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Entry
EC 6.3.3.7                  Enzyme                                 

Name
Ni-sirohydrochlorin a,c-diamide reductive cyclase;
cfbC (gene name);
cfbD (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Cyclo-ligases
BRITE hierarchy
Sysname
Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + Ni-sirohydrochlorin a,c-diamide + 3 reduced electron acceptor + H2O = ADP + phosphate + 15,173-seco-F430-173-acid + 3 electron acceptor [RN:R11628]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
Ni-sirohydrochlorin a,c-diamide [CPD:C21511];
reduced electron acceptor;
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512];
electron acceptor
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.3.3.7 created 2017
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21610  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC
K21611  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD
Genes
MJA: MJ_1423
MFE: Mefer_1398
MVU: Metvu_0736
MFS: MFS40622_0630
MIF: Metin_0570
MJH: JH146_0545
MIG: Metig_1723
MMP: MMP0428
MMQ: MmarC5_1209
MMX: MmarC6_0483
MMD: GYY_02215
MAE: Maeo_1313
MVO: Mvol_1630
MAC: MA_3627(nifH) MA_3628
MMA: MM_0514(nifH2) MM_0515
MCJ: MCON_0503(nifH) MCON_1930
MHU: Mhun_0670
MLA: Mlab_0520
MPI: Mpet_1002
MBN: Mboo_1419
MPL: Mpal_0679
MPD: MCP_0363 MCP_0364(nifH-1)
MEZ: Mtc_0063 Mtc_0064(nifH-1)
RCI: RCIX2002(nifH-2) RCIX2003
METE: tca_00613(nifH1_1) tca_01470(nifD_1)
MST: Msp_1120(nifH) Msp_1461
METH: MBMB1_0045 MBMB1_0311(nifH2)
MFI: DSM1535_0151(nifH2-1) DSM1535_1422
MCUB: MCBB_0063 MCBB_0533(nifH2)
MKA: MK1385(nifD)
MEAR: Mpt1_c08020(bchB2)
MARC: AR505_0362
 » show all
Taxonomy
Reference
1  [PMID:3691535]
  Authors
Pfaltz A, Kobelt A, Huster R, Thauer RK
  Title
Biosynthesis of coenzyme F430 in methanogenic bacteria. Identification of 15,17(3)-seco-F430-17(3)-acid as an intermediate.
  Journal
Eur J Biochem 170:459-67 (1987)
Reference
2  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO.
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.3.7
IUBMB Enzyme Nomenclature: 6.3.3.7
ExPASy - ENZYME nomenclature database: 6.3.3.7
BRENDA, the Enzyme Database: 6.3.3.7

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