KEGG   ENZYME: 7.2.1.3
Entry
EC 7.2.1.3                  Enzyme                                 

Name
ascorbate ferrireductase (transmembrane);
cytochrome b561 (ambiguous)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to oxidoreductase reactions
Sysname
Fe(III):ascorbate oxidorectuctase (electron-translocating)
Reaction(IUBMB)
ascorbate[side 1] + Fe(III)[side 2] = monodehydroascorbate[side 1] + Fe(II)[side 2] [RN:R09739]
Reaction(KEGG)
R09739
Substrate
ascorbate[side 1];
Fe(III)[side 2]
Product
monodehydroascorbate[side 1];
Fe(II)[side 2]
Comment
A diheme cytochrome that transfers electrons across a single membrane, such as the outer membrane of the enterocyte, or the tonoplast membrane of the plant cell vacuole. Acts on hexacyanoferrate(III) and other ferric chelates.
History
EC 7.2.1.3 created 2011 as EC 1.16.5.1, transferred 2018 to EC 7.2.1.3
Orthology
K08360  transmembrane ascorbate-dependent reductase
K08370  plasma membrane ascorbate-dependent reductase
K08371  transmembrane reductase
K16295  lysosomal membrane ascorbate-dependent ferrireductase
Genes
HSA: 11068(CYB561D2) 1534(CYB561) 220002(CYB561A3) 79901(CYBRD1)
PTR: 451235(CYB561A3) 454783(CYB561) 737081(CYBRD1) 744998(CYB561D2)
PPS: 100972759 100972845 100974743 100993774
GGO: 101127828 101129483 101141704 101145063
PON: 100172064(CYB561) 100172640(CYBRD1) 100440126 100453039
NLE: 100588435 100593374 100594652 100603451
MCC: 693992 694818(CYBRD1) 702280(CYB561D2) 717700(CYB561)
MCF: 102120369 102126833 102134487 102142038
CSAB: 103217305(CYBRD1) 103227679(CYB561D2) 103234484 103243239(CYB561)
CATY: 105573726 105577593 105579798 105590727
CJC: 100407785(CYB561) 100408533(CYBRD1) 100409196(CYB561D2) 100415396(CYBASC3)
MMU: 13056(Cyb561) 225912(Cyb561a3) 56368(Cyb561d2) 73649(Cybrd1)
RNO: 295669(Cybrd1) 303601(Cyb561) 361729(Cyb561a3) 363137(Cyb561d2)
CFA: 478796(CYBRD1) 483799(CYB561A3) 484759(CYB561D2) 610631(CYB561)
BTA: 317663(CYB561) 523966(CYB561D2) 534257(CYBRD1) 615893(CYB561A3)
SSC: 100048996(CYB561) 100144591(CYBRD1) 100517372 100519643
ECB: 100059672(CYB561A3) 100061714 100063657 100064861(CYB561)
GGA: 100857844(CYB561D2) 419952(CYB561) 423025(CYB561A3) 424152(CYBRD1)
AMJ: 102565817(CYB561A3) 102573519(CYB561) 102575142(CYBRD1) 102576699(CYB561D2)
XLA: 108702564 108702990(cybrd1.S) 108714610(cyb561d2.L) 445864(cybrd1.L) 594867(cyb561.L) 734554(cyb561d2.S)
XTR: 448092(cyb561) 496973(cyb561d2) 548408(cybrd1)
DRE: 100002371(cyb561a3a) 450082(cyb561d2) 552960(cybrd1) 564404(cyb561a3b) 568765(cyb561)
IPU: 108254765(Cyb561d2) 108255680(cyb561a3) 108257034(CYB561) 108266665
CIN: 100181837 493872(cytb561)
DME: Dmel_CG10165(CG10165) Dmel_CG1275(CG1275) Dmel_CG13077(CG13077)
DSI: Dsimw501_GD13402(Dsim_GD13402) Dsimw501_GD21747(Dsim_GD21747) Dsimw501_GD24227(Dsim_GD24227)
NVI: 100116554 100216461(Cyb561d1-like) 100680086
BTAB: 109029671
CEL: CELE_F55H2.5(F55H2.5)
BMY: Bm1_13595
AQU: 100640227
ATH: AT1G14730 AT1G26100 AT4G25570(ACYB-2) AT5G38630(CYB-1)
LJA: Lj0g3v0041159.1(Lj0g3v0041159.1) Lj0g3v0264389.1(Lj0g3v0264389.1) Lj2g3v1172590.1(Lj2g3v1172590.1) Lj4g3v2409490.1(Lj4g3v2409490.1) Lj5g3v2013830.1(Lj5g3v2013830.1)
DOSA: Os03t0717200-00(Os03g0717200) Os04t0533500-02(Os04g0533500) Os08t0101700-01(Os08g0101700) Os08t0384000-01(Os08g0384000) Os10t0118800-00(Os10g0118800) Os10t0504200-01(Os10g0504200)
PPP: 112275606
APRO: F751_2113
 » show all
Reference
1  [PMID:4332308]
  Authors
Flatmark T, Terland O
  Title
Cytochrome b 561 of the bovine adrenal chromaffin granules. A high potential b-type cytochrome.
  Journal
Biochim Biophys Acta 253:487-91 (1971)
DOI:10.1016/0005-2728(71)90052-1
Reference
2  [PMID:11230685]
  Authors
McKie AT, Barrow D, Latunde-Dada GO, Rolfs A, Sager G, Mudaly E, Mudaly M, Richardson C, Barlow D, Bomford A, Peters TJ, Raja KB, Shirali S, Hediger MA, Farzaneh F, Simpson RJ
  Title
An iron-regulated ferric reductase associated with the absorption of dietary iron.
  Journal
Science 291:1755-9 (2001)
DOI:10.1126/science.1057206
  Sequence
[mmu:73649]
Reference
3  [PMID:16911521]
  Authors
Su D, Asard H
  Title
Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases.
  Journal
FEBS J 273:3722-34 (2006)
DOI:10.1111/j.1742-4658.2006.05381.x
Reference
4  [PMID:17376442]
  Authors
Berczi A, Su D, Asard H
  Title
An Arabidopsis cytochrome b561 with trans-membrane ferrireductase capability.
  Journal
FEBS Lett 581:1505-8 (2007)
DOI:10.1016/j.febslet.2007.03.006
  Sequence
[ath:AT4G25570]
Reference
5  [PMID:18498772]
  Authors
Wyman S, Simpson RJ, McKie AT, Sharp PA
  Title
Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro.
  Journal
FEBS Lett 582:1901-6 (2008)
DOI:10.1016/j.febslet.2008.05.010
  Sequence
[mmu:73649]
Reference
6  [PMID:21103361]
  Authors
Glanfield A, McManus DP, Smyth DJ, Lovas EM, Loukas A, Gobert GN, Jones MK
  Title
A cytochrome b561 with ferric reductase activity from the parasitic blood fluke,  Schistosoma japonicum.
  Journal
PLoS Negl Trop Dis 4:e884 (2010)
DOI:10.1371/journal.pntd.0000884
Other DBs
ExplorEnz - The Enzyme Database: 7.2.1.3
IUBMB Enzyme Nomenclature: 7.2.1.3
ExPASy - ENZYME nomenclature database: 7.2.1.3
BRENDA, the Enzyme Database: 7.2.1.3

DBGET integrated database retrieval system