KEGG   ENZYME: 7.1.3.1Help
Entry
EC 7.1.3.1                  Enzyme                                 

Name
H+-exporting diphosphatase;
H+-PPase;
proton-pumping pyrophosphatase;
vacuolar H+-pyrophosphatase;
hydrogen-translocating pyrophosphatase;
proton-pumping dihosphatase
Class
Translocases;
Catalysing the translocation of hydrons;
Linked to the hydrolysis of diphosphate
BRITE hierarchy
Sysname
diphosphate phosphohydrolase (H+-transporting)
Reaction(IUBMB)
diphosphate + H2O + H+[side 1] = 2 phosphate + H+[side 2]
Substrate
diphosphate [CPD:C00013];
H2O [CPD:C00001];
H+[side 1]
Product
phosphate [CPD:C00009];
H+[side 2]
Comment
This enzyme, found in plants and fungi, couples the energy from diphosphate hydrolysis to active proton translocation across the tonoplast into the vacuole. The enzyme acts cooperatively with cytosolic soluble diphosphatases to regulate the cytosolic diphosphate level.
History
EC 7.1.3.1 created 2018
Orthology
K23025  H+-translocating diphosphatase
Genes
ATH: AT1G15690(AVP1) AT1G16780(VHP2;2) AT1G78920(VP2)
ALY: ARALYDRAFT_477059(AVP2) ARALYDRAFT_677599 ARALYDRAFT_888959(AVP1) ARALYDRAFT_889071
CRB: 111832662 17895094 17895417 17899023
CSAT: 104703231 104703395 104705099 104714174 104714331 104740254 104740361 104752317 104752473 104755880 104755999 104774389 104778744 104778745 104778747 109131963
EUS: EUTSA_v10006869mg EUTSA_v10018137mg EUTSA_v10018163mg EUTSA_v10029022mg
BRP: 103832369 103832483(AVP1-2) 103836019(AVP1-1) 103842889 103853151 103872357
BNA: 106346644 106354660 106354844 106367071 106381452 106381539 106381540 106381544 106387567 106403324 106403325 106414619 106430757 111197719 111207155
BOE: 106294603 106299969 106300469 106309512 106311519 106326947
THJ: 104808107 104812334 104812467 104813573 104815298 104826559
CPAP: 110807328 110815411 110821062 110826127
CIT: 102578049 102612154 102617625
CIC: CICLE_v10003214mg CICLE_v10003420mg CICLE_v10007524mg CICLE_v10013931mg CICLE_v10024946mg
TCC: 18588850 18595335 18595567 18600564
GRA: 105768017 105768790 105772855 105773126 105776918 105783195 105791042 105792472 105799109
GHI: 107889146 107891667 107893910 107897013 107901338 107902036 107906449 107912554 107925190 107930386 107933788 107962574
GAB: 108450768 108453029 108453143 108453215 108460448 108464253 108470008 108489322
DZI: 111274418 111275342 111277370 111278804 111280290 111294008 111296916 111300831 111303308
EGR: 104414666 104419828 104423194 104423279 104428252 104430494 104432046 104437836 104438616 104439977 104439978 104439979 104439980 104439983 104439987 104452526 104454834 104454835 108960841
GMX: 100775864 100776328 100784465 100787805 100793677 100794166 100803691 100812548
PVU: PHAVU_003G171500g PHAVU_010G164900g
VRA: 106768298 106777933 106779096 106779108
VAR: 108320596 108345536
CCAJ: 109807586 109807727 109807940 109817379
MTR: MTR_4g005280 MTR_4g115970
CAM: 101514301 101515471
LJA: Lj0g3v0276799.1(Lj0g3v0276799.1) Lj3g3v2027530.1(Lj3g3v2027530.1) Lj3g3v2027530.2(Lj3g3v2027530.2) Lj3g3v2172730.1(Lj3g3v2172730.1) Lj4g3v1936570.1(Lj4g3v1936570.1) Lj4g3v1936570.2(Lj4g3v1936570.2) Lj5g3v1514680.1(Lj5g3v1514680.1) Lj5g3v1514690.1(Lj5g3v1514690.1)
ADU: 107461422 107463769 107465246 107482363
AIP: 107614690 107614691 107617688 107617887 107635834 107640576 107643818
LANG: 109339792 109346005 109350629 109351406 109354702 109358489 109362215
FVE: 101303836 101308398 101314105 101314765
PPER: 18771632 18772546 18782476 18783468
PMUM: 103327448 103328067 103341138 103344065
PAVI: 110752644 110761656 110762863 110767435
MDM: 103405426 103406713 103415567 103417283 103423547 103426080 103433876 103436160 103443357 103451961 108169797
PXB: 103927435 103927764 103928924 103930851 103949175 103953877 103962309 103967655
ZJU: 107407705 107409636 107410535 107411770 112489932
CSV: 101205277 101217198 101222673(VP)
CMO: 103487401 103494311 103500610
MCHA: 111007149 111022029 111023264
CMAX: 111465445 111485119 111488556 111496068
CMOS: 111436191 111444356 111456089 111461438
CPEP: 111779886 111792635 111798289 111806788
RCU: 8259946 8261564 8263849 8269813 8282702
JCU: 105634813 105641261 105646133 105647416
HBR: 110639327 110640802 110641816 110648209 110649406 110665718 110665937 110671337 110671429
MESC: 110599668 110613840 110617341 110617500 110619939 110622984 110625528
POP: 112324981 18098598 18099906 18111071 7469460 7478904 7497772
JRE: 108987724 108995630 109005008 109005438 109012858 109019074
VVI: 100232894(VPP2) 100233104 100247980 100253207 100256710 100266984 104880318
SLY: 101246569 101253082(LeVP3) 101259424(SlVP2) 101261420 101263674 543761(vp1.1)
SPEN: 107005322 107014423 107017917 107021063 107025645 107025768
SOT: 102579479 102583477 102586995 102600043 102604491 107063290
CANN: 107839687 107840797 107862038 107867620 107876025 107877721
NTA: 107761395(ppa) 107774827 107776076 107776628(ppa) 107778409 107794544 107799531 107809014 107813411 107814653 107815824(ppa) 107828947
NSY: 104215140 104215382 104216758 104229096 104239144 104242725
NTO: 104090166 104091471 104094216 104105034 104118698 104120133
INI: 109147415 109170124 109176472 109178777
SIND: 105158354 105162240 105164876 105166431 105174795
OEU: 111390712 111391797 111397433 111397435 111402268 111403939 111405203
HAN: 110865390 110877370 110886632 110893917 110914685 110916370 110924809 110935741 110939579
LSV: 111877800 111881873 111898903 111899343 111908368 111910058
CCAV: 112500830 112505799 112506832 112509415 112511102 112514261 112516456 112516765 112529666
DCR: 108195861 108209376 108209970 108214208 108217725 108226560
BVG: 104885512 104901923 104904547 104908681
SOE: 110785597 110793775 110793903 110801873
CQI: 110687940 110698623 110708026 110725552 110726793
NNU: 104588605 104592540 104596277 104598796 104601609
PSOM: 113299984 113318088 113348954 113350208 113358789
OSA: 4326846 4328526 4329579 4331044 4337864 4340298 4341645
DOSA: Os01t0337500-00(Os01g0337500) Os02t0184200-01(Os02g0184200) Os02t0537900-01(Os02g0537900) Os02t0802500-01(Os02g0802500) Os05t0156900-01(Os05g0156900) Os06t0178900-01(Os06g0178900) Os06t0644200-01(Os06g0644200)
OBR: 102704490 102709145 102711708 102712041 102716422 102716473
BDI: 100827063 100831519 100832532 100833667 100836640
ATS: 109751043(LOC109751043) 109771576(LOC109771576) 109774055(LOC109774055) 109777267(LOC109777267) 109787080(LOC109787080)
SBI: 110430849 8058399 8065790 8070111 8075312 8076017 8079416 8084655
ZMA: 100126542 100272514 100280334 100286099 100382506 101027208 103628779 103635138 103637488 103645310 103648692 103649341 103650470 103654862 542328(vpp1)
SITA: 101758107 101761609 101763159 101767008 101768410 101774456 101780777 101780838
PDA: 103698431 103706475 103710117 103711472 103712654 103715891 103720114
EGU: 105033049 105034388 105034637 105039062 105042697 105049421 105050114 105052596
MUS: 103972237 103972488 103978161 103981328 103984832 103985418 103986815 103989956 103992412 103993690 103998428
DCT: 110100315 110107993 110115075
PEQ: 110021133 110021993 110031869 110034240 110034816
AOF: 109822824 109825116 109835594 109838127 109841169 109843029
ATR: 18431217 18440749 18442574
SMO: SELMODRAFT_156843 SELMODRAFT_157618 SELMODRAFT_233486 SELMODRAFT_270204 SELMODRAFT_270614
PPP: 112284684 112284687 112286837 112287610 112294453
CRE: CHLREDRAFT_137778
VCN: VOLCADRAFT_76494
MNG: MNEG_10641 MNEG_14597 MNEG_15836 MNEG_16286 MNEG_16652 MNEG_7415
OLU: OSTLU_31307 OSTLU_39838 OSTLU_48479
OTA: OT_ostta01g00980 OT_ostta01g03420 OT_ostta04g03800
BPG: Bathy01g00880 Bathy01g00900 Bathy01g04500 Bathy08g03020
MIS: MICPUN_107016 MICPUN_94241 MICPUN_97152
MPP: MICPUCDRAFT_34063 MICPUCDRAFT_45236 MICPUCDRAFT_46773
CSL: COCSUDRAFT_29300 COCSUDRAFT_36403
CVR: CHLNCDRAFT_143568 CHLNCDRAFT_32356
APRO: F751_4161
CME: CYME_CMO102C
GSL: Gasu_15740 Gasu_15900 Gasu_28190
CCP: CHC_T00006490001
PFA: PF3D7_1235200 PF3D7_1456800
PFD: PFDG_00012 PFDG_04702 PFDG_04708
PFH: PFHG_00686 PFHG_02084
PYO: PY17X_1324300(PY06858) PY17X_1452300(PY00513)
PCB: PCHAS_132380(PC000445.03.0) PCHAS_145210(PC000015.02.0)
PBE: PBANKA_132050 PBANKA_144980
PKN: PKH_124930 PKH_145370
PVX: PVX_100710 PVX_117625
PCY: PCYB_125830 PCYB_146090
TAN: TA07270
TPV: TP04_0216
TOT: TOT_040000685
BEQ: BEWA_004820
TGO: TGME49_248670
TET: TTHERM_00059370 TTHERM_000773801 TTHERM_000773802 TTHERM_00218790 TTHERM_00735340
PTM: GSPATT00014977001 GSPATT00017042001 GSPATT00017309001 GSPATT00020810001 GSPATT00021301001 GSPATT00021886001 GSPATT00027681001 GSPATT00031277001 GSPATT00031717001 GSPATT00032758001 GSPATT00036772001 GSPATT00037050001 GSPATT00038053001 GSPATT00039077001
SMIN: v1.2.001178.t1(symbB.v1.2.001178.t1) v1.2.024117.t1(symbB.v1.2.024117.t1) v1.2.024117.t2(symbB.v1.2.024117.t2) v1.2.027450.t1(symbB.v1.2.027450.t1) v1.2.032240.t1(symbB.v1.2.032240.t1)
PTI: PHATRDRAFT_15815 PHATRDRAFT_26190 PHATR_21183
FCY: FRACYDRAFT_207890 FRACYDRAFT_261851
TPS: THAPSDRAFT_32586 THAPSDRAFT_39520
AAF: AURANDRAFT_28746(VPP3) AURANDRAFT_29608(VPP1) AURANDRAFT_70885(VPP2)
PIF: PITG_05615 PITG_06731 PITG_22178
PSOJ: PHYSODRAFT_255048 PHYSODRAFT_297061
SPAR: SPRG_03678 SPRG_05568
EHX: EMIHUDRAFT_415047 EMIHUDRAFT_439740 EMIHUDRAFT_44772 EMIHUDRAFT_51239 EMIHUDRAFT_71048 EMIHUDRAFT_75032
GTT: GUITHDRAFT_145095 GUITHDRAFT_156810 GUITHDRAFT_157618 GUITHDRAFT_157894 GUITHDRAFT_162896
TBR: Tb927.4.4380 Tb927.8.7980
TCR: 510773.20 511385.30
LMA: LMJF_31_1220
LIF: LINJ_31_1240
LDO: LDBPK_311240
LMI: LMXM_30_1220
LBZ: LBRM_31_1450
NGR: NAEGRDRAFT_70050
 » show all
Taxonomy
Reference
1  [PMID:16664761]
  Authors
Rea PA, Poole RJ
  Title
Chromatographic resolution of h-translocating pyrophosphatase from h-translocating ATPase of higher plant tonoplast.
  Journal
Plant Physiol 81:126-9 (1986)
Reference
2  [PMID:16667022]
  Authors
Sarafian V, Poole RJ
  Title
Purification of an h-translocating inorganic pyrophosphatase from vacuole membranes of red beet.
  Journal
Plant Physiol 91:34-8 (1989)
Reference
3  [PMID:2479537]
  Authors
Hedrich R, Kurkdjian A, Guern J, Flugge UI
  Title
Comparative studies on the electrical properties of the H+ translocating ATPase and pyrophosphatase of the vacuolar-lysosomal compartment.
  Journal
EMBO J 8:2835-41 (1989)
Reference
4  [PMID:29691313]
  Authors
Segami S, Tomoyama T, Sakamoto S, Gunji S, Fukuda M, Kinoshita S, Mitsuda N, Ferjani A, Maeshima M
  Title
Vacuolar H(+)-Pyrophosphatase and Cytosolic Soluble Pyrophosphatases Cooperatively Regulate Pyrophosphate Levels in Arabidopsis thaliana.
  Journal
Plant Cell 30:1040-1061 (2018)
DOI:10.1105/tpc.17.00911
  Sequence
[ath:AT1G15690]
Other DBs
ExplorEnz - The Enzyme Database: 7.1.3.1
IUBMB Enzyme Nomenclature: 7.1.3.1
ExPASy - ENZYME nomenclature database: 7.1.3.1
BRENDA, the Enzyme Database: 7.1.3.1

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Gene (2118)   
   KEGG GENES (644)   
   KEGG MGENES (1474)   
Protein sequence (6634)   
   UniProt (6598)   
   SWISS-PROT (35)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
All databases (8753)   

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