KEGG   ENZYME: 6.3.4.11Help
Entry
EC 6.3.4.11                 Enzyme                                 

Name
biotin---[methylcrotonoyl-CoA-carboxylase] ligase;
biotin-[methylcrotonoyl-CoA-carboxylase] synthetase;
biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase;
beta-methylcrotonyl coenzyme A holocarboxylase synthetase;
holocarboxylase-synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
Reaction(IUBMB)
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] [RN:R04604]
Reaction(KEGG)
R04604;
(other) R01074 R05145
Show
Substrate
ATP [CPD:C00002];
biotin [CPD:C00120];
apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] [CPD:C04827]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] [CPD:C04801]
History
EC 6.3.4.11 created 1972
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01942  biotin---protein ligase
Genes
HSA: 3141(HLCS)
PTR: 473989(HLCS)
PPS: 100985942(HLCS)
GGO: 101135438(HLCS)
PON: 100457062(HLCS)
NLE: 100599352(HLCS)
MCC: 694733(HLCS)
MCF: 102133502(HLCS)
CSAB: 103218635(HLCS)
RRO: 104679174(HLCS)
RBB: 108543829(HLCS)
CJC: 100388312(HLCS)
SBQ: 101045875(HLCS)
MMU: 110948(Hlcs)
RNO: 288240(Hlcs)
CGE: 100752840(Hlcs)
NGI: 103750093 103750102
HGL: 101722847(Hlcs)
CCAN: 109693415(Hlcs)
OCU: 100349035(HLCS)
TUP: 102498435(HLCS)
CFA: 478412(HLCS)
AML: 100464483(HLCS)
UMR: 103673150(HLCS)
ORO: 101363115 101368585(HLCS)
FCA: 101100992(HLCS)
PTG: 102964368(HLCS)
AJU: 106966985(HLCS)
BTA: 534247(HLCS)
BOM: 102275692 102276987(HLCS)
BIU: 109561544(HLCS) 109563420
PHD: 102332380(HLCS)
CHX: 102179708(HLCS)
OAS: 101109588(HLCS)
SSC: 100515056(HLCS)
CFR: 102520771(HLCS)
CDK: 105089839(HLCS)
BACU: 103015318(HLCS)
LVE: 103086335(HLCS)
OOR: 101281208(HLCS)
ECB: 100061132(HLCS)
EPZ: 103550461(HLCS)
EAI: 106831403(HLCS)
MYB: 102263271(HLCS)
MYD: 102765347(HLCS)
HAI: 109391229(HLCS)
RSS: 109446664(HLCS)
PALE: 102889335(HLCS)
LAV: 100666961(HLCS)
TMU: 101340265
MDO: 100012694(HLCS)
SHR: 100914711(HLCS)
OAA: 100081454(HLCS) 100087267
GGA: 418516(HLCS)
MGP: 100544537(HLCS)
CJO: 107323321(HLCS)
APLA: 101793696(HLCS)
ACYG: 106036092(HLCS)
TGU: 100229815
GFR: 102039791(HLCS)
FAB: 101811028(HLCS)
PHI: 102113505(HLCS)
PMAJ: 107202517(HLCS)
CCW: 104696775 104696776(HLCS)
FPG: 101921711(HLCS)
FCH: 102053171(HLCS)
CLV: 102093696(HLCS)
EGZ: 104128244(HLCS)
AAM: 106494968(HLCS)
ASN: 102384054(HLCS)
AMJ: 102565173(HLCS)
PSS: 102452909(HLCS)
CMY: 102944554(HLCS)
CPIC: 101934162(HLCS)
ACS: 100562676(hlcs)
PVT: 110076819(HLCS)
PBI: 103067600(HLCS)
GJA: 107116049(HLCS)
XLA: 108707861(hlcs.L) 108709241
XTR: 100492512(hlcs)
NPR: 108785966(HLCS)
DRE: 337784(hlcs)
SRX: 107747605(hlcs)
SANH: 107676487(hlcs)
SGH: 107572952(hlcs)
CCAR: 109097448(hlcs)
IPU: 108277209(hlcs)
AMEX: 103022047(hlcs)
TRU: 101061285 105419148
TNG: GSTEN00016316G001
LCO: 104937128(hlcs)
NCC: 104958355(hlcs)
MZE: 101470218(hlcs)
OLA: 101169801(hlcs)
XMA: 102227719(hlcs)
PRET: 103476369(hlcs)
NFU: 107386340(hlcs)
CSEM: 103395776(hlcs)
LCF: 108900070(hlcs)
HCQ: 109519595(hlcs)
BPEC: 110170317(hlcs)
SASA: 106567688(hlcs)
ELS: 105023991(hlcs)
SFM: 108936248(hlcs)
LCM: 102347440(HLCS)
CMK: 103173081 103188738(hlcs)
BFO: BRAFLDRAFT_219676 BRAFLDRAFT_88607
CIN: 100179742
SPU: 577740
APLC: 110986169
SKO: 100369411
DME: Dmel_CG14670(Hcs)
DPO: Dpse_GA26365
DAN: Dana_GF17255
DER: Dere_GG12849
DPE: Dper_GL21666
DSE: Dsec_GM10811
DSI: Dsimw501_GD19789(Dsim_GD19789)
DWI: Dwil_GK11222
DYA: Dyak_GE25471
DGR: Dgri_GH18598
DMO: Dmoj_GI23080
DVI: Dvir_GJ22700
MDE: 101898108
AGA: AgaP_AGAP001481
AAG: 5571860
CQU: CpipJ_CPIJ007071 CpipJ_CPIJ007072
AME: 411759(Hcs)
BIM: 100741269
BTER: 100642502
SOC: 105208017
AEC: 105150986
ACEP: 105619994 105625408
PBAR: 105427000
HST: 105187433
CFO: 105254823
LHU: 105676227
PGC: 109853482
NVI: 100120765
TCA: 100141937
DPA: 109541261
NVL: 108566076
BMOR: 101743517
DPL: KGM_204685
PMAC: 106715388
PRAP: 110993032
API: 100166501
DNX: 107172306
PHU: Phum_PHUM492490
ZNE: 110833334
FCD: 110853379
DPX: DAPPUDRAFT_309177
ISC: IscW_ISCW015948
TUT: 107366528
NAI: NECAME_13093 NECAME_13444
BMY: Bm1_15240
LOA: LOAG_17932
HRO: HELRODRAFT_65278
LGI: LOTGIDRAFT_171251 LOTGIDRAFT_171252
CRG: 105332906
MYI: 110445704
OBI: 106879777 106880135
LAK: 106176354
SMM: Smp_153150
SHX: MS3_06202
OVI: T265_13178
NVE: NEMVE_v1g105387
EPA: 110242401
ADF: 107339212
HMG: 105849906
TAD: TRIADDRAFT_31020
AQU: 100632425
ATH: AT1G37150(HCS2) AT2G25710(HCS1)
ALY: ARALYDRAFT_473728 ARALYDRAFT_481423
CRB: 17888619 17889810
CSAT: 104703109 104714038 104752205 104752216
EUS: EUTSA_v10004827mg EUTSA_v10027838mg
BRP: 103852453
BNA: 106368386 106392404 106409576
BOE: 106316290 106324724
THJ: 104817066
CPAP: 110816651
CIT: 102613353
CIC: CICLE_v10001583mg
TCC: 18592271
GRA: 105770129
GHI: 107922700 107942037
DZI: 111312328 111315616
EGR: 104450472
GMX: 100813650 100818402
PVU: PHAVU_009G121400g
VRA: 106761009
VAR: 108330832
CCAJ: 109794594
MTR: MTR_3g073010
CAM: 101507301
LJA: Lj0g3v0203999.2(Lj0g3v0203999.2)
ADU: 107460788 107478225
AIP: 107606089
LANG: 109340049
FVE: 101294231
PPER: 18789279
PMUM: 103332920
PAVI: 110753343
MDM: 103401855 103421290
PXB: 103933707 103956690 103956969
ZJU: 107407500 107434996
CSV: 101206408
CMO: 103489963
MCHA: 111011837
CMAX: 111487622
CMOS: 111458666
CPEP: 111780897 111808204
RCU: 8260803 8274130
JCU: 105638886
HBR: 110665565
POP: 7495112
JRE: 109013665
VVI: 100248922
SLY: 101252547
SPEN: 107003210
SOT: 102584525
CANN: 107850582 107866583
NTA: 107787843 107819232
NSY: 104238135
NTO: 104085554
INI: 109160079 109177408 109183075 109183459
SIND: 105176554
OEU: 111377897 111383765
HAN: 110865661
LSV: 111893663 111915583
DCR: 108196570 108196611
BVG: 104885223
SOE: 110795054
OSA: 4328417
DOSA: Os02t0167000-00(Os02g0167000)
OBR: 102717040
BDI: 100835520 100844888
ATS: 109776075(LOC109776075)
SBI: 8074691
ZMA: 103626660
SITA: 101752965 101769375
PDA: 103719623
EGU: 105049052
MUS: 103995618
DCT: 110102880
AOF: 109831799
ATR: 18423244
SMO: SELMODRAFT_80973 SELMODRAFT_88773
PPP: 112286816
CRE: CHLREDRAFT_151096(BPL1) CHLREDRAFT_169728
VCN: VOLCADRAFT_120018
MNG: MNEG_2237 MNEG_3981
OTA: OT_ostta02g02000
BPG: Bathy14g02050
MIS: MICPUN_72068
MPP: MICPUCDRAFT_6647
CSL: COCSUDRAFT_18259
CVR: CHLNCDRAFT_135977 CHLNCDRAFT_26827
APRO: F751_4461 F751_5965
SCE: YDL141W(BPL1)
AGO: AGOS_ADR085W
ERC: Ecym_8066
KLA: KLLA0_F05049g
KMX: KLMA_60514(BPL1)
LTH: KLTH0H02024g
VPO: Kpol_1019p23
ZRO: ZYRO0F05940g
CGR: CAGL0I03806g
NCS: NCAS_0A13910(NCAS0A13910)
NDI: NDAI_0A02120(NDAI0A02120)
TPF: TPHA_0A03060(TPHA0A03060)
TBL: TBLA_0F02180(TBLA0F02180)
TDL: TDEL_0C02310(TDEL0C02310)
KAF: KAFR_0B01050(KAFR0B01050)
PPA: PAS_chr3_0569
DHA: DEHA2A13750g
PIC: PICST_69676(BPL1)
PGU: PGUG_01114
SPAA: SPAPADRAFT_48797
LEL: LELG_05238
CAL: CAALFM_CR10620CA(CaO19.7645)
CTP: CTRG_05783
COT: CORT_0A05280 CORT_0D00250
CDU: CD36_35420
CTEN: CANTEDRAFT_122779
YLI: YALI0E30591g
CLU: CLUG_02270
CLUS: A9F13_02g00264
CAUR: QG37_04056
SLB: AWJ20_1398(BPL1)
NCR: NCU05516
NTE: NEUTE1DRAFT124604(NEUTE1DRAFT_124604)
SMP: SMAC_00725
PAN: PODANSg2869
TTT: THITE_2110501
MTM: MYCTH_2119403
CTHR: CTHT_0044660
MGR: MGG_00436
TMN: UCRPA7_1182
FGR: FGSG_08329
FPU: FPSE_09477
FVR: FVEG_02363
FOX: FOXG_03496
NHE: NECHADRAFT_36078
TRE: TRIREDRAFT_77714
MAW: MAC_04795
MAJ: MAA_02354
CMT: CCM_05319
PLJ: VFPFJ_02589
VAL: VDBG_09198
VDA: VDAG_07355
CFJ: CFIO01_12603
ELA: UCREL1_3426
PFY: PFICI_10037
SSL: SS1G_04467
BFU: BCIN_01g05670(Bcbpl1)
MBE: MBM_09693
PSCO: LY89DRAFT_451641
GLZ: GLAREA_00139
ANI: AN6055.2
AFM: AFUA_2G09550
AOR: AO090011000708
ANG: ANI_1_850144(An16g06410)
AFV: AFLA_045250
ACT: ACLA_081340
NFI: NFIA_085040
PDP: PDIP_65150
CIM: CIMG_07858
CPW: CPC735_041520
PBL: PAAG_06513
PBN: PADG_00464
URE: UREG_02182
ABE: ARB_05148
TVE: TRV_07820
AJE: HCAG_08683
PNO: SNOG_08427
PTE: PTT_11266
BZE: COCCADRAFT_84592
BSC: COCSADRAFT_39903
BOR: COCMIDRAFT_90241
AALT: CC77DRAFT_1024071
ZTR: MYCGRDRAFT_67807
PFJ: MYCFIDRAFT_46146
BCOM: BAUCODRAFT_37668
NPA: UCRNP2_2382
TML: GSTUM_00004427001
SPO: SPBC30D10.07c
CNE: CNC00800
CNB: CNBC6470
CGI: CGB_C1330W
TMS: TREMEDRAFT_40864
TVS: TRAVEDRAFT_74836
DSQ: DICSQDRAFT_136396
PCO: PHACADRAFT_253991
SHS: STEHIDRAFT_146851
HIR: HETIRDRAFT_147935
PSQ: PUNSTDRAFT_59339
ADL: AURDEDRAFT_111555
FME: FOMMEDRAFT_74436
GTR: GLOTRDRAFT_65526
LBC: LACBIDRAFT_317063
MRR: Moror_6357
CCI: CC1G_15548
SCM: SCHCODRAFT_256476
ABP: AGABI1DRAFT114677(AGABI1DRAFT_114677)
ABV: AGABI2DRAFT226601(AGABI2DRAFT_226601)
CPUT: CONPUDRAFT_124809
SLA: SERLADRAFT_355394
WSE: WALSEDRAFT_59378
WIC: J056_004070
UMA: UMAG_03839
PFP: PFL1_06449
MGL: MGL_0053
PGR: PGTG_14205
MLR: MELLADRAFT_69028
DDI: DDB_G0289035(hlcs3)
DPP: DICPUDRAFT_18614
DFA: DFA_05534(hlcs3)
ACAN: ACA1_183520
PSOJ: PHYSODRAFT_486526
SPAR: SPRG_09434
GTT: GUITHDRAFT_144527
 » show all
Taxonomy
Reference
1  [PMID:5867144]
  Authors
Hopner T, Knappe J.
  Title
[Synthesis of biotin in beta-methylcrotonyl-CoA-carboxylase by holocarboxylase synthetase]
  Journal
Biochem Z 342:190-206 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.11
IUBMB Enzyme Nomenclature: 6.3.4.11
ExPASy - ENZYME nomenclature database: 6.3.4.11
BRENDA, the Enzyme Database: 6.3.4.11
CAS: 37318-68-6

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (8)   
   KEGG REACTION (3)   
   KEGG RCLASS (5)   
Gene (1511)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (434)   
   KEGG MGENES (207)   
   RefGene (845)   
   EGENES (23)   
Protein sequence (35)   
   UniProt (18)   
   SWISS-PROT (5)   
   RefSeq(pep) (12)   
DNA sequence (44)   
   RefSeq(nuc) (15)   
   GenBank (16)   
   EMBL (13)   
All databases (1611)   

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