KEGG   ENZYME: 6.3.4.10
Entry
EC 6.3.4.10                 Enzyme                                 
Name
biotin---[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase;
biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase;
biotin-propionyl coenzyme A carboxylase synthetase;
propionyl coenzyme A holocarboxylase synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
Sysname
biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
Reaction(IUBMB)
ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)] [RN:R04582]
Reaction(KEGG)
R04582;
(other) R01074 R05145
Substrate
ATP [CPD:C00002];
biotin [CPD:C00120];
apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] [CPD:C04763]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] [CPD:C04727]
History
EC 6.3.4.10 created 1972
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01942  biotin---protein ligase
Genes
HSA3141(HLCS)
PTR473989(HLCS)
PPS100985942(HLCS)
GGO101135438(HLCS)
PON100457062(HLCS)
NLE100599352(HLCS)
MCC694733(HLCS)
MCF102133502(HLCS)
CSAB103218635(HLCS)
CATY105575421(HLCS)
PANU101013764(HLCS)
TGE112621212(HLCS)
RRO104679174(HLCS)
RBB108543829(HLCS)
TFN117095757(HLCS)
PTEH111525767(HLCS)
CJC100388312(HLCS)
SBQ101045875(HLCS)
CSYR103254137(HLCS)
MMUR105881298(HLCS)
OGA100962733(HLCS)
MMU110948(Hlcs)
MCAL110311917(Hlcs)
MPAH110329965(Hlcs)
RNO288240(Hlcs)
MCOC116086167(Hlcs)
MUN110560965(Hlcs)
CGE100752840(Hlcs)
PLEU114700373(Hlcs)
NGI103750093 103750102
HGL101722847(Hlcs)
CPOC100716230(Hlcs)
CCAN109693415(Hlcs)
DORD105994008(Hlcs)
DSP122114310(Hlcs)
OCU100349035(HLCS)
OPI101523312(HLCS)
TUP102498435(HLCS)
CFA478412(HLCS)
VVP112911371(HLCS)
VLG121479299(HLCS)
AML100464483(HLCS)
UMR103673150(HLCS)
UAH113260107(HLCS)
UAR123802684(HLCS)
ELK111155824
LLV125094597
MPUF101682919(HLCS)
ORO101363115 101368585(HLCS)
EJU114218940(HLCS)
ZCA113917206(HLCS)
MLX118018863(HLCS)
FCA101100992(HLCS)
PYU121035949(HLCS)
PBG122491180(HLCS)
PTG102964368(HLCS)
PPAD109249774(HLCS)
AJU106966985(HLCS)
HHV120229710(HLCS)
BTA534247(HLCS)
BOM102275692 102276987(HLCS)
BIU109561544(HLCS) 109563420
BBUB102407054(HLCS)
CHX102179708(HLCS)
OAS101109588(HLCS)
ODA120880672(HLCS)
SSC100515056(HLCS)
CFR102520771(HLCS)
CBAI105070401(HLCS)
CDK105089839(HLCS)
VPC102538594(HLCS)
BACU103015318(HLCS)
LVE103086335(HLCS)
OOR101281208(HLCS)
DLE111163877(HLCS)
PCAD102981930(HLCS) 114485348
PSIU116753145(HLCS)
ECB100061132(HLCS)
EPZ103550461(HLCS)
EAI106831403(HLCS)
MYB102263271(HLCS)
MYD102765347(HLCS)
MMYO118675452(HLCS)
MLF102440948(HLCS)
MNA107543170(HLCS)
PKL118723485(HLCS)
HAI109391229(HLCS)
DRO112305753(HLCS)
SHON118983280(HLCS)
AJM119035750(HLCS)
PDIC114490841(HLCS)
PHAS123828033(HLCS)
MMF118617233(HLCS)
RFQ117034459(HLCS)
PALE102889335(HLCS)
PGIG120598588(HLCS)
PVP105295819(HLCS)
RAY107499284(HLCS)
MJV108398522(HLCS)
TOD119257083(HLCS)
SARA101557365(HLCS)
LAV100666961(HLCS)
TMU101340265
DNM101417266(HLCS)
MDO100012694(HLCS)
GAS123242479(HLCS)
SHR100914711(HLCS)
PCW110214863(HLCS)
GGA418516(HLCS)
PCOC116242079(HLCS)
MGP100544537(HLCS)
CJO107323321(HLCS)
NMEL110402806(HLCS)
APLA101793696(HLCS)
ACYG106036092(HLCS)
AFUL116493828(HLCS)
TGU105758711(HLCS)
LSR110469057(HLCS)
SCAN108961921(HLCS)
PMOA120511785(HLCS)
OTC121333572(HLCS)
PRUF121364465(HLCS)
GFR102039791(HLCS)
FAB101811028(HLCS)
PHI102113505(HLCS)
PMAJ107202517(HLCS)
CCAE111928640(HLCS)
CCW104696775(HLCS)
ETL114070498(HLCS) 114071342 114072950
FPG101921711(HLCS)
FCH102053171(HLCS)
CLV102093696(HLCS)
EGZ104128244(HLCS)
NNI104020182(HLCS)
ACUN113482863(HLCS)
TALA104367106(HLCS)
PADL103920277(HLCS)
ACHC115343774(HLCS)
AAM106494968(HLCS)
AROW112971860(HLCS)
NPD112959086(HLCS)
DNE112996144(HLCS)
ASN102384054(HLCS)
AMJ102565173(HLCS)
CPOO109305810(HLCS)
GGN109302688(HLCS)
PSS102452909(HLCS)
CMY102944554(HLCS)
CPIC101934162(HLCS)
TST117888291
CABI116834913(HLCS)
MRV120405524(HLCS)
ACS100562676(hlcs)
PVT110076819(HLCS)
SUND121924901(HLCS)
PBI103067600(HLCS)
PMUR107296825(HLCS)
TSR106540930(HLCS)
PGUT117679791(HLCS)
VKO123028983(HLCS)
PMUA114596081(HLCS)
ZVI118085627(HLCS)
GJA107116049(HLCS)
XLA108707861(hlcs.L)
XTR100492512(hlcs)
NPR108785966(HLCS)
RTEM120927941(HLCS)
BBUF120994491(HLCS)
BGAR122930793 122932980
DRE337784(hlcs)
SRX107747605(hlcs)
SANH107676487(hlcs)
SGH107572952(hlcs)
CCAR109097448(hlcs)
CAUA113054772
IPU108277209(hlcs)
PHYP113543599(hlcs)
SMEO124393475(hlcs)
AMEX103022047(hlcs)
EEE113581671(hlcs)
TRU101061285(hlcs)
TNGGSTEN00016316G001
LCO104937128(hlcs)
NCC104958355(hlcs)
CGOB115019227(hlcs)
ELY117266071(hlcs)
PLEP121952414(hlcs)
SLUC116058207(hlcs)
ECRA117955796(hlcs)
PFLV114567320(hlcs)
GAT120822345(hlcs)
PPUG119215381(hlcs)
MSAM119895079(hlcs)
MZE101470218(hlcs)
ONL100710097(hlcs)
OAU116335319(hlcs)
OLA101169801(hlcs)
OML112142766(hlcs)
XMA102227719(hlcs)
XCO114153743(hlcs)
XHE116727964(hlcs)
PRET103476369(hlcs)
PFOR103130816
PLAI106941182
PMEI106906378
GAF122845331(hlcs)
CVG107100031(hlcs)
CTUL119791207(hlcs)
GMU124876218(hlcs)
NFU107386340(hlcs)
KMR108247189
ALIM106534551(hlcs)
NWH119420346(hlcs)
AOCE111587326 111587992
CSEM103395776(hlcs)
POV109642009(hlcs)
SSEN122779783(hlcs)
HHIP117774943(hlcs)
LCF108900070(hlcs)
SDU111234598(hlcs)
SLAL111653972(hlcs)
XGL120802396(hlcs)
HCQ109519595(hlcs)
BPEC110170317(hlcs)
MALB109972019(hlcs)
SASA106567688(hlcs)
OTW112257954(hlcs)
OMY110537572(hlcs)
OGO123999580(hlcs)
ONE115105454(hlcs)
SALP111980678(hlcs)
SNH120030996(hlcs)
ELS105023991(hlcs)
SFM108936248(hlcs)
PKI111855789 111858423(hlcs)
AANG118235918(hlcs)
LOC102690116(hlcs)
PSPA121302870(hlcs)
ARUT117406319 117407164
LCM102347440(HLCS)
CMK103188738(hlcs)
RTP109917011 109936700
BFO118422809 118423079
BBEL109464518
CIN100179742
SCLV120336784
SPU577740
APLC110986169
SKO100369411
DMEDmel_CG14670(Hcs)
DER6552203
DSIDsimw501_GD19789(Dsim_GD19789)
DYADyak_GE25471
DSR110177272
DPODpse_GA26365
DPE6591344
DMN108155261
DWI6647187
DGR6563879
DMODmoj_GI23080
DAZ108614926
DNV108656012
DHE111603564
CCAT101453066
BOD106618089
MDE101898108
SCAC106086242
LCQ111680170
AGAAgaP_AGAP001481
ACOZ120949731
AARA120896139
AAG5571860
AALB109404810
CQUCpipJ_CPIJ007071 CpipJ_CPIJ007072
CPII120422427
CNS116339785
AME411759
ACER107996086
ALAB122719799
BIM100741269
BBIF117216160
BVK117231240
BVAN117155110
BTER100642502
BPYO122574687
CCAL113464824
OBB114881255
MGEN117224851
NMEA116427632
CGIG122396269
SOC105208017
MPHA105832368
AEC105150986
ACEP105619994 105625408
PBAR105427000
VEM105570280
HST105187433
DQU106752243
CFO105254823
FEX115245250
LHU105676227
PGC109853482
OBO105284641
PCF106785970
PFUC122519663
VPS122630628
NVI100120765
CSOL105362029
TPRE106659272
MDL103574421
CGLO123269121
FAS105273724
DAM107038805
AGIF122856527
CCIN107265728
TCA100141937
DPA109541261
SOY115877088
ATD109606168
CSET123319879
AGB108907126
LDC111507580
NVL108566076
APLN108744963
PPYR116161516
OTU111419464
BMOR101743517
BMAN114239389 114249541
MSEX115448234
DPLKGM_204685
BANY112047377
PMAC106715388
PPOT106110370
PXU106116842
PRAP110993032
ZCE119829075
HAW110377217
TNL113499624
OFU114359388
API100166501
DNX107172306
AGS114132498
RMD113551631
BTAB109033441
CLEC106662760
HHAL106678476
NLU111048036 111050202 111058010
PHUPhum_PHUM492490
FOC113208798
ZNE110833334
CSEC111863940
FCD110853379
DPXDAPPUDRAFT_309177
DMK116918782
PVM113823086
HAME121871525
EAF111714793
ISCIscW_ISCW015948
DSV119466650
RSAN119376304
RMP119176469
VDE111247532
VJA111262869
TUT107366528
DPTE113790808
DFR124496674
CSCU111640237
PTEP107438304
SDM118194372
LOALOAG_17932
NAINECAME_13093 NECAME_13444
HROHELRODRAFT_65278
LGILOTGIDRAFT_171251
PCAN112565926
BGT106066185 106068018
GAE121372513
HRF124117548 124146911
HRJ124260194
CRG105332906 105335319
MYI110445704
PMAX117336082 117339376
MMER123537203 123552941
OBI106879777 106880135
OSN115232536 115232587
LAK106176354
SMMSmp_153150
SHXMS3_0019437
OVIT265_13178
EGLEGR_07298
NVE5512817
EPA110242401
ATEN116291329
ADF107339212
AMIL114977487
PDAM113671831
SPIS111340632
DGT114537726
XEN124441389 124441538 124441541 124441869 124442559 124442932
HMG105849906
TADTRIADDRAFT_31020
AQU100632425
ATHAT1G37150(HCS2) AT2G25710(HCS1)
ALY9314944 9329987
CRB17888619 17889810
CSAT104703109 104714038 104752205 104752216
EUSEUTSA_v10004827mg EUTSA_v10027838mg
BRP103852453
BNA106368386 106392404 106409576
BOE106316290 106324724
RSZ108805431 108830160 108830804
THJ104817066
CPAP110816651
CIT102613353
CICCICLE_v10001583mg
PVY116132147
MINC123203292 123206093 123229157
TCC18592271
GRA105770129
GHI107922700 107942037
GAB108450088
DZI111312328 111315616
EGR104450472
GMX100813650 100818402
GSJ114410456 114415379
PVUPHAVU_009G121400g
VRA106761009
VAR108330832
VUN114162520
CCAJ109794594
APRC113873178
MTRMTR_3g073010
CAM101507301
ADU107460788
AIP107606089
AHF112706108 112764050
LANG109340049
FVE101294231
RCN112170520
PPER18789279
PMUM103332920
PAVI110753343
PDUL117626156
MDM103401855 103421290
PXB103933707 103956690 103956969
ZJU107406813 107407500 107434996
MNT21403054
CSV101206408
CMO103489963
BHJ120085048
MCHA111011837
CMAX111487622
CMOS111458666
CPEP111780897 111808204
RCU8260803 8274130
JCU105638886
HBR110665565
MESC110609471
POP7495112
PEU105116743 105127853
PALZ118041751
JRE109013665
QSU111992009 112036837 112037475
QLO115960411
TWL120008484
VVI100248922
VRI117907121
SLY101252547
SPEN107003210
SOT102584525
CANN107850582 107866583
NTA107787843 107819232
NSY104238135
NTO104085554
NAU109240668
INI109160079 109177408 109183075 109183459
ITR116027229 116027249
SIND105176554
OEU111377897 111383765
EGT105974439
SSPL121786473 121811335
HAN110865661
ECAD122590750
LSV111893663 111915583
CCAV112507572
DCR108196570 108196611
CSIN114266663 114315283
BVG104885223
SOE110795054
CQI110725327 110730819
MING122080726
TSS122662409
PSOM113346420 113356494
NCOL116261881
OSA4328417
DOSAOs02t0167000-00(Os02g0167000)
OBR102717040
BDI100835520 100844888
ATS109776075
TDC119315816 119324192
TAES123132409 123136485 123143975
SBI8074691
ZMA103626660
SITA101752965 101769375
SVS117836506 117864159
PVIR120661515
PHAI112875356
PDA103719623
EGU105049052
MUS103995618
DCT110102880
PEQ110038416
AOF109831799
ATR18423244
SMOSELMODRAFT_80973 SELMODRAFT_88773
PPP112286816
CRECHLRE_09g406000v5 CHLRE_12g508852v5
VCNVOLCADRAFT_120018
MNGMNEG_3981
CSLCOCSUDRAFT_18259
CVRCHLNCDRAFT_135977 CHLNCDRAFT_26827
APROF751_5965
OLUOSTLU_119606(hcs)
OTAOT_ostta02g02000
MISMICPUN_72068
MPPMICPUCDRAFT_6647
CMECYME_CMC080C
SCEYDL141W(BPL1)
AGOAGOS_ADR085W
ERCEcym_8066
KLAKLLA0_F05049g
KMXKLMA_60514(BPL1)
LTHKLTH0H02024g
VPOKpol_1019p23
ZROZYRO0F05940g
CGRCAGL0I03806g
NCSNCAS_0A13910(NCAS0A13910)
NDINDAI_0A02120(NDAI0A02120)
TPFTPHA_0A03060(TPHA0A03060)
TBLTBLA_0F02180(TBLA0F02180)
TDLTDEL_0C02310(TDEL0C02310)
TGBHG536_0B04920
KAFKAFR_0B01050(KAFR0B01050)
ZMKHG535_0E04840
PPAPAS_chr3_0569
DHADEHA2A13750g
PICPICST_69676(BPL1)
PGUPGUG_01114
SPAASPAPADRAFT_48797
LELLELG_05238
CALCAALFM_CR10620CA(CaO19.7645)
CTPCTRG_05783
COTCORT_0A05280 CORT_0D00250
CDUCD36_35420
CTENCANTEDRAFT_122779
YLIYALI0E30591g
CLUCLUG_02270
CLUSA9F13_02g00264
CAURCJI97_004183
SLBAWJ20_1398(BPL1)
PKZC5L36_0B05860
BNNFOA43_002895
BBRXBRETT_005194
NCRNCU05516
NTENEUTE1DRAFT124604(NEUTE1DRAFT_124604)
SMPSMAC_00725
PANPODANSg2869
TTTTHITE_2110501
MTMMYCTH_2119403
CTHRCTHT_0044660
MGRMGG_00436
TMNUCRPA7_1182
SSCKSPSK_02214
FGRFGSG_08329
FPUFPSE_09477
FVRFVEG_02363
FOXFOXG_03496
NHENECHADRAFT_36078
TRETRIREDRAFT_77714
TRRM419DRAFT_24638
MAWMAC_04795
MAJMAA_02354
CMTCCM_05319
PLJVFPFJ_02589
VALVDBG_09198
VDAVDAG_07355
CFJCFIO01_12603
SAPOSAPIO_CDS6266
ELAUCREL1_3426
PFYPFICI_10037
SSLSS1G_04467
BFUBCIN_01g05670(Bcbpl1)
MBEMBM_09693
PSCOLY89DRAFT_451641
GLZGLAREA_00139
ANIAN6055.2
AFMAFUA_2G09550
ACTACLA_081340
NFINFIA_085040
AORAO090011000708
ANGANI_1_850144(An16g06410)
AFVAFLA_008108
ALUCAKAW2_70524A(BPL1)
ACHEACHE_40684A(BPL1)
APUUAPUU_11146S(BPL1)
PDPPDIP_65150
TMFPMAA_087420
TRGTRUGW13939_01850
CIMCIMG_07858
CPWCPC735_041520
UREUREG_02182
PBLPAAG_06513
PBNPADG_00464
ABEARB_05148
TVETRV_07820
AJEHCAG_08683
BGHBDBG_06963
PNOSNOG_08427
PTEPTT_11266
BZECOCCADRAFT_84592
BSCCOCSADRAFT_39903
BORCOCMIDRAFT_90241
AALTCC77DRAFT_1024071
ZTRMYCGRDRAFT_67807
PFJMYCFIDRAFT_46146
BCOMBAUCODRAFT_37668
NPAUCRNP2_2382
TMLGSTUM_00004427001
SPOSPBC30D10.07c
CNECNC00800
CNBCNBC6470
CGICGB_C1330W
TMSTREMEDRAFT_40864
TASAA1Q1_02988
TVSTRAVEDRAFT_74836
DSQDICSQDRAFT_136396
PCOPHACADRAFT_253991
SHSSTEHIDRAFT_146851
HIRHETIRDRAFT_147935
PSQPUNSTDRAFT_59339
ADLAURDEDRAFT_111555
FMEFOMMEDRAFT_74436
GTRGLOTRDRAFT_65526
LBCLACBIDRAFT_317063
MRRMoror_6357
CCICC1G_15548
SCMSCHCODRAFT_256476
ABPAGABI1DRAFT114677(AGABI1DRAFT_114677)
ABVAGABI2DRAFT226601(AGABI2DRAFT_226601)
CPUTCONPUDRAFT_124809
SLASERLADRAFT_355394
WSEWALSEDRAFT_59378
WICJ056_004070
UMAUMAG_03839
PFPPFL1_06449
MGLMGL_0053
MRTMRET_1269
MSYMMSY001_1290
PGRPGTG_14205
MLRMELLADRAFT_69028
DDIDDB_G0289035(hlcs3)
DPPDICPUDRAFT_18614
DFADFA_05534(hlcs3)
PSOJPHYSODRAFT_486526
SPARSPRG_09434
GTTGUITHDRAFT_144527
 » show all
Reference
1  [PMID:14284697]
  Authors
SIEGEL L, FOOTE JL, COON MJ.
  Title
THE ENZYMATIC SYNTHESIS OF PROPIONYL COENZYME A HOLOCARBOXYLASE FROM D-BIOTINYL 5'-ADENYLATE AND THE APOCARBOXYLASE.
  Journal
J Biol Chem 240:1025-31 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.10
IUBMB Enzyme Nomenclature: 6.3.4.10
ExPASy - ENZYME nomenclature database: 6.3.4.10
BRENDA, the Enzyme Database: 6.3.4.10
CAS: 37318-67-5

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