Entry
Name
Ni-sirohydrochlorin a,c-diamide synthase;
cfbB (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Carbon-nitrogen ligases with glutamine as amido-N-donor
BRITE hierarchy
Sysname
Ni-sirohydrochlorin:L-glutamine amido-ligase (ADP-forming)
Reaction(IUBMB)
2 ATP + Ni-sirohydrochlorin + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + Ni-sirohydrochlorin a,c-diamide + 2 L-glutamate [RN:
R11627 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC
2.8.4.1 , coenzyme-B sulfoethylthiotransferase.
History
EC 6.3.5.12 created 2017
Pathway
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology
K22012 Ni-sirohydrochlorin a,c-diamide synthase
Genes
MBU : Mbur_1039(cbiA_cobB)
MEHF : MmiHf6_07000(cbiA_2)
MEES : MmiEs2_02350(cbiA_1)
» show all
Taxonomy
Reference
Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.5.12
ExPASy - ENZYME nomenclature database: 6.3.5.12