KEGG   ENZYME: 7.2.2.13Help
Entry
EC 7.2.2.13                 Enzyme                                 

Name
Na+/K+-exchanging ATPase;
(Na+ + K+)-activated ATPase;
Na,K-activated ATPase;
Na,K-pump;
Na+,K+-ATPase;
sodium/potassium-transporting ATPase;
Na+/K+-exchanging ATPase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (P-type, Na+/K+-exchanging)
Reaction(IUBMB)
ATP + H2O + Na+[side 1] + K+[side 2] = ADP + phosphate + Na+[side 2] + K+[side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+[side 1];
K+[side 2]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+[side 2];
K+[side 1]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.
History
EC 7.2.2.13 created 1984 EC 3.6.1.37, transferred 2000 to EC 3.6.3.9, modified 2001, transferred 2018 to EC 7.2.2.13
Orthology
K01539  sodium/potassium-transporting ATPase subunit alpha
Genes
HSA: 476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 100968564(ATP1A2) 100968910(ATP1A4) 100973141(ATP1A3) 100992562(ATP1A1)
GGO: 101132606(ATP1A2) 101133472(ATP1A4) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
NLE: 100585801(ATP1A2) 100586342(ATP1A4) 100596870(ATP1A1) 100604238(ATP1A3)
MCC: 706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MCF: 102122869(ATP1A3) 102124503(ATP1A1) 102144576(ATP1A4) 102145563(ATP1A2)
CSAB: 103223730(ATP1A4) 103223733(ATP1A2) 103224143(ATP1A1) 103234751(ATP1A3)
RRO: 104658863(ATP1A3) 104660405(ATP1A4) 104660406(ATP1A2) 104665933(ATP1A1)
RBB: 108524039(ATP1A4) 108524041(ATP1A2) 108528132(ATP1A1)
CJC: 100393318(ATP1A1) 100402438(ATP1A2) 100403160(ATP1A4) 100410682(ATP1A3)
SBQ: 101035314 101035941(ATP1A2) 101041249(ATP1A1) 101044048(ATP1A3) 104652875
MMU: 11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
MCAL: 110290752(Atp1a1) 110291780(Atp1a4) 110296540 110297290(Atp1a3)
MPAH: 110319913(Atp1a1) 110321177(Atp1a4) 110322617 110337068(Atp1a3)
RNO: 24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CGE: 100758209(Atp1a3) 100763191(Atp1a4) 100763478 100771378(Atp1a1)
NGI: 103734951(Atp1a1) 103740231(Atp1a2) 103740266(Atp1a4) 103744609(Atp1a3)
HGL: 101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
CCAN: 109681948 109688512(Atp1a3) 109690073(Atp1a4) 109690076
OCU: 100008756(ATP1A2) 100302415(ATP1A1) 100349382(ATP1A3) 100358269(ATP1A4) 103346768
TUP: 102475448(ATP1A3) 102483255(ATP1A2) 102483989 102483994(ATP1A1)
CFA: 403992(ATP1A1) 488636 612463(ATP1A3)
VVP: 112910077 112910081 112916773(ATP1A1) 112931443(ATP1A3)
AML: 100477585(ATP1A3) 100477989(ATP1A1) 100480641(ATP1A2) 100480890(ATP1A4)
UMR: 103669413(ATP1A1) 103672049(ATP1A4) 103672113(ATP1A2) 103680185(ATP1A3)
UAH: 113243247(ATP1A3) 113244381(ATP1A1) 113246653(ATP1A4) 113246737
ORO: 101366083(ATP1A1) 101376936(ATP1A3) 101379349(ATP1A2) 101379646(ATP1A4)
FCA: 101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4) 101096785
PTG: 102954810 102955336(ATP1A3) 102955398 102957431(ATP1A4) 102971148(ATP1A1)
PPAD: 109257219 109257221(ATP1A2) 109257944(ATP1A3) 109261900 109272127(ATP1A1)
AJU: 106969643(ATP1A1) 106978517(ATP1A4) 106985576 106987698(ATP1A3)
BTA: 282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
BOM: 102270922(ATP1A3) 102271837(ATP1A2) 102272122(ATP1A4) 102287260(ATP1A1)
BIU: 109555876(ATP1A1) 109571737(ATP1A3) 109578704(ATP1A4) 109578722
BBUB: 102396896(ATP1A3) 102404308(ATP1A1) 102405290 102405960(ATP1A4)
CHX: 102179588(ATP1A3) 102183561(ATP1A1) 102186069(ATP1A4) 102186539(ATP1A2)
OAS: 101103751(ATP1A3) 101118148(ATP1A2) 101118398 443381(ATP1A1)
SSC: 100157711 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
CFR: 102509736(ATP1A1) 102516053(ATP1A2) 102516646(ATP1A4) 102517975(ATP1A3)
CDK: 105089616(ATP1A1) 105090227(ATP1A3) 105100141(ATP1A2)
BACU: 102998568(ATP1A1) 103005321(ATP1A4) 103005600(ATP1A2) 103011003(ATP1A3)
LVE: 103068908(ATP1A3) 103074614(ATP1A4) 103074894(ATP1A2) 103085693(ATP1A1)
OOR: 101279507(ATP1A1) 101280223(ATP1A3) 101288540(ATP1A4) 101288792(ATP1A2)
DLE: 111166986 111166987 111179983(ATP1A1) 111180802(ATP1A3)
ECB: 100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
EAI: 106835689(ATP1A1) 106835754(ATP1A4) 106835755(ATP1A2) 106847933(ATP1A3)
MYB: 102242637(ATP1A3) 102243691(ATP1A1) 102243972(ATP1A4) 102244267(ATP1A2) 102260737
MYD: 102757270(ATP1A2) 102757556(ATP1A4) 102762810(ATP1A3) 102770472(ATP1A1)
MNA: 107534181(ATP1A3) 107538442(ATP1A2) 107538456 107545330(ATP1A1)
HAI: 109374442 109374464(ATP1A3) 109386454 109386501(ATP1A2) 109392813(ATP1A1)
DRO: 112313776(ATP1A1) 112315807 112317734(ATP1A2) 112320186(ATP1A3)
PALE: 102884868(ATP1A4) 102885125 102888359(ATP1A1) 102893697(ATP1A3)
RAY: 107499819(ATP1A1) 107502600(ATP1A3) 107507459 107507949(ATP1A2) 107507966(ATP1A4)
MJV: 108390973(ATP1A1) 108393642(ATP1A3) 108402828 108402834
LAV: 100661428(ATP1A1) 100667801 100668326(ATP1A3) 100674070(ATP1A2)
MDO: 100029754(ATP1A4) 100029759(ATP1A2)
SHR: 100914130 100918637 100922123(ATP1A3) 100928210(ATP1A1)
PCW: 110203112(ATP1A2) 110203115 110219354(ATP1A1) 110220180(ATP1A3)
OAA: 100083795 100088125(ATP1A3) 100088592(ATP1A1)
GGA: 396530(ATP1A1)
MGP: 100303690(ATP1A1) 104915899
NMEL: 110391860 110399227(ATP1A1)
APLA: 101801864(ATP1A1)
ACYG: 106029333 106037472(ATP1A1)
TGU: 100190719(ATP1A1) 105760330
SCAN: 103827109(ATP1A1)
GFR: 102036467(ATP1A1) 102044935
PHI: 102099305 102104980 102106372(ATP1A1) 102107817(ATP1A2)
PMAJ: 107207264(ATP1A1)
CCW: 104687046(ATP1A1)
ETL: 114055106(ATP1A1) 114073036
FPG: 101914787(ATP1A1) 101915017(ATP1A2)
FCH: 102050259(ATP1A1) 102059303(ATP1A2)
CLV: 102092496(ATP1A1) 102093141
EGZ: 104126505(ATP1A1)
NNI: 104008633(ATP1A1) 104012600(ATP1A2)
PADL: 103921389(ATP1A1)
AAM: 106490649(ATP1A1) 106500059(ATP1A2)
AMJ: 102567591(ATP1A1) 102575084(ATP1A2) 106737151
CMY: 102936217(ATP1A1) 102938341(ATP1A2) 102943620
CPIC: 101931556(ATP1A3) 101933418(ATP1A1) 101934511 101950302(ATP1A2)
PMUR: 107289344(ATP1A1) 107298220 107299011(ATP1A3) 107301816
PMUA: 114585062 114586449 114587332(ATP1A1) 114603364(ATP1A3)
XLA: 108697760 108699431 380132(atp1a3.L) 398583(atp1a1.S) 398752(atp1a2.S) 399285(atp1a1.L)
XTR: 100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 245703(atp1a1a.5) 64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64613(atp1a1a.2) 64614(atp1a1a.3) 64615(atp1a1a.4) 64616(atp1a1b)
LCM: 102346835 102352604(ATP1A2) 102353554(ATP1A1) 102356851(ATP1A3)
SPU: 404637
APLC: 110976714
SKO: 100370816(ATP1A1)
DME: Dmel_CG45062(CG45062) Dmel_CG45760 Dmel_CG5670(Atpalpha)
DSI: Dsimw501_GD19388(Dsim_GD19388) Dsimw501_GD19691(Dsim_GD19691) Dsimw501_GD29095(Dsim_GD29095)
MDE: 101893028
LCQ: 111678276
AAG: 5575790
CLEC: 106667156
CEL: CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2) CELE_Y105E8A.12(catp-1)
CBR: CBG01656 CBG09434(Cbr-eat-6)
BMY: Bm1_51740
CRG: 105338008
MYI: 110459295
OBI: 106880261
EGL: EGR_08003
DGT: 114524594
QSU: 111989924
PIC: PICST_60178(PMR2)
CAL: CAALFM_CR01630CA(CaO19.2552) CAALFM_CR01640CA(CaO19.2553)
SLB: AWJ20_4150(PMR1)
MBE: MBM_04409
ANI: AN8941.2
ANG: ANI_1_1014084(An09g00930) ANI_1_352124(An14g02290)
PTE: PTT_00480
SMIN: v1.2.000245.t1(symbB.v1.2.000245.t1) v1.2.028598.t1(symbB.v1.2.028598.t1)
TCX: Tcr_1065
CYQ: Q91_1618
DAR: Daro_1851
GUR: Gura_3300
GEO: Geob_1849
PCA: Pcar_2279
SAT: SYN_02485
MAC: MA_4378
MBAR: MSBR2_3266
MBAK: MSBR3_3261
MMA: MM_1069
MMAC: MSMAC_0238
METM: MSMTP_0268
MHOR: MSHOH_0294
MBU: Mbur_0431
MPY: Mpsy_0778
 » show all
Taxonomy
Reference
1  [PMID:13412736]
  Authors
SKOU JC.
  Title
The influence of some cations on an adenosine triphosphatase from peripheral nerves.
  Journal
Biochim Biophys Acta 23:394-401 (1957)
DOI:10.1016/0006-3002(57)90343-8
Reference
2  [PMID:14284759]
  Authors
POST RL, SEN AK, ROSENTHAL AS.
  Title
A PHOSPHORYLATED INTERMEDIATE IN ADENOSINE TRIPHOSPHATE-DEPENDENT SODIUM AND POTASSIUM TRANSPORT ACROSS KIDNEY MEMBRANES.
  Journal
J Biol Chem 240:1437-45 (1965)
Reference
3  [PMID:2166689]
  Authors
Skou JC.
  Title
The fourth Datta lecture. The energy coupled exchange of Na+ for K+ across the cell membrane. The Na+, K(+)-pump.
  Journal
FEBS Lett 268:314-24 (1990)
DOI:10.1016/0014-5793(90)81278-V
Reference
4  [PMID:26205423]
  Authors
Castillo JP, Rui H, Basilio D, Das A, Roux B, Latorre R, Bezanilla F, Holmgren M
  Title
Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.
  Journal
Nat Commun 6:7622 (2015)
DOI:10.1038/ncomms8622
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.13
IUBMB Enzyme Nomenclature: 7.2.2.13
ExPASy - ENZYME nomenclature database: 7.2.2.13
BRENDA, the Enzyme Database: 7.2.2.13

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