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Entry
EC 6.3.4.23                 Enzyme                                 

Name
formate---phosphoribosylaminoimidazolecarboxamide ligase;
5-formaminoimidazole-4-carboxamide ribonucleotide synthetase;
5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase;
purP (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
formate:5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide ligase (ADP-forming)
Reaction(IUBMB)
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [RN:R06975]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
formate [CPD:C00058];
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [CPD:C04677]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [CPD:C04734]
Comment
This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyses a step in the synthesis of purine nucleotides. It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. cf. EC 2.1.2.3, phosphoribosylaminoimidazolecarboxamide formyltransferase.
History
EC 6.3.4.23 created 2013
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K06863  5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase
Genes
PRF: PeribacterA2_0725 PeribacterA2_0726
MJA: MJ_0136
MFE: Mefer_0308
MVU: Metvu_0168
MFS: MFS40622_1004
MIF: Metin_0767
MJH: JH146_0737
MIG: Metig_0553
MMP: MMP1373
MMQ: MmarC5_0205
MMD: GYY_07695(purP)
MAE: Maeo_1327
MVO: Mvol_0265
MBU: Mbur_1029(purP) Mbur_1626(purP)
MPY: Mpsy_0967(purP) Mpsy_1916
MPD: MCP_2462(purP-1) MCP_2481(purP-2) MCP_2482(purP-3)
MEZ: Mtc_2399(purP)
RCI: RCIX2374(purP)
MTH: MTH_1201
MMG: MTBMA_c15790(purP)
METC: MTCT_1094
MWO: MWSIV6_1594(purP)
METE: tca_01158
MST: Msp_0240
MSI: Msm_0506
MRU: mru_0595(purP)
MEB: Abm4_1385(purP)
MMIL: sm9_0511(purP)
MEYE: TL18_02305(purP)
MOL: YLM1_0256
METH: MBMB1_0083(purP)
MFC: BRM9_0147(purP)
MFI: DSM1535_1470(purP)
MCUB: MCBB_2033(purP)
MSUB: BK009_10205(purP)
METN: BK008_05830(purP)
MFV: Mfer_0393
MKA: MK0588
MEAR: Mpt1_c09180(purP1) Mpt1_c13110(purP2)
PHO: PH0324(PH0324) PH1348(PH1348)
PFI: PFC_01190 PFC_06820(purP)
THE: GQS_02000(purP) GQS_05740(purP) GQS_05765
SMR: Smar_1525
STO: STK_02890(purP) STK_02900(purP)
NCT: NMSP_0725(purP_1) NMSP_0856(purP_2)
NGA: Ngar_c02760(purP1) Ngar_c27450(purP2)
NVN: NVIE_014230(purP1) NVIE_015540(purP2)
NCV: NCAV_0743(purP) NCAV_1281(purP)
NDV: NDEV_1117(purP) NDEV_1244(purP)
BARB: AOA66_0604(purP)
 » show all
Taxonomy
Reference
1  [PMID:15623504]
  Authors
Ownby K, Xu H, White RH.
  Title
A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis.
  Journal
J Biol Chem 280:10881-7 (2005)
DOI:10.1074/jbc.M413937200
  Sequence
[mja:MJ_0136]
Reference
2  [PMID:18069798]
  Authors
Zhang Y, White RH, Ealick SE
  Title
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
  Journal
Biochemistry 47:205-17 (2008)
DOI:10.1021/bi701406g
  Sequence
[mja:MJ_0136] [pfu:PF1517]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.23
IUBMB Enzyme Nomenclature: 6.3.4.23
ExPASy - ENZYME nomenclature database: 6.3.4.23
BRENDA, the Enzyme Database: 6.3.4.23
CAS: 9032-03-5

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