KEGG   ENZYME: 6.4.1.6
Entry
EC 6.4.1.6                  Enzyme                                 

Name
acetone carboxylase
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
Sysname
acetone:carbon-dioxide ligase (AMP-forming)
Reaction(IUBMB)
acetone + CO2 + ATP + 2 H2O = acetoacetate + AMP + 2 phosphate [RN:R05735]
Reaction(KEGG)
R05735
Substrate
acetone [CPD:C00207];
CO2 [CPD:C00011];
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
acetoacetate [CPD:C00164];
AMP [CPD:C00020];
phosphate [CPD:C00009]
Comment
Requires Mg2+ and ATP. The enzyme from Xanthobacter sp. strain Py2 also carboxylates butan-2-one to 3-oxopentanoate.
History
EC 6.4.1.6 created 2001
Orthology
K10854  acetone carboxylase, alpha subunit
K10855  acetone carboxylase, beta subunit
K10856  acetone carboxylase, gamma subunit
Genes
GHO: AL542_03630 AL542_03635 AL542_03640
AVN: Avin_20910(acxA) Avin_20920(acxB) Avin_20930(acxC)
AVL: AvCA_20910(acxA) AvCA_20920(acxB) AvCA_20930(acxC)
AVD: AvCA6_20910(acxA) AvCA6_20920(acxB) AvCA6_20930(acxC)
ACX: Achr_24430(acxC) Achr_24440(acxB) Achr_24450(acxA)
PAR: Psyc_1448 Psyc_1450(acxC)
PPIS: B1L02_05720 B1L02_05725 B1L02_05730
GAG: Glaag_3576
KIM: G3T16_12200
AEH: Mlg_1029 Mlg_1030 Mlg_1031
CNC: CNE_2c13060(acxA) CNE_2c13070(acxB) CNE_2c13080(acxC) CNE_BB1p08470(acxC)
RME: Rmet_4105(acxA) Rmet_4106(acxB) Rmet_4107(acxC)
BOK: DM82_4513(acxC) DM82_4514(acxB) DM82_4515(acxA)
BMK: DM80_3943
BCT: GEM_3539
AMIM: MIM_c06390(acxA) MIM_c06400(acxB) MIM_c06410(acxC)
EBA: ebA4700(acxA) ebA4701(acxB) ebA4702(acxC)
AZA: AZKH_0561(acxA) AZKH_0562(acxB) AZKH_0563(acxC) AZKH_3165(apc) AZKH_3167(apc)
HPY: HP0697
HPJ: jhp_0631
HPL: HPB8_896(hyuA3) HPB8_897(acxB) HPB8_898(acxC)
HAC: Hac_0949 Hac_0950(hyuB)
PLA: Plav_1150
SME: SM_b20408
HMC: HYPMC_0473(acxC) HYPMC_0474(acxB) HYPMC_0475(acxA)
MMED: Mame_04504(acxA) Mame_04505(acxB) Mame_04506(acxC)
RCP: RCAP_rcc01336(acxA) RCAP_rcc01337(acxB) RCAP_rcc01338(acxC)
SMIC: SmB9_09020
BMET: BMMGA3_02520(acxA) BMMGA3_02525(acxB) BMMGA3_02530(acxC)
BFD: NCTC4823_02247(acxC) NCTC4823_02248(acxB_4) NCTC4823_02249(acxA_4)
MVA: Mvan_4899
PDX: Psed_5912
PAUT: Pdca_35830
RXY: Rxyl_1849
 » show all
Reference
1  [PMID:9237998]
  Authors
Sluis MK, Ensign SA.
  Title
Purification and characterization of acetone carboxylase from Xanthobacter strain Py2.
  Journal
Proc Natl Acad Sci U S A 94:8456-61 (1997)
DOI:10.1073/pnas.94.16.8456
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.6
IUBMB Enzyme Nomenclature: 6.4.1.6
ExPASy - ENZYME nomenclature database: 6.4.1.6
BRENDA, the Enzyme Database: 6.4.1.6
CAS: 189258-15-9

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