KEGG   ENZYME: 6.3.4.23
Entry
EC 6.3.4.23                 Enzyme                                 
Name
formate---phosphoribosylaminoimidazolecarboxamide ligase;
5-formaminoimidazole-4-carboxamide ribonucleotide synthetase;
5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase;
purP (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
Sysname
formate:5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide ligase (ADP-forming)
Reaction(IUBMB)
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [RN:R06975]
Reaction(KEGG)
R06975
Substrate
ATP [CPD:C00002];
formate [CPD:C00058];
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [CPD:C04677]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [CPD:C04734]
Comment
This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyses a step in the synthesis of purine nucleotides. It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. cf. EC 2.1.2.3, phosphoribosylaminoimidazolecarboxamide formyltransferase.
History
EC 6.3.4.23 created 2013
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K06863  5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase
Genes
VABWPS_12340 WPS_12360
PRFPeribacterA2_0725 PeribacterA2_0726
MJAMJ_0136
MFEMefer_0308
MVUMetvu_0168
MFSMFS40622_1004
MIFMetin_0767
MJHJH146_0737
MESGMLAUSG7_1026(purP)
MESAMLASG1_0751(purP)
MIGMetig_0553
MMPMMP1373
MMQMmarC5_0205
MMXMmarC6_1300
MMZMmarC7_0618
MMDGYY_07695(purP)
MMAKMMKA1_15970(purP)
MMAOMMOS7_14780(purP)
MMADMMJJ_14660
MAEMaeo_1327
MVNMevan_0683
MVOMvol_0265
MOKMetok_0595
METFCFE53_06120(purP)
MTHMTH_1201
MMGMTBMA_c15790(purP)
MWOMWSIV6_1594(purP)
MTEEMTTB_02260(purP)
METCMTCT_1094
METEtca_01158
METZMETMT2_1203
METKFVF72_05615
MTHMFZP57_07640
MSTMsp_0240
METBAW729_05985(purP)
MEISPXD04_04980
MRUmru_0595(purP)
MSIMsm_0506
MEBAbm4_1385(purP)
MMILsm9_0511(purP)
MEYETL18_02305(purP)
MOLYLM1_0256
MAROMarbSA_08230(purP)
METVK4897_03040
MELMetbo_0324
MEWMSWAN_2096
METHMBMB1_0083(purP)
MFCBRM9_0147(purP)
MFIDSM1535_1470(purP)
MCUBMCBB_2033(purP)
MSUBBK009_10205(purP)
METNBK008_05830(purP)
METTCIT01_03875(purP)
METOCIT02_06600(purP)
MEMEHYG87_05155
MFEGGCM10025860_03410(purP)
MFVMfer_0393
MKAMK0588
AFUAF_0113 AF_0256
AFGAFULGI_00001100 AFULGI_00002440
APOArcpr_1226 Arcpr_1231
AVEArcve_0590 Arcve_1105
ASTAsulf_00339 Asulf_00414
FPLFerp_0934 Ferp_1822
GACGACE_1955 GACE_2044
GAHGAH_00649 GAH_00717
PFUPF0421 PF1517
PFIPFC_01190 PFC_06820(purP)
PHOPH0324(PH0324) PH1348(PH1348)
PABPAB0547 PAB1272
PYNPNA2_0941 PNA2_1924
PYAPYCH_06270 PYCH_10750 PYCH_16070
PYSPy04_0506 Py04_1238
PYCTQ32_03685 TQ32_10365
TKOTK0196 TK0203 TK0431
TGATGAM_0751(purP) TGAM_0757 TGAM_1267
TSITSIB_0049 TSIB_0059
TBATERMP_02032 TERMP_02040
THEGQS_02000(purP) GQS_05740(purP) GQS_05765
THATAM4_1003 TAM4_813
THMCL1_0040 CL1_0780 CL1_0784
TLTOCC_05274 OCC_06571 OCC_06656
TNUBD01_0510 BD01_1742 BD01_1747
TEUTEU_00655 TEU_00705 TEU_09520
TGYX802_06580 X802_06610 X802_10035
THVADU37_CDS22240 ADU37_CDS22310 ADU37_CDS22690
TCHCHITON_1151 CHITON_1566
TPEPA0127_02245 A0127_02990 A0127_03015
TPIEA7C91_05460 A7C91_05480 A7C91_09085
TCEA3L02_01430 A3L02_01515 A3L02_01970
TBSA3L01_00110 A3L01_00130
THHCDI07_00150 CDI07_00175
TSLA3L11_03840 A3L11_03860
TTDA3L14_01400 A3L14_01430 A3L14_05520
TPRFA3L09_06380 A3L09_08495 A3L09_08525
TRLA3L10_09820 A3L10_09840
TPAFA3L08_03260 A3L08_03280 A3L08_06910
THYA3L12_03075 A3L12_03145 A3L12_03165
TICFH039_02150 FH039_02230 FH039_06480
TCQTIRI35C_0238(purP) TIRI35C_0244(purP) TIRI35C_0997
THEMFPV09_02900 FPV09_07110 FPV09_07135
THEIK1720_03315 K1720_03365
PPACPAP_00555 PAP_00655
MBAMbar_A0288 Mbar_A1334
MBYMSBRM_0231 MSBRM_2665
MBWMSBRW_0708 MSBRW_3391
MBARMSBR2_2150 MSBR2_2623
MBAKMSBR3_2218 MSBR3_2802
MACMA_0206 MA_3689
MMAMM_0593 MM_1493 MM_2913
MMAZMmTuc01_0600 MmTuc01_1548 MmTuc01_2988
MMJMSMAS_0716 MSMAS_1802 MSMAS_3175
MMACMSMAC_0717 MSMAC_1314 MSMAC_3195
MVCMSVAZ_0238 MSVAZ_0647
MEKMSKOL_0231 MSKOL_0625
MLSMSLAZ_0127 MSLAZ_2268
METMMSMTP_0909 MSMTP_3081
MEFMSWH1_0142 MSWH1_2406
MEQMSWHS_0140 MSWHS_2641
MSJMSSAC_0179 MSSAC_3519
MSZMSSIH_0165 MSSIH_3038
MSWMSSIT_0169 MSSIT_3096
MTHRMSTHT_1985 MSTHT_2423
MTHEMSTHC_0859 MSTHC_1299
MHORMSHOH_0831 MSHOH_2312 MSHOH_3913
MFZAOB57_003310 AOB57_009245
MBUMbur_1029(purP) Mbur_1626(purP)
MMETMCMEM_1511 MCMEM_2123
MELOJ7W08_06365 J7W08_09580
MMHMmah_0026 Mmah_1404
MHAZBHR79_03335 BHR79_06655
MEVMetev_0086 Metev_0565
MZHMzhil_0081 Mzhil_0477
MPYMpsy_0967(purP) Mpsy_1916
MZIHWN40_03700 HWN40_12625
MMAVRE476_06515 RE476_10895
MSEBRE474_01995 RE474_07470
MHZMetho_0136 Metho_0550
MEHFMmiHf6_07840 MmiHf6_15440
MEESMmiEs2_00040 MmiEs2_03160
MTPMthe_0184 Mthe_1099
MCJMCON_1268 MCON_3207
MHIMhar_0372 Mhar_0580
MPDMCP_2462(purP-1) MCP_2481(purP-2) MCP_2482(purP-3)
MEZMtc_2399(purP)
RCIRCIX2374(purP)
MEAMMU439_05700 MU439_05705
MEAEQEN48_04455 QEN48_04460
TARTALC_00174 TALC_01295
MAXMMALV_01620 MMALV_13860
MERMMINT_01670(purP) MMINT_02910
MEARMpt1_c09180(purP1) Mpt1_c13110(purP2)
MEUZKRP56_00920 KRP56_06745
MARCAR505_0257 AR505_1667
SMRSmar_1525
IHOIgni_0442 Igni_0943
IISEYM_01025 EYM_07900
IPCIPA_00050 IPA_03630
DKADKAM_0529 DKAM_0531
DFDDesfe_0493 Desfe_0495
IAGIgag_0271 Igag_0273
PFMPyrfu_0237 Pyrfu_0911
PDLPyrde_0289 Pyrde_0749
PABIPABY_04650 PABY_24630
STOSTK_02890(purP) STK_02900(purP)
SOHD1869_00985 D1869_00990
SSOSSO0239 SSO0241
SOLSsol_1218 Ssol_1219
SSOASULA_1258 SULA_1259
SSOLSULB_1259 SULB_1260
SSOFSULC_1257 SULC_1258
SSHIJ5U23_00015 J5U23_00016
SCASSACC_01530 SACC_01540
SAISaci_0707 Saci_0708
SACNSacN8_03410(purP) SacN8_03415
SACRSacRon12I_03400(purP) SacRon12I_03405
SACSSUSAZ_03180 SUSAZ_03185
SISLS215_2006 LS215_2007
SIAM1425_1897 M1425_1898
SIMM1627_1974 M1627_1975
SIDM164_1904 M164_1905
SIYYG5714_1973 YG5714_1974
SINYN1551_0946 YN1551_0947
SIILD85_2118 LD85_2119
SIHSiH_1834 SiH_1836
SIRSiRe_1754 SiRe_1756
SICSiL_1747 SiL_1748
SULABFU36_04630 BFU36_04635
SULEGFS03_10400 GFS03_10405
SULOGFS33_02215 GFS33_02220
SULLEWF20_02450 EWF20_02455
MSEMsed_0016 Msed_0017
MEMJMJ1HA_0016 MJ1HA_0017
MCNMcup_0016 Mcup_0017
MHKDFR87_07050 DFR87_07055
MPRUDFR88_06610 DFR88_06615
MTENGWK48_05105 GWK48_05110
MJNMjAS7_0603 MjAS7_0604
AHOAhos_0764 Ahos_0765
AMANB6F84_07270 B6F84_07275
ABRIDFR85_07650 DFR85_07655
ASULDFR86_06330 DFR86_06335
AAMBD1866_11640 D1866_11645
ACIHHS5_21380 HS5_21390
SACDHS1genome_0014 HS1genome_0015
SAZOD1868_01780 D1868_01785
CSTYKN1_18510 KN1_18520
STEPIC006_1811 IC006_1812
SMETRQ359_000029 RQ359_000030
PAIPAE0604 PAE0608
PISPisl_0094 Pisl_0095
PCLPcal_0449 Pcal_2033
PASPars_2262 Pars_2265
PYRP186_2114 P186_2117
POGPogu_2597 Pogu_2600
TNETneu_1918 Tneu_1919
PYWPYWP30_02163 PYWP30_02165
CMACmaq_0021 Cmaq_0022
TTNTTX_0542 TTX_0543
TUZTUZN_0184 TUZN_0185
VDIVdis_0677 Vdis_0678
VMOVMUT_1944 VMUT_1945
VSOVsou_00990 Vsou_01000
FFOFFONT_0566 FFONT_0568
NMRNmar_0770 Nmar_0872
NIRNSED_04285 NSED_04890(purP)
NKRNKOR_04240 NKOR_04920(purP)
NIDNPIRD3C_1324(purP) NPIRD3C_1455
NINNADRNF5_1179(purP) NADRNF5_1308
NIWNisw_00370 Nisw_00920
NCLC5F47_04390 C5F47_05060
NOXC5F49_04300 C5F49_04985
NUEC5F50_05790 C5F50_06470
NIPNsoK4_03660 NsoK4_04330
NZTNZOSNM25_001050 NZOSNM25_001167
NCTNMSP_0725(purP_1) NMSP_0856(purP_2)
NICDSQ20_04355
NGANgar_c02760(purP1) Ngar_c27450(purP2)
NVNNVIE_014230(purP1) NVIE_015540(purP2)
NEVNTE_00824 NTE_02840
TAANMY3_02655 NMY3_03715
NFNNFRAN_0263(purP) NFRAN_1004(purP)
NCVNCAV_0743(purP) NCAV_1281(purP)
CSYCENSYa_0242 CENSYa_0907
CSUCSUB_C0852 CSUB_C0853
NBVT478_0670 T478_0775
TAHSU86_001715 SU86_002275
NIUDSQ19_04515 DSQ19_05280
NCKQVH35_08620
NDVNDEV_1117(purP) NDEV_1244(purP)
CCAINAS2_1505 NAS2_1506
KCRKcr_0400 Kcr_0401
BARBAOA66_0604(purP)
FLTSv326_1155 Sv326_1156
 » show all
Reference
1  [PMID:15623504]
  Authors
Ownby K, Xu H, White RH
  Title
A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis.
  Journal
J Biol Chem 280:10881-7 (2005)
DOI:10.1074/jbc.M413937200
  Sequence
[mja:MJ_0136]
Reference
2  [PMID:18069798]
  Authors
Zhang Y, White RH, Ealick SE
  Title
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
  Journal
Biochemistry 47:205-17 (2008)
DOI:10.1021/bi701406g
  Sequence
[mja:MJ_0136] [pfu:PF1517]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.23
IUBMB Enzyme Nomenclature: 6.3.4.23
ExPASy - ENZYME nomenclature database: 6.3.4.23
BRENDA, the Enzyme Database: 6.3.4.23
CAS: 9032-03-5

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