR128524690(ttll4) 128542658(ttll7)
NGRA132891977(ttll4) 132899569(ttll7)
TRN134324144(ttll4) 134331280(ttll7)
AMEX103028996(ttll7) 103047112(ttll4)
CMAO118806856(ttll4) 118819281(ttll7)
EEE113578546(ttll4) 113581915(ttll7)
CHAR105892837(ttll4) 105895086(ttll7)
SPIL134078830(ttll4) 134102127(ttll7)
TRU101062715(ttll7) 101063555(ttll4)
TFS130528157(ttll7) 130529807(ttll4)
TNGGSTEN00022856G001 GSTEN00029112G001
LCO104917772(ttll7) 104932502(ttll4)
NCC104942931(ttll4)
TBEN117481157(ttll4) 117495556(ttll7)
CGOB115007336(ttll7) 115026269(ttll4)
PGEO117445884(ttll7) 117466542(ttll4)
GACU117544605(ttll4) 117555207(ttll7)
EMAC134867538(ttll4) 134869247(ttll7)
ELY117251215(ttll4) 117254442(ttll7)
EFO125895467(ttll7) 125899504(ttll4)
PLEP121941377(ttll7) 121948954(ttll4)
SLUC116055263(ttll4) 116055322(ttll7)
ECRA117950625(ttll7) 117952443(ttll4)
ESP116689066(ttll4) 116695536(ttll7)
PFLV114561165(ttll7) 114564346(ttll4)
GAT120823937(ttll7) 120833599(ttll4)
PPUG119216422(ttll7) 119228506(ttll4)
AFB129094490(ttll7) 129104775(ttll4)
CLUM117729745(ttll7) 117750338(ttll4)
PSWI130193453(ttll7) 130201480(ttll4)
CANA137783125(ttll4) 137794517(ttll7)
CVE137870320(ttll7) 137890097(ttll4)
MSAM119900628(ttll7) 119904534(ttll4)
SCHU122877682(ttll7) 122885587(ttll4)
CUD121511787(ttll7) 121522429(ttll4)
SPUL138592324(ttll4) 138607913(ttll7)
LMIX132964675(ttll7) 132986563(ttll4)
ALAT119025781(ttll4) 119029017(ttll7)
ASTR137599487(ttll7) 137605189(ttll4)
MZE101473151(ttll7) 101485525(ttll4)
ONL100691840(ttll7) 100703475 109194236
OAU116332025(ttll4) 116333064(ttll7)
OLA101160724(ttll7) 101171290(ttll4)
OML112150621(ttll7) 112155068(ttll4)
CSAI133446179(ttll4) 133458485(ttll7)
XMA102225205(ttll4) 102230009(ttll7)
XCO114148416(ttll4) 114151283(ttll7)
XHE116723242(ttll4) 116726118(ttll7)
PRET103464160(ttll7) 103482271(ttll4)
PFOR103130793(ttll7) 103149939(ttll4)
PLAI106954892(ttll7) 106963233(ttll4)
PMEI106923624(ttll7) 106930970(ttll4)
GAF122838693(ttll7) 122839439(ttll4)
PPRL129353152(ttll4) 129373385(ttll7)
CVG107087229(ttll7) 107101415(ttll4)
CTUL119774609(ttll7) 119794058(ttll4)
GMU124871291(ttll4) 124874040(ttll7)
NFU107390278(ttll4) 107392710(ttll7)
KMR108232327(ttll4) 108234362(ttll7)
ALIM106511281(ttll7) 106534065(ttll4)
NWH119419440(ttll4) 119430788(ttll7)
AOCE111575237(ttll4)
EJA138198538(ttll7) 138201181(ttll4)
BFRE138618756(ttll7) 138633918(ttll4)
MCEP125009642(ttll7) 125018049(ttll4)
CSEM103391740(ttll4) 103392188(ttll7)
POV109625303(ttll7) 109647088(ttll4)
SSEN122760193(ttll4) 122780801(ttll7)
SSOE131444427(ttll4) 131465830(ttll7)
HHIP117755111(ttll4) 117759912(ttll7)
HSP118120110(ttll4) 118121427(ttll7)
PPLT128448243(ttll7) 128456327(ttll4)
SMAU118282599(ttll4) 118318455(ttll7)
LCF108872818 108881270
SDU111218044(ttll4) 111231765(ttll7)
SLAL111658499(ttll7) 111673152(ttll4)
XGL120790322(ttll7) 120801410(ttll4)
HCQ109519274(ttll4) 109522034(ttll7)
SSCV125969418(ttll7) 125974159(ttll4)
SBIA133503970(ttll7) 133512700(ttll4)
PEE133406688(ttll7) 133410852(ttll4)
PTAO133480667(ttll7) 133487159(ttll4)
BPEC110156166(ttll4) 110160029(ttll7)
ENY140353744(ttll7) 140359826(ttll4)
MALB109952773(ttll4) 109958207(ttll7)
BSPL114847495(ttll4) 114854426(ttll7)
SJO128361876(ttll7) 128367673(ttll4)
SSCO133984643(ttll7) 133992962(ttll4)
GMH115556141(ttll7) 115560969
SASA106586929(ttll4) 106613441(ttll7)
STRU115157936(ttll7) 115161437(ttll4)
OTW112217411(ttll7) 112239702(ttll4)
OMY110520665(ttll4) 110521953(ttll7)
OGO123994966(ttll7) 124025754 124044303(ttll4)
ONE115126815 115139543(ttll7)
OKI109866726(ttll7) 109884686(ttll4)
OKE118381397(ttll4) 118386774(ttll7)
OMM135557348(ttll7)
OCLA139405537 139406907
SALP111975871(ttll7) 112076868 112078168
SNH120036268 120054596(ttll7) 120064055
CCLU121554995(ttll4) 121572317(ttll7)
ELS105027968(ttll4)
OEP134011403(ttll7) 134017290(ttll4)
SFM108920721(ttll4) 108923527(ttll7)
PKI111840808(ttll4) 111860533(ttll7)
AANG118214548 118223157(ttll4) 118226502(ttll7)
AROT135241132 135251731(ttll4) 135253740(ttll7)
CCOG133117016 133123139(ttll4) 133126923(ttll7)
LOC102685677(ttll4) 102689936(ttll7)
PSPA121323628(ttll4) 121331093
ARUT117401365 117402312(ttll4) 117416709
PSEX120514759(ttll7) 120531234(ttll4)
LCM102365237(TTLL7) 102365402(TTLL4)
CMK103174713(ttll7) 103190531(ttll4)
RTP109917784(ttll7) 109918572(ttll4)
CPLA122551803(ttll4) 122554118(ttll7)
HOC132817719(ttll4) 132818860(ttll7)
LERI129699131(ttll4) 129700702
HAKA140728047(ttll4) 140736704(ttll7)
PMRN116943918
LRJ133356720
BFO118424100 118431376
BBEL109461787 109475180
CIN100179385 100180570
SCLV120336349 120342420
SPU115918125 576625 586239
LPIC129271117 129274272
AJJ139958901 139978528
APLC110973515 110977456
ARUN117298020 117300108
AAMU139946170 139948760
AFIL140143363 140150581 140151519
AJC117102428 117109902
SKO100371126 100378590
PFLL139138778 139138828 139140062 139140549
DMEDmel_CG16833(TTLL4A) Dmel_CG3964(TTLL4B)
DER6541351 6541370
DSE6612097 6613295
DSIDsimw501_GD23261(Dsim_GD23261) Dsimw501_GD23748(Dsim_GD23748)
DYADyak_GE18264 Dyak_GE18502
DAN6497854 6498645
DSR110183483 110187566
DPO26533298 4817303
DPE6588704 6589002
DMN108161704 108162564
DWI6641981 6642282
DGR6561583 6562134
DMODmoj_GI18116 Dmoj_GI18156
DAZ108610682 108610958
DNV115562500 115564103
DHE111592604 111605519
DVI6627759(TTLL4A) 6635693(TTLL4B)
CCAT101449645
BOD106619791
BDR105222731
RZE108377756
AOQ129247390
ALUD128863216
TDA119687015 119690178
MDE101893320 101894992 109613485
SCAC106091855
LCQ111678548 111679952
LSQ119601648 119602676
CVJ135951313(TTLL4A) 135951958(TTLL4B)
GFS119633196 119633755
ECOE129951197 129952634
CLON129608201 129608545
HIS119647082 119647249 119658843
AGA1280107
ACOZ120958467
AARA120903633
AMER121595167
ASTE118514512
AMAP126565785
AFUN125763901
AMOU128301369
AMRS128715798
ACOS131266739
AAG5572804
AALB109427916
ASUA134213183
CQUCpipJ_CPIJ018042 CpipJ_CPIJ020016
CPII120412789
CBRI134829386
CNS116336987
BCOO119078727
LLL129788963
PPAP129806405
AME102654331 413213 724379
ACER107998098 108004451 108004483
ALAB122712282 122715553 122715587
ADR102676917 102681113 102681230
AFLR100863125 100868848 100869125
BIM100744079 100744994 112212130
BBIF117205869 117212966 117213028
BVK117235531 117241993 117242000
BVAN117153846 117154993 117154994
BHUN126873464 126873465
BTER100647821 100647942 105667155
BAFF126915981 126923557 126923558
BPYO122566396 122575218 122575219
BPAS132905294 132913824 132913825
FVI122530966 122530967 122532364
CCAL108627987 108627989 113464708
OBB114873886 114873887 114880192
OLG117604386 117604387 117608032
MGEN117219088 117219089 117220296
NMEA116428980 116428981
CGIG122403791 122403798
SOC120356746
MPHA105834028
AEC105153034
ACEP105622882
PBAR105434240
VEM105567090
COBS139108833
TLN139816615
HST105192320
DQU106747079
CFO105256308
FEX115244092
PMEC138943011
LHU105670992
PGC109856479
OBO105277337
PCF106785064 106785090
PFUC122519395 122519399 122520270
VPS122632090 122632091 122632092
VCRB124426419
VVE124952397
LHT122506050
LBD127283191 127283192
MDL103572983
CGLO123275252
FAS105272057
DAM107038619
AGIF122852316
CINS118067882
VCAN122407510 122407954
CCIN107273442
DSM124412701 124414476 124416303 124416304 124416674
NPT124210655 124223748 124224853
NFB124187079 124187703 124187917 124187918 124188063
NLO107221208 107227671 107227673 107227674
NVG124309490 124310057 124310125 124310302 124310303
AROA105684378 105684475 125500627
TCA103314096
TMOL138139386
DPA109544552
ESIM136417856
EFOR136350808
SOY115891650
AGRG126734650
ATD109600356
CSET123316383
HAXR123682900
AGB108915089
LDC111511480
DVV114327501
NVL108564577
APLN108733051 108738847
PPYR116178677
OTU111413600
BMOR101739701
BMAN114250173
MSEX115444446
DPLKGM_212027
BANY112046572
MJU123876870
VCD124538944
MCIX123663933
PMAC106717465
PPOT106104195
PXU106116741
BPHI137920170
PRAP110992482
ZCE119829086
LSIN126971651
AAGE121735749
HAW110373737
HZE124640561
TNL113499469
SLIU111348676
OFU114352356
ONU135081866
ATRA106131593
GMW113520259
PGW126380553
LGLY125239285
CSTB134741001
CFUM141439240
CCRN123301553
API100164638 100166302 100167599
DNX107171588 107173180
AGS114121021 114127729 114128106 114128347
RMD113556368 113556903 113557238 113558398
ACOO126838099
DVT126900806
BTAB109038658
DCI103505298
CLEC106667057
HHAL106684985
NLU111052023
HVI124361858
MQU128988754
PHUPhum_PHUM529500
FOC113210128
ZNE110834225
CSEC111864263
PAME138704818
BROR134542667
IEL124171690
HAMR139685696
FCD110859235
DPXDAPPUDRAFT_311295
DMK116927575
DPZ124327049
AFRA136026353
PVM138861208
PJA122265484
PCHN125042369
HAME121864599
PCLA123746524
CQD128692398
PTRU123499602
ESN127004560
MNZ135220922
MRJ136834264
PORN139752850
HAZT108678371
EAF111697541 111702235 111709314 111710889
LSM121113632 121114688
TCF131880325 131882276
RSAN119385494
RMP119178459
VDE111244608
VJA111272337
GOE100902540
DPTE113795553
DFR124499428
CSCU111613060 111636319
CVS136981351
PTEP107454048
ABRU129969352
UDV129232154
SDM118188641
LPOL106457821
CELCELE_ZK1128.6(ttll-4)
CBRCBG_09874(Cbr-ttll-4)
CRQGCK72_009601
NAINECAME_05644
BMYBM_BM7636(Bma-ttll-4)
LOALOAG_09898
TSPTsp_01754
HROHELRODRAFT_155740
LGILOTGIDRAFT_139346 LOTGIDRAFT_228133
PVUL126807855 126819208
PCAN112563835 112574512
LSAX138967002 138982434
BGT106059335 106069449
GAE121375051 121380976
HRF124129056 124145450
HRJ124276781 124279877
HASI137256098 137291617
HCRA139470070 139478652
CRG105348489 105348914
CANU128162380 128166437
CVN111112129 111119326
OED125665904 125668725
MYI110457542 110463175
PMAX117325288 117343465
AIRR138314709 138325673
MCAF127735138
MMER123524432 123532844
RPHI132726678 132754065
DPOL127856446 127862170 127877774
MAEA128214811 128234617
OBI106872256 106880354
OSN115216319 115223633
LJP135470437 135478252
LAK106154113 106154290 106154713 106154733 106154734 106157142 106157788 106157789 106157793 106164269 106164270 106164467 106164765 106164767 106165181 106165182 106176035 106176036 106176051
SMMSmp_155240 Smp_163450 Smp_181160
SHXMS3_00002122(TTLL4_1) MS3_00005084(TTLL4_3) MS3_00009034(TTLL7_1)
OVIT265_08919 T265_11606 T265_14005
EGLEGR_03267 EGR_05164
LLON135486974 135500321
NVE5509694 5517456
EPA110241167 110247421
ATEN116286940 116308370
ADF107338270 107340561
AMIL114968390 114971559
MCAZ138024167 138044060
MFOO137973595 138013131
PDAM113678639 113683888
SPIS111322632 111333776
DGT114519928 114521942 114535920
XEN124439889 124445396 124456526
HMG100201129
HSY130622256 130629897
RES135694924
TADTRIADDRAFT_22586 TRIADDRAFT_59327
AQU100633602 100635385 109584099
MBRMONBRDRAFT_28196 MONBRDRAFT_8219
SREPTSG_04117
TETTTHERM_00758970
PTMGSPATT00001174001 GSPATT00002846001 GSPATT00020419001 GSPATT00023650001
PIFPITG_02465
PSOJPHYSODRAFT_467093
SPARSPRG_00915
TBRTb09.211.1170
TBGTbgDal_IX5460
TCR506885.270
LMALMJF_35_4930
LIFLINJ_35_4980
LDOLDBPK_354980
LMILMXM_34_4930
LMAT92511387(LSCM1_01253)
LBZLBRM_34_4880
LPANLPMP_344770
LOI92357675(LSCM4_01694)
LEIS94176900(GH5_01294)
LENR94168559(CUR178_01275)
LEIN94185041(JIQ42_01297)
PHET94287613(JKF63_01489)
TVA4747017(TVAGG3_0246220) 4762786(TVAGG3_0535060) 4769809(TVAGG3_0365950) 4770258(TVAGG3_0228010) 4770386(TVAGG3_1050580) 4772326(TVAGG3_0505090) 4774892(TVAGG3_0978850) 5464304(TVAGG3_0013600)
GLAGL50803_008592
SSAO94294289(SS50377_20266) 94294463(SS50377_20440) 94295100(SS50377_21077) 94300968(SS50377_26945)
EHXEMIHUDRAFT_42604 EMIHUDRAFT_42614
GTTGUITHDRAFT_115074 GUITHDRAFT_135992
 » show all
Reference
1  [PMID:9622491]
  Authors
Regnard C, Audebert S, Desbruyeres, Denoulet P, Edde B.
  Title
Tubulin polyglutamylase: partial purification and enzymatic properties.
  Journal
Biochemistry 37:8395-404 (1998)
DOI:10.1021/bi9804131
Reference
2  [PMID:10564646]
  Authors
Regnard C, Desbruyeres E, Denoulet P, Edde B.
  Title
Tubulin polyglutamylase: isozymic variants and regulation during the cell cycle in HeLa cells.
  Journal
J Cell Sci 112 ( Pt 23):4281-9 (1999)
Reference
3  [PMID:16901895]
  Authors
Ikegami K, Mukai M, Tsuchida J, Heier RL, Macgregor GR, Setou M.
  Title
TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites.
  Journal
J Biol Chem 281:30707-16 (2006)
DOI:10.1074/jbc.M603984200
  Sequence
[mmu:70892]
Reference
4  [PMID:18045879]
  Authors
van Dijk J, Miro J, Strub JM, Lacroix B, van Dorsselaer A, Edde B, Janke C.
  Title
Polyglutamylation is a post-translational modification with a broad range of substrates.
  Journal
J Biol Chem 283:3915-22 (2008)
DOI:10.1074/jbc.M705813200
  Sequence
[mmu:67534]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.62
IUBMB Enzyme Nomenclature: 6.3.2.62
ExPASy - ENZYME nomenclature database: 6.3.2.62
BRENDA, the Enzyme Database: 6.3.2.62

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