KEGG   ENZYME: 6.3.4.6Help
Entry
EC 6.3.4.6                  Enzyme                                 

Name
urea carboxylase;
urease (ATP-hydrolysing);
urea carboxylase (hydrolysing);
ATP---urea amidolyase;
urea amidolyase;
UALase;
UCA
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
urea:carbon-dioxide ligase (ADP-forming)
Reaction(IUBMB)
ATP + urea + HCO3- = ADP + phosphate + urea-1-carboxylate [RN:R00774]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
urea [CPD:C00086];
HCO3- [CPD:C00288]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
urea-1-carboxylate [CPD:C01010]
Comment
A biotinyl-protein. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 3.5.1.54 allophanate hydrolase, thus bringing about the hydrolysis of urea to CO2 and NH3. Previously also listed as EC 3.5.1.45. The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates [4].
History
EC 6.3.4.6 created 1972, modified 1986 (EC 3.5.1.45 created 1978, incorporated 1986)
Pathway
ec00220  Arginine biosynthesis
ec00791  Atrazine degradation
ec01100  Metabolic pathways
Orthology
K01941  urea carboxylase
K14541  urea carboxylase / allophanate hydrolase
Genes
EPA: 110248952
CRE: CHLREDRAFT_133000(DUR1)
VCN: VOLCADRAFT_98356
MNG: MNEG_1218
CSL: COCSUDRAFT_19857
CVR: CHLNCDRAFT_133810
SCE: YBR208C(DUR1)
AGO: AGOS_ADR051C
ERC: Ecym_1184
KLA: KLLA0_E08119g
KMX: KLMA_40362(DUR1)
NCS: NCAS_0B02280(NCAS0B02280)
NDI: NDAI_0C05400(NDAI0C05400)
TPF: TPHA_0L01560(TPHA0L01560)
TDL: TDEL_0B03290(TDEL0B03290)
PIC: PICST_28452(DUR1)
CAL: CAALFM_C104660WA(DUR1)
CAUR: QG37_06077
SLB: AWJ20_5191(DUR1)
MAW: MAC_09102
MAJ: MAA_09279
CMT: CCM_01972
ANI: AN0887.2
ANG: ANI_1_1870014(An01g13810)
PTE: PTT_09186
ABP: AGABI1DRAFT77573(AGABI1DRAFT_77573)
ABV: AGABI2DRAFT212287(AGABI2DRAFT_212287)
ENC: ECL_02194
EEC: EcWSU1_02002(accC)
ESA: ESA_01768
CSK: ES15_1950
CTU: CTU_21860(DUR1)
KPE: KPK_2626(uca)
KVA: Kvar_2572
KOX: KOX_20285
KOE: A225_2924
LEI: C2U54_15650(uca)
EBC: C2U52_27950(uca)
PSTS: E05_21390
SPE: Spro_1419
SRL: SOD_c13050(accA1)
SPLY: Q5A_007115(accA1)
SMAF: D781_1328
SMAR: SM39_0852
SERF: L085_21505
SERA: Ser39006_001450(uca)
SERM: CLM71_06505(uca)
RAA: Q7S_00365
DDQ: DDI_4360
DFN: CVE23_00310(uca)
ETA: ETA_06880(uahA)
EBI: EbC_06390
EGE: EM595_0656(DUR1)
PAM: PANA_4072
PVA: Pvag_0052(uaha1) Pvag_pPag30288(uahA)
PAGG: AL522_02055(uca) AL522_07245(uca)
PSTW: DSJ_05895
XAC: XAC4326(uahA)
XCI: XCAW_04698(accC)
XPH: XppCFBP6546_12175(XppCFBP6546P_12175)
PSUW: WQ53_06110
PSD: DSC_01225
PMK: MDS_1390
PCQ: PcP3B5_39090(accA1_3)
PSB: Psyr_3977
PSYR: N018_05605
PFE: PSF113_1393(uahA)
PMAN: OU5_2033
PPUU: PputUW4_01257(uca)
PKC: PKB_4201(DUR1)
PANR: A7J50_1570
PSET: THL1_4354
PSIL: PMA3_22620
ACB: A1S_1277
ABY: ABAYE2428
ABB: ABBFA_002251(uca)
ABX: ABK1_1729
ABH: M3Q_1653
ABAD: ABD1_13050
ABAZ: P795_11020
ABAU: IX87_04040
ADV: DJ533_07135(uca)
SAZ: Sama_0022
SLO: Shew_0007
MAD: HP15_3149
SDE: Sde_1127
TTU: TERTU_3485(uca)
TCX: Tcr_1792
HHA: Hhal_2361
TGR: Tgr7_3089
HAM: HALO3020
HHH: CLM76_17320(uca)
HAF: C8233_04075(uca)
ABO: ABO_1892(uahA)
ADI: B5T_00740 B5T_01163(uahA)
KAK: Kalk_13750(uca)
TOL: TOL_2418
BSAN: CHH28_05045(uca)
TAU: Tola_2899
SALN: SALB1_0445
BMA: BMAA1883
BMAL: DM55_3901
BMAE: DM78_4820
BMAQ: DM76_4598
BMAI: DM57_06615
BMAF: DM51_3574
BMAZ: BM44_3860
BMAB: BM45_4636
BPS: BPSS0195
BPSE: BDL_6086
BPSM: BBQ_6017
BPSU: BBN_3577
BPSD: BBX_5256
BPK: BBK_5389
BPSH: DR55_5166
BPSA: BBU_5937
BPSO: X996_4935
BUT: X994_4483
BOK: DM82_4197
BOC: BG90_3825
BVE: AK36_4856 AK36_5070(uca)
BCN: Bcen_5558
BCEN: DM39_3027 DM39_3454(uca)
BCEW: DM40_5322(uca)
BMU: Bmul_0366
BMUL: NP80_3056
BCED: DM42_2132 DM42_6767(uca)
BDL: AK34_5498(uca)
BCON: NL30_04570
BLAT: WK25_17280
BTEI: WS51_26365
BSEM: WJ12_17615
BMEC: WJ16_26390
BSTG: WT74_18115
BGU: KS03_4629
BGO: BM43_148 BM43_6293(uca)
BXE: Bxe_B1384
BXB: DR64_6689(uca)
BPH: Bphy_3979
BFN: OI25_3647(uca)
PARB: CJU94_22275(uca)
PHS: C2L64_19380(uca)
PTER: C2L65_17255(uca)
PAPI: SG18_19935
BPT: Bpet0293
BHZ: ACR54_01301(accA1_1)
BTRM: SAMEA390648701057(kipI_2)
AXX: ERS451415_00215(kipI_1) ERS451415_05058(accA1_3)
ODI: ODI_R0883
PNA: Pnap_0036
HYR: BSY239_965(uca)
CBAA: SRAA_0219
THI: THI_3696
NEU: NE2420
NLC: EBAPG3_006860(uca)
MEH: M301_2218
MEP: MPQ_0992
SLT: Slit_0080
GCA: Galf_0781
DAR: Daro_0074
ACOM: CEW83_17200(uca)
WSU: WS1115(UAHA)
ARC: ABLL_1820
SMUL: SMUL_2950
SHAL: SHALO_2739
SULJ: SJPD1_2634
SCL: sce4915
PLA: Plav_1892
ARA: Arad_10038(uca)
AVI: Avi_2502(pccA)
RLG: Rleg_6105
BBT: BBta_2438
BRK: CWS35_00975(uca)
RPA: RPA1405
RPC: RPC_4531
RPD: RPD_2188
RPE: RPE_1219
RPT: Rpal_1588
XAU: Xaut_1222
AZC: AZC_4402
MEX: Mext_3722
MDI: METDI4686
MCH: Mchl_4017
MPO: Mpop_3900
META: Y590_18480
MSL: Msil_2606
BVR: BVIR_3168
CCR: CC_1829
CAK: Caul_4449
LVS: LOKVESSMR4R_03019(accA1)
NAR: Saro_0606
SPMI: K663_03320
SPHY: CHN51_14495(uca)
BLAS: BSY18_2816(uca)
EFV: CHH26_15245(uca)
PHZ: CHX26_13135(uca)
GOH: B932_3129
ACR: Acry_2727
ASZ: ASN_561(uahA)
ATO: CIW82_09545(uca)
MGY: MGMSRv2__0110(duR)
NCB: C0V82_20990(uca) C0V82_24160(uca)
BMD: BMD_0982(uca)
BMEG: BG04_3270(uca)
BAG: Bcoa_0867
PMW: B2K_38450
AAC: Aaci_0766
AAD: TC41_0744
CLT: CM240_3172(DUR1)
CTYK: CTK_C20920
RIX: RO1_30980
RIM: ROI_33660
SGY: Sgly_0807
SAY: TPY_2884
MMC: Mmcs_1840
MKM: Mkms_1887
MJL: Mjls_1821
MVQ: MYVA_0191
MABB: MASS_4103
MABO: NF82_20505
MCHE: BB28_21080
MSTE: MSTE_04270
ASD: AS9A_1077
CEF: CE0713
NFA: NFA_22190
NFR: ERS450000_00322(kipI_1) ERS450000_01878(kipI_3)
RER: RER_29550
REY: O5Y_13495
RHB: NY08_3512
RFA: A3L23_01647(kipA_1)
RHS: A3Q41_01707(kipA_2)
RHU: A3Q40_01989(accA1_3) A3Q40_02481(kipA_1)
GBR: Gbro_3888
TPR: Tpau_1594
SMA: SAVERM_6698(uahA)
SBH: SBI_01438(uahA)
SHY: SHJG_1246
SALS: SLNWT_1828
KSK: KSE_50750
CMI: CMM_0120(uahA)
CMS: CMS2364
CMC: CMN_02369
AGM: DCE93_06100(uca)
ART: Arth_3669
ARN: CGK93_01135(uca)
ARTH: C3B78_01315(uca)
AAU: AAur_0187(uca)
IDO: I598_2366(accA1_2)
CFL: Cfla_0710
KRA: Krad_0904
AMD: AMED_2635
AMN: RAM_13390
AMM: AMES_2607
AMZ: B737_2608
AOI: AORI_2622
PSEA: WY02_02180
PSEE: FRP1_11155
PSEH: XF36_10875
ALL: CRK57359
ASE: ACPL_6108(lamA)
ACTS: ACWT_5976
CAI: Caci_3728
GVI: gll0958
GLJ: GKIL_2274
CAA: Caka_2069
VBH: CMV30_15935(uca)
 » show all
Taxonomy
Reference
1
  Authors
Roon, R.J. and Levenberg, B.
  Title
ATP-Urea amidolyase (ADP) (Candida utilis).
  Journal
Methods Enzymol 17A:317-324 (1970)
Reference
2  [PMID:4556303]
  Authors
Roon RJ, Levenberg B.
  Title
Urea amidolyase. I. Properties of the enzyme from Candida utilis.
  Journal
J Biol Chem 247:4107-13 (1972)
Reference
3  [PMID:6124544]
  Authors
Sumrada RA, Cooper TG.
  Title
Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast.
  Journal
J Biol Chem 257:9119-27 (1982)
Reference
4  [PMID:15090492]
  Authors
Kanamori T, Kanou N, Atomi H, Imanaka T.
  Title
Enzymatic characterization of a prokaryotic urea carboxylase.
  Journal
J Bacteriol 186:2532-9 (2004)
DOI:10.1128/JB.186.9.2532-2539.2004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.6
IUBMB Enzyme Nomenclature: 6.3.4.6
ExPASy - ENZYME nomenclature database: 6.3.4.6
BRENDA, the Enzyme Database: 6.3.4.6
CAS: 9058-98-4

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