KEGG   ENZYME: 6.3.4.11Help
Entry
EC 6.3.4.11                 Enzyme                                 

Name
biotin---[methylcrotonoyl-CoA-carboxylase] ligase;
biotin-[methylcrotonoyl-CoA-carboxylase] synthetase;
biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase;
beta-methylcrotonyl coenzyme A holocarboxylase synthetase;
holocarboxylase-synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
Reaction(IUBMB)
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] [RN:R04604]
Reaction(KEGG)
R04604;
(other) R01074 R05145
Show
Substrate
ATP [CPD:C00002];
biotin [CPD:C00120];
apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] [CPD:C04827]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] [CPD:C04801]
History
EC 6.3.4.11 created 1972
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01942  biotin---protein ligase
Genes
HSA: 3141(HLCS)
PTR: 473989(HLCS)
PPS: 100985942(HLCS)
GGO: 101135438(HLCS)
PON: 100457062(HLCS)
NLE: 100599352(HLCS)
MCC: 694733(HLCS)
MCF: 102133502(HLCS)
CSAB: 103218635(HLCS)
RRO: 104679174(HLCS)
RBB: 108543829(HLCS)
CJC: 100388312(HLCS)
SBQ: 101045875(HLCS)
MMU: 110948(Hlcs)
RNO: 288240(Hlcs)
CGE: 100752840(Hlcs)
HGL: 101722847(Hlcs)
CCAN: 109693415(Hlcs)
OCU: 100349035(HLCS)
TUP: 102498435(HLCS)
CFA: 478412(HLCS)
AML: 100464483(HLCS)
UMR: 103673150(HLCS)
ORO: 101363115 101368585(HLCS)
FCA: 101100992(HLCS)
PTG: 102964368(HLCS)
AJU: 106966985(HLCS)
BTA: 534247(HLCS)
BOM: 102275692 102276987(HLCS)
BIU: 109561544(HLCS) 109563420
PHD: 102332380(HLCS)
CHX: 102179708(HLCS)
OAS: 101109588(HLCS)
SSC: 100515056(HLCS)
CFR: 102520771(HLCS)
CDK: 105089839(HLCS)
BACU: 103015318(HLCS)
LVE: 103086335(HLCS)
OOR: 101281208(HLCS)
ECB: 100061132(HLCS)
EPZ: 103550461(HLCS)
EAI: 106831403(HLCS)
MYB: 102263271(HLCS)
MYD: 102765347(HLCS)
HAI: 109391229(HLCS)
RSS: 109446664(HLCS)
PALE: 102889335(HLCS)
LAV: 100666961(HLCS)
TMU: 101340265
MDO: 100012694(HLCS)
SHR: 100914711(HLCS)
OAA: 100081454(HLCS) 100087267
GGA: 418516(HLCS)
MGP: 100544537(HLCS)
CJO: 107323321(HLCS)
APLA: 101793696(HLCS)
ACYG: 106036092(HLCS)
TGU: 100229815
GFR: 102039791(HLCS)
FAB: 101811028(HLCS)
PHI: 102113505(HLCS)
PMAJ: 107202517(HLCS)
CCW: 104696775 104696776(HLCS)
FPG: 101921711(HLCS)
FCH: 102053171(HLCS)
CLV: 102093696(HLCS)
EGZ: 104128244(HLCS)
AAM: 106494968(HLCS)
ASN: 102384054(HLCS)
AMJ: 102565173(HLCS)
PSS: 102452909(HLCS)
CMY: 102944554(HLCS)
CPIC: 101934162(HLCS)
ACS: 100562676(hlcs)
PVT: 110076819(HLCS)
PBI: 103067600(HLCS)
GJA: 107116049(HLCS)
XLA: 108707861(hlcs.L) 108709241
XTR: 100492512(hlcs)
NPR: 108785966(HLCS)
DRE: 337784(hlcs)
SRX: 107747605(hlcs)
SANH: 107676487(hlcs)
SGH: 107572952(hlcs)
CCAR: 109097448(hlcs)
IPU: 108277209(hlcs)
AMEX: 103022047(hlcs)
LCO: 104937128(hlcs)
NCC: 104958355(hlcs)
MZE: 101470218(hlcs)
OLA: 101169801(hlcs)
XMA: 102227719(hlcs)
PRET: 103476369(hlcs)
NFU: 107386340(hlcs)
CSEM: 103395776(hlcs)
LCF: 108900070(hlcs)
HCQ: 109519595(hlcs)
BPEC: 110170317(hlcs)
SASA: 106567688(hlcs)
ELS: 105023991(hlcs)
SFM: 108936248(hlcs)
LCM: 102347440(HLCS)
CMK: 103173081 103188738(hlcs)
CIN: 100179742
SPU: 577740
APLC: 110986169
SKO: 100369411
DME: Dmel_CG14670(Hcs)
DSI: Dsimw501_GD19789(Dsim_GD19789)
MDE: 101898108
AAG: 5571860
AME: 411759(Hcs)
BIM: 100741269
BTER: 100642502
SOC: 105208017
AEC: 105150986
PBAR: 105427000
HST: 105187433
CFO: 105254823
LHU: 105676227
PGC: 109853482
NVI: 100120765
TCA: 100141937
DPA: 109541261
NVL: 108566076
BMOR: 101743517
PMAC: 106715388
PRAP: 110993032
API: 100166501
DNX: 107172306
ZNE: 110833334
FCD: 110853379
TUT: 107366528
BMY: Bm1_15240
CRG: 105332906
MYI: 110445704
LAK: 106176354
SHX: MS3_06202
EPA: 110242401
ADF: 107339212
HMG: 105849906
AQU: 100632425
ATH: AT1G37150(HCS2) AT2G25710(HCS1)
BRP: 103852453
THJ: 104817066
CPAP: 110816651
CIT: 102613353
TCC: 18592271
GRA: 105770129
EGR: 104450472
VRA: 106761009
VAR: 108330832
CCAJ: 109794594
CAM: 101507301
LJA: Lj0g3v0203999.2(Lj0g3v0203999.2)
AIP: 107606089
LANG: 109340049
FVE: 101294231
PPER: 18789279
PMUM: 103332920
PAVI: 110753343
CSV: 101206408
CMO: 103489963
MCHA: 111011837
CMAX: 111487622
CMOS: 111458666
JCU: 105638886
HBR: 110665565
POP: 7495112
JRE: 109013665
VVI: 100248922
SLY: 101252547
SPEN: 107003210
SOT: 102584525
NSY: 104238135
NTO: 104085554
SIND: 105176554
HAN: 110865661
BVG: 104885223
SOE: 110795054
OSA: 4328417
DOSA: Os02t0167000-00(Os02g0167000)
OBR: 102717040
ATS: 109776075(LOC109776075)
SBI: 8074691
ZMA: 103626660
PDA: 103719623
EGU: 105049052
MUS: 103995618
DCT: 110102880
AOF: 109831799
ATR: 18423244
PPP: 112286816
SCE: YDL141W(BPL1)
ERC: Ecym_8066
KMX: KLMA_60514(BPL1)
NCS: NCAS_0A13910(NCAS0A13910)
NDI: NDAI_0A02120(NDAI0A02120)
TPF: TPHA_0A03060(TPHA0A03060)
TBL: TBLA_0F02180(TBLA0F02180)
TDL: TDEL_0C02310(TDEL0C02310)
KAF: KAFR_0B01050(KAFR0B01050)
PIC: PICST_69676(BPL1)
CAL: CAALFM_CR10620CA(CaO19.7645)
CAUR: QG37_04056
SLB: AWJ20_1398(BPL1)
NCR: NCU05516
NTE: NEUTE1DRAFT124604(NEUTE1DRAFT_124604)
MGR: MGG_00436
MAW: MAC_04795
MAJ: MAA_02354
CMT: CCM_05319
BFU: BCIN_01g05670(Bcbpl1)
MBE: MBM_09693
ANI: AN6055.2
ANG: ANI_1_850144(An16g06410)
ABE: ARB_05148
TVE: TRV_07820
PTE: PTT_11266
CNE: CNC00800
CNB: CNBC6470
ABP: AGABI1DRAFT114677(AGABI1DRAFT_114677)
ABV: AGABI2DRAFT226601(AGABI2DRAFT_226601)
MGL: MGL_0053
DDI: DDB_G0289035(hlcs3)
DFA: DFA_05534(hlcs3)
SPAR: SPRG_09434
 » show all
Taxonomy
Reference
1  [PMID:5867144]
  Authors
Hopner T, Knappe J.
  Title
[Synthesis of biotin in beta-methylcrotonyl-CoA-carboxylase by holocarboxylase synthetase]
  Journal
Biochem Z 342:190-206 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.11
IUBMB Enzyme Nomenclature: 6.3.4.11
ExPASy - ENZYME nomenclature database: 6.3.4.11
BRENDA, the Enzyme Database: 6.3.4.11
CAS: 37318-68-6

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