KEGG   ENZYME: 6.3.4.24
Entry
EC 6.3.4.24                 Enzyme                                 

Name
tyramine---L-glutamate ligase;
mfnD (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
Sysname
tyramine:L-glutamate gamma-ligase (ADP-forming)
Reaction(IUBMB)
ATP + tyramine + L-glutamate = ADP + phosphate + gamma-glutamyltyramine [RN:R10902]
Reaction(KEGG)
R10902
Substrate
ATP [CPD:C00002];
tyramine [CPD:C00483];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
gamma-glutamyltyramine [CPD:C20926]
Comment
The enzyme, which has been characterized from the archaea Methanocaldococcus fervens, participates in the biosynthesis of the cofactor methanofuran. Requires a divalent cation for activity, with Mn2+ giving the highest activity, followed by Mg2+, Co2+, Zn2+, and Fe2+.
History
EC 6.3.4.24 created 2014
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
Orthology
K06914  tyramine---L-glutamate ligase
Genes
EMO: DM558_09860
MCA: MCA2868
METU: GNH96_03505
MMT: Metme_2270
MDN: JT25_019360
MDH: AYM39_08565
MKO: MKLM6_1783
METL: U737_14795
MAH: MEALZ_2433
MBUR: EQU24_09090
MMAI: sS8_3388
MEJ: Q7A_50
MEC: Q7C_1777
NOC: Noc_0257
NHL: Nhal_3881
NWA: Nwat_0355
NTT: TAO_1759
MPT: Mpe_A2621
LCH: Lcho_3138
RGE: RGE_40360
MFA: Mfla_1650
MMB: Mmol_1335
MEH: M301_1544
MEP: MPQ_1556
XAU: Xaut_1790
SNO: Snov_0746
RBA: RB11969
PSL: Psta_3591
RUL: UC8_21010
PLM: Plim_0283
FTJ: FTUN_7518
SACI: Sinac_1217
MOX: DAMO_2657
MJA: MJ_0815
MMP: MMP0564
MMD: GYY_03655
MMAD: MMJJ_04200
MAE: Maeo_0448
MVO: Mvol_0760
MTH: MTH_835
METC: MTCT_0749
MWO: MWSIV6_1212(mfnD)
METE: tca_00802
MST: Msp_0387
MRU: mru_1696
MSI: Msm_0852
MEB: Abm4_0504
MMIL: sm9_1779
MEYE: TL18_07950
MOL: YLM1_1164
METH: MBMB1_0690
MFC: BRM9_1505
MCUB: MCBB_0701(mfnD)
MFV: Mfer_0210
MKA: MK0114
AFU: AF_1061
FPL: Ferp_2285
GAC: GACE_0439
GAH: GAH_01280
MBAR: MSBR2_1211
MBAK: MSBR3_1316
MAC: MA_1475
MMA: MM_2510
MMAC: MSMAC_2261
METM: MSMTP_0947
MTHR: MSTHT_0225
MTHE: MSTHC_0507
MHOR: MSHOH_2802
MBU: Mbur_1315
MMET: MCMEM_1762
MMH: Mmah_1619
MPY: Mpsy_2546
MTP: Mthe_1641
MCJ: MCON_1686
MHI: Mhar_1058
MHU: Mhun_0571
MLA: Mlab_0268
MEMA: MMAB1_1685
MPI: Mpet_1053
MBN: Mboo_0920
MPL: Mpal_0581
MPD: MCP_1324
MEZ: Mtc_1029
RCI: RCIX2220
BARB: AOA66_0934(mptN)
LOKI: Lokiarch_26760(ddl)
 » show all
Reference
1  [PMID:25211225]
  Authors
Wang Y, Xu H, Harich KC, White RH
  Title
Identification and characterization of a tyramine-glutamate ligase (MfnD) involved in methanofuran biosynthesis.
  Journal
Biochemistry 53:6220-30 (2014)
DOI:10.1021/bi500879h
  Sequence
[mja:MJ_0815] [mfe:Mefer_1180]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.24
IUBMB Enzyme Nomenclature: 6.3.4.24
ExPASy - ENZYME nomenclature database: 6.3.4.24
BRENDA, the Enzyme Database: 6.3.4.24

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