KEGG   ENZYME: 7.2.2.11Help
Entry
EC 7.2.2.11                 Enzyme                                 

Name
ABC-type Ni2+ transporter;
nickel ABC transporter;
nickel-transporting ATPase;
ABC-type nickel-transporter
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, Ni2+-importing)
Reaction(IUBMB)
ATP + H2O + Ni2+-[nickel-binding protein][side 1] = ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Ni2+-[nickel-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Ni2+[side 2];
[nickel-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of Ni2+; the identity of the nickel species transported has not been conclusively established. Does not undergo phosphorylation during the transport process.
History
EC 7.2.2.11 created 2000 as EC 3.6.3.24, transferred 2018 to EC 7.2.2.11
Orthology
K10824  nickel transport system ATP-binding protein
K15587  nickel transport system ATP-binding protein
Genes
ECO: b3479(nikD) b3480(nikE)
ECJ: JW3444(nikD) JW3445(nikE)
ECD: ECDH10B_3653(nikD) ECDH10B_3654(nikE)
EBW: BWG_3170(nikD) BWG_3171(nikE)
ECOK: ECMDS42_2918(nikD) ECMDS42_2919(nikE)
ECE: Z4871(nikD) Z4872(nikE)
ECS: ECs4346(nikD) ECs4347(nikE)
ECF: ECH74115_4819(nikD) ECH74115_4820(nikE)
ETW: ECSP_4453(nikD) ECSP_4454(nikE)
ELX: CDCO157_4083(nikD) CDCO157_4084(nikE)
EOJ: ECO26_4566(nikD) ECO26_4567(nikE)
EOI: ECO111_4287(nikD) ECO111_4288(nikE)
EOH: ECO103_4199(nikD) ECO103_4200(nikE)
ECOO: ECRM13514_4452(nikD) ECRM13514_4453(nikE)
ECOH: ECRM13516_4250(nikD) ECRM13516_4251(nikE)
ECG: E2348C_3720(nikD) E2348C_3721(nikE)
EOK: G2583_4200(nikD) G2583_4201(nikE)
ESO: O3O_23985(nikD) O3O_23990(nikE)
ESM: O3M_01700(nikE) O3M_01705(nikD)
ESL: O3K_01655(nikE) O3K_01660(nikD)
ECW: EcE24377A_3963(nikD) EcE24377A_3964(nikE)
EUN: UMNK88_4249(nikD) UMNK88_4250(nikE)
ECC: c4272(nikD) c4273(nikE)
ECI: UTI89_C3996(nikD) UTI89_C3997(nikE)
ECV: APECO1_2974(nikE) APECO1_2975(nikD)
ECX: EcHS_A3678(nikD) EcHS_A3679(nikE)
ECM: EcSMS35_3763(nikD) EcSMS35_3764(nikE)
ECR: ECIAI1_3626(nikD) ECIAI1_3627(nikE)
ECQ: ECED1_4152(nikD) ECED1_4153(nikE)
ECK: EC55989_3887(nikD) EC55989_3888(nikE)
ECT: ECIAI39_3960(nikD) ECIAI39_3961(nikE)
EOC: CE10_4003(nikD) CE10_4004(nikE)
EUM: ECUMN_3960(nikD) ECUMN_3961(nikE)
ECZ: ECS88_3882(nikD) ECS88_3883(nikE)
ELO: EC042_3759(nikD) EC042_3760(nikE)
ELN: NRG857_17250(nikD) NRG857_17255(nikE)
EBR: ECB_03328(nikD) ECB_03329(nikE)
EKF: KO11_05370(nikE) KO11_05375(nikD)
EAB: ECABU_c39090(nikD) ECABU_c39100(nikE)
EIH: ECOK1_3908(nikD) ECOK1_3909(nikE)
ENA: ECNA114_3588(nikD) ECNA114_3589(nikE)
ELU: UM146_17520(nikD) UM146_17525(nikE)
ELW: ECW_m3741(nikD) ECW_m3742(nikE)
ELL: WFL_18270(nikD) WFL_18275(nikE)
ELC: i14_3942(nikD) i14_3943(nikE)
ELD: i02_3942(nikD) i02_3943(nikE)
ELP: P12B_c3576(nikD) P12B_c3577(nikE)
EBL: ECD_03328(nikD) ECD_03329(nikE)
EBE: B21_03281(nikD) B21_03282(nikE)
ELF: LF82_1491(nikD) LF82_1492(nikE)
ECOI: ECOPMV1_03800(gsiA_7) ECOPMV1_03801(gsiA_8)
ECOS: EC958_3873(nikD) EC958_3874(nikE)
EAL: EAKF1_ch2474c(nikE) EAKF1_ch2475c(nikD)
EMA: C1192_15330(nikD) C1192_15335(nikE)
SFL: SF3497(nikD) SF3498(nikE)
SFX: S4265(nikE) S4266(nikD)
SFV: SFV_3482(nikD) SFV_3483(nikE)
SFE: SFxv_3813(nikD) SFxv_3814(nikE)
SFT: NCTC1_03779(nikD) NCTC1_03780(nikE)
SSN: SSON_3717(nikD) SSON_3718(nikE)
SBO: SBO_3476(nikD) SBO_3477(nikE)
SBC: SbBS512_E3841(nikE) SbBS512_E3842(nikD)
SDY: SDY_3634(nikD) SDY_3635(nikE)
SHQ: A0259_21155(nikD) A0259_21160(nikE)
ENR: H650_13785(nikD) H650_13790(nikE)
ENF: AKI40_0299(nikE) AKI40_0300(nikD)
KPN: KPN_03853(nikD) KPN_03854(nikE)
KPU: KP1_5192(nikD) KP1_5193(nikE)
KPH: KPNIH24_24960(nikD) KPNIH24_24965(nikE)
KPZ: KPNIH27_23880(nikD) KPNIH27_23885(nikE)
KPV: KPNIH29_24800(nikD) KPNIH29_24805(nikE)
KPW: KPNIH30_25250(nikD) KPNIH30_25255(nikE)
KPY: KPNIH31_24305(nikD) KPNIH31_24310(nikE)
KPG: KPNIH32_26120(nikD) KPNIH32_26125(nikE)
KPC: KPNIH10_24925(nikD) KPNIH10_24930(nikE)
KPQ: KPR0928_24445(nikD) KPR0928_24450(nikE)
KPT: VK055_3616(nikE3) VK055_3617
KPE: KPK_0259(nikE) KPK_0260(nikD)
KPO: KPN2242_22275(nikD) KPN2242_22280(nikE)
KPR: KPR_5063
KPX: PMK1_01355(nikD) PMK1_01356(nikE)
KPB: FH42_15600(nikD) FH42_15605(nikE)
KPNE: KU54_001340(nikE) KU54_001345(nikD)
KPNU: LI86_01335(nikE) LI86_01340(nikD)
KPNK: BN49_0263(nikE) BN49_0264(nikD)
KPK: A593_09470(nikD) A593_09475(nikE)
KOX: KOX_05120(nikD) KOX_05125(nikE)
KOY: J415_04630(nikE) J415_04635(nikD)
KOM: HR38_03600(nikD) HR38_03605(nikE)
KOK: KONIH1_27650(nikD) KONIH1_27655(nikE)
KOC: AB185_08740(nikE) AB185_08745(nikD)
EAE: EAE_05730(nikD) EAE_05735(nikE)
KQV: B8P98_01355(nikE) B8P98_01360(nikD)
CRO: ROD_43171(nikE) ROD_43181(nikD)
CAMA: F384_18955(nikD) F384_18960(nikE)
CAF: AL524_01620(nikD) AL524_01625(nikE)
CFAR: CI104_01230(nikD)
CIR: C2U53_08205(nikD) C2U53_08210(nikE)
EBT: EBL_c18430(nikD) EBL_c18440(nikE)
ROR: RORB6_20080(nikE) RORB6_20085(nikD)
RON: TE10_00910(nikD) TE10_00915(nikE)
RAO: DSD31_01415(nikE) DSD31_01420(nikD)
PGE: LG71_23340(nikE) LG71_23345(nikD)
KLE: AO703_09095(nikE) AO703_09100(nikD)
KOR: AWR26_01270(nikE) AWR26_01275(nikD)
KRD: A3780_23460(nikD) A3780_23465(nikE)
KOT: EH164_01235(nikE) EH164_01240(nikD)
LEW: DAI21_16615(nikE) DAI21_16620(nikD)
METY: MRY16398_03180(nikE) MRY16398_03190(nikD)
AHN: NCTC12129_03655(nikD_2) NCTC12129_03656(nikE)
EBC: C2U52_09820(nikE) C2U52_09825(nikD)
EBU: CUC76_16900(nikE) CUC76_16905(nikD)
ETR: ETAE_1375(nikE) ETAE_1376(nikD)
ETD: ETAF_1278(nikE) ETAF_1279(nikD)
ETE: ETEE_3364(nikE) ETEE_3365(nikD)
ETC: ETAC_06500(nikE) ETAC_06505(nikD)
EDW: QY76_13060(nikD) QY76_13065(nikE)
EDL: AAZ33_07155(nikE) AAZ33_07160(nikD)
KIN: AB182_26985(nikE) AB182_26990(nikD)
MSU: MS0462(oppF) MS0463(dppD)
PPU: PP_3345(nikD) PP_3346(nikE)
PFZ: AV641_09925(nikE) AV641_09930(nikD)
PLQ: AA042_21065(nikD) AA042_21070(nikE)
PPSY: AOC04_06810(nikE) AOC04_06815(nikD)
HHE: HH_0414(nikE) HH_0415(nikD)
HCP: HCN_0693(nikE)
HCB: HCBAA847_1296(nikE) HCBAA847_1297(nikCD)
WSU: WS0977(dppF) WS0978(OPP-1D) WS0987(OPP-1D) WS0988
AHS: AHALO_0705(nikE) AHALO_0706(nikD)
DDS: Ddes_1029
DMA: DMR_12000(nikE) DMR_12010(nikD)
AVI: Avi_7617(nikD) Avi_7618(nikE)
BMEL: DK63_2751(nikE) DK63_2752(nikD)
BMI: BMEA_B0779(nikE) BMEA_B0780(nikD)
BMZ: BM28_B0769(nikE) BM28_B0770(nikD)
BMG: BM590_B0767(nikE) BM590_B0768(nikD)
BMEE: DK62_2647(nikD) DK62_2648(nikE)
BMB: BruAb2_0431(nikD) BruAb2_0432(nikE)
BABO: DK55_2425(nikD) DK55_2426(nikE)
BABR: DO74_2840(nikD) DO74_2841(nikE)
BABT: DK49_2813(nikE) DK49_2814(nikD)
BABB: DK48_2265(nikE) DK48_2266(nikD)
BABU: DK53_2428(nikD) DK53_2429(nikE)
BABS: DK51_3010(nikD) DK51_3011(nikE)
BABC: DO78_2629(nikE) DO78_2630(nikD)
BMS: BRA0800(nikE) BRA0801(nikD)
BSI: BS1330_II0793(nikE) BS1330_II0794(nikD)
BSF: BSS2_II0759(nikE) BSS2_II0760(nikD)
BSUI: BSSP1_II0741(nikE) BSSP1_II0742(nikD)
BSUP: BSPT1_II0739(nikE) BSPT1_II0740(nikD)
BSUV: BSPT2_II0741(nikE) BSPT2_II0742(nikD)
BSUC: BSSP2_II0752(nikE) BSSP2_II0753(nikD)
BMT: BSUIS_B0792(nikE) BSUIS_B0793(nikD)
BSZ: DK67_2757(nikE) DK67_2758(nikD)
BSV: BSVBI22_B0792(nikE) BSVBI22_B0793(nikD)
BSW: IY71_15010(nikE) IY71_15015(nikD)
BSG: IY72_14965(nikE) IY72_14970(nikD)
BOV: BOV_A0750(nikE)
BCS: BCAN_B0814(nikE) BCAN_B0815(nikD)
BOL: BCOUA_II0800(nikE) BCOUA_II0801(nikD)
BCAR: DK60_2493(nikE) DK60_2494(nikD)
BCAS: DA85_14300(nikE) DA85_14305(nikD)
BMR: BMI_II794(nikE) BMI_II795(nikD)
BPP: BPI_II856(nikE) BPI_II857(nikD)
BPV: DK65_2843(nikD) DK65_2844(nikE)
MAQU: Maq22A_c23670(dppF) Maq22A_c23675(dppD)
RSU: NHU_03949(nikD) NHU_03950(nikE)
RRU: Rru_A2273(nikE) Rru_A2274(nikD)
RRF: F11_11690(nikE) F11_11695(nikD)
ATI: AL072_10200(nikD) AL072_10205(nikE)
THAC: CSC3H3_23880(nikE) CSC3H3_23885(nikD)
BLI: BL02421(appDB) BL02422(appFB)
BLD: BLi02814(appD2) BLi02815(appF2)
BLH: BaLi_c29090(appD2) BaLi_c29100(appF2)
BMQ: BMQ_1718(nikD) BMQ_1719(nikE)
BMD: BMD_1705(nikD) BMD_1706(nikE)
BMEG: BG04_4027(nikD) BG04_4028(nikE)
BKW: BkAM31D_01695(oppD_2) BkAM31D_01700(oppF_2)
LSP: Bsph_2973(nikE) Bsph_2974(dppD)
SAU: SA2251(opp-1F) SA2252(opp-1D)
SAM: MW2387(opp-1F) MW2388(opp-1D)
SAR: SAR2550(opp-1F) SAR2551(opp-1D)
SAE: NWMN_2360(opp1F) NWMN_2361(opp1D)
SUJ: SAA6159_02360(opp-1F) SAA6159_02361(opp-1D)
SUK: SAA6008_02504(opp-1F) SAA6008_02505(opp-1D)
SUX: SAEMRSA15_23610(opp-1F) SAEMRSA15_23620(opp-1D)
SUW: SATW20_25910(opp-1F) SATW20_25920(opp-1D)
SUF: SARLGA251_22430(opp-1F) SARLGA251_22440(opp-1D)
SAUE: RSAU_002301(opp1F) RSAU_002302(opp1D)
SAUS: SA40_2211(opp-1F) SA40_2212(opp-1D)
SAUU: SA957_2295(opp-1F) SA957_2296(opp-1D)
SAUG: SA268_2368(opp-1F) SA268_2369(opp-1D)
SAUZ: SAZ172_2566(opp-1F) SAZ172_2567(opp-1D)
SAB: SAB2346c(opp1F) SAB2347c(opp1D)
SUY: SA2981_2400(opp-1F) SA2981_2401(opp-1D)
SAUB: C248_2513(opp-1F) C248_2514(opp-1D)
SLN: SLUG_01490(opp-1D) SLUG_01500(opp-1F)
SXO: SXYL_00074(nikD) SXYL_00075(nikE)
BLR: BRLA_c028600(nikE_1)
PPM: PPSC2_24670(nikE) PPSC2_24675(nikD)
PPO: PPM_4902(nikE) PPM_4903(nikD)
ASOC: CB4_02653(nikE) CB4_02655(oppD_1)
SAK: SAK_1538(nikE) SAK_1539(nikD)
SGC: A964_1421(nikE) A964_1422(nikD)
SAGL: GBS222_1255(nikE) GBS222_1256(nikD)
SSA: SSA_0503 SSA_0504(amiF)
SANC: SANR_1336
AWO: Awo_c00450(oppD4) Awo_c00460(oppF4)
MANA: MAMMFC1_00010(gsiA_1)
LET: O77CONTIG1_00102(nikE)
TPED: TPE_2548(nikE) TPE_2549(nikC)
 » show all
Taxonomy
Reference
1  [PMID:7569321]
  Authors
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr.
  Title
Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
  Journal
Res Microbiol 146:271-8 (1995)
DOI:10.1016/0923-2508(96)81050-3
Reference
2  [PMID:9294450]
  Authors
Hendricks JK, Mobley HL.
  Title
Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity.
  Journal
J Bacteriol 179:5892-902 (1997)
DOI:10.1128/JB.179.18.5892-5902.1997
Reference
3  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Reference
4
  Authors
Griffiths, J.K. and Sansom, C.E.
  Title
The Transporter Factsbook, Academic Press, San Diego, 1998.
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.11
IUBMB Enzyme Nomenclature: 7.2.2.11
ExPASy - ENZYME nomenclature database: 7.2.2.11
BRENDA, the Enzyme Database: 7.2.2.11

DBGET integrated database retrieval system