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Entry
EC 7.2.2.15                 Enzyme                                 

Name
P-type Ag+ transporter;
Ag+-exporting ATPase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (P-type, Ag+-exporting)
Reaction(IUBMB)
ATP + H2O + Ag+[side 1] = ADP + phosphate + Ag+[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Ag+[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Ag+[side 2]
Comment
A P-type ATPase that exports Ag+ ions from some bacteria, archaea as well as from some animal tissues. The proteins also transport Cu+ ions (cf. EC 7.2.2.8, P-type Cu+ transporter).
History
EC 7.2.2.15 created 2000 as EC 3.6.3.53, transferred 2018 to EC 7.2.2.15
Orthology
K23254  P-type Ag+ transporter
Genes
ESO: O3O_24100
ESM: O3M_01590
ESL: O3K_01545
ELH: ETEC_0224
ECV: APECO1_O1R116(silP)
ECK: EC55989_3910(silP)
ECL: EcolC_3420
ELP: P12B_c3605(silP)
SENH: CFSAN002069_14200
SEEC: CFSAN002050_22065
ECLX: LI66_21485
ECLY: LI62_23505
ECLZ: LI64_20590
ESA: ESA_04245
CTU: Ctu_3p00600(silP)
KPN: KPN_pKPN3p05945(silP)
KPU: KP1_p145(silP)
KPJ: N559_5295
KPX: PMK1_a00110(silP)
KPNE: KU54_00340
KPNU: LI86_27195
CAMA: F384_23500
AHN: NCTC12129_00243(silP_1) NCTC12129_00244(silP_2) NCTC12129_00245(silP_3)
 » show all
Taxonomy
Reference
1  [PMID:9930866]
  Authors
Gupta A, Matsui K, Lo JF, Silver S.
  Title
Molecular basis for resistance to silver cations in Salmonella.
  Journal
Nat Med 5:183-8 (1999)
DOI:10.1038/5545
  Sequence
Reference
2  [PMID:10448119]
  Authors
Bury NR, Grosell M, Grover AK, Wood CM.
  Title
ATP-dependent silver transport across the basolateral membrane of rainbow trout gills.
  Journal
Toxicol Appl Pharmacol 159:1-8 (1999)
DOI:10.1006/taap.1999.8706
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.15
IUBMB Enzyme Nomenclature: 7.2.2.15
ExPASy - ENZYME nomenclature database: 7.2.2.15
BRENDA, the Enzyme Database: 7.2.2.15

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