KEGG   ENZYME: 7.1.3.1Help
Entry
EC 7.1.3.1                  Enzyme                                 

Name
H+-exporting diphosphatase;
H+-PPase;
proton-pumping pyrophosphatase;
vacuolar H+-pyrophosphatase;
hydrogen-translocating pyrophosphatase;
proton-pumping dihosphatase
Class
Translocases;
Catalysing the translocation of hydrons;
Linked to the hydrolysis of diphosphate
BRITE hierarchy
Sysname
diphosphate phosphohydrolase (H+-transporting)
Reaction(IUBMB)
diphosphate + H2O + H+[side 1] = 2 phosphate + H+[side 2]
Substrate
diphosphate [CPD:C00013];
H2O [CPD:C00001];
H+[side 1]
Product
phosphate [CPD:C00009];
H+[side 2]
Comment
This enzyme, found in plants and fungi, couples the energy from diphosphate hydrolysis to active proton translocation across the tonoplast into the vacuole. The enzyme acts cooperatively with cytosolic soluble diphosphatases to regulate the cytosolic diphosphate level.
History
EC 7.1.3.1 created 2018
Orthology
K23025  H+-translocating diphosphatase
Genes
SLAL: 111667379
ATH: AT1G15690(AVP1) AT1G16780(VHP2;2) AT1G78920(VP2)
ALY: ARALYDRAFT_477059(AVP2) ARALYDRAFT_677599 ARALYDRAFT_888959(AVP1) ARALYDRAFT_889071
CRB: 111832662 17895094 17895417 17899023
CSAT: 104703231 104703395 104705099 104714174 104714331 104740254 104740361 104752317 104752473 104755880 104755999 104774389 104778744 104778745 104778747 109131963
EUS: EUTSA_v10006869mg EUTSA_v10018137mg EUTSA_v10018163mg EUTSA_v10029022mg
BRP: 103832369 103832483(AVP1-2) 103836019(AVP1-1) 103842889 103853151 103872357
BNA: 106346644 106354660 106354844 106367071 106381452 106381539 106381540 106381544 106387567 106403324 106403325 106414619 106430757 111197719 111207155
BOE: 106294603 106299969 106300469 106309512 106311519 106326947
RSZ: 108805087 108820134 108822185 108827356 108828450 108843556
LJA: Lj0g3v0276799.1(Lj0g3v0276799.1) Lj3g3v2027530.1(Lj3g3v2027530.1) Lj3g3v2027530.2(Lj3g3v2027530.2) Lj3g3v2172730.1(Lj3g3v2172730.1) Lj4g3v1936570.1(Lj4g3v1936570.1) Lj4g3v1936570.2(Lj4g3v1936570.2) Lj5g3v1514680.1(Lj5g3v1514680.1) Lj5g3v1514690.1(Lj5g3v1514690.1)
DOSA: Os01t0337500-00(Os01g0337500) Os02t0184200-01(Os02g0184200) Os02t0537900-01(Os02g0537900) Os02t0802500-01(Os02g0802500) Os05t0156900-01(Os05g0156900) Os06t0178900-01(Os06g0178900) Os06t0644200-01(Os06g0644200)
ATS: 109751043(LOC109751043) 109771576(LOC109771576) 109774055(LOC109774055) 109777267(LOC109777267) 109787080(LOC109787080)
APRO: F751_4161
PYO: PY17X_1324300(PY06858) PY17X_1452300(PY00513)
PCB: PCHAS_132380(PC000445.03.0) PCHAS_145210(PC000015.02.0)
TAN: TA07270
TPV: TP04_0216
SMIN: v1.2.001178.t1(symbB.v1.2.001178.t1) v1.2.024117.t1(symbB.v1.2.024117.t1) v1.2.024117.t2(symbB.v1.2.024117.t2) v1.2.027450.t1(symbB.v1.2.027450.t1) v1.2.032240.t1(symbB.v1.2.032240.t1)
 » show all
Taxonomy
Reference
1  [PMID:16664761]
  Authors
Rea PA, Poole RJ
  Title
Chromatographic resolution of h-translocating pyrophosphatase from h-translocating ATPase of higher plant tonoplast.
  Journal
Plant Physiol 81:126-9 (1986)
Reference
2  [PMID:16667022]
  Authors
Sarafian V, Poole RJ
  Title
Purification of an h-translocating inorganic pyrophosphatase from vacuole membranes of red beet.
  Journal
Plant Physiol 91:34-8 (1989)
Reference
3  [PMID:2479537]
  Authors
Hedrich R, Kurkdjian A, Guern J, Flugge UI
  Title
Comparative studies on the electrical properties of the H+ translocating ATPase and pyrophosphatase of the vacuolar-lysosomal compartment.
  Journal
EMBO J 8:2835-41 (1989)
Reference
4  [PMID:29691313]
  Authors
Segami S, Tomoyama T, Sakamoto S, Gunji S, Fukuda M, Kinoshita S, Mitsuda N, Ferjani A, Maeshima M
  Title
Vacuolar H(+)-Pyrophosphatase and Cytosolic Soluble Pyrophosphatases Cooperatively Regulate Pyrophosphate Levels in Arabidopsis thaliana.
  Journal
Plant Cell 30:1040-1061 (2018)
DOI:10.1105/tpc.17.00911
  Sequence
[ath:AT1G15690]
Other DBs
ExplorEnz - The Enzyme Database: 7.1.3.1
IUBMB Enzyme Nomenclature: 7.1.3.1
ExPASy - ENZYME nomenclature database: 7.1.3.1
BRENDA, the Enzyme Database: 7.1.3.1

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