KEGG   ENZYME: 7.2.2.13
Entry
EC 7.2.2.13                 Enzyme                                 

Name
Na+/K+-exchanging ATPase;
(Na+ + K+)-activated ATPase;
Na,K-activated ATPase;
Na,K-pump;
Na+,K+-ATPase;
sodium/potassium-transporting ATPase;
Na+/K+-exchanging ATPase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (P-type, Na+/K+-exchanging)
Reaction(IUBMB)
ATP + H2O + Na+[side 1] + K+[side 2] = ADP + phosphate + Na+[side 2] + K+[side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+[side 1];
K+[side 2]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+[side 2];
K+[side 1]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.
History
EC 7.2.2.13 created 1984 EC 3.6.1.37, transferred 2000 to EC 3.6.3.9, modified 2001, transferred 2018 to EC 7.2.2.13
Orthology
K01539  sodium/potassium-transporting ATPase subunit alpha
Genes
HSA: 476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 100968564(ATP1A2) 100968910(ATP1A4) 100973141(ATP1A3) 100992562(ATP1A1)
GGO: 101132606(ATP1A2) 101133472(ATP1A4) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
NLE: 100585801(ATP1A2) 100586342(ATP1A4) 100596870(ATP1A1) 100604238(ATP1A3)
MCC: 706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MCF: 102122869(ATP1A3) 102124503(ATP1A1) 102144576(ATP1A4) 102145563(ATP1A2)
CSAB: 103223730(ATP1A4) 103223733(ATP1A2) 103224143(ATP1A1) 103234751(ATP1A3)
RRO: 104658863(ATP1A3) 104660405(ATP1A4) 104660406(ATP1A2) 104665933(ATP1A1)
RBB: 108524039(ATP1A4) 108524041(ATP1A2) 108528132(ATP1A1)
CJC: 100393318(ATP1A1) 100402438(ATP1A2) 100403160(ATP1A4) 100410682(ATP1A3)
SBQ: 101035314 101035941(ATP1A2) 101041249(ATP1A1) 101044048(ATP1A3)
MMU: 11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
MCAL: 110290752(Atp1a1) 110291780(Atp1a4) 110296540 110297290(Atp1a3)
MPAH: 110319913(Atp1a1) 110321177(Atp1a4) 110322617 110337068(Atp1a3)
RNO: 24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CGE: 100758209(Atp1a3) 100763191(Atp1a4) 100763478(Atp1a2) 100771378(Atp1a1)
NGI: 103734951(Atp1a1) 103740231(Atp1a2) 103740266(Atp1a4) 103744609(Atp1a3)
HGL: 101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
CCAN: 109681948 109688512(Atp1a3) 109690073(Atp1a4) 109690076
OCU: 100008756(ATP1A2) 100302415(ATP1A1) 100349382(ATP1A3) 100358269(ATP1A4)
TUP: 102475448(ATP1A3) 102483255(ATP1A2) 102483994(ATP1A1)
CFA: 403992(ATP1A1) 488636 612463(ATP1A3)
VVP: 112910077 112910081 112916773(ATP1A1) 112931443(ATP1A3)
AML: 100477585(ATP1A3) 100477989(ATP1A1) 100480641 100480890(ATP1A4)
UMR: 103669413(ATP1A1) 103672049(ATP1A4) 103672113(ATP1A2) 103680185(ATP1A3)
UAH: 113243247(ATP1A3) 113244381(ATP1A1) 113246653(ATP1A4) 113246737
ORO: 101366083(ATP1A1) 101376936(ATP1A3) 101379349(ATP1A2) 101379646(ATP1A4)
FCA: 101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4) 101096785
PTG: 102954810 102955336(ATP1A3) 102955398 102971148(ATP1A1)
PPAD: 109257219 109257221(ATP1A2) 109257944(ATP1A3) 109272127(ATP1A1)
AJU: 106969643(ATP1A1) 106978517(ATP1A4) 106985576 106987698(ATP1A3)
BTA: 282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
BOM: 102270922(ATP1A3) 102271837(ATP1A2) 102272122(ATP1A4) 102287260(ATP1A1)
BIU: 109555876(ATP1A1) 109571737(ATP1A3) 109578704(ATP1A4) 109578722
BBUB: 102396896(ATP1A3) 102404308(ATP1A1) 102405290 102405960(ATP1A4)
CHX: 102179588(ATP1A3) 102183561(ATP1A1) 102186069(ATP1A4) 102186539(ATP1A2)
OAS: 101103751(ATP1A3) 101118148(ATP1A2) 101118398 443381(ATP1A1)
SSC: 100157711 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
CFR: 102509736(ATP1A1) 102516053(ATP1A2) 102516646(ATP1A4) 102517975(ATP1A3)
CDK: 105089616(ATP1A1) 105090227(ATP1A3) 105100141(ATP1A2) 116147050(ATP1A4)
BACU: 102998568(ATP1A1) 103005321(ATP1A4) 103005600(ATP1A2) 103011003(ATP1A3)
LVE: 103068908(ATP1A3) 103074614(ATP1A4) 103074894(ATP1A2) 103085693(ATP1A1)
OOR: 101279507(ATP1A1) 101280223(ATP1A3) 101288540(ATP1A4) 101288792(ATP1A2)
DLE: 111166986 111166987 111179983(ATP1A1) 111180802(ATP1A3)
PCAD: 102981487 102982135 102983659(ATP1A1) 102985775(ATP1A3)
ECB: 100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
EPZ: 103543741 103547749(ATP1A1) 103551135(ATP1A4) 103551139(ATP1A2)
EAI: 106835689(ATP1A1) 106835754(ATP1A4) 106835755(ATP1A2) 106847933(ATP1A3)
MYB: 102242637(ATP1A3) 102243691(ATP1A1) 102243972(ATP1A4) 102244267(ATP1A2)
MYD: 102757270(ATP1A2) 102757556(ATP1A4) 102762810(ATP1A3) 102770472(ATP1A1)
MNA: 107534181(ATP1A3) 107538456 107545330(ATP1A1)
HAI: 109374464(ATP1A3) 109386501(ATP1A2) 109392813(ATP1A1)
DRO: 112313776(ATP1A1) 112315807 112317734(ATP1A2) 112320186(ATP1A3)
PALE: 102884868(ATP1A4) 102885125 102888359(ATP1A1) 102893697(ATP1A3)
RAY: 107499819(ATP1A1) 107502600(ATP1A3) 107507949(ATP1A2) 107507966(ATP1A4)
MJV: 108390973(ATP1A1) 108393642(ATP1A3) 108402828 108402834
LAV: 100661428(ATP1A1) 100667801 100668326(ATP1A3) 100674070(ATP1A2)
MDO: 100029754(ATP1A4) 100029759(ATP1A2)
SHR: 100914130(ATP1A2) 100918637 100922123(ATP1A3) 100928210(ATP1A1)
PCW: 110203112(ATP1A2) 110203115 110219354(ATP1A1) 110220180(ATP1A3)
OAA: 100083795 100088125(ATP1A3) 100088592(ATP1A1) 103166927
GGA: 396530(ATP1A1)
MGP: 100303690(ATP1A1) 104915899
NMEL: 110399227(ATP1A1)
APLA: 101801864(ATP1A1)
ACYG: 106029333 106037472(ATP1A1)
TGU: 100190719(ATP1A1) 105760330
SCAN: 103827109(ATP1A1)
GFR: 102036467(ATP1A1)
FAB: 101813002(ATP1A1) 101813385
PHI: 102104980 102106372(ATP1A1) 102107817(ATP1A2)
PMAJ: 107207264(ATP1A1)
CCAE: 111938980(ATP1A1)
CCW: 104687046(ATP1A1)
ETL: 114055106(ATP1A1)
FPG: 101914787(ATP1A1) 101915017(ATP1A2)
FCH: 102050259(ATP1A1) 102059303(ATP1A2)
CLV: 102092496(ATP1A1) 102093141
EGZ: 104126505(ATP1A1)
NNI: 104008633(ATP1A1) 104012600(ATP1A2)
ACUN: 113485715
PADL: 103921389(ATP1A1)
AAM: 106490649(ATP1A1) 106500059(ATP1A2)
AMJ: 102567591(ATP1A1) 102575084(ATP1A2) 106737151
CMY: 102936217(ATP1A1) 102938341(ATP1A2)
CPIC: 101931556(ATP1A3) 101933418(ATP1A1) 101950302(ATP1A2)
PMUR: 107289344(ATP1A1) 107298220 107299011(ATP1A3)
PMUA: 114585062 114586449 114587332(ATP1A1) 114603364(ATP1A3)
XLA: 108697760 108699431 380132(atp1a3.L) 398583(atp1a1.S) 398752(atp1a2.S) 399285(atp1a1.L)
XTR: 100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 245703(atp1a1a.5) 64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64613(atp1a1a.2) 64614(atp1a1a.3) 64615(atp1a1a.4) 64616(atp1a1b)
LCM: 102352604(ATP1A2) 102353554(ATP1A1) 102356851(ATP1A3)
BFO: 118424338
APLC: 110976714
SKO: 100370816(ATP1A1)
DME: Dmel_CG45062(CG45062) Dmel_CG45760 Dmel_CG5670(Atpalpha)
DSI: Dsimw501_GD19388(Dsim_GD19388) Dsimw501_GD19691(Dsim_GD19691) Dsimw501_GD29095(Dsim_GD29095)
DAN: 6500777
DVI: 6632311
MDE: 101893028
LCQ: 111678276
AAG: 5575790
NVI: 100116320
CLEC: 106667156
ZNE: 110827645
CEL: CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2) CELE_Y105E8A.12(catp-1)
CBR: CBG01656 CBG08751(Cbr-catp-1) CBG09434(Cbr-eat-6) CBG19651
CRG: 105338008
MYI: 110459295
OBI: 106880261
EGL: EGR_08003
ADF: 107343492
DGT: 114524594
AQU: 100634317
QSU: 111989924
PIC: PICST_60178(PMR2)
CAL: CAALFM_CR01630CA(CaO19.2552) CAALFM_CR01640CA(CaO19.2553)
SLB: AWJ20_4150(PMR1)
MBE: MBM_04409
ANI: AN8941.2
ANG: ANI_1_1014084(An09g00930) ANI_1_352124(An14g02290)
PTE: PTT_00480
TASA: A1Q1_02917
SMIN: v1.2.028598.t1(symbB.v1.2.028598.t1)
METL: U737_16210
MMAI: sS8_5209
TCX: Tcr_1065
HMAR: HVMH_1068
CYQ: Q91_1618
TAU: Tola_1844
PSE: NH8B_2287
SLT: Slit_1198
GCA: Galf_2615
SLAC: SKTS_18720
DAR: Daro_1851
AZA: AZKH_2708
SULR: B649_05270
GUR: Gura_3300
GEO: Geob_1849
PCA: Pcar_2279
PPD: Ppro_1564
SAT: SYN_02485
MGRY: MSR1_15930
MAGX: XM1_2567
MAGN: WV31_04655
LBF: LBF_2665
ABAC: LuPra_03991(yloB_2)
NDE: NIDE3786
CTHI: THC_0765
MOX: DAMO_0992
MBAR: MSBR2_3266
MBAK: MSBR3_3261
MAC: MA_4378
MMA: MM_1069
MMAC: MSMAC_0238
METM: MSMTP_0268
MHOR: MSHOH_0294
MBU: Mbur_0431
MPY: Mpsy_0778
 » show all
Reference
1  [PMID:13412736]
  Authors
SKOU JC.
  Title
The influence of some cations on an adenosine triphosphatase from peripheral nerves.
  Journal
Biochim Biophys Acta 23:394-401 (1957)
DOI:10.1016/0006-3002(57)90343-8
Reference
2  [PMID:14284759]
  Authors
POST RL, SEN AK, ROSENTHAL AS.
  Title
A PHOSPHORYLATED INTERMEDIATE IN ADENOSINE TRIPHOSPHATE-DEPENDENT SODIUM AND POTASSIUM TRANSPORT ACROSS KIDNEY MEMBRANES.
  Journal
J Biol Chem 240:1437-45 (1965)
Reference
3  [PMID:2166689]
  Authors
Skou JC.
  Title
The fourth Datta lecture. The energy coupled exchange of Na+ for K+ across the cell membrane. The Na+, K(+)-pump.
  Journal
FEBS Lett 268:314-24 (1990)
DOI:10.1016/0014-5793(90)81278-V
Reference
4  [PMID:26205423]
  Authors
Castillo JP, Rui H, Basilio D, Das A, Roux B, Latorre R, Bezanilla F, Holmgren M
  Title
Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.
  Journal
Nat Commun 6:7622 (2015)
DOI:10.1038/ncomms8622
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.13
IUBMB Enzyme Nomenclature: 7.2.2.13
ExPASy - ENZYME nomenclature database: 7.2.2.13
BRENDA, the Enzyme Database: 7.2.2.13

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