KEGG   ENZYME: 7.1.1.12
Entry
EC 7.1.1.12                 Enzyme                                 
Name
succinate dehydrogenase (electrogenic, proton-motive force generating)
Class
Translocases;
Catalysing the translocation of protons;
Linked to oxidoreductase reactions
Sysname
succinate:quinone oxidoreductase (electrogenic, proton-motive force generating)
Reaction(IUBMB)
succinate + menaquinone + 2 H+[side 1] = fumarate + menaquinol + 2 H+[side 2]
Substrate
succinate [CPD:C00042];
menaquinone [CPD:C00828];
H+[side 1]
Product
fumarate [CPD:C00122];
menaquinol [CPD:C05819];
H+[side 2]
Comment
The enzyme is very similar to EC 1.3.5.1, succinate dehydrogenase, but differs by containing two heme molecules (located in the membrane anchor component) in addition to FAD and three iron-sulfur clusters. Unlike EC 1.3.5.1, this enzyme catalyses an electrogenic reaction, enabled by electron-bifurcation via the heme molecules. In the direction of succinate oxidation by menaquinone, which is endergonic, the reaction is driven by the transmembrane electrochemical proton potential. In the direction of fumarate reduction, the electrogenic electron transfer reaction is compensated by transmembrane proton transfer pathway known as the E-pathway, which results in overall electroneutrality.
History
EC 7.1.1.12 created 2022
Orthology
K00233  succinate dehydrogenase flavoprotein subunit
K25995  succinate dehydrogenase iron-sulfur subunit
Genes
SLIGGTU79_24250 GTU79_24255
SONSO_0398(frdA) SO_0399(frdB)
SFRSfri_0457 Sfri_0458 Sfri_0678 Sfri_0679
SAZSama_3219 Sama_3220
SBLSbal_3750 Sbal_3751 Sbal_3934 Sbal_3935
SBMShew185_0614 Shew185_0615 Shew185_3959 Shew185_3960
SBNSbal195_0641 Sbal195_0642 Sbal195_4075 Sbal195_4076
SBPSbal223_0636 Sbal223_0637 Sbal223_3882 Sbal223_3883
SBTSbal678_0657 Sbal678_0658 Sbal678_4108 Sbal678_4109
SBSSbal117_3904 Sbal117_3905 Sbal117_4093 Sbal117_4094
SBBSbal175_0471 Sbal175_0472 Sbal175_0702 Sbal175_0703
SLOShew_0334 Shew_0335
SPCSputcn32_3438 Sputcn32_3439
SHPSput200_3576 Sput200_3577
SSESsed_4113 Ssed_4114
SPLSpea_0394 Spea_0395
SHEShewmr4_0404 Shewmr4_0405
SHMShewmr7_3620 Shewmr7_3621
SHNShewana3_0403 Shewana3_0404
SHWSputw3181_0500 Sputw3181_0501
SHLShal_3896 Shal_3897
SWDSwoo_0509 Swoo_0510
SWPswp_0430 swp_0431
SHFCEQ32_14110(frdB) CEQ32_14115
SJASJ2017_3768 SJ2017_3769
SPSWSps_03073 Sps_03074
SBJCF168_18795(frdB) CF168_18800
SMAVCFF01_01650 CFF01_01655(frdB)
SHEWCKQ84_05485(frdB) CKQ84_05490 CKQ84_11225(frdB) CKQ84_11230
SALGBS332_04920(frdB)
SLJEGC82_17960 EGC82_17965
SMAIEXU30_13305
SPOLFH971_02195 FH971_02200
SBKSHEWBE_4503(frdB) SHEWBE_4504(frdA)
SKHSTH12_03139(frdB) STH12_03140(frdA)
SAESHBH39_02115 HBH39_02120
SLITJQC75_16475 JQC75_16480
SDKKHX94_06600
SCAATUM17387_34830(frdB) TUM17387_34840(frdA)
SPSHFM037_24975 FM037_24980
SEURFM038_002580 FM038_002585
SYKKDN34_01930 KDN34_01935
SCYPJYB88_01785 JYB88_01790
SAVIJYB87_16385 JYB87_16390
SSEMJYB85_01965 JYB85_01970
SGLAFJ709_17495 FJ709_17500
SINVK8B83_20960 K8B83_20965
SXMMKD32_18935 MKD32_18940
SVMKDH10_002558 KDH10_002559
SHEJMZ182_18225 MZ182_18230
SSEHN7V09_00320
SCHKGII14_01650 GII14_01655
SACHK0H61_01515 K0H61_01520
SAEGK0H80_01685 K0H80_01690
SDEOD0436_02860 D0436_02865
SMESK0I73_01560 K0I73_01565
SHAOK0H81_01745 K0H81_01750
SZHK0H63_17595 K0H63_17600
SSPAK0I31_01705 K0I31_01710
SHNSK0J45_01725 K0J45_01730
SRHSK0I63_01710 K0I63_01715
SPSJK0I62_17495 K0I62_17500
SMAYK0H60_02360 K0H60_02365
SOGRA178_03015 RA178_03020 RA178_19930 RA178_19935
COZA3Q34_01940(frdB)
FBLFbal_0457 Fbal_0458
FESHER31_17875 HER31_17880
MYAMORIYA_1691(frdB) MORIYA_1692
TTUTERTU_3684 TERTU_3685
HALCEY643_12455 EY643_12460
TNITVNIR_1263(frdA_[H]) TVNIR_1264(frdB_[H])
TTITHITH_10595(frdB) THITH_10600
LHKLHK_02341(frdA) LHK_02342
SUTTSUTMEG_18970(frdB) SUTMEG_18980(frdA)
SUTKFG381_05405 FG381_05410
SWSI6J16_00910 I6J16_00915
BBAYA4V04_04230 A4V04_04235(frdB)
UPLDSM104440_00987(frdB_1) DSM104440_00988(frdA_1)
DARDaro_1776 Daro_1777
QAUKI612_11860 KI612_11865
TMZTmz1t_1493 Tmz1t_1494
HPYHP_0191 HP_0192
HEOC694_00950(frdB) C694_00955
HPJjhp_0177(frdB) jhp_0178(frdA)
HPAHPAG1_0185 HPAG1_0186
HPSHPSH_00980(frdB) HPSH_00985
HHPHPSH112_00940(frdB) HPSH112_00945
HHQHPSH169_00940(frdB) HPSH169_00945
HHRHPSH417_00955(frdB) HPSH417_00960
HPGHPG27_175(frdB) HPG27_176(frdA)
HPPHPP12_0192(frdB) HPP12_0193(frdA)
HPBHELPY_0194(frdB) HELPY_0195(frdA)
HPLHPB8_1375(frdA) HPB8_1376(frdB)
HPCHPPC_00955(frdB) HPPC_00960
HCAHPPC18_00950(frdB) HPPC18_00955
HPMHPSJM_01040(frdB) HPSJM_01045
HPEHPELS_05825 HPELS_05830(frdB)
HPOHMPREF4655_20431 HMPREF4655_20432
HPIhp908_0200 hp908_0201
HPQhp2017_0195(frdB) hp2017_0196(frdA)
HPWhp2018_0198 hp2018_0199
HPUHPCU_00925(frdB) HPCU_00930
HEFHPF16_0197(frdB) HPF16_0198(frdA)
HPFHPF30_1102(frdA) HPF30_1103(frdB)
HEQHPF32_0199(frdB) HPF32_0200(frdA)
HEXHPF57_0209(frdB) HPF57_0210(frdA)
HPTHPSAT_00940(frdB) HPSAT_00945
HPZHPKB_0199(sdhB) HPKB_0200
HPVHPV225_0205 HPV225_0206
HPXHMPREF0462_0244 HMPREF0462_0245
HENHPSNT_01135(frdB) HPSNT_01140
HPHHPLT_01000(frdB) HPLT_01005
HEGHPGAM_00975(frdB) HPGAM_00980
HPNHPIN_06180 HPIN_06185(frdB)
HEPHPPN120_00970(frdB) HPPN120_00975
HEUHPPN135_00965(frdB) HPPN135_00970
HESHPSA_00960(frdB) HPSA_00965
HPYSHPSA20_0211 HPSA20_0212
HCNHPB14_00925(frdB) HPB14_00930
HPDKHP_0190(frdB) KHP_0191(frdA)
HEYMWE_0265(frdB) MWE_0266(frdA)
HERC695_00950(frdB) C695_00955
HEIC730_00950(frdB) C730_00955
HPYAHPAKL117_00950(frdB) HPAKL117_00955
HPYKHPAKL86_06030 HPAKL86_06035(frdB)
HPYOHPOK113_0199(frdB) HPOK113_0200(frdA)
HPYLHPOK310_0196(frdB) HPOK310_0197(frdA)
HPYBHPOKI102_01250(frdB) HPOKI102_01255
HPYCHPOKI112_01245(frdB) HPOKI112_01250
HPYDHPOKI128_01050(frdB) HPOKI128_01055
HPYEHPOKI154_01030(frdB) HPOKI154_01035
HPYFHPOKI422_01245(frdB) HPOKI422_01250
HPYGHPOKI673_01030(frdB) HPOKI673_01035
HPYHHPOKI828_01030(frdB) HPOKI828_01035
HPYJHPOKI898_01255(frdB) HPOKI898_01260
HPYRK747_09605(frdB) K747_09610
HPYIK750_07595 K750_07600(frdB)
HPYUK751_06675 K751_06680(frdB)
HPYMK749_04725 K749_04730(frdB)
HEMK748_03145 K748_03150(frdB)
HEBU063_0531 U063_0532
HEZU064_0532 U064_0533
HHEHH_0686(frdA) HH_0687(frdB)
HACHac_0376(frdB) Hac_0377(frdA)
HMSHMU13890(frdA) HMU13900(frdB)
HFEHFELIS_14080(frdA) HFELIS_14090(frdB)
HBIHBZC1_01910 HBZC1_01920
HCEHCW_02975(frdB) HCW_02980
HCMHCD_00305 HCD_00310(frdB)
HCPHCN_1823(frdA) HCN_1824(frdB)
HCBHCBAA847_2106(frdA) HCBAA847_2107(frdB)
HHMBN341_9980 BN341_9990
HTYBN2458_PEG1913 BN2458_PEG1914
HBLXJ32_00490(frdB) XJ32_00495
HADCDV25_00885(frdB) CDV25_00890
HETBBW65_00665 BBW65_00670(frdB)
HCLNCTC13205_00119(frdA) NCTC13205_00120(frdB)
HWIA0Z60_06885 A0Z60_06890
HSHNHP194022_14110(frdB) NHP194022_14120(frdA)
HPULNCTC13154_00314(frdB) NCTC13154_00315(frdA)
HAILASB7_00350(frdA) ASB7_00360(frdB)
WSUWS0830(FRDB) WS0831(FRDA)
SULGFJR48_07325 FJR48_07330
SBALHUE88_05145 HUE88_05150
SMASHUE87_06115 HUE87_06120
SAQTGJV85_04580 GJV85_04585
CJECj0409(frdA) Cj0410(frdB)
CJBBN148_0409(frdA) BN148_0410(frdB)
CJJCJJ81176_0433(frdA) CJJ81176_0434(frdB)
CJUC8J_0384(frdA) C8J_0385(frdB)
CJNICDCCJ07001_373 ICDCCJ07001_374
CJICJSA_0382(frdA) CJSA_0383(frdB)
CJMCJM1_0387(frdA) CJM1_0388(frdB)
CJSCJS3_0399 CJS3_0400
CJPA911_01990 A911_01995(frdB)
CJEJN564_00392 N564_00393(frdB)
CJEUN565_00441 N565_00442(frdB)
CJENN755_00443(frdB) N755_01955
CJEIN135_00453 N135_00454(frdB)
CJERH730_02610 H730_02615(frdB)
CJVMTVDSCj20_0379(frdA) MTVDSCj20_0380(frdB)
CJYQZ67_00412(frdA_1) QZ67_00413(frdB_1)
CJQUC78_0395(frdA_1) UC78_0396(frdB_1)
CJLPJ17_01990 PJ17_01995(frdB)
CJWPJ18_01990 PJ18_01995(frdB)
CJRCJE0458(frdA) CJE0459(frdB)
CJDJJD26997_1547(frdB) JJD26997_1548(frdA)
CJZM635_06355 M635_06360(frdB)
CJXBN867_03820 BN867_03830
CFFCFF8240_0414 CFF8240_0415
CFTCFF04554_0413(frdB) CFF04554_0414(frdA)
CFVCFVI03293_0412(frdB) CFVI03293_0413(frdA)
CFXCFV97608_0415(frdB) CFV97608_0416(frdA)
CFZCSG_4940 CSG_4950
CAMPCFT03427_0423(frdB) CFT03427_0424(frdA)
CFPCR44_02130(frdB) CR44_02135
CCVCCV52592_2205(frdA) CCV52592_2206(frdB)
CHACHAB381_0857 CHAB381_0858
CCOCCC13826_0424(frdB) CCC13826_0425(frdA)
CCOCCCON33237_1361(frdA) CCON33237_1362(frdB)
CLACLA_0334(frdA) CLA_0335(frdB)
CLRUPTC16701_0335(frdA) UPTC16701_0336(frdB)
CLMUPTC16712_0338(frdA) UPTC16712_0339(frdB)
CLQUPTC4110_0329(frdA) UPTC4110_0330(frdB)
CLNUPTC3659_0351(frdA) UPTC3659_0352(frdB)
CLLCONCH_0342(frdA) CONCH_0343(frdB)
CCOLBN865_00140c BN865_00150c
CCCG157_06590(frdB) G157_06595
CCQN149_0406 N149_0407
CCFYSQ_07835(frdB) YSQ_07840
CCYYSS_01820 YSS_01825(frdB)
CCOIYSU_06835(frdB) YSU_06840
CCOFVC76_02140(frdA) VC76_02145(frdB)
CCOOATE51_03394(frdB) ATE51_03396(frdA)
CAJCIG1485E_0522(frdB) CIG1485E_0523(frdA)
CISCINS_0328(frdA) CINS_0329(frdB)
CVOCVOL_0328(frdA) CVOL_0329(frdB)
CPELCPEL_0340(frdA) CPEL_0341(frdB)
CAMRCAQ16704_0340(frdA) CAQ16704_0341(frdB)
CSMCSUB8521_0366(frdA) CSUB8521_0367(frdB)
CSFCSUB8523_0348(frdA) CSUB8523_0349(frdB)
CGRACGRAC_0798(frdA) CGRAC_0799(frdB)
CURECUREO_0978(frdB) CUREO_0979(frdA)
CHYOCHH_0441(frdA) CHH_0442(frdB)
CHVCHELV3228_0753(frdA) CHELV3228_0754(frdB)
CSPFCSF_0572(frdA) CSF_0573(frdB)
CPINCPIN18020_1280(frdA) CPIN18020_1281(frdB)
CCUNCCUN_0506(frdA) CCUN_0507(frdB)
CLXCLAN_1062(frdA) CLAN_1063(frdB)
CAVICAV_0912(frdB) CAV_0913(frdA)
CHWA2J15_007545 A2J15_007550
CAMZCVIC12175_1025(frdA) CVIC12175_1026(frdB)
CAMYCSUIS_1150(frdA) CSUIS_1151(frdB)
COJCORN_0338(frdA) CORN_0339(frdB)
CUXCUP3940_1031(frdB) CUP3940_1032(frdA)
CRXCRECT_0617(frdA) CRECT_0618(frdB)
CGEOCGEO_1122(frdB) CGEO_1123(frdA)
CBLACBLAS_1060(frdB) CBLAS_1061(frdA)
CCORCCORG_0640(frdA) CCORG_0641(frdB)
CARMCARM_0305(frdA) CARM_0306(frdB)
CMUCCMCT_0385(frdA) CMCT_0386(frdB)
CSHOCSHOW_1471(frdB) CSHOW_1472(frdA)
CINFCINF_0575(frdA) CINF_0576(frdB)
CNVCNZW441b_0437(frdA) CNZW441b_0438(frdB)
CVUCVULP_0599(frdA) CVULP_0600(frdB)
SDLSdel_0395 Sdel_0396
SBASulba_0440 Sulba_0441
SMULSMUL_0551(frdA) SMUL_0552(frdB)
SHALSHALO_0543 SHALO_0544
SULSSdiek1_0506 Sdiek1_0507
SULJSJPD1_0506 SJPD1_0507
SULTFA592_09560 FA592_09565
ABUAbu_0299(frdB) Abu_0300(frdA)
ABTABED_0282 ABED_0283
ABLA7H1H_0301(frdB) A7H1H_0302(frdA)
ASKEI285_08330 EI285_08335
ATPATR_0350(frdB) ATR_0351(frdA)
ACIBACBT_1905(frdA) ACBT_1906(frdB)
ACREACRYA_1668(frdA) ACRYA_1669(frdB)
ALANALANTH_0352(frdB) ALANTH_0353(frdA)
AFCAFAEC_1928(frdA) AFAEC_1929(frdB)
ATHRATH_1702(frdB) ATH_1703(frdA)
ANTArnit_0446 Arnit_0447 Arnit_2667 Arnit_2668
AELLAELL_0449(frdB) AELL_0450(frdA)
AAQIAAQM_0368(frdB) AAQM_0369(frdA)
ASUIASUIS_0387(frdB) ASUIS_0388(frdA)
ACLOACLO_0426(frdB) ACLO_0427(frdA)
AVPAVENP_0455(frdB1) AVENP_0456(frdA1) AVENP_2879(frdB2) AVENP_2880(frdA2)
ADZADFLV_0456(frdB) ADFLV_0457(frdA)
ARCABLL_0442 ABLL_0443
PACOAACT_0494(frdB) AACT_0495(frdA)
APOCAPORC_1808(frdB) APORC_1809(frdA)
AROSNJU99_12680 NJU99_12685
ALKALEK_2980(frdA) ALEK_2981(frdB)
ALPLPB137_12020 LPB137_12025(frdB)
AHSAHALO_2293(frdA1) AHALO_2294(frdB1) AHALO_2459(frdB2) AHALO_2460(frdA2)
AMYTAMYT_2348(frdA1) AMYT_2349(frdB1) AMYT_2523(frdB2) AMYT_2524(frdA2)
AMARAMRN_2381(frdA1) AMRN_2382(frdB1) AMRN_2570(frdB2) AMRN_2571(frdA2)
ACAAACAN_2386(frdA1) ACAN_2387(frdB1) ACAN_2576(frdB2) ACAN_2577(frdA2)
AMOLAMOL_2365(frdA1) AMOL_2366(frdB1) AMOL_2527(frdB2) AMOL_2528(frdA2)
APAIAPAC_2193(frdA) APAC_2194(frdB)
HBVABIV_0323(frdB) ABIV_0324(frdA)
HEBRAEBR_0390(frdB1) AEBR_0391(frdA1) AEBR_0394(frdB2) AEBR_0395(frdA2) AEBR_2576(frdA3) AEBR_2577(frdB3)
AANAAANAER_0393(frdB1) AANAER_0394(frdA1) AANAER_2544(frdA2) AANAER_2545(frdB2)
HCJHCR_01450(frdB) HCR_01460(frdA_1)
NSANitsa_1312 Nitsa_1313
SUNSUN_0413 SUN_0414
SLHYH65_09140(frdB) YH65_09145
DDSDdes_1531 Ddes_1532
DFIAXF13_15140 AXF13_15145(frdB)
DEFCNY67_05315(frdB) CNY67_05320
DFLDFE_0590(frdA) DFE_0591
PSYFN1030_12775 N1030_12780
DSBLN040_12020 LN040_12025
DMADMR_05770(frdA) DMR_05780(frdB) DMR_34280(frdA) DMR_34290(frdB)
DCBC3Y92_04760(frdB) C3Y92_04765
DGGDGI_0827(frdAII) DGI_0828(frdBII) DGI_1569(fdrA) DGI_1570(fdrB)
DDEDde_1256 Dde_1257
DMSE8L03_11955 E8L03_11960 E8L03_12265 E8L03_12270
DSADesal_0721 Desal_0722
DHYDESAM_20177(frdB) DESAM_20178(frdA)
DAFDesaf_1687 Desaf_1688
DASDaes_2065 Daes_2066
DPIBN4_10023(frdA) BN4_10024(frdB) BN4_10581(frdA) BN4_10582(frdB)
DEJAWY79_10165 AWY79_10170(frdB) AWY79_17525 AWY79_17530(frdB)
PPRFDPRO_0023(frdA) DPRO_0024(frdB)
PSELGM415_12145 GM415_12150
DDNDND132_0816 DND132_0817 DND132_2879 DND132_2880
PSEFPSDVSF_08280(frdB) PSDVSF_08290(fdrA)
PPORJCM14722_05850(frdB_1) JCM14722_05860(fdrA_1) JCM14722_09080(fdrA_2) JCM14722_09090(frdB_2)
PNWSYK_05600(frdB_1) SYK_05610(fdrA_1) SYK_09920(frdB_2) SYK_09930(fdrA_2)
PTHELF599_02980 LF599_02985 LF599_11290 LF599_11295
DSXGD604_12610 GD604_12615
DSDGD606_02445 GD606_02450
PBIZLWC08_10375 LWC08_10380 LWC08_12080 LWC08_12085
DVUDVU_3262(fdrA) DVU_3263(frdB)
DVLDvul_0126 Dvul_0127
DVMDvMF_2459 DvMF_2460
DVGDeval_3017 Deval_3018
CLIHKPS_002863 KPS_002864
DBADbac_3064 Dbac_3065
DOAAXF15_04080 AXF15_04085(frdB)
DESUNLA06_15285 NLA06_15290
THEWTDMWS_03650(fdrA) TDMWS_03660(frdB)
DRTDret_1066 Dret_1067
DATHRM2_32410(sdhB) HRM2_32420(sdhA)
DTOTOL2_C01620(frdA1) TOL2_C01630(frdB1) TOL2_C05100(frdA2) TOL2_C05110(frdB2)
DAODesac_0860 Desac_0861
SFUSfum_1998 Sfum_1999
AFXJZ786_08465 JZ786_08470 JZ786_24210 JZ786_24215
ACURJZ785_12670 JZ785_12675 JZ785_13345 JZ785_13350
EFFskT53_22510(fdrA) skT53_22520(frdB)
DCADesca_1387 Desca_1388
PTHPTH_1017(SdhA) PTH_1018(SdhB)
DKUDesku_0434 Desku_0435
DAUDaud_1930 Daud_1931
DGIDesgi_3997 Desgi_3998
 » show all
Reference
1  [PMID:12409197]
  Authors
Lancaster CR.
  Title
Wolinella succinogenes quinol:fumarate reductase-2.2-A resolution crystal structure and the E-pathway hypothesis of coupled transmembrane proton and electron transfer.
  Journal
Biochim Biophys Acta 1565:215-31 (2002)
DOI:10.1016/s0005-2736(02)00571-0
Reference
2  [PMID:17154542]
  Authors
Madej MG, Nasiri HR, Hilgendorff NS, Schwalbe H, Unden G, Lancaster CR.
  Title
Experimental evidence for proton motive force-dependent catalysis by the diheme-containing succinate:menaquinone oxidoreductase from the Gram-positive bacterium Bacillus licheniformis.
  Journal
Biochemistry 45:15049-55 (2006)
DOI:10.1021/bi0618161
Reference
3  [PMID:18793177]
  Authors
Lancaster CR, Herzog E, Juhnke HD, Madej MG, Muller FG, Paul R, Schleidt PG.
  Title
Electroneutral and electrogenic catalysis by dihaem-containing succinate:quinone oxidoreductases.
  Journal
Biochem Soc Trans 36:996-1000 (2008)
DOI:10.1042/BST0360996
Reference
4  [PMID:23466335]
  Authors
Lancaster CR.
  Title
The di-heme family of respiratory complex II enzymes.
  Journal
Biochim Biophys Acta 1827:679-87 (2013)
DOI:10.1016/j.bbabio.2013.02.012
Reference
5  [PMID:30297797]
  Authors
Guan HH, Hsieh YC, Lin PJ, Huang YC, Yoshimura M, Chen LY, Chen SK, Chuankhayan P, Lin CC, Chen NC, Nakagawa A, Chan SI, Chen CJ.
  Title
Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas.
  Journal
Sci Rep 8:14935 (2018)
DOI:10.1038/s41598-018-33193-5
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 7.1.1.12
IUBMB Enzyme Nomenclature: 7.1.1.12
ExPASy - ENZYME nomenclature database: 7.1.1.12
BRENDA, the Enzyme Database: 7.1.1.12

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