KEGG   ENZYME: 6.4.1.9Help
Entry
EC 6.4.1.9                  Enzyme                                 

Name
coenzyme F430 synthetase;
cfbE (gene name)
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
15,173-seco-F430-173-acid cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + 15,173-seco-F430-173-acid = ADP + phosphate + coenzyme F430 [RN:R11629]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
coenzyme F430 [CPD:C05777]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.4.1.9 created 2017
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21612  coenzyme F430 synthetase
Genes
MJA: MJ_0258
MFE: Mefer_0369
MVU: Metvu_0835
MFS: MFS40622_0485
MIF: Metin_0369
MJH: JH146_0166
MIG: Metig_0368
MMP: MMP0173
MMQ: MmarC5_1502
MMX: MmarC6_0778
MMD: GYY_00885
MAE: Maeo_1414
MVO: Mvol_1454
MTH: MTH_873
MMG: MTBMA_c12680(murF)
METC: MTCT_0791
METE: tca_00838(murF)
MST: Msp_1331
MSI: Msm_0880
MRU: mru_1745
MEB: Abm4_0460
MMIL: sm9_1831
MEYE: TL18_08530
MOL: YLM1_1199
METH: MBMB1_0355
MFC: BRM9_1909
MCUB: MCBB_0331
MFV: Mfer_1205
MKA: MK1590(murF)
MARC: AR505_0361
MAC: MA_3630(murD)
MBAR: MSBR2_1805
MBAK: MSBR3_2860
MMA: MM_0516
MMAC: MSMAC_0769
METM: MSMTP_0888
MTHE: MSTHC_0833
MTHR: MSTHT_2449
MHOR: MSHOH_0893
MFZ: AOB57_003180(cfbE)
MBU: Mbur_1036
MMET: MCMEM_1518
MMH: Mmah_1411
MPY: Mpsy_0961
MTP: Mthe_0105
MCJ: MCON_1929
MHI: Mhar_2390
MHU: Mhun_0669
MLA: Mlab_0519
MPI: Mpet_1001
MBN: Mboo_1418
MPL: Mpal_0680
MPD: MCP_0362
MEZ: Mtc_0062(murD)
RCI: RCIX2005(murD)
 » show all
Taxonomy
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO.
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3630]
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.9
IUBMB Enzyme Nomenclature: 6.4.1.9
ExPASy - ENZYME nomenclature database: 6.4.1.9
BRENDA, the Enzyme Database: 6.4.1.9

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