Entry
Name
urea carboxylase;
urease (ATP-hydrolysing);
urea carboxylase (hydrolysing);
ATP---urea amidolyase;
urea amidolyase;
UALase;
UCA
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
urea:carbon-dioxide ligase (ADP-forming)
Reaction(IUBMB)
ATP + urea + HCO3- = ADP + phosphate + urea-1-carboxylate [RN:
R00774 ]
Reaction(KEGG)
Substrate
Product
Comment
A biotinyl-protein. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC
3.5.1.54 allophanate hydrolase, thus bringing about the hydrolysis of urea to CO2 and NH3. Previously also listed as EC
3.5.1.45 . The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates [4].
History
EC 6.3.4.6 created 1972, modified 1986 (EC 3.5.1.45 created 1978, incorporated 1986)
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K14541 urea carboxylase / allophanate hydrolase
Genes
NCS : NCAS_0B02280(NCAS0B02280)
NDI : NDAI_0C05400(NDAI0C05400)
TPF : TPHA_0L01560(TPHA0L01560)
TDL : TDEL_0B03290(TDEL0B03290)
KNG : KNAG_0A03800(KNAG0A03800)
LBG : 92207816(LODBEIA_P26200)
CAL : CAALFM_C104660WA(DUR1)
CTEN : 18248852(PSN45_004114) 18250437(DUR1)
ASAU : 88173788(PUMCH_002724)
PKZ : C5L36_0A05680 C5L36_0B06440
BBRX : BRETT_003123(DUR1) BRETT_004561
OPA : HPODL_01823 HPODL_01974
YLI : 2912284(YALI2_F00479g) 2912433(YALI2_E00159g)
FVR : FVEG_04571 FVEG_11593
FOX : FOXG_07646 FOXG_12848
NHE : NECHADRAFT_44732 NECHADRAFT_79968
FFC : NCS54_00648600 NCS54_00902200
FKR : NCS57_00688700 NCS57_00909300
FMU : J7337_006612 J7337_009998
TATV : 25783783(TrAtP1_004585)
MAW : 19253413(J3458_014298)
MBRN : 26243842(G6M90_00g084500)
PCHM : VFPPC_03852 VFPPC_13829
PLJ : 28884076(PLICBS_005352) 28884138(PLICBS_005409)
PTKZ : JDV02_003952 JDV02_004007 JDV02_004980
CFJ : CFIO01_04268 CFIO01_12769
CLUP : CLUP02_01485 CLUP02_03173
CHIG : CH63R_02411 CH63R_10383
CDET : 87937148(CDEST_00645) 87943489(CDEST_06986)
PFY : PFICI_00100 PFICI_00808
PTRR : 6347695(PtrM4_126230)
BSC : COCSADRAFT_193941 COCSADRAFT_91374
ADAC : 96085487(ACET3X_005165)
NPA : UCRNP2_1608 UCRNP2_84
CDEC : 89992747(IAS62_005978)
CTEG : 91993120(I308_106265)
CBAS : 91985920(I312_105876)
KMG : 30166377(I203_102444)
KNE : 92182820(IAR55_005562)
KDJ : 28969311(I303_104942)
KBI : 30210715(I302_106426)
KPIN : 30170415(I206_104515)
KSH : 87956661(IL334_004530)
KER : 91101483(V865_002679)
CCAC : CcaHIS019_0600220(CcaverHIS019_0600220)
ABP : AGABI1DRAFT77573(AGABI1DRAFT_77573)
ABV : AGABI2DRAFT212287(AGABI2DRAFT_212287)
CCON : AFK62_09845 AFK62_19285
CMW : AFK63_08595 AFK63_19335
REE : electrica_02561(accA1)
RTG : NCTC13098_03737(accA1)
CLAP : NCTC11466_02328(accA1)
KOR : AWR26_11275(uca) AWR26_16855(uca)
KRD : A3780_07405 A3780_12820
KOU : C0557_07835(uca) C0557_13850(uca)
KIE : NCTC12125_02716(accA1)
KLU : K7B04_10495(uca) K7B04_17505(uca)
AHN : NCTC12129_00122(accC_1) NCTC12129_02476(accC_3) NCTC12129_02477(oadA)
ASUB : NLZ15_00550(uca) NLZ15_11445(uca)
PSGC : G163CM_08880(carB_1) G163CM_17320(carB_2)
PVJ : LMA04_02880(uca) LMA04_16690(uca)
MPHG : MPHASIOC01_001182(uca) MPHASIOC01_004267(uca)
FPUL : ACBV55_11445(uca) ACBV55_21880(uca)
SFJ : SAMEA4384070_1468(accA1)
SGRI : SGBXF1_01372(accA1)
RBAD : H2866_07525(uca) H2866_07745(uca)
NIG : C1N62_00345(uca) C1N62_20125(uca)
SERA : Ser39006_001450(uca)
PATR : EV46_09205 EV46_10250
PATO : GZ59_24220 GZ59_26840
PCC : PCC21_022420 PCC21_025000
PWA : Pecwa_2502 Pecwa_2680
PPAR : A8F97_05245 A8F97_06140
PWS : A7983_19840 A7983_20765
PPOA : BJK05_05825 BJK05_06835
PBRA : B5S52_09795 B5S52_10880
PPUJ : E2566_11345(uca) E2566_12425(uca)
PARI : I2D83_11590(uca) I2D83_12810(uca)
PAQU : DMB82_0009655(uca) DMB82_0010220(uca)
PVZ : OA04_18620 OA04_21110(ucaA)
PQU : IG609_010660(uca) IG609_011315(uca)
PPOO : LW347_11135(uca) LW347_12160(uca)
PCAC : OI450_08505(uca) OI450_09215(uca)
PACB : M9782_13250(uca) M9782_14535(uca)
PARL : PEC302110_21380(uca)
PPEU : DUT67_09100(uca) DUT67_10290(uca)
DZE : Dd1591_0045 Dd1591_2748
DSO : A4U42_09390 A4U42_20020
DIC : Dpoa569_0003869(uca)
EPE : CI789_08100(uca) CI789_15270(uca)
ERWI : GN242_10500(uca) GN242_17985(uca)
ERP : LJN55_11840(uca) LJN55_19820(uca)
PLF : PANA5342_3669(uca) PANA5342_p10223(uca)
PAQ : PAGR_g3552 PAGR_p152
PVA : Pvag_0052(uaha1) Pvag_pPag30288(uahA)
PAGG : AL522_02055(uca) AL522_07245(uca)
PAO : Pat9b_0101 Pat9b_0598
KLN : LH22_01780 LH22_19210
PAGC : BEE12_10005 BEE12_20320
PANS : FCN45_00510(uca) FCN45_03065(uca)
PEY : EE896_16315(uca) EE896_20920(uca)
PJI : KTJ90_16180(uca) KTJ90_20440(uca)
PANO : OJ965_01385(uca) OJ965_18050(uca)
PALF : K6R05_15910(uca) K6R05_20950(uca)
PPHO : CTZ24_00555(uca) CTZ24_03155(uca)
PDIP : KFZ74_03685(uca) KFZ74_19125(uca)
PANE : P6287_00530(uca) P6287_03220(uca)
PAMT : IAI47_16270(uca) IAI47_20190(uca)
PANZ : NR302_00535(uca) NR302_03345(uca)
TCI : A7K98_16530 A7K98_20435
XPH : XppCFBP6546_12175(uca)
PCQ : PcP3B5_39090(accA1_3)
PFV : Psefu_3274 Psefu_4073
PVD : CFBP1590__1311(DUR1)
PSES : PSCI_4417 PSCI_4770
PSEJ : HNQ25_17690(uca) HNQ25_20760(uca)
PSLP : BHQ29_15550 BHQ29_18640
PTY : JWV26_14420(uca) JWV26_17425
PHF : NLY38_03540(uca) NLY38_18360(uca)
PCHE : QYM18_11280(uca) QYM18_14495(uca)
PPHA : BVH74_07875 BVH74_08240
MARA : D0851_07780 D0851_07785 D0851_09810(uca)
MALL : PBN92_15105(uca) PBN92_17070(uca)
ABB : ABBFA_02220(accA1_3)
AJO : RZ95_03725 RZ95_08970
AHL : AHTJS_08070 AHTJS_08185
AJN : BVL33_09890 BVL33_10065
ACUM : C9E88_006635(uca) C9E88_012445(uca)
ALW : FOB21_01840(uca) FOB21_14715(uca)
AGYL : FPL18_16870(uca) FPL18_18395(uca)
AVZ : HWI77_08390(uca) HWI77_09450(uca)
ACOI : NQU59_13235(uca) NQU59_14420(uca)
ASUE : F2A31_07615(uca) F2A31_07715(uca)
ACOT : QLH32_00850(uca) QLH32_01540(uca)
CEB : B0D95_00670 B0D95_10495
CELL : CBR65_18200 CBR65_19900
CEK : D0B88_07885(uca) D0B88_08825(uca)
CEG : D0C16_11380(uca) D0C16_22005(uca)
MKE : OOT55_10280(uca) OOT55_17465(uca)
THIO : AYJ59_03330 AYJ59_04300
HNA : Hneap_0798 Hneap_1105
HAZ : A9404_00120 A9404_08250
HAA : A5892_15570 A5892_18615
ALCA : ASALC70_01824(accA1_1) ASALC70_03441(accA1_2)
ADI : B5T_00740 B5T_01163(uahA)
APAC : S7S_02705 S7S_12175
FCE : JN531_004965(uca) JN531_005950(uca)
PSPW : BJG93_15790(uca) BJG93_33415(uca)
PLG : NCTC10937_01303(accA1_1)
BHZ : ACR54_01301(accA1_1)
AXX : ERS451415_05058(accA1_3)
PVAC : HC248_02604(accA1_2)
SPLB : SFPGR_15760 SFPGR_15850
RBS : RHODOSMS8_03364(accA1)
ALEG : CFBP4996_01355(uca)
RTR : RTCIAT899_PC07770(uca)
RLW : RlegWSM1455_32800(uca)
LVS : LOKVESSMR4R_03019(accA1)
NCB : C0V82_20990(uca) C0V82_24160(uca)
MGRY : MSR1_01220(accA1_1)
TMV : OH491_16230(uca) OH491_18200
MTHN : 4412656_02193(accA1_1)
MHAS : MHAS_01265(accA1_3)
MSAL : DSM43276_03931(kipA_1)
CPRE : Csp1_19630(accA1_3)
NFR : ERS450000_01878(kipI_3)
NSL : BOX37_01445 BOX37_28780
NSR : NS506_01456 NS506_03809
NGP : LTT66_14380(uca) LTT66_17075
NSPU : IFM12276_04980 IFM12276_67410
RHA : RHA1_ro02135 RHA1_ro06922
ROA : Pd630_LPD03538 Pd630_LPD06315
RAV : AAT18_12655 AAT18_19825
RRZ : CS378_02380 CS378_09310(uca)
RHU : A3Q40_01989(accA1_3) A3Q40_02481(kipA_1)
RRT : 4535765_01457 4535765_03780(accA1_3)
RCR : NCTC10994_01344 NCTC10994_03486(accA1_2)
RTM : G4H71_14995(uca) G4H71_20755
RKO : JWS14_11170(uca) JWS14_37235
ROZ : CBI38_07465 CBI38_16755
RPSK : JWS13_06960 JWS13_34700(uca)
RHOU : KZJ41_13780 KZJ41_20935(uca)
RHOW : A4U64_04890 A4U64_12060
RHOJ : JVH1_01375 JVH1_26600(uca)
RHOS : QWW67_02400 QWW67_09600(uca)
RHOQ : QWW98_02405 QWW98_09605(uca)
RHOY : QNA09_10185 QNA09_17460(uca)
RHJS : OYT95_02245 OYT95_28000(uca)
RHZQ : GO592_03890(uca) GO592_15255
RHPD : U9J23_07200 U9J23_18500(uca)
PSOW : ABI214_03195 ABI214_18760(uca)
SCI : B446_01065 B446_34230
SGE : DWG14_06847(accA1_3)
AAGI : NCTC2676_1_01188(accC_2)
PSNI : NIBR502771_03900(uca)
CELH : GXP71_14845(uca) GXP71_19665(uca)
» show all
Taxonomy
Reference
1
Authors
Roon RJ, Levenberg B.
Title
ATP-Urea amidolyase (ADP) (Candida utilis).
Journal
Methods Enzymol 17A:317-324 (1970)
Reference
Authors
Roon RJ, Levenberg B.
Title
Urea amidolyase. I. Properties of the enzyme from Candida utilis.
Journal
J Biol Chem 247:4107-13 (1972)
Reference
Authors
Sumrada RA, Cooper TG.
Title
Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast.
Journal
J Biol Chem 257:9119-27 (1982)
Reference
Authors
Kanamori T, Kanou N, Atomi H, Imanaka T
Title
Enzymatic characterization of a prokaryotic urea carboxylase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.6
ExPASy - ENZYME nomenclature database: 6.3.4.6
BRENDA, the Enzyme Database: 6.3.4.6