KEGG   ENZYME: 7.2.1.3Help
Entry
EC 7.2.1.3                  Enzyme                                 

Name
ascorbate ferrireductase (transmembrane);
cytochrome b561 (ambiguous)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to oxidoreductase reactions
BRITE hierarchy
Sysname
Fe(III):ascorbate oxidorectuctase (electron-translocating)
Reaction(IUBMB)
ascorbate[side 1] + Fe(III)[side 2] = monodehydroascorbate[side 1] + Fe(II)[side 2] [RN:R09739]
Reaction(KEGG)
Substrate
ascorbate[side 1];
Fe(III)[side 2]
Product
monodehydroascorbate[side 1];
Fe(II)[side 2]
Comment
A diheme cytochrome that transfers electrons across a single membrane, such as the outer membrane of the enterocyte, or the tonoplast membrane of the plant cell vacuole. Acts on hexacyanoferrate(III) and other ferric chelates.
History
EC 7.2.1.3 created 2011 as EC 1.16.5.1, transferred 2018 to EC 7.2.1.3
Orthology
K08360  cytochrome b-561
K08370  cytochrome b reductase 1
Genes
HSA: 1534(CYB561) 79901(CYBRD1)
PTR: 454783(CYB561) 737081(CYBRD1)
PPS: 100972759 100993774
GGO: 101141704 101145063
PON: 100172064(CYB561) 100172640(CYBRD1)
NLE: 100593374 100603451
MCC: 694818(CYBRD1) 717700(CYB561)
MCF: 102120369 102126833
CSAB: 103217305(CYBRD1) 103243239(CYB561)
RRO: 104673524 104675477
CJC: 100407785(CYB561) 100408533(CYBRD1)
MMU: 13056(Cyb561) 73649(Cybrd1)
RNO: 295669(Cybrd1) 303601(Cyb561)
CFA: 478796(CYBRD1) 610631(CYB561)
BTA: 317663(CYB561) 534257(CYBRD1)
CHX: 100861136(CYBRD1) 102171650
OAS: 100048995(CYB561) 101106919
SSC: 100048996(CYB561) 100144591(CYBRD1)
ECB: 100063657 100064861(CYB561)
GGA: 419952(CYB561) 424152(CYBRD1)
ETL: 114066936
AAM: 106499316
AMJ: 102573519(CYB561) 102575142(CYBRD1)
ACS: 100557049
XLA: 108702564 108702990(cybrd1.S) 445864(cybrd1.L) 594867(cyb561.L)
XTR: 448092(cyb561) 548408(cybrd1)
DRE: 552960(cybrd1) 568765(cyb561)
IPU: 108257034(CYB561) 108266665
CSEM: 103393598
SASA: 106581770(CYBR1) 106586222(CYBR1) 106601255 106607179
ELS: 105013410
CIN: 493872(cytb561)
SKO: 100375613
DME: Dmel_CG1275(CG1275)
DER: 6546416
DSI: Dsimw501_GD13402(Dsim_GD13402)
DSR: 110188879
DPE: 6601252
DMN: 108151561
DWI: 6645004
DAZ: 108613785
DNV: 108651717
DHE: 111598672
MDE: 101892876
LCQ: 111676889
AAG: 5576849
AME: 102653815
BIM: 105680615
BTER: 105665781
CCAL: 108631742
OBB: 114876015
SOC: 105196371
MPHA: 105833226
AEC: 105146760
ACEP: 105617558
PBAR: 105428175
VEM: 105557724
HST: 105187427
DQU: 106752201
CFO: 105249325
LHU: 105676266
PGC: 109853405
OBO: 105279458
PCF: 106790116
NVI: 100116554
CSOL: 105359638
MDL: 103579995
TCA: 103313372
DPA: 109537074
NVL: 108559273
BMOR: 101741447
PMAC: 106720394
HAW: 110369904
TNL: 113505853
PXY: 105395397
BTAB: 109029671
FCD: 110846271
DPX: DAPPUDRAFT_309046(CB561)
PVM: 113808424
CEL: CELE_F55H2.5(F55H2.5)
CBR: CBG10069
BMY: Bm1_13595
PCAN: 112564419
CRG: 105330881
MYI: 110451809
OBI: 106867894
SHX: MS3_10028
EGL: EGR_06957
EPA: 110233264
ADF: 107336029
AMIL: 114957289
HMG: 100210950
ATH: AT1G14730 AT1G26100 AT4G25570(ACYB-2) AT5G38630(CYB-1)
LJA: Lj0g3v0041159.1(Lj0g3v0041159.1) Lj0g3v0264389.1(Lj0g3v0264389.1) Lj2g3v1172590.1(Lj2g3v1172590.1) Lj4g3v2409490.1(Lj4g3v2409490.1) Lj5g3v2013830.1(Lj5g3v2013830.1)
DOSA: Os02t0642300-01(Os02g0642300) Os03t0717200-00(Os03g0717200) Os04t0533500-02(Os04g0533500) Os08t0384000-01(Os08g0384000) Os10t0118800-00(Os10g0118800) Os10t0504200-01(Os10g0504200)
ATS: 109740617(LOC109740617) 109742180(LOC109742180) 109748026(LOC109748026) 109753829(LOC109753829) 109762793(LOC109762793) 109768401(LOC109768401)
PPP: 112275606
APRO: F751_2113
 » show all
Taxonomy
Reference
1  [PMID:4332308]
  Authors
Flatmark T, Terland O
  Title
Cytochrome b 561 of the bovine adrenal chromaffin granules. A high potential b-type cytochrome.
  Journal
Biochim Biophys Acta 253:487-91 (1971)
DOI:10.1016/0005-2728(71)90052-1
Reference
2  [PMID:11230685]
  Authors
McKie AT, Barrow D, Latunde-Dada GO, Rolfs A, Sager G, Mudaly E, Mudaly M, Richardson C, Barlow D, Bomford A, Peters TJ, Raja KB, Shirali S, Hediger MA, Farzaneh F, Simpson RJ
  Title
An iron-regulated ferric reductase associated with the absorption of dietary iron.
  Journal
Science 291:1755-9 (2001)
DOI:10.1126/science.1057206
  Sequence
[mmu:73649]
Reference
3  [PMID:16911521]
  Authors
Su D, Asard H
  Title
Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases.
  Journal
FEBS J 273:3722-34 (2006)
DOI:10.1111/j.1742-4658.2006.05381.x
Reference
4  [PMID:17376442]
  Authors
Berczi A, Su D, Asard H
  Title
An Arabidopsis cytochrome b561 with trans-membrane ferrireductase capability.
  Journal
FEBS Lett 581:1505-8 (2007)
DOI:10.1016/j.febslet.2007.03.006
  Sequence
[ath:AT4G25570]
Reference
5  [PMID:18498772]
  Authors
Wyman S, Simpson RJ, McKie AT, Sharp PA
  Title
Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro.
  Journal
FEBS Lett 582:1901-6 (2008)
DOI:10.1016/j.febslet.2008.05.010
  Sequence
[mmu:73649]
Reference
6  [PMID:21103361]
  Authors
Glanfield A, McManus DP, Smyth DJ, Lovas EM, Loukas A, Gobert GN, Jones MK
  Title
A cytochrome b561 with ferric reductase activity from the parasitic blood fluke,  Schistosoma japonicum.
  Journal
PLoS Negl Trop Dis 4:e884 (2010)
DOI:10.1371/journal.pntd.0000884
Other DBs
ExplorEnz - The Enzyme Database: 7.2.1.3
IUBMB Enzyme Nomenclature: 7.2.1.3
ExPASy - ENZYME nomenclature database: 7.2.1.3
BRENDA, the Enzyme Database: 7.2.1.3

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