KEGG   ENZYME: 6.4.1.9Help
Entry
EC 6.4.1.9                  Enzyme                                 

Name
coenzyme F430 synthetase;
cfbE (gene name)
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
15,173-seco-F430-173-acid cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + 15,173-seco-F430-173-acid = ADP + phosphate + coenzyme F430 [RN:R11629]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
coenzyme F430 [CPD:C05777]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.4.1.9 created 2017
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21612  coenzyme F430 synthetase
Genes
MJA: MJ_0258
MFE: Mefer_0369
MVU: Metvu_0835
MFS: MFS40622_0485
MIF: Metin_0369
MJH: JH146_0166
MIG: Metig_0368
MMP: MMP0173
MMQ: MmarC5_1502
MMX: MmarC6_0778
MMD: GYY_00885
MAE: Maeo_1414
MVO: Mvol_1454
MAC: MA_3630(murD)
MBAR: MSBR2_1805
MBAK: MSBR3_2860
MMA: MM_0516
MMAC: MSMAC_0769
METM: MSMTP_0888
MTHE: MSTHC_0833
MTHR: MSTHT_2449
MHOR: MSHOH_0893
MBU: Mbur_1036
MMET: MCMEM_1518
MMH: Mmah_1411
MPY: Mpsy_0961
MTP: Mthe_0105
MCJ: MCON_1929
MHI: Mhar_2390
MHU: Mhun_0669
MLA: Mlab_0519
MPI: Mpet_1001
MBN: Mboo_1418
MPL: Mpal_0680
MPD: MCP_0362
MEZ: Mtc_0062(murD)
RCI: RCIX2005(murD)
MTH: MTH_873
MMG: MTBMA_c12680(murF)
METC: MTCT_0791
METE: tca_00838(murF)
MST: Msp_1331
MSI: Msm_0880
MRU: mru_1745
MEB: Abm4_0460
MMIL: sm9_1831
MEYE: TL18_08530
MOL: YLM1_1199
METH: MBMB1_0355
MFC: BRM9_1909
MCUB: MCBB_0331
MFV: Mfer_1205
MKA: MK1590(murF)
MARC: AR505_0361
 » show all
Taxonomy
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO.
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3630]
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.9
IUBMB Enzyme Nomenclature: 6.4.1.9
ExPASy - ENZYME nomenclature database: 6.4.1.9
BRENDA, the Enzyme Database: 6.4.1.9

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