Entry
Name
tRNAIle-lysidine synthase;
TilS;
mesJ (gene name);
yacA (gene name);
isoleucine-specific transfer ribonucleate lysidine synthetase;
tRNAIle-lysidine synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
L-lysine:[tRNAIle2]-cytidine34 ligase (AMP-forming)
Reaction(IUBMB)
[tRNAIle2]-cytidine34 + L-lysine + ATP = [tRNAIle2]-lysidine34 + AMP + diphosphate + H2O [RN:
R09597 ]
Reaction(KEGG)
Substrate
[tRNAIle2]-cytidine34;
L-lysine [CPD:
C00047 ];
ATP [CPD:
C00002 ]
Product
Comment
The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNAIle at the oxo group in position 2 of cytidine34. This modification determines both codon and amino acid specificities of tRNAIle.
History
EC 6.3.4.19 created 2011
Orthology
K04075 tRNA(Ile)-lysidine synthase
K15780 bifunctional protein TilS/HprT
Genes
CAL : CAALFM_C604510CA(CaO19.2137)
ANG : ANI_1_1180164(An18g02520)
ABP : AGABI1DRAFT68155(AGABI1DRAFT_68155)
ABV : AGABI2DRAFT199017(AGABI2DRAFT_199017)
ECOO : ECRM13514_0196(tilS)
ECOH : ECRM13516_0198(tilS)
ELR : ECO55CA74_00920(tilS)
ECW : EcE24377A_0192(tilS)
ECOA : APECO78_04370(tilS)
EDJ : ECDH1ME8569_0181(tilS)
ECOI : ECOPMV1_00194(tilS)
SEM : STMDT12_C02370(tilS)
SETC : CFSAN001921_16220(tilS)
SEEN : SE451236_07200(tilS)
SENH : CFSAN002069_07965(tilS)
SEEH : SEEH1578_10300(tilS)
SENJ : CFSAN001992_09795(tilS)
SEEC : CFSAN002050_07720(tilS)
SEEB : SEEB0189_018125(tilS)
SENC : SEET0819_08110(tilS)
RTG : NCTC13098_06060(tilS)
REE : electrica_04145(tilS)
SENM : TRABTM_A_01110(tilS)
CLAP : NCTC11466_03739(tilS)
KIE : NCTC12125_02835(tilS)
CMIK : PMARG_ME00243(tilS)
METY : MRY16398_46110(tilS)
AHN : NCTC12129_00988(tilS)
PTF : PROFFT_A_05200(tilS)
PSHI : SAMEA2665130_2468(tilS)
YPG : YpAngola_A3417(tilS)
YPI : YpsIP31758_1031(tilS)
SMW : SMWW4_v1c38860(tilS)
SERS : SERRSCBI_18810(tilS)
SFJ : SAMEA4384070_3885(tilS)
SOF : NCTC11214_02882(tilS)
PAQU : DMB82_0015650(tilS)
DIC : Dpoa569_002776(tilS)
EHD : ERCIPSTX3056_661(tilS)
BAPF : BUMPF009_CDS00485(mesj)
BAPG : BUMPG002_CDS00486(mesj)
BAPU : BUMPUSDA_CDS00484(mesj)
BAPW : BUMPW106_CDS00485(mesj)
TPTY : NCTC11468_03009(tilS)
PHEI : NCTC12003_03039(tilS)
PRJ : NCTC6933_03138(tilS)
LRI : NCTC12151_00754(tilS)
HIC : NTHIC486_00582(tilS)
HPIT : NCTC13334_01994(tilS)
HHZ : NCTC10839_00066(tilS)
HAEG : NCTC8502_00737(tilS)
HPAZ : K756_08255 K756_11330
PDAG : 4362423_00892(tilS)
ADP : NCTC12871_01167(tilS)
ALIG : NCTC10568_01883(mesJ)
ASEG : NCTC10977_01700(tilS)
AVT : NCTC3438_01596(tilS)
RPNE : NCTC8284_01260(tilS)
PAET : NCTC13378_01076(tilS)
XFU : XFF4834R_chr18720(tilS)
XPH : XppCFBP6546_22075(tilS)
XHD : LMG31886_15770(tilS)
VAU : VANGNB10_cI2030c(tilS)
PAEB : NCGM1900_2638(mesJ)
PPUD : DW66_1154 DW66_1488
PVD : CFBP1590__4028(tilS)
PPRC : PFLCHA0_c12130(tilS)
PFW : PF1751_v1c12340(tilS)
PPUU : PputUW4_01105(tilS)
PTRT : HU722_0007495(tilS)
PTW : TUM18999_46100(tilS)
PTAE : NCTC10697_03440(tilS)
PSYC : DABAL43B_0199(tilS)
MCAT : MC25239_01542(tilS)
MCUN : NCTC10297_00206(tilS)
SCAA : TUM17387_27300(tilS)
SALH : HMF8227_02137(tilS)
CBS : COXBURSA331_A1692(tilS)
LLG : 44548918_01730(tilS)
LJR : NCTC11533_01904(tilS)
LCJ : NCTC11976_02802(mesJ)
LWA : SAMEA4504053_1114(tilS)
LSS : NCTC12082_00784(tilS)
LADL : NCTC12735_01365(tilS)
LANT : TUM19329_13520(tilS)
MISZ : MishRS11D_13570(tilS)
TSE : THMIRHAS_12910(tilS)
TZO : THMIRHAT_15240(tilS)
TNI : TVNIR_1891(tilS_[H])
GAI : IMCC3135_23815(tilS)
AEL : NCTC12917_03183(tilS)
CHJ : NCTC10426_01169(tilS)
CDIZ : CEDIAZO_01212(tilS)
NME : NMB1140(tilS-1) NMB1178(tilS-2)
NMQ : NMBM04240196_1022(tilS)
NMZ : NMBNZ0533_1152(tilS)
NMX : NMA510612_1501(tilS)
NWE : SAMEA3174300_0509(tilS)
NZO : SAMEA4504057_1897(tilS)
NCI : NCTC10296_01271(tilS)
NCZ : NCTC10294_00753(tilS)
NANI : NCTC12227_00559(tilS)
ECOR : SAMEA4412678_0301(tilS)
BMV : BMASAVP1_A2156(tilS)
BML : BMA10229_A3159(tilS)
BPM : BURPS1710b_2678(mesJ)
BPL : BURPS1106A_2593(tilS)
BUE : BRPE67_ACDS17790(tilS)
PLG : NCTC10937_01484(tilS)
LMIR : NCTC12852_02052(tilS)
BUO : BRPE64_ACDS17820(tilS)
VTR : MYVALT_F_02640(tilS)
BTRM : SAMEA390648700055(mesJ)
BOZ : DBV39_07650 DBV39_07655(tilS)
LIM : L103DPR2_02212(tilS)
LIH : L63ED372_01633(tilS)
URU : DSM104443_02835(tilS)
UPL : DSM104440_02534(tilS)
FPHO : SHINM1_003120(tilS)
HPO : HMPREF4655_20878(tilS)
HPX : HMPREF0462_0684(tilS)
HHM : BN341_6830 BN341_6860
HCL : NCTC13205_01008(tilS)
HSH : NHP194022_09890(tilS)
SULG : FJR48_09555(tilS) FJR48_11940(tilS)
CJV : MTVDSCj20_1419(tilS)
CFV : CFVI03293_1410(tilS)
CAMP : CFT03427_1335(tilS)
CCOC : CCON33237_0852(tilS)
CLR : UPTC16701_0265(tilS)
CLM : UPTC16712_0269(tilS)
CAMR : CAQ16704_0270(tilS)
CHV : CHELV3228_1348(tilS)
CPIN : CPIN18020_1090(tilS)
CAMZ : CVIC12175_0383(tilS)
GBN : GEOBRER4_16230(tilS)
APH : APH_1056 APH_1093 APH_1180(tilS)
APHA : WSQ_04880 WSQ_05060
RBS : RHODOSMS8_02205(tilS)
SMEL : SM2011_c02940(tilS)
SFD : USDA257_c51960(tilS)
SAME : SAMCFNEI73_Ch3147(tilS)
ALF : CFBP5473_03580(tilS)
REL : REMIM1_CH03525(tilS)
REP : IE4803_CH03810(tilS)
REI : IE4771_CH03750(tilS)
RPUS : CFBP5875_17155(tilS)
RGA : RGR602_CH03362(tilS)
RPHA : AMC79_CH03622(tilS)
NEN : NCHU2750_26750(mesJ)
BIO : BR141012304_11007(tilS)
BSEP : HAP48_0009430(tilS)
VGO : GJW-30_1_04214(tilS)
BBK : BARBAKC583_0167(tilS)
BART : BJB15x_010740 BJB15x_010750
BARR : Bra60_011970 Bra60_011980
BEZ : NCTC12898_01405(tilS)
MAQU : Maq22A_c07090(mesJ)
MMES : MMSR116_05275(tilS)
MTUN : MTUNDRAET4_4180(tilS)
FIL : BN1229_v1_0242(tilS)
FIY : BN1229_v1_0246(tilS)
LABR : CHH27_15845 CHH27_15850(tilS)
BVY : NCTC9239_02705(tilS)
TSV : DSM104635_03240(tilS)
SINL : DSM14862_00791(tilS)
SPSE : SULPSESMR1_02196(tilS)
RMM : ROSMUCSMR3_01979(tilS)
AHT : ANTHELSMS3_00266(tilS)
LVS : LOKVESSMR4R_00666(tilS)
SFLA : SPHFLASMR4Y_03327(tilS)
BAZ : BAMTA208_00340(tilS)
BSON : S101395_00083(tilS)
BFD : NCTC4823_04144(yacA)
BPF : BpOF4_08315(tilS_mesJ)
BLEN : NCTC4824_00078(yacA)
SUQ : HMPREF0772_10010(tilS)
SUF : SARLGA251_04430(tilS)
SAUV : SAI7S6_1003760(tilS)
SAUW : SAI5S5_1003750(tilS)
SAUX : SAI6T6_1003760(tilS)
SAUY : SAI8T7_1003760(tilS)
SDP : NCTC12225_02505(tilS)
SPIC : SAMEA4384060_2381(tilS)
SSH : NCTC13712_00441(tilS)
SSIM : SAMEA4384339_0435(tilS)
SSTE : SAMEA4384403_2368(tilS)
LMOQ : LM6179_0509(tilS_hprT)
LMR : LMR479A_0228(tilS_hprT)
LMOG : BN389_02330(tilS_hprT)
LGZ : NCTC10812_00210(tilS)
GMO : NCTC11323_01641(tilS)
GHA : NCTC10459_01665(tilS)
PPQ : PPSQR21_000560(mesJ)
PCHI : PC41400_03220(tilS)
COHN : KCTCHS21_00730(tilS)
SPYM : M1GAS476_0010(tilS)
SPH : MGAS10270_Spy0011(tilS)
SPI : MGAS10750_Spy0011(tilS)
SPJ : MGAS2096_Spy0011(tilS)
SPK : MGAS9429_Spy0011(tilS)
STG : MGAS15252_0011(tilS)
STZ : SPYALAB49_000012(tilS)
SNC : HMPREF0837_10299(tilS)
SGG : SGGBAA2069_c00130(tilS)
SCP : HMPREF0833_11486(tilS)
SVB : NCTC12167_00013(tilS)
SMEN : SAMEA4412692_1852(tilS)
SFER : NCTC12278_00012(tilS)
SCAI : NCTC12191_00590(tilS)
SPSU : NCTC13786_01195(tilS)
SPOC : NCTC10925_00012(tilS)
SPAB : KQ224_00365 KQ224_06710(tilS)
SAUP : NCTC3168_00761(tilS)
SURN : NCTC13766_02291(tilS)
SVF : NCTC3166_00012(tilS)
LPW : LpgJCM5343_02720(mesJ)
LRU : HMPREF0538_21445(tilS)
LOR : AYI71_00020 AYI71_08200
LHO : LOOC260_104070(tilS)
AUR : HMPREF9243_0495(tilS)
CCOH : SAMEA4530647_2362(mesJ)
CLO : HMPREF0868_0903(tilS)
SMAN : C12CBH8_15220(tilS)
PFAA : MM59RIKEN_15400(tilS)
VFA : MM35RIKEN_18680(tilS)
BPRO : PMF13cell1_02491(tilS)
CSCI : HDCHBGLK_01301(tilS_1)
ACEL : acsn021_02130(tilS)
ACHT : bsdcttw_47080(tilS)
PDF : CD630DERM_35600(tilS)
FAA : HMPREF0389_00530(tilS)
PHX : KGNDJEFE_00007(tilS)
CBAR : PATL70BA_2211(tilS)
AMIC : Ami3637_10520(tilS)
ABUT : Ami103574_13770(tilS)
ETM : CE91St48_07940(tilS)
CDIA : CaldiYA01_18140(tilS)
PHAR : NCTC13077_00495(tilS)
PIV : NCTC13079_00543(tilS)
VRM : 44547418_00522(tilS)
VDN : NCTC11831_01438(tilS)
MANA : MAMMFC1_01927(tilS)
PFAC : PFJ30894_02372(tilS)
ABSI : A9CBEGH2_16980(tilS)
FIT : Fi14EGH31_01200(tilS)
MGN : HFMG06NCA_5036(tilS)
MGS : HFMG95NCA_5062(tilS)
MGT : HFMG01NYA_5125(tilS)
MGV : HFMG94VAA_5133(tilS)
MGW : HFMG01WIA_4980(tilS)
MGAC : HFMG06CAA_5182(tilS)
MGAN : HFMG08NCA_4968(tilS)
MGNC : HFMG96NCA_5250(tilS)
MMYI : mycmycITA_00042(tilS)
MCAP : MCCPF38_00015(tilS)
MCAR : MCCPILRI181_00014(tilS)
MPUT : MPUT9231_0140(tilS)
MNU : NCTC10166_00548(tilS)
MOE : NCTC10151_00198(tilS)
MGLY : NCTC10194_00042(tilS)
MCOU : NCTC10179_00502(tilS)
MCOM : NCTC10178_00636(tilS)
MPU : MYPU_7800(MYPU_7800)
MGAL : NCTC10186_00096(tilS_1) NCTC10186_00460(tilS_2)
MCIT : NCTC10181_00574(tilS)
MMAU : NCTC10168_00544(tilS)
MMEL : NCTC10153_00560(tilS)
MCOB : NCTC10184_00348(tilS)
MBP : MBSPM3_v1c4560(mesJ)
AHK : NCTC10172_01118(tilS)
AAXA : NCTC10138_00436(tilS)
MTAB : MTABA_v1c07250(tilS)
MCOL : MCOLE_v1c06870(tilS)
EFR : EFREU_v1c06970(tilS)
EML : EMELA_v1c08910(tilS)
ELJ : ELUMI_v1c01510(tilS)
ESX : ESOMN_v1c07190(tilS)
SCR : SCHRY_v1c00120(tilS)
SSYR : SSYRP_v1c00120(tilS)
SDI : SDIMI_v3c00120(tilS)
STAI : STAIW_v1c00120(tilS)
SAPI : SAPIS_v1c00130(tilS)
SCQ : SCULI_v1c00120(tilS)
SSAB : SSABA_v1c00120(tilS)
SATR : SATRI_v1c00120(tilS)
SERI : SERIO_v1c00120(tilS)
SLL : SLITO_v1c00110(tilS)
SCJ : SCANT_v1c00120(tilS)
SHJ : SHELI_v1c00120(tilS)
SFZ : SFLOR_v1c00120(tilS)
SCOU : SCORR_v1c00110(tilS)
SPRN : S100390_v1c00120(tilS)
SPIT : STU14_v1c00120(tilS)
STAB : STABA_v1c00120(tilS)
SMOO : SMONO_v1c00120(tilS)
SALX : SALLE_v1c00120(tilS)
SGQ : SGLAD_v1c00120(tilS)
SCHI : SCHIN_v1c00120(tilS)
MALA : NCTC10135_01002(tilS)
MSAI : NCTC10113_01331(tilS_2)
MBO : BQ2027_MB3649C(mesJ)
MMAE : MMARE11_49470(mesJ)