| Entry |
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| Name |
UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase;
MurD synthetase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase;
uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase;
D-glutamate-adding enzyme;
D-glutamate ligase;
UDP-Mur-NAC-L-Ala:D-Glu ligase;
UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming);
UDP-N-acetylmuramoylalanine---D-glutamate ligase;
UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (ADP-forming)
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| Class |
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
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| Sysname |
UDP-N-acetyl-alpha-D-muramoyl-L-alanine:D-glutamate ligase (ADP-forming)
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| Reaction(IUBMB) |
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [RN: R02783]
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| Reaction(KEGG) |
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| Substrate |
ATP [CPD: C00002];
UDP-N-acetyl-alpha-D-muramoyl-L-alanine [CPD: C01212];
D-glutamate [CPD: C00217]
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| Product |
ADP [CPD: C00008];
phosphate [CPD: C00009];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [CPD: C00692]
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| Comment |
Involved in the synthesis of a cell-wall peptide in bacteria.
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| History |
EC 6.3.2.9 created 1965, modified 2002
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| Pathway |
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| Orthology |
| K01925 | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Genes |
| ECOO: | ECRM13514_0092(murD) |
| ECOH: | ECRM13516_0095(murD) |
| ELR: | ECO55CA74_00435(murD) |
| ECW: | EcE24377A_0090(murD) |
| EDJ: | ECDH1ME8569_0085(murD) |
| ECOI: | ECOPMV1_00091(murD) |
| SEM: | STMDT12_C01260(murD) |
| SETC: | CFSAN001921_16790(murD) |
| SEEN: | SE451236_06645(murD) |
| SENH: | CFSAN002069_08595(murD) |
| SEEH: | SEEH1578_09660(murD) |
| SENJ: | CFSAN001992_10375(murD) |
| SEEC: | CFSAN002050_07075(murD) |
| SEEB: | SEEB0189_018755(murD) |
| SENC: | SEET0819_07510(murD) |
| REE: | electrica_04245(murD) |
| RTG: | NCTC13098_06206(murD) |
| CLAP: | NCTC11466_03835(murD) |
| KIE: | NCTC12125_02948(murD) |
| AHN: | NCTC12129_04167(murD_1) NCTC12129_04168(murD_2) |
| METY: | MRY16398_47300(murD) |
| PTF: | PROFFT_A_01730(murD) |
| PSHI: | SAMEA2665130_0386(murD) |
| YPG: | YpAngola_A2920(murD) |
| YPI: | YpsIP31758_3389(murD) |
| SMW: | SMWW4_v1c07450(murD) |
| SERS: | SERRSCBI_03425(murD) |
| SFJ: | SAMEA4384070_0783(murD) |
| SOF: | NCTC11214_00766(murD) |
| PAQU: | DMB82_0017175(murD) |
| DIC: | Dpoa569_000602(murD) |
| EHD: | ERCIPSTX3056_383(murD) |
| BAPF: | BUMPF009_CDS00376(murd) |
| BAPG: | BUMPG002_CDS00377(murd) |
| BAPU: | BUMPUSDA_CDS00376(murd) |
| BAPW: | BUMPW106_CDS00377(murd) |
| TPTY: | NCTC11468_03095(murD_1) |
| PHEI: | NCTC12003_01244(murD) |
| PRJ: | NCTC6933_02765(murD) |
| LRI: | NCTC12151_02614(murD) |
| HIC: | NTHIC486_01606(murD) |
| HPIT: | NCTC13334_01197(murD) |
| HHZ: | NCTC10839_01089(murD) |
| HAEG: | NCTC8502_01260(murD) |
| PDAG: | 4362423_00240(murD) |
| ADP: | NCTC12871_01080(murD) |
| ALIG: | NCTC10568_00018(murD) |
| ASEG: | NCTC10977_00975(murD) |
| AVT: | NCTC3438_00978(murD) |
| RPNE: | NCTC8284_03147(murD) |
| PAET: | NCTC13378_01316(murD) |
| VAU: | VANGNB10_cI2171c(murD) |
| VPL: | SA104470976_00423(murD) |
| PAEB: | NCGM1900_2244(murD) |
| PSAV: | PSA3335_05380(murD) |
| PVD: | CFBP1590__1171(murD) |
| PPRC: | PFLCHA0_c50380(murD) |
| PMUD: | NCTC8068_04357(murD) |
| PFW: | PF1751_v1c09050(murD) |
| PFF: | PFLUOLIPICF703605(murD) |
| PPUU: | PputUW4_04505(murD) |
| PTRT: | HU722_0005935(murD) |
| PTW: | TUM18999_13390(murD) |
| PTAE: | NCTC10697_00859(murD) |
| MSHE: | MAALD49_08940(murD) |
| PSYC: | DABAL43B_2659(murD) |
| MCAT: | MC25239_01471(murD) |
| MCUN: | NCTC10297_00106(murD) |
| SCAA: | TUM17387_03620(murD) |
| SALH: | HMF8227_02472(murD) |
| CBS: | COXBURSA331_A0221(murD) |
| LLG: | 44548918_02413(murD) |
| LJR: | NCTC11533_02580(murD) |
| LCJ: | NCTC11976_03320(murD) |
| LWA: | SAMEA4504053_3103(murD) |
| LSS: | NCTC12082_00193(murD_1) NCTC12082_01755(murD_2) |
| LANT: | TUM19329_06100(murD) |
| MISZ: | MishRS11D_06380(murD) |
| TIB: | THMIRHAM_16550(murD) |
| TSE: | THMIRHAS_19270(murD) |
| TZO: | THMIRHAT_06550(murD) |
| TNI: | TVNIR_2606(murD_[H]) |
| GAI: | IMCC3135_29190(murD) |
| THIC: | TspCOW1_31460(murD) |
| HAXI: | HAALTHF_32440n(murD) |
| AEL: | NCTC12917_03784(murD) |
| CHJ: | NCTC10426_02281(murD) |
| CDIZ: | CEDIAZO_03161(murD) |
| NMM: | NMBM01240149_1668(murD) |
| NMS: | NMBM01240355_0429(murD) |
| NMQ: | NMBM04240196_0428(murD) |
| NMZ: | NMBNZ0533_1829(murD) |
| NMX: | NMA510612_2331(murD) |
| NWE: | SAMEA3174300_1588(murD) |
| NZO: | SAMEA4504057_0378(murD) |
| NCI: | NCTC10296_00542(murD) |
| NCZ: | NCTC10294_01269(murD) |
| NANI: | NCTC12227_02079(murD) |
| ECOR: | SAMEA4412678_0479(murD) |
| BMV: | BMASAVP1_A0474(murD) |
| BML: | BMA10229_A1333(murD) |
| BPM: | BURPS1710b_3547(murD) |
| BPL: | BURPS1106A_3552(murD) |
| BUE: | BRPE67_ACDS23670(murD) |
| PLG: | NCTC10937_01075(murD) |
| LMIR: | NCTC12852_00830(murD) |
| BUO: | BRPE64_ACDS24190(murD) |
| VTR: | MYVALT_F_00060(murD) |
| BTRM: | SAMEA390648700551(murD) |
| AXX: | ERS451415_00803(murD) |
| LIM: | L103DPR2_02754(murD) |
| LIH: | L63ED372_02320(murD) |
| URU: | DSM104443_00676(murD) |
| UPL: | DSM104440_00642(murD) |
| FPHO: | SHINM1_017260(murD) |
| RTT: | RTTH1527_01950(murD) |
| RTB: | RTB9991CWPP_01960(murD) |
| WEM: | CAI20_00030 CAI20_06400 |
| RBS: | RHODOSMS8_01898(murD) |
| SMEL: | SM2011_c01864(murD) |
| SFD: | USDA257_c45020(murD) |
| SAME: | SAMCFNEI73_Ch2464(murD) |
| AGR: | AGROH133_07441(murD) |
| AVV: | RvVAT039_03540(murD) |
| AVF: | RvVAR031_24220(murD) |
| ASAL: | CFBP5507_09285(murD) |
| ALEG: | CFBP4996_08820(murD) |
| REC: | RHECIAT_CH0003000(murD) |
| REL: | REMIM1_CH02897(murD) |
| REP: | IE4803_CH03074(murD) |
| REI: | IE4771_CH03112(murD) |
| RTR: | RTCIAT899_CH11370(murD) |
| RGA: | RGR602_CH02498(murD) |
| RPHA: | AMC79_CH03012(murD) |
| RLW: | RlegWSM1455_14385(murD) |
| NEN: | NCHU2750_14820(murD) |
| LAS: | CLIBASIA_05005(murD) |
| BIO: | BR141012304_11279(murD) |
| BRC: | BCCGELA001_09965(murD) |
| BSEP: | HAP48_0002800(murD) |
| BCAN: | BcanWSM471_29055(murD) |
| VGO: | GJW-30_1_01842(murD) |
| BHS: | BM1374165_01166(murD) |
| BBK: | BARBAKC583_0949(murD) |
| BTX: | BM1374166_01520(murD) |
| BEZ: | NCTC12898_01032(murD) |
| MAQU: | Maq22A_c02230(murD) |
| FIL: | BN1229_v1_3984(murD) |
| FIY: | BN1229_v1_3971(murD) |
| BVY: | NCTC9239_00713(murD) |
| TSV: | DSM104635_02829(murD) |
| RLI: | RLO149_c025740(murD) |
| PHP: | PhaeoP97_00923(murD) |
| PPIC: | PhaeoP14_00876(murD) |
| SINL: | DSM14862_01096(murD) |
| SPSE: | SULPSESMR1_01946(murD) |
| RMM: | ROSMUCSMR3_01063(murD) |
| AHT: | ANTHELSMS3_04272(murD) |
| LALG: | LentiSH36_00848(murD) |
| LVS: | LOKVESSMR4R_00998(murD) |
| AALK: | LGT41_0008820(murD) |
| SBIN: | SBA_ch1_35030(murD) |
| SFLA: | SPHFLASMR4Y_00087(murC) |
| VSU: | P3M64_01855(murD) P3M64_12295 |
| HPO: | HMPREF4655_21110(murD) |
| HPX: | HMPREF0462_0925(murD) |
| HPYA: | HPAKL117_02475(murD) |
| HPYK: | HPAKL86_04100(murD) |
| HCL: | NCTC13205_01198(murD) |
| HSH: | NHP194022_10510(murD) |
| HPUL: | NCTC13154_00609(murD) |
| CJV: | MTVDSCj20_0406(murD) |
| CFV: | CFVI03293_1397(murD) |
| CAMP: | CFT03427_1322(murD) |
| CCOC: | CCON33237_1498(murD) |
| CLR: | UPTC16701_0273(murD) |
| CLM: | UPTC16712_0275(murD) |
| CAMR: | CAQ16704_0277(murD) |
| CHV: | CHELV3228_0538(murD) |
| CPIN: | CPIN18020_0149(murD) |
| CAMZ: | CVIC12175_0397(murD) |
| GBN: | GEOBRER4_04870(murD) |
| PPOR: | JCM14722_12410(murD) |
| BBA: | Bd0052(murD) Bd3200(murD) |
| BBAT: | Bdt_0049(murD) Bdt_3130(murD) |
| BBAC: | EP01_01295 EP01_12285 |
| BDQ: | CIK05_00520(murD) CIK05_03240(murD) |
| BDC: | DOE51_00270(murD) DOE51_15885(murD) |
| BDZ: | DOM22_00245(murD) DOM22_03220(murD) |
| BDK: | HW988_00240(murD) HW988_03230(murD) |
| BMX: | BMS_0063(murD) BMS_2225 |
| HAX: | BALOs_0093(murD) BALOs_1345(murD) |
| BSTO: | C0V70_00375(murD) C0V70_07635(murD) |
| BAZ: | BAMTA208_09550(murD) |
| BAE: | BATR1942_05395(murD) |
| BSON: | S101395_03216(murD) |
| BTHR: | YBT1520_20785(murD) |
| BTHU: | YBT1518_21440(murD) |
| BFD: | NCTC4823_02572(murD) |
| BACI: | B1NLA3E_06100(murD) |
| BKW: | BkAM31D_15265(murD_2) |
| PARG: | PspKH34_27010(murD) |
| BLEN: | NCTC4824_02753(murD) |
| SAX: | USA300HOU_1123(murD) |
| SUQ: | HMPREF0772_12049(murD) |
| SUX: | SAEMRSA15_10160(murD) |
| SUF: | SARLGA251_10940(murD) |
| SAUT: | SAI1T1_2008390(murD) |
| SAUJ: | SAI2T2_1008410(murD) |
| SAUK: | SAI3T3_1008400(murD) |
| SAUQ: | SAI4T8_1008390(murD) |
| SAUV: | SAI7S6_1008400(murD) |
| SAUW: | SAI5S5_1008360(murD) |
| SAUX: | SAI6T6_1008370(murD) |
| SAUY: | SAI8T7_1008400(murD) |
| SDP: | NCTC12225_01865(murD) |
| SPIC: | SAMEA4384060_1772(murD) |
| SSH: | NCTC13712_01128(murD) |
| SSIM: | SAMEA4384339_1071(murD) |
| SSTE: | SAMEA4384403_1648(murD) |
| LMOC: | LMOSLCC5850_2098(murD) |
| LMW: | LMOSLCC2755_2098(murD) |
| LMX: | LMOSLCC2372_2103(murD) |
| LMZ: | LMOSLCC2482_2094(murD) |
| LMON: | LMOSLCC2376_1989(murD) |
| LMOS: | LMOSLCC7179_2008(murD) |
| LMOO: | LMOSLCC2378_2060(murD) |
| LMOY: | LMOSLCC2479_2100(murD) |
| LMOT: | LMOSLCC2540_2129(murD) |
| LMOA: | LMOATCC19117_2056(murD) |
| LGZ: | NCTC10812_00809(murD) |
| GMO: | NCTC11323_01093(murD) |
| GHA: | NCTC10459_00674(murD) |
| BAYD: | BSPP4475_06580(murD) |
| PPQ: | PPSQR21_033520(murD) |
| COHN: | KCTCHS21_40740(murD) |
| SPOR: | SporoP33_13845(murD) |
| SPOP: | SporoP37_14180(murD) |
| SURE: | SporoP32a_14475(murD) |
| SPYM: | M1GAS476_1319(murD) |
| SPH: | MGAS10270_Spy1269(murD) |
| SPI: | MGAS10750_Spy1361(murD) |
| SPJ: | MGAS2096_Spy1272(murD) |
| SPK: | MGAS9429_Spy1248(murD) |
| STG: | MGAS15252_1137(murD) |
| STZ: | SPYALAB49_001235(murD) |
| SNV: | SPNINV200_06080(murD) |
| SNC: | HMPREF0837_10978(murD) |
| SPNG: | HMPREF1038_00713(murD) |
| SPNE: | SPN034156_16800(murD) |
| SPNU: | SPN034183_06320(murD) |
| SPNM: | SPN994038_06210(murD) |
| SPNO: | SPN994039_06220(murD) |
| SMC: | SmuNN2025_1424(murD) |
| SDG: | SDE12394_07870(murD) |
| SGG: | SGGBAA2069_c05400(murD) |
| SCP: | HMPREF0833_10057(murD) |
| STRS: | SSAL8618_04200(murD) |
| SVB: | NCTC12167_00771(murD) |
| SMEN: | SAMEA4412692_0045(murD) |
| SFER: | NCTC12278_00506(murD) |
| SCAI: | NCTC12191_01232(murD) |
| SPSU: | NCTC13786_00709(murD) |
| SPOC: | NCTC10925_00536(murD) |
| SAUP: | NCTC3168_00188(murD) |
| SURN: | NCTC13766_00541(murD) |
| SVF: | NCTC3166_00585(murD) |
| LPW: | LpgJCM5343_12060(murD) |
| LRU: | HMPREF0538_21832(murD) |
| LOR: | AYI71_03515(murD) AYI71_06070(murD) |
| LHO: | LOOC260_113810(murD) |
| LALI: | LA20249_01645(murD) |
| EFAU: | EFAU085_00836(murD) |
| EFU: | HMPREF0351_10793(murD) |
| ECEC: | NCTC12421_01748(murD) |
| AUR: | HMPREF9243_1418(murD) |
| AMIT: | DBT49_0003420(murD) |
| CCB: | Clocel_3281 Clocel_3777 |
| CARG: | RSJ17_03345 RSJ17_18800 |
| CCOH: | SAMEA4530647_2352(murD) |
| CMAH: | C1I91_03235 C1I91_11895 |
| CGEL: | psyc5s11_01260(murD) |
| SMAN: | C12CBH8_22800(murD) |
| PFAA: | MM59RIKEN_32460(murD) |
| VFA: | MM35RIKEN_06710(murD) |
| VCOP: | MM50RIKEN_11380(murD) |
| RRK: | H8S51_004705 H8S51_008400(murD) |
| BPRO: | PMF13cell1_04923(murD_2) |
| BLUI: | Blut17040_27650(murD) |
| CSCI: | HDCHBGLK_03440(murD) |
| CHYL: | CE91St63_22190(murD) |
| ACEL: | acsn021_28380(murD) |
| ACHT: | bsdcttw_32280(murD) |
| CBIL: | EUBC25_03410(murD) EUBC25_16190(murD) |
| PDF: | CD630DERM_26530(murD) |
| FAA: | HMPREF0389_00306(murD) |
| PHX: | KGNDJEFE_00829(murD) |
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