Entry
Name
2-amino-2'-deoxyadenylo-succinate synthase;
purZ (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
dGMP:L-aspartate ligase (ADP-forming)
Reaction(IUBMB)
ATP + dGMP + L-aspartate = ADP + phosphate + 2-amino-2'-deoxy-N6-[(2S)-succino]adenylate [RN:
R12786 ]
Reaction(KEGG)
Substrate
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
2-amino-2'-deoxy-N6-[(2S)-succino]adenylate [CPD:
C22395 ]
Comment
The enzyme, characterized from a number of bacteriophages, participates in the biosynthesis of dZTP, which replaces dATP in the genome of these phages.
History
EC 6.3.4.25 created 2021
Pathway
Orthology
K24972 2-amino-2'-deoxyadenylo-succinate synthase
Reference
Authors
Zhou Y, Xu X, Wei Y, Cheng Y, Guo Y, Khudyakov I, Liu F, He P, Song Z, Li Z, Gao Y, Ang EL, Zhao H, Zhang Y, Zhao S
Title
A widespread pathway for substitution of adenine by diaminopurine in phage genomes.
Journal
Reference
Authors
Sleiman D, Garcia PS, Lagune M, Loc'h J, Haouz A, Taib N, Rothlisberger P, Gribaldo S, Marliere P, Kaminski PA.
Title
A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.25
ExPASy - ENZYME nomenclature database: 6.3.4.25