KEGG   ENZYME: 7.1.3.1
Entry
EC 7.1.3.1                  Enzyme                                 
Name
H+-exporting diphosphatase;
H+-PPase;
proton-pumping pyrophosphatase;
vacuolar H+-pyrophosphatase;
hydrogen-translocating pyrophosphatase;
proton-pumping dihosphatase
Class
Translocases;
Catalysing the translocation of hydrons;
Linked to the hydrolysis of diphosphate
Sysname
diphosphate phosphohydrolase (H+-transporting)
Reaction(IUBMB)
diphosphate + H2O + H+[side 1] = 2 phosphate + H+[side 2]
Substrate
diphosphate [CPD:C00013];
H2O [CPD:C00001];
H+[side 1]
Product
phosphate [CPD:C00009];
H+[side 2]
Comment
This enzyme, found in plants and fungi, couples the energy from diphosphate hydrolysis to active proton translocation across the tonoplast into the vacuole. The enzyme acts cooperatively with cytosolic soluble diphosphatases to regulate the cytosolic diphosphate level.
History
EC 7.1.3.1 created 2018
Orthology
K23025  H+-translocating diphosphatase
Genes
ATH: AT1G15690(AVP1) AT1G16780(VHP2;2) AT1G78920(VP2)
ALY: 9325283 9326182 9326251
CRB: 17895094 17895417 17899023
CSAT: 104703231 104703395 104714174 104714331 104740254 104740361 104752317 104752473 104755880 104755999 104774389 104778744 104778745
EUS: EUTSA_v10006869mg EUTSA_v10018137mg EUTSA_v10018163mg
BRP: 103832369 103832483(AVP1-2) 103836019(AVP1-1) 103842889 103853151 103872357
BNA: 106346644 106354660 106354844 106367071 106381452 106381539 106381540 106381544 106387567 106403324 106403325 106414619 106430757 111197719 111207155
BOE: 106294603 106299969 106300469 106309512 106311519 106326947
RSZ: 108805087 108820134 108822185 108827356 108828450 108843556
THJ: 104808107 104812334 104812467 104813573 104815298 104826559
CPAP: 110807328 110815411 110821062 110826127
CIT: 102578049 102612154 102617625
CIC: CICLE_v10007524mg CICLE_v10013931mg CICLE_v10024946mg
PVY: 116105970 116107838 116120967 116140187
MINC: 123194156 123200302 123209173 123211449 123218102 123218770
TCC: 18588850 18595335 18595567 18600564
GRA: 105768017 105768790 105772855 105773126 105776918 105783195 105791042 105792472 105799109
GHI: 107889146 107891667 107893910 107897013 107901338 107906449 107912554 107925190 107930386 107933788 107962574 121205114 121212597 121217449 121217696 121225237 121229212 121230698
GAB: 108450768 108453029 108453143 108453215 108460448 108464253 108470008 108489322
DZI: 111274418 111275342 111277370 111278804 111280290 111294008 111296916 111300831 111303308
EGR: 104414666 104419828 104423194 104423279 104428252 104430494 104437836 104438616 104439977 104439978 104439979 104439980 104439983 104439987 104452526 104454834
GMX: 100775864 100784465 100787805 100794166 100803691 100812548
GSJ: 114373752 114402910 114417869 114418087 114422468 114422549
PVU: PHAVU_003G171500g PHAVU_010G164900g
VRA: 106768298 106779108
VAR: 108320596 108345536
VUN: 114166707 114176081 114176955 114176956
CCAJ: 109807586 109807727 109807940 109817379
APRC: 113847663 113854116 113857037 113857281 113871089
MTR: MTR_4g005280 MTR_4g115970
CAM: 101514301 101515471
LJA: Lj3g3v2027530.1(Lj3g3v2027530.1) Lj3g3v2027530.2(Lj3g3v2027530.2) Lj3g3v2172730.1(Lj3g3v2172730.1) Lj4g3v1936570.1(Lj4g3v1936570.1) Lj4g3v1936570.2(Lj4g3v1936570.2)
ADU: 107461422 107463769 107465246 107482363
AIP: 107614690 107614691 107617688 107617887 107635834 107640576
AHF: 112701447 112709778 112710745 112723337 112740786 112775484 112775929 112776816 112795506
LANG: 109339792 109346005 109350629 109354702 109358489 109362215
FVE: 101303836 101308398 101314105 101314765
RCN: 112186295 112188033 112189182 112193806
PPER: 18771632 18772546 18782476 18783468
PMUM: 103327448 103328067 103341138 103344065
PAVI: 110752644 110761656 110762863 110767435
PDUL: 117620659 117620886 117629678 117634117
MDM: 103415567 103423547 103426080 103433876 103436160 103443357 103451968
PXB: 103927435 103927764 103928924 103930851 103949175 103953877 103962309 103967655
ZJU: 107407705 107410535 107411770
MNT: 21384663 21387616 21396996 21407647 21408417
CSV: 101205277 101217198 101222673(VP)
CMO: 103487401 103494311 103500610
BHJ: 120070563 120079565 120085968
MCHA: 111007149 111022029 111023264
CMAX: 111465445 111485119 111488556 111496068
CMOS: 111436191 111444356 111456089 111461438
CPEP: 111779886 111792635 111798289 111806788
RCU: 8259946 8263849 8269813 8282702
JCU: 105634813 105641261 105646133 105647416
HBR: 110639327 110640802 110641816 110648209 110649406 110665718 110665937 110671337 110671429
MESC: 110599668 110613840 110617341 110617500 110619939 110622984 110625528
POP: 112324981 18098598 18099906 18111071 7469460 7478904 7497772
PEU: 105121078 105122668 105125152 105131688 105134291 105141142
PALZ: 118032617 118047668 118052052 118060211 118060942 118062205
JRE: 108987724 108995630 109005008 109005438 109012858 109019074
QSU: 111988386 112024341 112028747 112034339
QLO: 115973796 115979923 115981712 115989622 115991818
TWL: 119997292 120004774 120007657 120009640 120010796 120011470
VVI: 100232894(VPP2) 100233104 100247980 100256710
VRI: 117921486 117922148 117922157 117925041 117929518
SLY: 101246569 101253082(LeVP3) 101259424(VP2) 101261420 101263674 543761(VP1)
SPEN: 107005322 107014423 107017917 107021063 107025645 107025768
SOT: 102579479 102583477 102586995 102600043 102604491
CANN: 107839687 107840797 107862038 107867620 107876025 107877721
NTA: 107761395(ppa) 107774827 107776076 107776628(ppa) 107778409 107794544 107799531 107809014 107813411 107814653 107815824(ppa)
NSY: 104215140 104215382 104216758 104229096 104239144 104242725
NTO: 104090166 104091471 104094216 104105034 104118698 104120133
NAU: 109208365 109223323 109234434 109237019 109241675
INI: 109147415 109170124 109176472 109178777
ITR: 116002099 116007896 116013260 116025378
SIND: 105158354 105162240 105164876 105166431 105174795
OEU: 111390712 111391797 111397433 111397435 111402268 111403939 111405203
EGT: 105948827 105955010 105960664 105972331 105975782
SSPL: 121746977 121749585 121752076 121775354 121777618 121796172 121799915 121805061
HAN: 110877370 110886632 110893917 110916370 110935741 110939579
ECAD: 122587009 122593437 122596225 122606687 122607663
LSV: 111877800 111881873 111898903 111899343 111908368 111910058
CCAV: 112500830 112505799 112506832 112509415 112511102 112516456 112516765
DCR: 108195861 108209376 108209970 108214208 108217725 108226560
CSIN: 114266246 114271697 114290771 114295637 114305513 114308480 114319251
BVG: 104901923 104904547 104908681
SOE: 110785597 110793903 110801873
CQI: 110687940 110698623 110708026 110725552 110726793
NNU: 104588605 104592540 104598796 104601609
MING: 122071997 122073969 122081104 122081557
TSS: 122652803 122661378 122668067
PSOM: 113299984 113318088 113348954 113350208 113358789
NCOL: 116248776 116250144 116252884 116254281 116263769 116264291
OSA: 4326846 4328526 4329579 4331044 4337864 4340298 4341645
DOSA: Os01t0337500-00(Os01g0337500) Os02t0537900-01(Os02g0537900) Os02t0802500-01(Os02g0802500) Os05t0156900-01(Os05g0156900) Os06t0178900-01(Os06g0178900) Os06t0644200-01(Os06g0644200)
OBR: 102704490 102709145 102711708 102712041 102716422 102716473 102719389
BDI: 100827063 100831519 100832532 100833667 100836640
ATS: 109751043 109771576 109774055 109777267 109787080
TDC: 119278836 119318192 119323061 119327172 119329055 119331368 119336913 119341335 119343077 119366471
TAES: 100136960 123039083 123055218 123113270 123128671 123132401 123138732 123145805 123149539 123158100 123159822 123164763 123180583 123181973 543450
TUA: 125514977 125517315 125520334 125550889
SBI: 110430849 8058399 8065790 8070111 8075312 8076017 8079416 8084655
ZMA: 100126542 100280334 100286099 100382506 101027208 103635138 103650470 103654862 542328
SITA: 101758107 101761609 101763159 101767008 101768410 101774456 101780777 101780838
SVS: 117838460 117845055 117847910 117848664 117852914 117852966 117855316 117865337
PVIR: 120645252 120654873 120657510 120665759 120667261 120670087 120671284 120676010 120697501 120698994 120702796 120704042 120706829
PHAI: 112874098 112884273 112885752 112886604 112890035 112891165 112891576 112901085
PDA: 103698431 103706475 103710117 103711472 103712654 103715891 103720114
EGU: 105033049 105039062 105042697 105049421 105050114 105052596
MUS: 103972488 103978161 103984832 103985418 103986815 103989956 103992412 103993690 103998428
DCT: 110100315 110107993 110115075
PEQ: 110021133 110021993 110031869
AOF: 109822824 109825116 109835594 109838127 109841169
ATR: 18431217 18440749 18442574
SMO: SELMODRAFT_156843 SELMODRAFT_157618 SELMODRAFT_270204 SELMODRAFT_270614
PPP: 112284684 112284687 112286837 112287610 112294453
CRE: CHLRE_09g394436v5
VCN: VOLCADRAFT_76494
CSL: COCSUDRAFT_29300 COCSUDRAFT_36403
CVR: CHLNCDRAFT_143568 CHLNCDRAFT_32356
APRO: F751_4161
OLU: OSTLU_31307 OSTLU_39838
OTA: OT_ostta01g00980 OT_ostta04g03800
BPG: Bathy01g00880 Bathy08g03020
MIS: MICPUN_107016 MICPUN_94241 MICPUN_97152
MPP: MICPUCDRAFT_34063 MICPUCDRAFT_45236 MICPUCDRAFT_46773
CME: CYME_CMO102C
GSL: Gasu_15740 Gasu_15900 Gasu_28190
PFA: PF3D7_1235200 PF3D7_1456800
PFD: PFDG_00012 PFDG_04702
PFH: PFHG_00686 PFHG_02084
PREI: PRSY57_1234400 PRSY57_1456100
PGAB: PGSY75_1235200 PGSY75_1456800
PYO: PY17X_1324300 PY17X_1452300
PCB: PCHAS_132380(PC000445.03.0) PCHAS_145210(PC000015.02.0)
PBE: PBANKA_1320500 PBANKA_1449800
PVV: PVVCY_1302200 PVVCY_1405190
PKN: PKNH_1225000 PKNH_1454900
PVX: PVX_100710 PVX_117625
PCY: PCYB_125830 PCYB_146090
TGO: TGME49_248670
TET: TTHERM_000773801 TTHERM_00218790 TTHERM_00735340
PTM: GSPATT00014977001 GSPATT00017042001 GSPATT00020810001 GSPATT00021301001 GSPATT00021886001 GSPATT00027681001 GSPATT00031717001 GSPATT00032758001 GSPATT00036772001 GSPATT00037050001
SMIN: v1.2.024117.t1(symbB.v1.2.024117.t1) v1.2.024117.t2(symbB.v1.2.024117.t2) v1.2.032240.t1(symbB.v1.2.032240.t1)
PTI: PHATRDRAFT_26190 PHATR_21183
FCY: FRACYDRAFT_207890
TPS: THAPSDRAFT_39520
AAF: AURANDRAFT_29608(VPP1) AURANDRAFT_70885(VPP2)
PIF: PITG_05615 PITG_06731
PSOJ: PHYSODRAFT_255048 PHYSODRAFT_297061
SPAR: SPRG_03678 SPRG_05568
EHX: EMIHUDRAFT_415047 EMIHUDRAFT_51239 EMIHUDRAFT_75032
GTT: GUITHDRAFT_145095 GUITHDRAFT_156810 GUITHDRAFT_157618 GUITHDRAFT_157894 GUITHDRAFT_162896
TBR: Tb927.4.4380 Tb927.8.7980
TBG: TbgDal_IV4470 TbgDal_VIII8300
TCR: 510773.20 511385.30
LMA: LMJF_31_1220
LIF: LINJ_31_1240
LDO: LDBPK_311240
LMI: LMXM_30_1220
LBZ: LBRM_31_1450
LPAN: LPMP_311140
NGR: NAEGRDRAFT_70050
 » show all
Reference
1  [PMID:16664761]
  Authors
Rea PA, Poole RJ
  Title
Chromatographic resolution of h-translocating pyrophosphatase from h-translocating ATPase of higher plant tonoplast.
  Journal
Plant Physiol 81:126-9 (1986)
DOI:10.1104/pp.81.1.126
Reference
2  [PMID:16667022]
  Authors
Sarafian V, Poole RJ
  Title
Purification of an h-translocating inorganic pyrophosphatase from vacuole membranes of red beet.
  Journal
Plant Physiol 91:34-8 (1989)
DOI:10.1104/pp.91.1.34
Reference
3  [PMID:2479537]
  Authors
Hedrich R, Kurkdjian A, Guern J, Flugge UI
  Title
Comparative studies on the electrical properties of the H+ translocating ATPase and pyrophosphatase of the vacuolar-lysosomal compartment.
  Journal
EMBO J 8:2835-41 (1989)
DOI:10.1002/j.1460-2075.1989.tb08430.x
Reference
4  [PMID:29691313]
  Authors
Segami S, Tomoyama T, Sakamoto S, Gunji S, Fukuda M, Kinoshita S, Mitsuda N, Ferjani A, Maeshima M
  Title
Vacuolar H(+)-Pyrophosphatase and Cytosolic Soluble Pyrophosphatases Cooperatively Regulate Pyrophosphate Levels in Arabidopsis thaliana.
  Journal
Plant Cell 30:1040-1061 (2018)
DOI:10.1105/tpc.17.00911
  Sequence
[ath:AT1G15690]
Other DBs
ExplorEnz - The Enzyme Database: 7.1.3.1
IUBMB Enzyme Nomenclature: 7.1.3.1
ExPASy - ENZYME nomenclature database: 7.1.3.1
BRENDA, the Enzyme Database: 7.1.3.1

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Gene (2164)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (766)   
   KEGG MGENES (1397)   
Protein sequence (14774)   
   UniProt (14738)   
   SWISS-PROT (35)   
   RefSeq(pep) (1)   
DNA sequence (35)   
   RefSeq(nuc) (1)   
   GenBank (22)   
   EMBL (12)   
Protein domain (1)   
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