KEGG ENZYME: 7.1.3.1

ENZYME: 7.1.3.1

Entry

EC 7.1.3.1                  Enzyme

Name

H+-exporting diphosphatase;
H+-PPase;
proton-pumping pyrophosphatase;
vacuolar H+-pyrophosphatase;
hydrogen-translocating pyrophosphatase;
proton-pumping dihosphatase

Class

Translocases;
Catalysing the translocation of protons;
Linked to the hydrolysis of diphosphate

Sysname

diphosphate phosphohydrolase (H+-transporting)

Reaction(IUBMB)

diphosphate + H2O + H+[side 1] = 2 phosphate + H+[side 2]

Substrate

diphosphate [CPD:C00013];
H2O [CPD:C00001];
H+[side 1]

Product

phosphate [CPD:C00009];
H+[side 2]

Comment

This enzyme, found in plants and fungi, couples the energy from diphosphate hydrolysis to active proton translocation across the tonoplast into the vacuole. The enzyme acts cooperatively with cytosolic soluble diphosphatases to regulate the cytosolic diphosphate level.

History

EC 7.1.3.1 created 2018

Orthology

K23025

H+-translocating diphosphatase

Genes

CLON:

129618346

PAME:

138694253

ATH:	AT1G15690(AVP1) AT1G16780(VHP2;2) AT1G78920(VP2)

ALY:	9325283 9326182 9326251

CRB:	17895094 17895417 17899023

CSAT:

104703231 104703395 104714174 104714331 104740254 104740361 104752317 104752473 104755880 104755999 104774389 104778744 104778745

EUS:	EUTSA_v10006869mg EUTSA_v10018137mg EUTSA_v10018163mg

BRP:	103832369 103832483(AVP1-2) 103836019(AVP1-1) 103842889 103853151 103872357

BNA:	106346644 106354660 106367071 106381452 106381539 106381540 106381544 106387567 106396122 106403325 106414619 106430757 111207155 125591287 125591288

BOE:	106294603 106299969 106300469 106309512 106311519 106326947

RSZ:	108805087 108820134 108822185 108827356 108828450

THJ:	104808107 104812334 104812467 104813573 104815298 104826559

CPAP:

110807328 110815411 110821062 110826127

CIT:	102578049 102612154 102617625

CIC:	CICLE_v10007524mg CICLE_v10013931mg CICLE_v10024946mg

PVY:	116105970 116107838 116120967 116140187

MINC:

123194156 123200302 123209173 123211449 123218102 123218770

TCC:	18588850 18595335 18595567 18600564

GRA:	105768017 105768790 105772855 105773126 105776918 105783195 105791042 105792472 105799109

GHI:	107889146 107891667 107893910 107897013 107901338 107906449 107912554 107925190 107930386 107933788 107962574 121205114 121212597 121217449 121217696 121225237 121229212 121230698

GAB:	108453029 108453143 108453215 108460448 108464253 108465412 108470008 108489322

HSYR:

120119594 120133374 120149226 120150235 120161686 120161705 120166599 120175809 120175837 120192729 120203773 120218991

DZI:	111274418 111275342 111277370 111278804 111280290 111294008 111296916 111300831 111303308

EGR:	104414666 104419828 104423194 104423279 104428252 104430686 104437836 104438616 104439977 104439978 104439979 104439980 104452526 104454834 120288320

RARG:

115726608 115738058 115750973 115751202 115752768 115752858 115755827

GMX:	100775864 100784465 100787805 100794166 100803691 100812548

GSJ:	114373752 114402910 114417869 114418087 114422468 114422549

PVU:	137807596 137819612

VRA:	106768298 106779108

VAR:	108320596 108345536

VUN:	114166707 114176081 114176955 114176956

VUM:	124835949 124842006

CCAJ:

109807586 109807727 109807940 109817379

APRC:

113847663 113854116 113857037 113857281 113871089

MTR:	11438181 25491158

TPRA:

123881896 123924749

CAM:	101514301 101515471

PSAT:

127073245 127073475 127080971 127081293 127084299 127086393 127093907 127095372 127104896 127107166 127114651 127118300 127118403 127126791 127137526 127138216

VVO:	131601056 131631168 131633021 131634541 131639176

LJA:	130715392 130745636 130745779

ADU:	107461422 107463769 107465246 107482363

AIP:	107614690 107614691 107617688 107617887 107635834 107640576

AHF:	112701447 112709778 112710745 112723337 112740786 112775484 112775929 112776816 112795506

LANG:

109339792 109346005 109350629 109354702 109358489 109362215

PCIN:

129288346 129288438 129290460 129308786 129320881

QSA:	O6P43_002456 O6P43_011039 O6P43_017852 O6P43_017992 O6P43_023964 O6P43_027904

FVE:	101303836 101308398 101314105 101314765

AANS:

126792595 126797507 126797579 126797882

RCN:	112186295 112188033 112189182 112193806

PPER:

18771632 18772546 18782476 18783468

PMUM:

103327448 103328067 103341138 103344065

PAVI:

110752644 110761656 110762863 110767435

PDUL:

117620659 117620886 117629678 117634117

MDM:	103415567 103423547 103426080 103433876 103436160 103443357 103451968

MSYL:

126582295 126587677 126594147 126603877 126611311 126611606 126618466

PXB:	103927435 103927764 103928924 103930851 103949175 103953877 103962309 103967655

PCOX:

137707889 137708403 137723616 137735116 137738959 137738975 137745582 137747563

ZJU:	107407705 107408197 107410535 107411770

MNT:	21384663 21387616 21396996 21407647 21408417

CSAV:

115707880 115712638 115721188 115725066

CSV:	101205277 101217198 101222673(VP)

CMO:	103487401 103494311 103500610

BHJ:	120070563 120079565 120085968

MCHA:

111007149 111022029 111023264

CMAX:

111465445 111485119 111488556 111496068

CMOS:

111436191 111444356 111456089 111461438

CPEP:

111779886 111792635 111798289 111806788

RCU:	8259946 8263849 8269813 8282702

MEAN:

126653797 126674312 126674678 126681326

JCU:	105634813 105641261 105646133 105647416

HBR:	110639327 110640802 110641816 110648209 110649406 110665718 110665937 110671337 110671429

MESC:

110599668 110613840 110617341 110617500 110619939 110622984 110625528

POP:	18098598 18099906 18111071 7469460 7478904 7497772

PEU:	105121078 105122668 105125152 105131688 105134291 105141142

PALZ:

118032617 118047668 118052052 118060211 118060942 118062205

PNZ:	133669737 133674735 133688643 133694941 133696928

JRE:	108987724 108995630 109005008 109005438 109012858 109019074

CILL:

122279251 122284489 122300840 122305202 122315942 122318441

CAVE:

132166650 132171275 132186806 132187720 132190794

AGLU:

133852443 133856698 133862459 133863020

QSU:	111988386 112024341 112028747 112034339

QLO:	115973796 115979923 115981712 115989622 115991818

TWL:	119997292 120004774 120007657 120009640 120010796 120011470

VVI:	100232894(VPP2) 100233104 100247980 100256710 100266984

VRI:	117921486 117922148 117922157 117925041 117929518

SLY:	101246569 101253082(LeVP3) 101259424(VP2) 101261420 101263674 543761(VP1)

SPEN:

107005322 107014423 107017917 107021063 107025645 107025768

SOT:	102579479 102583477 102586995 102600043 102604491

SSTN:

125853708 125854572 125855113 125858240 125875921

SDUL:

129871112 129891439 129894070 129902121

CANN:

107839687 107840797 107862038 107867620 107876025 107877721

LBB:	132603108 132627360 132633071 132636988

NTA:	107761395(ppa) 107774827 107776076 107776628(ppa) 107778409 107794544 107799531 107809014 107813411 107814653 107815824(ppa)

NSY:	104215140 104215382 104216758 104229096 104239144 104242725

NTO:	104090166 104091471 104094216 104105034 104118698 104120133

NAU:	109208365 109223323 109234434 109237019 109241675

INI:	109147415 109170124 109176472 109178777

ITR:	116002099 116007896 116013260 116025378

SIND:

105158354 105162240 105164876 105166431 105174795

OEU:	111390712 111391797 111397433 111397435 111402268 111403939 111405203

EGT:	105948827 105955010 105960664 105972331 105975782

SSPL:

121746977 121749585 121752076 121775354 121777618 121796172 121799915 121805061

SMIL:

130987025 130988214 130989239 130992258 131004282 131005094

SHIS:

125186710 125190665 125196924 125199978 125219612

APAN:

127243578 127247330 127262981 127266343

HPUM:

140860292 140872986 140890068

PHUA:

140960847 140968069 140975740 140978636 140979378 140980704 140981462

PEBU:

140803441 140820274 140825401 140829248 140830821 140832270 140833959 140834964

HAN:	110877370 110886632 110893917 110916370 110935741 110939579

ECAD:

122587009 122593437 122596225 122606687 122607663

LSV:	111877800 111881873 111898903 111899343 111908368 111910058

CCAV:

112500830 112505799 112506832 112509415 112511102 112516456 112516765

DCR:	108195861 108209376 108209970 108214208 108217725 108226560

CSIN:

114266246 114271697 114290771 114295637 114305513 114308480 114319251

RVL:	131312111 131320274 131325628 131335379 131336081

AEW:	130750421 130750467 130758226 130767160 130773174 130786706 130788386 130788440

DLT:	127790066 127794346 127794892 127806445

BVG:	104901923 104904547 104908681

SOE:	110785597 110793903 110801873

CQI:	110687940 110698623 110708026 110725552 110726793

ATRI:

130812591 130812762 130815985 130827889 130828224

MOF:	131154547 131157568 131158005 131158177 131163001

NNU:	104588605 104592540 104598796 104601609

MING:

122071997 122073969 122081104 122081557

TSS:	122652803 122661378 122668067

PSOM:

113299984 113318088 113348954 113350208 113358789

OSA:	4326846 4328526 4329579 4331044 4337864 4340298 4341645

DOSA:

Os01g0337500 Os02g0537900 Os02g0802500 Os05g0156900 Os06g0178900 Os06g0644200

OBR:	102704490 102709145 102711708 102712041 102716422 102716473 102719389

OGL:	127762353 127763916 127763942 127773613 127776466 127777930

BDI:	100827063 100831519 100832532 100833667 100836640

ATS:	109751043 109771576 109774055 109777267 109787080

TDC:	119278836 119318192 119323061 119327172 119329055 119331368 119336913 119341335 119343077 119366471

TAES:

100136960 123039083 123055218 123113270 123128671 123132401 123138732 123145805 123149539 123158100 123159822 123164763 123180583 123181973 543450

TUA:	125514977 125517315 125520334 125550889

LPER:

127305672 127316833 127317985 127326958

LRD:	124666438 124685141 124693328 124701511 124701549

SBI:	110430849 8058399 8065790 8070111 8075312 8076017 8079416 8084655

ZMA:	100126542 100280334 100286099 100382506 101027208 103635138 103650470 103654862 542328

MFLO:

136449942 136466727 136466731 136467925 136475844 136504952 136507977 136510529 136516907 136519459 136519520 136522207 136528838 136531907 136537865

SITA:

101758107 101761609 101763159 101767008 101768410 101774456 101780777 101780838

SVS:	117838460 117845055 117847910 117848664 117852914 117852966 117855316 117865337

PVIR:

120645252 120654873 120657510 120665759 120667261 120670087 120671284 120676010 120697501 120698994 120702796 120704042 120706829

PHAI:

112874098 112884273 112885752 112886604 112890035 112891165 112891576 112901085

PAUA:

133883361 133884431 133894942 133898377 133900880 133918505 133920015 133920996 133922523 133926346 133927103 133930760

TANG:

140759861 140761272 140762267 140767530 140776627 140777626

PDA:	103698431 103706475 103710117 103711472 103712654 103715891 103720114

EGU:	105033049 105039062 105042697 105049421 105052596 140859713

MUS:	103984832 135585063 135599004 135605428 135607351 135614282 135615977 135617661 135618791

ZOF:	121969180 121971107 121974295 121974561 121982120 121985999 121992768 121996731 122009302 122015454 122033154 122036581 122043137 122047669

DCT:	110100315 110107993 110115075

PEQ:	110021133 110021993 110031869

AOF:	109822824 109825116 109835594 109838127 109841169

MSIN:

131225439 131254849 131256606 131258391

ACAK:

137936161 137937000 137940340 137942104 137942848 137955733 137958953

NCOL:

116248776 116250144 116252884 116254281 116263769 116264291

ATR:	18431217 18440749 18442574

CJF:	131072801 131075050 131077362

SMO:	SELMODRAFT_156843 SELMODRAFT_157618 SELMODRAFT_270204 SELMODRAFT_270614

PPP:	112284684 112284687 112286837 112287610 112294453

CRE:	CHLRE_09g394436v5

VCN:	VOLCADRAFT_76494

CSL:	COCSUDRAFT_29300 COCSUDRAFT_36403

CVR:	CHLNCDRAFT_143568 CHLNCDRAFT_32356

APRO:

F751_4161

OLU:	OSTLU_31307 OSTLU_39838

OTA:	OT_ostta01g00980 OT_ostta04g03800

BPG:	Bathy01g00880 Bathy08g03020

MIS:	MICPUN_107016 MICPUN_94241 MICPUN_97152

MPP:	MICPUCDRAFT_34063 MICPUCDRAFT_45236 MICPUCDRAFT_46773

CME:	CYME_CMO102C

GSL:	Gasu_15740 Gasu_15900 Gasu_28190

PFA:	PF3D7_1235200 PF3D7_1456800

PFD:	PFDG_00012 PFDG_04702

PFH:	PFHG_00686 PFHG_02084

PREI:

PRSY57_1234400 PRSY57_1456100

PGAB:

PGSY75_1235200 PGSY75_1456800

PLAG:

39743066(PADL01_1235800) 39744505(PADL01_1456800)

PYO:	PY17X_1324300 PY17X_1452300

PCB:	PCHAS_1323800 PCHAS_1452100

PBE:	PBANKA_1320500 PBANKA_1449800

PVV:	PVVCY_1302200 PVVCY_1405190

PKN:	PKNH_1225000 PKNH_1454900

PVX:	PVX_100710 PVX_117625

PCY:	PCYB_125830 PCYB_146090

PMAL:

PMUG01_12060100(VP1) PMUG01_14069400(VP2)

PBRS:

92372606(MKS88_004519) 92373828(MKS88_005741)

PREL:

PRELSG_1224100(VP1) PRELSG_1451300(VP2)

PCOT:

PCOAH_00045470 PCOAH_00053180

TGO:	TGME49_248670

BBES:

BESB_004840

TET:	TTHERM_000773801 TTHERM_00218790 TTHERM_00735340

PTM:	GSPATT00014977001 GSPATT00017042001 GSPATT00020810001 GSPATT00021301001 GSPATT00021886001 GSPATT00027681001 GSPATT00031717001 GSPATT00032758001 GSPATT00036772001 GSPATT00037050001

PTI:	PHATRDRAFT_26190 PHATR_21183

FCY:	FRACYDRAFT_207890

TPS:	THAPSDRAFT_39520

AAF:	AURANDRAFT_29608(VPP1) AURANDRAFT_70885(VPP2)

PIF:	PITG_05615 PITG_06731

PSOJ:

PHYSODRAFT_255048 PHYSODRAFT_297061

BLAC:

94344362(CCR75_000584) 94344978(CCR75_001203) 94349699(CCR75_005954)

SPAR:

SPRG_03678 SPRG_05568

TBR:	Tb927.4.4380 Tb927.8.7980

TBG:	TbgDal_IV4470 TbgDal_VIII8300

TCR:	510773.20 511385.30

LMA:	LMJF_31_1220

LIF:	LINJ_31_1240

LDO:	LDBPK_311240

LMI:	LMXM_30_1220

LMAT:

92511545(LSCM1_01418)

LBZ:	LBRM_31_1450

LPAN:

LPMP_311140

PHET:

94289926(JKF63_03852)

NGR:	NAEGRDRAFT_70050

EHX:	EMIHUDRAFT_415047 EMIHUDRAFT_51239 EMIHUDRAFT_75032

GTT:	GUITHDRAFT_145095 GUITHDRAFT_156810 GUITHDRAFT_157618 GUITHDRAFT_157894 GUITHDRAFT_162896

» show all

Reference

1 [PMID:16664761]

Authors

Rea PA, Poole RJ

Title

Chromatographic resolution of h-translocating pyrophosphatase from h-translocating ATPase of higher plant tonoplast.

Journal

Plant Physiol 81:126-9 (1986)
DOI:10.1104/pp.81.1.126

Reference

2 [PMID:16667022]

Authors

Sarafian V, Poole RJ

Title

Purification of an h-translocating inorganic pyrophosphatase from vacuole membranes of red beet.

Journal

Plant Physiol 91:34-8 (1989)
DOI:10.1104/pp.91.1.34

Reference

3 [PMID:2479537]

Authors

Hedrich R, Kurkdjian A, Guern J, Flugge UI

Title

Comparative studies on the electrical properties of the H+ translocating ATPase and pyrophosphatase of the vacuolar-lysosomal compartment.

Journal

EMBO J 8:2835-41 (1989)
DOI:10.1002/j.1460-2075.1989.tb08430.x

Reference

4 [PMID:29691313]

Authors

Segami S, Tomoyama T, Sakamoto S, Gunji S, Fukuda M, Kinoshita S, Mitsuda N, Ferjani A, Maeshima M

Title

Vacuolar H(+)-Pyrophosphatase and Cytosolic Soluble Pyrophosphatases Cooperatively Regulate Pyrophosphate Levels in Arabidopsis thaliana.

Journal

Plant Cell 30:1040-1061 (2018)
DOI:10.1105/tpc.17.00911

Sequence

[ath:AT1G15690]

Other DBs

ExplorEnz - The Enzyme Database:

7.1.3.1

IUBMB Enzyme Nomenclature:

7.1.3.1

ExPASy - ENZYME nomenclature database:

7.1.3.1

BRENDA, the Enzyme Database:

7.1.3.1

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DNA sequence (229)   
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   GenBank (117)   
   EMBL (111)   
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