KEGG   ENZYME: 6.4.1.5Help
Entry
EC 6.4.1.5                  Enzyme                                 

Name
geranoyl-CoA carboxylase;
geranoyl coenzyme A carboxylase;
geranyl-CoA carboxylase
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranoyl-CoA:carbon-dioxide ligase (ADP-forming)
Reaction(IUBMB)
ATP + geranoyl-CoA + HCO3- = ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA [RN:R03494]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
geranoyl-CoA [CPD:C01920];
HCO3- [CPD:C00288]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA [CPD:C01291]
Comment
A biotinyl-protein. Also carboxylates dimethylpropenoyl-CoA and farnesoyl-CoA.
History
EC 6.4.1.5 created 1972
Pathway
ec00281  Geraniol degradation
Orthology
K13777  geranyl-CoA carboxylase alpha subunit
K13778  geranyl-CoA carboxylase beta subunit
Genes
DJI: CH75_09960 CH75_09970
PAE: PA2888(atuC) PA2891(atuF)
PAEV: N297_2991 N297_2994
PAEI: N296_2991 N296_2994
PAU: PA14_26670 PA14_26720(mccB)
PAP: PSPA7_2263 PSPA7_2266
PAG: PLES_21731(atuF) PLES_21761(atuC)
PAF: PAM18_2072(atuF) PAM18_2075(atuC)
PNC: NCGM2_3999(mccB) NCGM2_4002
PAEB: NCGM1900_3420 NCGM1900_3423(mccB)
PAEU: BN889_03226(atuC) BN889_03229(atuF)
PCQ: PcP3B5_19970(accA1_1) PcP3B5_20000
PFL: PFL_4196(atuC) PFL_4199(atuF)
PPRC: PFLCHA0_c42590(yngE2) PFLCHA0_c42620(accA3)
PPRO: PPC_4293(atuC) PPC_4296(atuF)
PFC: PflA506_3698(atuC) PflA506_3701(atuF)
PKC: PKB_3703(l(2)04524) PKB_3706(MCCC1)
PSOS: POS17_4284(atuC) POS17_4287(atuF)
SAGA: M5M_01905
MICC: AUP74_02722 AUP74_02725(accA1_2)
CYQ: Q91_1219 Q91_1221(accB1)
ABO: ABO_0986(accA) ABO_0989(accD)
REH: H16_A2144(pccB)
CNC: CNE_1c27010(accA4) CNE_1c27040(pccB)
RME: Rmet_1721(pccB) Rmet_1724(accC)
MXA: MXAN_0081(accB) MXAN_0082(accC)
CCX: COCOR_03097(accB) COCOR_03098(accC1)
BJA: blr0986(mccB) blr0987(mccA)
BRS: S23_68190(mccA) S23_68200(mccB)
 » show all
Taxonomy
Reference
1  [PMID:14087299]
  Authors
SEUBERT W, FASS E, REMBERGER U.
  Title
[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOID COMPOUNDS. III. PURIFICATION AND PROPERTIES OF GERANYL CARBOXYLASE.]
  Journal
Biochem Z 338:265-75 (1963)
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.5
IUBMB Enzyme Nomenclature: 6.4.1.5
ExPASy - ENZYME nomenclature database: 6.4.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 6.4.1.5
BRENDA, the Enzyme Database: 6.4.1.5
CAS: 37324-35-9

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