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Entry
EC 6.6.1.2                  Enzyme                                 

Name
cobaltochelatase;
hydrogenobyrinic acid a,c-diamide cobaltochelatase;
CobNST;
CobNCobST
Class
Ligases;
Forming nitrogen-D-metal bonds;
Forming coordination complexes
BRITE hierarchy
Sysname
hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)
Reaction(IUBMB)
ATP + hydrogenobyrinic acid a,c-diamide + Co2+ + H2O = ADP + phosphate + cob(II)yrinic acid a,c-diamide + H+ [RN:R05227]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
hydrogenobyrinic acid a,c-diamide [CPD:C06503];
Co2+ [CPD:C00175];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
cob(II)yrinic acid a,c-diamide [CPD:C06504];
H+ [CPD:C00080]
Comment
This enzyme, which forms part of the aerobic cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP-dependent. It comprises two components, one of which corresponds to CobN and the other is composed of two polypeptides, specified by cobS and cobT in Pseudomonas denitrificans, and named CobST [1]. Hydrogenobyrinic acid is a very poor substrate. ATP can be replaced by dATP or CTP but the reaction proceeds more slowly. CobN exhibits a high affinity for hydrogenobyrinic acid a,c-diamide. The oligomeric protein CobST possesses at least one sulfhydryl group that is essential for ATP-binding. Once the Co2+ is inserted, the next step in the pathway ensures that the cobalt is ligated securely by reducing Co(II) to Co(I). This step is carried out by EC 1.16.8.1, cob(II)yrinic acid a,c-diamide reductase.
History
EC 6.6.1.2 created 2004
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
Orthology
K02230  cobaltochelatase CobN
K09882  cobaltochelatase CobS
K09883  cobaltochelatase CobT
Genes
EOI: ECO111_p1-046
ESM: O3M_25964
EUN: pUMNK88_95
ECV: APECO1_O1R35
STY: HCM1.111 HCM2.0016c
SEX: STBHUCCB_p250
SETC: CFSAN001921_24260
SEE: SNSL254_p_0106
SEEC: CFSAN002050_00045
ECLE: ECNIH2_24160 ECNIH2_25365
ECLX: LI66_23790
ECLZ: LI64_22620
KPX: PMK1_b00074(cobS) PMK1_ndm00195(nirQ)
EAR: CCG28694
CAMA: F384_26480
YPE: YPMT1.88(cobS)
YPK: cobS.pl(cobS)
YPH: YPC_4832
YPM: YP_pMT076
YPZ: YPZ3_pMT0053(cobS)
YPD: YPD4_pMT0053(cobS)
YPX: YPD8_pMT0055(cobS)
YPW: CH59_4384
YPJ: CH55_4276
YPV: BZ15_4262
YPL: CH46_4234
PMR: PMI2445
PSX: DR96_1741
PRG: RB151_016890(cobS_1) RB151_018010(cobS_2)
ETE: ETEE_p1093(cobS)
PAE: PA1923 PA2944(cobN)
PAEV: N297_1985 N297_3048(cobN)
PAEI: N296_1985 N296_3048(cobN)
PAF: PAM18_2018(cobN) PAM18_3116(cobN)
PNC: NCGM2_2843(cobN) NCGM2_4056(cobN)
PAEB: NCGM1900_3365(cobN) NCGM1900_4562(cobN)
PDK: PADK2_09640(cobN) PADK2_16020(cobN)
PSG: G655_10075(cobN) G655_15490(cobN)
PAEU: BN889_03289(cobN_1) BN889_03290(cobN_2)
PAEC: M802_1983 M802_3045(cobN)
PAEO: M801_1984 M801_2913(cobN)
PMY: Pmen_4586
PPSE: BN5_4397(cobN)
PCQ: PcP3B5_08310(cobN)
PPU: PP_3507(cobN)
PPF: Pput_2269
PPT: PPS_2576
PPB: PPUBIRD1_2289(cobN) PPUBIRD1_2290(cobN_2)
PPI: YSA_00004
PPX: T1E_1713(cobN)
PPUH: B479_12455(cobN)
PPUN: PP4_23330(cobN)
PPUD: DW66_2835
PMON: X969_11940
PMOT: X970_11595
PSB: Psyr_3015(cobN)
PSYR: N018_11475
PSP: PSPPH_2225(cobN)
PFL: PFL_3654(cobN)
PPRC: PFLCHA0_c36950(cobN)
PPRO: PPC_3795(cobN)
PFS: PFLU_2670
PFE: PSF113_3253(cobN)
PFC: PflA506_2482(cobN)
PFW: PF1751_v1c23350(cobN)
PPZ: H045_07020(cobN)
PFB: VO64_5762
PEN: PSEEN2433
PSA: PST_1796(cobN)
PSZ: PSTAB_1693(cobN)
PSR: PSTAA_1814(cobN)
PPUU: PputUW4_02362(cobN)
PDR: H681_03060(cobN)
PKC: PKB_0666(cobN)
PSES: PSCI_4338(cobN)
PSEM: TO66_19245
PSEC: CCOS191_2297(cobN)
PSOS: POS17_3808(cobN)
PANR: A7J50_2435
PSET: THL1_750
PSIL: PMA3_12265
ACX: Achr_22450(cobN) Achr_f1250(cobS) Achr_f670(cobN)
ABAZ: P795_18230
SVO: SVI_2667
SPSW: Sps_01550
PSEN: PNC201_22535(cobN)
MAQ: Maqu_4067
MAD: HP15_132
MBS: MRBBS_0218(bchH)
AMAL: I607_13860
AMAE: I876_14360
AMAO: I634_14275
AMAG: I533_05685
MVS: MVIS_3626(cobN)
TTU: TERTU_3326(cobN)
MEJ: Q7A_852
MEC: Q7C_514
TVR: TVD_04680
GAI: IMCC3135_08080(cobS_1) IMCC3135_08085(cobT_1) IMCC3135_08655(cobN) IMCC3135_32695(cobT_3)
HCH: HCH_06504(cobN)
HEL: HELO_1832(cobN)
HAM: HALO2052
HCO: LOKO_01329(cobS_1)
HBE: BEI_2589(cobS) BEI_2590(cobT)
EME: CEM_293(cobN)
ADI: B5T_02529(cobN)
AXE: P40_12140
OAI: OLEAN_C15180(cobN)
SVA: SVA_3063
CVI: CV_1571(cobN)
PSE: NH8B_1628(cobS) NH8B_1629(cobT) NH8B_1840(cobN)
RSO: RSp0626(cobN)
RSN: RSPO_m00974(cobN)
RSE: F504_4599
REH: H16_B1887(cobT2) H16_B1888(cobS2)
CNC: CNE_2c18430(cobT) CNE_2c18440(cobS)
CTI: RALTA_B1586(cobT2) RALTA_B1587(cobS2)
CGD: CR3_4157(cobT) CR3_4158(cobS)
BMA: BMA1170
BMAL: DM55_2988(cobN)
BMAE: DM78_1454(cobN)
BMAQ: DM76_2970(cobN)
BMAI: DM57_53
BMAF: DM51_899(cobN)
BMAZ: BM44_2191(cobN)
BMAB: BM45_1755(cobN)
BPS: BPSL1768(cobN)
BPM: BURPS1710b_2099(cobN)
BPL: BURPS1106A_1954(cobN)
BPD: BURPS668_1938(cobN)
BPR: GBP346_A1978(cobN)
BPSE: BDL_292(cobN)
BPSM: BBQ_1629(cobN)
BPSU: BBN_1754(cobN)
BPSD: BBX_2229(cobN)
BPZ: BP1026B_I1725(cobN)
BPK: BBK_3254 BBK_3255(cobN)
BPSH: DR55_2866(cobN)
BPSA: BBU_465(cobN)
BPSO: X996_2483(cobN)
BUT: X994_938(cobN)
BTE: BTH_I2407(cobN)
BTJ: BTJ_843(cobN)
BTZ: BTL_2086(cobN)
BTD: BTI_2050(cobN)
BTV: BTHA_2285(cobN)
BTHE: BTN_2682(cobN)
BTHM: BTRA_2365(cobN)
BTHA: DR62_2829
BTHL: BG87_2307(cobN)
BOK: DM82_1282(cobN)
BOC: BG90_3410(cobN)
BVE: AK36_2245(cobN)
BCN: Bcen_1177
BCEW: DM40_2289(cobN)
BCEO: I35_1623(cobN) I35_5025(cobS) I35_5026
BAM: Bamb_1557
BMJ: BMULJ_01661(cobN)
BMK: DM80_3339(cobN) DM80_3688 DM80_3689(cobS)
BCT: GEM_1757
BCED: DM42_39(cobN) DM42_3912 DM42_3913(cobS)
BDL: AK34_1445(cobN)
BUB: BW23_69(cobN)
BLAT: WK25_08150
BTEI: WS51_18825
BMEC: WJ16_08300
BSTG: WT74_08550
BUK: MYA_1482
BUL: BW21_2115(cobN)
PPUL: RO07_12125
PUT: PT7_1884
AMIM: MIM_c36590(cobT) MIM_c36600(cobS)
ODI: ODI_R3622
POL: Bpro_5501
VPD: VAPA_1c39390(cobS2) VAPA_1c39400(cobT2)
HSE: Hsero_2657(cobN)
HRB: Hrubri_2746(cobN)
RGE: RGE_06060(cobN) RGE_44520(cobN)
PBH: AAW51_4833(cobN)
NEU: NE0757
MFA: Mfla_0118
MMB: Mmol_0276
MEP: MPQ_0161(cobN)
EBA: p1B92
AZO: azo2630
AOA: dqs_2786
GSU: GSU2158
GUR: Gura_0774
DEU: DBW_0325
DVU: DVU2037
DVL: Dvul_2608
DDE: Dde_2922
LIP: LI0185
LIR: LAW_00188
SFU: Sfum_0496
AMIH: CO731_01703(cobS_1) CO731_01704(cobT) CO731_02905(cobN)
SME: SMc00700(cobS) SMc00701(cobT) SMc04303(cobN)
SMI: BN406_01687(cobN) BN406_02529(cobT3) BN406_02530(cobS3)
RHI: NGR_c18190(cobN) NGR_c27170(cobT) NGR_c27180(cobS)
SFH: SFHH103_01748(cobN) SFHH103_02641(cobt3) SFHH103_02642(cobs3) SFHH103_06813(cobT)
SIX: BSY16_3514(cobT) BSY16_3515(cobS) BSY16_787(cobN)
EAD: OV14_0133(cobT) OV14_0134(cobS) OV14_3189(cobN)
ATU: Atu2804(cobN) Atu3621(cobT) Atu3622(cobS)
ARA: Arad_2797(cobN) Arad_4228(cobT) Arad_4229(cobS)
ATF: Ach5_26880(cobN) Ach5_34700(cobT) Ach5_34710(cobS)
AVI: Avi_2647(cobN) Avi_4045(cobT) Avi_4046(cobS)
AGC: BSY240_3187(cobS) BSY240_3188(cobT) BSY240_814(cobN)
RET: RHE_CH02489(cobN) RHE_CH03820(cobT) RHE_CH03821(cobS)
REL: REMIM1_CH02513(cobN) REMIM1_CH03906(cobT-1) REMIM1_CH03907(cobS-1)
REP: IE4803_CH02539(cobN) IE4803_CH04195(cobT-1) IE4803_CH04196(cobS-1)
REI: IE4771_CH02626(cobN) IE4771_CH04136(cobT-1) IE4771_CH04137(cobS-1)
RLE: RL2830(cobN) RL4348(cobT) RL4349(cobS)
RIR: BN877_I2892(cobN) BN877_II0627(cobT) BN877_II0628(cobS)
RHL: LPU83_2120(cobN) LPU83_3847(cobT3) LPU83_3848(cobS3)
RGA: RGR602_CH02277(cobN) RGR602_CH03740(cobT-1) RGR602_CH03741(cobS-1)
RHN: AMJ98_CH02550(cobN) AMJ98_CH04044(cobT-1) AMJ98_CH04045(cobS-1)
RPHA: AMC79_CH02619(cobN) AMC79_CH04025(cobT-1) AMC79_CH04026(cobS-1)
RHT: NT26_3122(cobN) NT26_3442(cobT) NT26_3443(cobS)
RHX: AMK02_CH02564(cobN) AMK02_CH03942(cobT-1) AMK02_CH03943(cobS-1)
BMEL: DK63_1384(cobT) DK63_1385(cobS) DK63_733(cobN)
BMEE: DK62_121(cobN) DK62_1562(cobS) DK62_1563(cobT)
BABO: DK55_1302(cobN) DK55_1955(cobT) DK55_1956(cobS)
BABR: DO74_2019(cobS) DO74_2020(cobT) DO74_589(cobN)
BABT: DK49_1058(cobN) DK49_1712(cobT) DK49_1713(cobS)
BABB: DK48_163(cobS) DK48_164(cobT) DK48_818(cobN)
BABU: DK53_1285(cobN) DK53_1940(cobT) DK53_1941(cobS)
BABS: DK51_1601(cobS) DK51_1602(cobT) DK51_175(cobN)
BABC: DO78_1206(cobN) DO78_1859(cobT) DO78_1860(cobS)
BMS: BR1306(cobN) BR2021 BR2022
BMT: BSUIS_A1356(cobN) BSUIS_A1862(cobT) BSUIS_A1863(cobS)
BSZ: DK67_343(cobS) DK67_344(cobT) DK67_992(cobN)
BOV: BOV_1269(cobN) BOV_1945(cobT-1) BOV_1946(cobS-1)
BCS: BCAN_A1329(cobN) BCAN_A2067(cobT) BCAN_A2068(cobS)
BCAR: DK60_1345(cobN) DK60_1997(cobT) DK60_1998(cobS)
BMR: BMI_I1319(cobN) BMI_I2043(cobT) BMI_I2044
BPP: BPI_I1358(cobN) BPI_I2080(cobT-2) BPI_I2081
BPV: DK65_1512(cobS) DK65_1513(cobT) DK65_74(cobN)
OAH: DR92_1365(cobN) DR92_455(cobS) DR92_456(cobT)
BJA: bll0178(cobT) bll0180(cobS) blr3263(cobN)
BRA: BRADO0617(cobS) BRADO0618(cobT) BRADO4907
BBT: BBta_3144 BBta_7564(cobT) BBta_7565(cobS)
BRS: S23_06280(cobS) S23_06290(cobT) S23_47410(cobN)
BRO: BRAD285_0087(cobS) BRAD285_0088(cobT) BRAD285_2329(CobN)
RPA: RPA0496(cobT2) RPA0498(cobS2) RPA0716(cobN) RPA2399
OCA: OCAR_4069(cobT) OCAR_4070(cobS)
OCG: OCA5_c04370(cobS) OCA5_c04380(cobT1) OCA5_c23580(cobT2)
OCO: OCA4_c04360(cobS) OCA4_c04370(cobT1) OCA4_c23570(cobT2)
BOS: BSY19_4576(cobT) BSY19_4578(cobS) BSY19_877(cobN)
VGO: GJW-30_1_02365(cobS)
BHE: BH15880(cobS) BH15890(cobT2)
BHN: PRJBM_01574(cobS) PRJBM_01575(cobT2)
BHS: BM1374165_01645(cobS) BM1374165_01646(cobT2)
BQU: BQ12800(cobS) BQ12810(cobT)
BTR: BT_2554(cobS) BT_2555(cobT2)
BTX: BM1374166_02210(cobS) BM1374166_02211(cobT2)
BGR: Bgr_19470(cobS) Bgr_19480(cobT2)
BCD: BARCL_1309(cobS) BARCL_1310(cobT)
BAUS: BAnh1_12240(cobS) BAnh1_12250(cobT2)
BVN: BVwin_14400(cobS) BVwin_14410(cobT2)
AZC: AZC_3679(cobS) AZC_3680(cobT) AZC_3935(cobN)
MEA: Mex_1p1328 Mex_1p3440(cobT) Mex_1p3441(cobS)
MDI: METDI2100 METDI4017(cobT) METDI4018(cobS)
MOR: MOC_3495(cobN) MOC_4223 MOC_4225(cobT)
HMC: HYPMC_0687 HYPMC_4412(cobT) HYPMC_4413(cobS)
MMED: Mame_02231(cobT) Mame_02232(cobS_1)
HCI: HCDSEM_003(cobN) HCDSEM_045(cobT) HCDSEM_046
HCT: HCTETULN_003(cobN) HCTETULN_046(cobT) HCTETULN_047(pcobS)
HCC: HCTETUND1_110(cobN) HCTETUND1_159(cobT) HCTETUND1_160(cobS2)
THD: BHV28_15770(cobT) BHV28_15780(cobS)
HDI: HDIA_3057(cobN) HDIA_4332(cobT) HDIA_4333(cobS)
BVC: CEP68_00635(cobS) CEP68_06420(cobT)
RSP: RSP_1976(cobT) RSP_1977(cobS) RSP_2827(cobN)
RCP: RCAP_rcc00835(cobT) RCAP_rcc00836(cobS) RCAP_rcc02047(cobN)
RDE: RD1_3339(cobS) RD1_3340(cobT) RD1_3827(cobN)
PARU: CYR75_09195(cobT) CYR75_09200(cobS)
PAMN: JCM7685_0438(cobN) JCM7685_0917(cobT1) JCM7685_0918(cobS)
DSH: Dshi_0158(cobN) Dshi_2711(cobS2) Dshi_2719(cobT1)
KVU: EIO_1744 EIO_1747(cobT)
KVL: KVU_1211(cobS) KVU_1214(cobT)
KRO: BVG79_01456(cobS) BVG79_01459(cobT)
PSF: PSE_0073(cobS) PSE_0074(cobT) PSE_3495(cobN)
PGA: PGA1_c08170(cobN) PGA1_c09770(cobT2) PGA1_c09780(cobS)
PGL: PGA2_c07950(cobN) PGA2_c09650(cobT2) PGA2_c09660(cobS)
PPIC: PhaeoP14_00739(cobN) PhaeoP14_00897(cobT2) PhaeoP14_00898(cobS)
OTM: OSB_01750(cobN) OSB_11210(cobT) OSB_11250(cobS_2)
PTP: RCA23_c05050(cobN) RCA23_c10570(cobT2) RCA23_c10580(cobS2)
THAS: C6Y53_02670(cobS) C6Y53_02675(cobT)
HNE: HNE_3493(cobT) HNE_3494(cobS)
ZMC: A265_01610(cobS) A265_01611(cobT)
ZMR: A254_01610(cobS) A254_01611(cobT)
SPHK: SKP52_04895(cobT1) SKP52_04905(cobS1) SKP52_07655
SGI: SGRAN_1341(cobT2) SGRAN_1344(cobS)
SPHO: C3E99_03545(cobT) C3E99_03560(cobS)
SPHC: CVN68_11360(cobS) CVN68_11455(cobT)
SJP: SJA_C1-01070(cobT) SJA_C1-01100(cobS) SJA_C2-03070(cobN)
SPHB: EP837_01375(cobS) EP837_01378(cobT) EP837_03438(cobN)
SPHR: BSY17_1344(cobS) BSY17_1348(cobT)
SHYD: CJD35_04345(cobS) CJD35_04360(cobT)
SPHY: CHN51_11630(cobT) CHN51_11655(cobS)
BLAS: BSY18_1450(cobT) BSY18_1452(cobS)
RDI: CMV14_22060(cobS) CMV14_22070(cobT)
EFV: CHH26_05625(cobT) CHH26_11375(cobS)
AAY: WYH_00943(cobT) WYH_01014(cobS) WYH_01837(cobN)
ANH: A6F65_01156(cobS) A6F65_02049(cobT)
ADO: A6F68_01458(cobS) A6F68_01803(cobT)
PHZ: CHX26_07785(cobS)
GOY: GLS_c00530(cobS) GLS_c00540(cobT)
AMV: ACMV_17550(cobT) ACMV_17560(cobS) ACMV_P1_00630(cobN)
GDI: GDI1892(cobT) GDI1893(cobS)
KEU: S101446_00938(cobT) S101446_00939(cobS) S101446_02478(cobN)
APT: APA01_11100(cobT) APA01_11110(cobS) APA01_22520(cobN)
APW: APA42C_11100(cobT) APA42C_11110(cobS) APA42C_22520(cobN)
APF: APA03_11100(cobT) APA03_11110(cobS) APA03_22520(cobN)
APU: APA07_11100(cobT) APA07_11110(cobS) APA07_22520(cobN)
APG: APA12_11100(cobT) APA12_11110(cobS) APA12_22520(cobN)
APQ: APA22_11100(cobT) APA22_11110(cobS) APA22_22520(cobN)
APX: APA26_11100(cobT) APA26_11110(cobS) APA26_22520(cobN)
APZ: APA32_11100(cobT) APA32_11110(cobS) APA32_22520(cobN)
APK: APA386B_1111(cobN) APA386B_2631(cobT) APA386B_2632(cobS)
ASZ: ASN_3533(cobN) ASN_3749(cobS) ASN_3750(cobT)
ABG: Asbog_00563(cobN) Asbog_01145(cobT) Asbog_01146(cobS)
MGY: MGMSRv2__0898(cobN) MGMSRv2__4074(cobT) MGMSRv2__4075(cobS)
MAGX: XM1_0706(cobN) XM1_1438(cobT) XM1_1439(cobS) XM1_1734
AZL: AZL_000750(cobT) AZL_000760(cobS) AZL_d03280(cobN)
ALI: AZOLI_2951(cobS) AZOLI_2953(cobT) AZOLI_p40248(cobN)
ABS: AZOBR_40113(cobS) AZOBR_p140031(cobN)
TMO: TMO_0335(cobT) TMO_0336(cobS) TMO_2759(cobN)
THAL: A1OE_867(cobS) A1OE_868(cobT)
EFK: P856_496(cobS) P856_497(cobT)
MAGQ: MGMAQ_0051(cobN) MGMAQ_0987(cobT) MGMAQ_0988(cobS)
NAO: Y958_01115(cobT) Y958_01120(cobS) Y958_29300(cobN)
NCB: C0V82_12215(cobS) C0V82_12230(cobT)
PUB: SAR11_0448(cobT) SAR11_0449(cobS)
MAI: MICA_1471(cobS) MICA_1472(cobT)
AFR: AFE_1297
AOE: Clos_2328
DSY: DSY3871(cobN)
AWO: Awo_c10320(cobN1) Awo_c10370(cobN2) Awo_c10400(cobN3)
TKI: TKV_c05110(cobN2) TKV_c09690(bchH) TKV_c10280(cobN3) TKV_c10300 TKV_c16570(cobN4)
ADG: Adeg_1646
VPR: Vpar_0072
MTU: Rv2062c(cobN)
MTC: MT2121(cobN)
MRA: MRA_2075(cobN)
MTG: MRGA327_12690(cobN)
MTUR: CFBS_2182(cobN)
MTO: MTCTRI2_2100(cobN)
MTD: UDA_2062c(cobN)
MTN: ERDMAN_2276(cobN)
MTX: M943_10685(cobN)
MTUH: I917_14515(cobN)
MTUL: TBHG_02020
MTUT: HKBT1_2176(cobN)
MTUU: HKBT2_2177(cobN)
MTQ: HKBS1_2181(cobN)
MBO: BQ2027_MB2088C(cobN)
MBB: BCG_2081c(cobN)
MBT: JTY_2075(cobN)
MBM: BCGMEX_2064c(cobN)
MBX: BCGT_1886
MBZ: LH58_10945(cobN)
MAF: MAF_20770(cobN)
MCE: MCAN_20851(cobN)
MCQ: BN44_40353(cobN)
MCV: BN43_31254(cobN)
MCX: BN42_30372(cobN)
MCZ: BN45_50368(cobN)
MMIC: RN08_2285
MPA: MAP_1805c(cobN)
MAO: MAP4_2023
MAVI: RC58_10080(cobN)
MAVU: RE97_10090(cobN)
MAV: MAV_2437(cobN)
MAVD: NF84_10980(cobN)
MAVR: LA63_11210(cobN)
MAVA: LA64_11245(cobN)
MIT: OCO_24340
MIA: OCU_24210
MIE: LG41_11440(cobN)
MID: MIP_03365
MYO: OEM_22790
MIR: OCQ_22880
MUL: MUL_2277(cobN)
MMC: Mmcs_2496
MKM: Mkms_2541
MJL: Mjls_2533
MMI: MMAR_3037(cobN)
MMAE: MMARE11_29600(cobN)
MMM: W7S_11740(cobN)
MLI: MULP_02773(cobN)
MKN: MKAN_01805(cobN)
MKS: LG40_01820(cobN)
MKI: LH54_01830(cobN)
MYV: G155_17525(cobN)
MYE: AB431_14790(cobN)
MHAD: B586_10830(cobN)
MYN: MyAD_14155(cobN)
MSM: MSMEG_3864(cobN)
MSG: MSMEI_3774(cobN)
MSB: LJ00_19190(cobN)
MSN: LI99_19195(cobN)
MSH: LI98_19200(cobN)
MVA: Mvan_3426
MGI: Mflv_3112
MNE: D174_14415(cobN)
MGO: AFA91_20065(cobN) AFA91_20740(cobN)
MPHL: MPHLCCUG_02562(cobN)
MVQ: MYVA_3332(cobN)
MAB: MAB_2201
MMV: MYCMA_1172(cobN)
MABB: MASS_2128(cobN)
MAY: LA62_11200(cobN)
MABO: NF82_10995(cobN)
MAZ: LA61_11090(cobN)
MAK: LH56_12905(cobN)
MYS: NF92_13375(cobN)
MYC: NF90_13375(cobN)
MCHE: BB28_11070(cobN)
MSTE: MSTE_02140
MSAO: MYCSP_09450(cobN)
MJD: JDM601_3180(cobN)
MTER: 4434518_03165(cobN)
ASD: AS9A_2046(cobN)
CDI: DIP1229(cobN)
CDP: CD241_1160(cobN)
CDH: CDB402_1139(cobN)
CDT: CDHC01_1159(cobN)
CDE: CDHC02_1138(cobN)
CDR: CDHC03_1133(cobN)
CDA: CDHC04_1143(cobN)
CDZ: CD31A_1241(cobN)
CDB: CDBH8_1208(cobN)
CDS: CDC7B_1224(cobN)
CDD: CDCE8392_1131(cobN)
CDW: CDPW8_1209(cobN)
CDV: CDVA01_1100(cobN)
CDIP: ERS451417_01230(cobN)
CKP: ckrop_0897(cobN)
CPU: cpfrc_01023(cobN)
CPL: Cp3995_1042(cobN)
CPG: Cp316_1063(cobN)
CPP: CpP54B96_1038(cobN)
CPK: Cp1002_1019(cobN)
CPQ: CpC231_1018(cobN)
CPX: CpI19_1024(cobN)
CPZ: CpPAT10_1018(cobN)
COR: Cp267_1067(cobN)
COP: Cp31_1028(cobN)
COD: Cp106_1001(cobN)
COS: Cp4202_1011(cobN)
COI: CpCIP5297_1036(cobN)
COE: Cp258_1033(cobN)
COU: Cp162_1016(cobN)
CPSE: CPTA_01590
CPSU: CPTB_02174
CPSF: CPTC_01580
CUL: CULC22_01093(cobN)
CUC: CULC809_01078(cobN)
CUE: CULC0102_1200(cobN)
CUN: Cul210932_1132(cobN)
CUS: CulFRC11_1102(cobN)
CUQ: Cul210931_1084(cobN)
CUZ: Cul05146_1158(cobN)
CUJ: CUL131002_1116c(cobN)
CAZ: CARG_04695(cobN)
CVT: B843_06955(cobN)
COA: DR71_83(cobN)
CKU: UL82_05105(cobN)
CEI: CEPID_06290(cobN)
CLW: CLAC_06575(cobN)
CAQU: CAQU_06260(cobN)
CSPH: CSPHI_06805(cobN)
NFA: NFA_31370
NFR: ERS450000_00935(cobN)
NCY: NOCYR_3300(cobN)
NBR: O3I_026615(cobN)
NNO: NONO_c34310(cobN)
NSR: NS506_05031(cobN)
RER: RER_31410(cobN)
REY: O5Y_14420(cobN)
REB: XU06_14640(cobN)
ROP: ROP_02910(cobN) ROP_33530(cobS) ROP_33540(cobT)
REQ: REQ_23600(cobN)
RPY: Y013_10490(cobN) Y013_14610(cobN)
RHB: NY08_989
RAV: AAT18_20420(cobN)
RFA: A3L23_04240(cobN)
RHS: A3Q41_04026(cobN)
RHU: A3Q40_01747(cobN)
RHOD: AOT96_25870(cobN)
GBR: Gbro_2482
GPO: GPOL_c24160(cobN)
GOR: KTR9_2391
GOQ: ACH46_17980(cobN)
TPR: Tpau_2196
DPC: A6048_01065(cobN)
DLU: A6035_16355(cobN)
SCO: SCO1849(cobN)
SMA: SAVERM_6415(cobN)
SGR: SGR_3825
SGB: WQO_16610
SCB: SCAB_9771(cobN)
SCT: SCAT_1048(cobN) SCAT_p1408(cobN)
SFA: Sfla_3028
SBH: SBI_01764(cobN)
SHY: SHJG_3307
SVE: SVEN_3516
SDV: BN159_6671(cobN)
SALB: XNR_4667
SALS: SLNWT_3407
STRP: F750_3739
SFI: SFUL_3821
SCI: B446_09610(cobN)
SRC: M271_06560(cobN)
SALU: DC74_4102
SALL: SAZ_21865(cobN)
SLV: SLIV_28470(cobN)
SGU: SGLAU_08235(cobN)
STRE: GZL_04793
SCW: TU94_07845(cobN)
SLD: T261_4280
STRM: M444_26930
STRC: AA958_05340(cobN)
SAMB: SAM23877_1921(cobN)
SPRI: SPRI_5138
SCX: AS200_33990(cobN)
SRW: TUE45_02327(cobN)
SLE: sle_52840(sle_52840)
SRN: A4G23_02853(cobN)
STSI: A4E84_09330(cobN)
STRD: NI25_29965(cobN)
SMAL: SMALA_7102
SLAU: SLA_3558
SALF: SMD44_01997(cobN)
SALJ: SMD11_0880(cobN)
SLX: SLAV_09395(cobN)
SFK: KY5_6081c
KSK: KSE_64800(cobN)
DNI: HX89_07900(cobN)
LMOI: VV02_21345(cobN)
JTE: ASJ30_05385(cobN)
DCO: SAMEA4475696_0359(cobN)
PAC: PPA0102
PAW: PAZ_c01100(cobN) PAZ_c08410(bchH)
PACC: PAC1_00525
CGRN: 4412665_00463(cobN)
MPH: MLP_03840(cobN)
NCA: Noca_2878
NDK: I601_3856(cobN)
KFL: Kfla_3121
PSIM: KR76_17150(cobN)
AER: AERYTH_14730(cobN)
TFU: Tfu_0319
NDA: Ndas_1611
NAL: B005_0623(cobN)
TCU: Tcur_1291
SRO: Sros_5591
FAL: FRAAL2330(cobN)
NML: Namu_0145
GOB: Gobs_0583
BSD: BLASA_1266(cobN)
MMAR: MODMU_0665(cobN)
SEN: SACE_5955(cobN)
AMD: AMED_7069(cobN)
AMN: RAM_36270(cobN)
AMM: AMES_6961(cobN)
AMZ: B737_6961(cobN)
AOI: AORI_1656(cobN) AORI_4752(cobS) AORI_4753(cobT)
AMQ: AMETH_5490(cobN)
PDX: Psed_3023
PSEE: FRP1_14335(cobN)
PSEH: XF36_14615(cobN)
PSEQ: AD006_22000(cobN)
PECQ: AD017_01585(cobN)
AMI: Amir_1784
SESP: BN6_25840(cobN)
KAL: KALB_7259
KPHY: AOZ06_33675(cobN)
ALL: CRK57393
SAQ: Sare_2710
MIL: ML5_4314
ASE: ACPL_6898(cobN)
ACTN: L083_6533(cobN)
AFS: AFR_33975(cobN)
ACTS: ACWT_6767
CAI: Caci_6126
TBI: Tbis_2495
RXY: Rxyl_0635
AFO: Afer_0816
SYN: sll1890(cobN) slr1211(cobN)
SYZ: MYO_116360(cobN) MYO_18240(cobN)
SYY: SYNGTS_0819(cobN) SYNGTS_1621(cobN)
SYT: SYNGTI_0819(cobN) SYNGTI_1621(cobN)
SYS: SYNPCCN_0818(cobN) SYNPCCN_1620(cobN)
SYQ: SYNPCCP_0818(cobN) SYNPCCP_1620(cobN)
SYJ: D082_00100(cobN) D082_06660(cobN)
SYW: SYNW1240(CobN)
SYC: syc1407_d(cobN)
SYG: sync_1355(cobN)
SYR: SynRCC307_1207(cobN)
SYX: SynWH7803_1275(cobN)
SYNR: KR49_02120
SYND: KR52_09705
SYH: Syncc8109_1301(CobN)
SYNW: SynWH8103_01378(cobN)
TEL: tlr0900(cobN)
THN: NK55_11080(cobN)
CYI: CBM981_0564(cobN)
LET: O77CONTIG1_00807(cobN_1) O77CONTIG1_00808(cobN_2) O77CONTIG1_00809(cobN_3)
LBO: LBWT_1520
HHG: XM38_050230(cobN)
PMA: Pro_0957(cobN)
PMM: PMM0879(CobN)
PMT: PMT_0727
PMB: A9601_09821(cobN)
PMC: P9515_09611(cobN)
PMF: P9303_14911(cobN)
PMG: P9301_09801(cobN)
PMH: P9215_10131(cobN)
PMJ: P9211_08851(cobN)
PME: NATL1_10041(cobN)
PRC: EW14_1013
PRM: EW15_1020
AMR: AM1_4431(cobN)
MAR: MAE_43720(cobN)
MPK: VL20_2598
CHON: NIES4102_13890(cobN)
CYT: cce_4752(cobN)
TER: Tery_0132
ARP: NIES39_A02240(cobN)
GVI: gvip423(cobN)
ANA: alr1689(CobN)
NON: NOS3756_36920(cobN)
AVA: Ava_1167
NAZ: Aazo_0562
ANB: ANA_C12368(cobN)
CALH: IJ00_22745
CTHE: Chro_0274
STAN: STA3757_22520(cobN)
RCA: Rcas_0648
CAU: Caur_2579
CAG: Cagg_1278
HAU: Haur_1059
CAP: CLDAP_16580(cobN)
DGE: Dgeo_2352
DDR: Deide_2p01670(cobN)
PIR: VN12_12560(cobN)
PLS: VT03_10655(cobN)
TDE: TDE0749
BTHO: Btheta7330_01992(cobN)
BVU: BVU_2194
BOA: Bovatus_01257(cobN)
BCEL: BcellWH2_00352(cobN)
PGN: PGN_0556
TFO: BFO_2075
PSAC: PSM36_0371
CPI: Cpin_4488
SMIZ: 4412673_01716(cobN)
DFE: Dfer_5367
COC: Coch_0753
NDO: DDD_0676
TJE: TJEJU_2894(cobN)
TTK: TST_0240(cobN)
MMP: MMP0493
MVO: Mvol_0679
MMA: MM_1602(cobN) MM_1998(cobN)
MTHR: MSTHT_1253
MMET: MCMEM_0408
MPY: Mpsy_0980(cobN) Mpsy_0981
MCJ: MCON_0660(cobN1) MCON_0667(cobN2) MCON_2203
MBG: BN140_0216(cobN1) BN140_2365(cobN3)
MEZ: Mtc_1698
METE: tca_00292(cobN_2) tca_00420(cobN_3) tca_00489(cobN_4) tca_00646(cobN_5) tca_01317(cobN_6)
MST: Msp_1110(cobN)
MRU: mru_2047(bchH)
MEB: Abm4_1146
MMIL: sm9_0224(cobN1) sm9_1341
MEYE: TL18_09825
MOL: YLM1_1795
MFC: BRM9_1699(cobN1) BRM9_1700(cobN2) BRM9_1714(cobN3)
GAH: GAH_00936
HAL: VNG_1566G(cobN)
HSL: OE_3230F(cobN)
HHB: Hhub_2903(cobN)
HALH: HTSR_1848(cobN)
HHSR: HSR6_1917(cobN)
HMA: rrnAC3019(cobN)
HHI: HAH_0274(cobN)
NPH: NP_1092A(cobN)
NMO: Nmlp_1046(cobN)
HMU: Hmuk_1859
HWA: HQ_2296A(cobN)
HWC: Hqrw_2540(cobN)
HVO: HVO_B0050(cobN)
HME: HFX_5054(cobN)
HLA: Hlac_3461
HTU: Htur_1005
NAT: NJ7G_3581
PTO: PTO0179
FAI: FAD_0585
PYN: PNA2_0540
TON: TON_1875
THE: GQS_05885
THS: TES1_0116
PPAC: PAP_03955
MSE: Msed_2089
MCN: Mcup_0200
PIS: Pisl_0228
TNE: Tneu_0376
VDI: Vdis_1903
 » show all
Taxonomy
Reference
1  [PMID:1429466]
  Authors
Debussche L, Couder M, Thibaut D, Cameron B, Crouzet J, Blanche F.
  Title
Assay, purification, and characterization of cobaltochelatase, a unique complex enzyme catalyzing cobalt insertion in hydrogenobyrinic acid a,c-diamide during coenzyme B12 biosynthesis in Pseudomonas denitrificans.
  Journal
J Bacteriol 174:7445-51 (1992)
DOI:10.1128/JB.174.22.7445-7451.1992
  Sequence
Reference
2  [PMID:12195810]
  Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
  Title
The biosynthesis of adenosylcobalamin (vitamin B12).
  Journal
Nat Prod Rep 19:390-412 (2002)
Other DBs
ExplorEnz - The Enzyme Database: 6.6.1.2
IUBMB Enzyme Nomenclature: 6.6.1.2
ExPASy - ENZYME nomenclature database: 6.6.1.2
BRENDA, the Enzyme Database: 6.6.1.2
CAS: 81295-49-0

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